|
US5112739A
(en)
|
1988-08-02 |
1992-05-12 |
Polaroid Corporation |
Enzyme controlled release system
|
|
US5266575A
(en)
|
1991-11-06 |
1993-11-30 |
Minnesota Mining And Manufacturing Company |
2-ethyl 1H-imidazo[4,5-ciquinolin-4-amines
|
|
DE19512484A1
(de)
|
1995-04-04 |
1996-10-17 |
Bayer Ag |
Kohlenhydratmodifizierte Cytostatika
|
|
DK0795334T3
(da)
|
1996-03-12 |
2006-06-06 |
Sanofi Aventis Deutschland |
Nye prodrugs til behandling af tumorer og betændelsessygdomme
|
|
US6218519B1
(en)
|
1996-04-12 |
2001-04-17 |
Pro-Neuron, Inc. |
Compounds and methods for the selective treatment of cancer and bacterial infections
|
|
JP2001505194A
(ja)
|
1996-11-05 |
2001-04-17 |
ブリストル―マイヤーズ・スクイブ・カンパニー |
分枝ペプチド・リンカー
|
|
US6759509B1
(en)
|
1996-11-05 |
2004-07-06 |
Bristol-Myers Squibb Company |
Branched peptide linkers
|
|
WO1999057301A1
(en)
|
1998-04-30 |
1999-11-11 |
Maruha Corporation |
Compounds having glucuronic acid derivatives and glucosamine derivatives in the structure, process for producing the same and utilization thereof
|
|
GB0226593D0
(en)
|
2002-11-14 |
2002-12-24 |
Consultants Ltd |
Compounds
|
|
JP2006510626A
(ja)
|
2002-12-05 |
2006-03-30 |
シエーリング アクチエンゲゼルシャフト |
増殖疾患の処理における部位特異的供給のためのエポチロン類似体
|
|
US7498298B2
(en)
|
2003-11-06 |
2009-03-03 |
Seattle Genetics, Inc. |
Monomethylvaline compounds capable of conjugation to ligands
|
|
JP2007517035A
(ja)
|
2003-12-29 |
2007-06-28 |
スリーエム イノベイティブ プロパティズ カンパニー |
アリールアルケニルおよびアリールアルキニル置換されたイミダゾキノリン
|
|
US20070259881A1
(en)
|
2004-06-18 |
2007-11-08 |
Dellaria Joseph F Jr |
Substituted Imidazo Ring Systems and Methods
|
|
PE20100251A1
(es)
|
2004-09-10 |
2010-04-10 |
Wyeth Corp |
Anticuerpos anti-5t4 humanizados y conjugados anticuerpo anti-5t4/calicheamicina
|
|
WO2006091647A2
(en)
|
2005-02-23 |
2006-08-31 |
Coley Pharmaceutical Group, Inc. |
Method of preferentially inducing the biosynthesis of interferon
|
|
HUE035853T2
(en)
|
2005-07-18 |
2018-05-28 |
Seattle Genetics Inc |
Beta-glucuronide-linker-drug conjugates
|
|
CN101287500A
(zh)
|
2005-08-19 |
2008-10-15 |
恩多塞特公司 |
多药物配体缀合物
|
|
TW200815474A
(en)
|
2006-08-03 |
2008-04-01 |
Astrazeneca Ab |
Antibodies alphaVbeta6 and uses thereof
|
|
JP2010503706A
(ja)
|
2006-09-15 |
2010-02-04 |
エンゾン ファーマスーティカルズ インコーポレイテッド |
リジン系ポリマーリンカー
|
|
CN101573384B
(zh)
|
2006-10-27 |
2013-02-20 |
健泰科生物技术公司 |
抗体和免疫偶联物及其用途
|
|
CN103073641B
(zh)
|
2006-11-10 |
2015-01-21 |
株式会社立富泰克 |
在体内具有抗肿瘤活性的抗人Dlk-1抗体
|
|
CL2007003622A1
(es)
|
2006-12-13 |
2009-08-07 |
Medarex Inc |
Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales.
|
|
WO2009016647A1
(en)
*
|
2007-08-01 |
2009-02-05 |
Council Of Scientific & Industrial Research |
Pyrrolo [2,1-c][1, 4] benzodiazepine-glycoside prodrugs useful as a selective anti tumor agent
|
|
MX2010003718A
(es)
|
2007-10-19 |
2010-04-21 |
Genentech Inc |
Anticuerpos anti-tenb2 producidos por ingenieria de cisteina y conjugados de farmaco y anticuerpo.
|
|
ES2527521T3
(es)
|
2008-03-17 |
2015-01-26 |
Livtech Inc. |
Anticuerpos antihumanos frente a Dlk-1 que tienen actividad antitumoral
|
|
ES2667054T3
(es)
|
2008-03-24 |
2018-05-09 |
Biontech Ag |
Nuevas imidazoquinolinas sustituidas
|
|
GB0819097D0
(en)
|
2008-10-17 |
2008-11-26 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
WO2010124188A1
(en)
|
2009-04-23 |
2010-10-28 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Anti-human ror1 antibodies
|
|
US9353140B2
(en)
|
2009-11-25 |
2016-05-31 |
Academia Sinica |
BQC-G, a tumor-selective anti-cancer prodrug
|
|
KR20110075542A
(ko)
|
2009-12-28 |
2011-07-06 |
주식회사 효성 |
연료전지 시스템의 워터트랩 장치
|
|
DK2528625T3
(da)
|
2010-04-15 |
2013-10-14 |
Spirogen Sarl |
Pyrrolobenzodiazepiner og konjugater deraf
|
|
US8697688B2
(en)
|
2010-04-15 |
2014-04-15 |
Seattle Genetics Inc. |
Pyrrolobenzodiazepines used to treat proliferative diseases
|
|
FR2960153B1
(fr)
|
2010-05-20 |
2012-08-17 |
Centre Nat Rech Scient |
Nouveaux bras autoreactifs et prodrogues les comprenant
|
|
US9591882B2
(en)
|
2010-08-05 |
2017-03-14 |
Robert LaGrand Duffin |
Absorbent sleeve
|
|
EP3828205A1
(en)
|
2010-10-01 |
2021-06-02 |
Oxford BioTherapeutics Ltd |
Anti-ror1 antibodies
|
|
GB201020995D0
(en)
|
2010-12-10 |
2011-01-26 |
Bioinvent Int Ab |
Biological materials and uses thereof
|
|
KR20120107741A
(ko)
|
2011-03-22 |
2012-10-04 |
한국생명공학연구원 |
패혈증 단백질 치료제의 효능 분석 및 스크리닝 방법
|
|
KR101438265B1
(ko)
|
2011-04-04 |
2014-09-05 |
한국생명공학연구원 |
Dlk1 특이적 인간 항체 및 이를 포함하는 약학적 조성물
|
|
WO2012138102A2
(ko)
|
2011-04-04 |
2012-10-11 |
한국생명공학연구원 |
Dlk1 특이적 인간 항체 및 이를 포함하는 약학적 조성물
|
|
WO2012148427A1
(en)
|
2011-04-29 |
2012-11-01 |
Hewlett-Packard Development Company, L.P. |
Systems and methods for in-memory processing of events
|
|
HUE045348T2
(hu)
|
2011-05-08 |
2019-12-30 |
Legochem Biosciences Inc |
Fehérje-hatóanyag konjugátumok és eljárás elõállításukra
|
|
ES2945932T3
(es)
|
2011-10-14 |
2023-07-10 |
Seagen Inc |
Pirrolobenzodiazepinas y conjugados dirigidos
|
|
JP6228551B2
(ja)
|
2012-01-03 |
2017-11-08 |
インビクタス オンコロジー プライベート リミテッド |
リガンド−標的指向分子およびその方法
|
|
CA2871172C
(en)
|
2012-04-30 |
2020-08-25 |
Spirogen Sarl |
Pyrrolobenzodiazepines
|
|
US10751346B2
(en)
|
2012-10-12 |
2020-08-25 |
Medimmune Limited |
Pyrrolobenzodiazepine—anti-PSMA antibody conjugates
|
|
CN105189507A
(zh)
|
2012-12-21 |
2015-12-23 |
斯皮罗根有限公司 |
吡咯并苯并二氮杂卓及其结合物
|
|
CA2905181C
(en)
*
|
2013-03-13 |
2020-06-02 |
Medimmune Limited |
Pyrrolobenzodiazepines and conjugates thereof for providing targeted therapy
|
|
KR20220041957A
(ko)
|
2013-03-15 |
2022-04-01 |
아비에 도이치란트 게엠베하 운트 콤파니 카게 |
항-egfr 항체 약물 접합체 제형
|
|
WO2014194030A2
(en)
|
2013-05-31 |
2014-12-04 |
Immunogen, Inc. |
Conjugates comprising cell-binding agents and cytotoxic agents
|
|
GB201317982D0
(en)
|
2013-10-11 |
2013-11-27 |
Spirogen Sarl |
Pyrrolobenzodiazepines and conjugates thereof
|
|
WO2015052533A1
(en)
*
|
2013-10-11 |
2015-04-16 |
Spirogen Sàrl |
Pyrrolobenzodiazepine-antibody conjugates
|
|
ES2826398T3
(es)
|
2013-10-15 |
2021-05-18 |
Seagen Inc |
Enlazadores-fármacos pegilados para una mejor farmacocinética de los conjugados ligando-fármaco
|
|
WO2015079376A1
(en)
|
2013-11-26 |
2015-06-04 |
Novartis Ag |
Methods for oxime conjugation to ketone-modified polypeptides
|
|
JP6701077B2
(ja)
|
2013-12-19 |
2020-05-27 |
シアトル ジェネティックス, インコーポレイテッド |
標的化薬物結合体と使用するためのメチレンカルバメートリンカー
|
|
EP2913064A1
(en)
|
2014-02-26 |
2015-09-02 |
celares GmbH |
Branched drug-linker conjugates for the coupling to biological targeting molecules
|
|
KR101628872B1
(ko)
|
2014-05-28 |
2016-06-09 |
주식회사 레고켐 바이오사이언스 |
자가-희생 기를 포함하는 화합물
|
|
TWI805109B
(zh)
|
2014-08-28 |
2023-06-11 |
美商奇諾治療有限公司 |
對cd19具專一性之抗體及嵌合抗原受體
|
|
SI3900742T1
(sl)
|
2014-09-11 |
2024-10-30 |
Seagen Inc. |
Ciljana dostava zdravilnih snovi, ki vsebujejo terciarne amine
|
|
KR102111983B1
(ko)
|
2014-10-24 |
2020-05-18 |
주식회사 소니 인터랙티브 엔터테인먼트 |
제어 장치, 제어 방법, 및 정보 기억 매체
|
|
WO2016063595A1
(ja)
|
2014-10-24 |
2016-04-28 |
ソニー株式会社 |
画像処理装置、画像処理方法及びプログラム
|
|
BR112017012342A2
(pt)
|
2014-12-09 |
2018-02-27 |
Abbvie Inc |
compostos inibitórios de bcl-xl e conjugados de anticorpo-fármaco incluindo os mesmos
|
|
KR20160080832A
(ko)
|
2014-12-29 |
2016-07-08 |
주식회사 레고켐 바이오사이언스 |
리피바디 유도체-약물 복합체, 그 제조방법 및 용도
|
|
EP3244926B8
(en)
|
2015-01-14 |
2024-08-21 |
The Brigham and Women's Hospital, Inc. |
Treatment of cancer with anti-lap monoclonal antibodies
|
|
JP6865688B2
(ja)
|
2015-01-16 |
2021-04-28 |
ジュノー セラピューティクス インコーポレイテッド |
Ror1に特異的な抗体およびキメラ抗原受容体
|
|
HUE055644T2
(hu)
|
2015-01-30 |
2022-03-28 |
Sutro Biopharma Inc |
Hemiasterlin származékok konjugációra és terápiára
|
|
US11673957B2
(en)
|
2015-03-10 |
2023-06-13 |
Eureka Therapeutics, Inc. |
Anti-ROR2 antibodies
|
|
EP3842072A1
(en)
|
2015-05-18 |
2021-06-30 |
Eureka Therapeutics, Inc. |
Anti-ror1 antibodies
|
|
WO2017051254A1
(en)
|
2015-09-25 |
2017-03-30 |
Legochem Biosciences, Inc. |
Compositions and methods related to anti-egfr antibody drug conjugates
|
|
WO2017051249A1
(en)
|
2015-09-25 |
2017-03-30 |
Legochem Biosciences, Inc. |
Compositions and methods related to anti-cd19 antibody drug conjugates
|
|
IL299203A
(en)
|
2015-10-13 |
2023-02-01 |
Eureka Therapeutics Inc ׂ A Delaware Corp |
Antibody factors specific for human differentiation group 19 and their uses
|
|
KR102847350B1
(ko)
|
2015-11-25 |
2025-08-19 |
주식회사 리가켐바이오사이언스 |
분지된 링커를 포함하는 항체-약물 접합체 및 이의 제조방법
|
|
AU2016359234B2
(en)
|
2015-11-25 |
2022-09-08 |
Ligachem Biosciences Inc. |
Conjugates comprising peptide groups and methods related thereto
|
|
HRP20240795T1
(hr)
|
2015-11-25 |
2024-09-13 |
Ligachem Biosciences Inc. |
Konjugati koji se sastoje od samozapaljujućih skupina i postupci povezani s njima
|
|
RU2651776C2
(ru)
|
2015-12-01 |
2018-04-23 |
Общество с ограниченной ответственностью "Международный биотехнологический центр "Генериум" ("МБЦ "Генериум") |
Биспецифические антитела против cd3*cd19
|
|
SG11201806120WA
(en)
|
2016-01-20 |
2018-08-30 |
Scripps Research Inst |
Ror1 antibody compositions and related methods
|
|
MA43821A
(fr)
|
2016-03-14 |
2018-11-28 |
Afferent Pharmaceuticals Inc |
Pyrimidines et variantes de celles-ci, et leurs utilisations
|
|
HRP20220936T1
(hr)
|
2016-04-07 |
2022-10-28 |
Glaxosmithkline Intellectual Property Development Limited |
Heterociklički amidi korisni kao modulatori proteina
|
|
WO2017181128A1
(en)
|
2016-04-15 |
2017-10-19 |
Dynavax Technologies Corporation |
Intratumoral administration of particles containing a toll-like receptor 9 agonist and a tumor antigen for treating cancer
|
|
GB201617466D0
(en)
|
2016-10-14 |
2016-11-30 |
Medimmune Ltd |
Pyrrolobenzodiazepine conjugates
|
|
EP3535299A1
(en)
|
2016-11-04 |
2019-09-11 |
Novimmune S.A. |
Anti-cd19 antibodies and methods of use thereof
|
|
TWI822055B
(zh)
|
2016-11-21 |
2023-11-11 |
台灣浩鼎生技股份有限公司 |
共軛生物分子、醫藥組成物及方法
|
|
WO2018119314A1
(en)
|
2016-12-22 |
2018-06-28 |
Ardeagen Corporation |
Anti-ror1 antibody and conjugates thereof
|
|
SI3579883T1
(sl)
|
2017-02-08 |
2021-12-31 |
Adc Therapeutics Sa |
Konjugati pirolobenzodiazepin-protitelo
|
|
MX2019011655A
(es)
|
2017-03-29 |
2019-12-19 |
Legochem Biosciences Inc |
Profarmaco de dimero de pirrolobenzodiazepina y compuesto conjugado ligando-conector de este.
|
|
WO2018182341A1
(ko)
|
2017-03-29 |
2018-10-04 |
주식회사 레고켐 바이오사이언스 |
피롤로벤조디아제핀 이량체 전구체 및 이의 리간드-링커 접합체 화합물
|
|
AR113224A1
(es)
|
2017-04-28 |
2020-02-19 |
Novartis Ag |
Conjugados de anticuerpo que comprenden un agonista de sting
|
|
MX2019015057A
(es)
|
2017-06-23 |
2020-08-03 |
Velosbio Inc |
Inmunoconjugados de anticuerpos receptor huérfano similar al receptor tirosina cinasa 1 (ror1).
|
|
KR20190018400A
(ko)
|
2017-08-14 |
2019-02-22 |
주식회사 레고켐 바이오사이언스 |
EGFRvIII에 대한 항체를 포함하는 항체 약물 접합체
|
|
KR102125032B1
(ko)
|
2017-09-08 |
2020-06-19 |
주식회사 와이바이오로직스 |
인간 dlk1에 대한 항체 및 이의 용도
|
|
WO2019051489A1
(en)
|
2017-09-11 |
2019-03-14 |
Sperovie Biosciences, Inc. |
COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISEASE
|
|
EP3717021A1
(en)
|
2017-11-27 |
2020-10-07 |
Mersana Therapeutics, Inc. |
Pyrrolobenzodiazepine antibody conjugates
|
|
EP3725798B1
(en)
|
2017-12-15 |
2026-03-04 |
Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. |
Bioactive conjugate, preparation method therefor and use thereof
|
|
JP7459063B2
(ja)
|
2018-05-09 |
2024-04-01 |
レゴケム バイオサイエンシズ, インク. |
抗-cd19抗体薬物複合体に関連する組成物および方法
|
|
WO2019225777A1
(ko)
|
2018-05-23 |
2019-11-28 |
에이비엘바이오 주식회사 |
항-ror1 항체 및 그 용도
|
|
ES2929415T3
(es)
|
2018-05-25 |
2022-11-29 |
Incyte Corp |
Compuestos heterocíclicos tricíclicos como activadores de STING
|
|
WO2019243825A1
(en)
|
2018-06-21 |
2019-12-26 |
Curadev Pharma Limited |
Small molecule modulators of human sting, conjugates and therapeutic applications
|
|
CN110903395A
(zh)
|
2018-09-14 |
2020-03-24 |
四川科伦博泰生物医药股份有限公司 |
抗体、偶联物及其制备方法和用途
|
|
WO2020092617A1
(en)
|
2018-10-31 |
2020-05-07 |
Novartis Ag |
Dc-sign antibody conjugates comprising sting agonists
|
|
KR20200084802A
(ko)
|
2019-01-03 |
2020-07-13 |
주식회사 레고켐 바이오사이언스 |
안전성이 향상된 피롤로벤조디아제핀 이량체 화합물 및 이의 용도
|
|
EP3936150A4
(en)
|
2019-03-06 |
2023-03-29 |
LegoChem Biosciences, Inc. |
ANTIBODY-DRUG CONJUGATES COMPRISING ANTIBODY AGAINST HUMAN DLK1 AND USE THEREOF
|
|
WO2020249773A1
(en)
|
2019-06-12 |
2020-12-17 |
Ryvu Therapeutics S.A. |
Next-generation modulators of stimulator of interferon genes (sting)
|
|
LT4004002T
(lt)
|
2019-07-22 |
2024-10-25 |
Lupin Limited |
Makrocikliniai junginiai kaip sting agonistai ir jų naudojimo būdai bei metodai
|
|
CA3149482A1
(en)
|
2019-08-02 |
2021-02-11 |
Mersana Therapeutics, Inc. |
Bis-[n-((5-carbamoyl)-1h-benzo[d]imidazol-2-yl)-pyrazol-5-carboxamide] derivatives and related compounds as sting (stimulator of interferon genes) agonists for the treatment of cancer
|
|
KR20210028544A
(ko)
|
2019-09-04 |
2021-03-12 |
주식회사 레고켐 바이오사이언스 |
인간 ror1에 대한 항체를 포함하는 항체 약물 접합체 및 이의 용도
|
|
WO2021046426A1
(en)
|
2019-09-06 |
2021-03-11 |
Sperovie Biosciences, Inc. |
Cyclic dinucleotide sting agonists tethered to a pd-1 or ctla-4 antibodies
|
|
US11184191B1
(en)
|
2019-09-12 |
2021-11-23 |
Trend Micro Incorporated |
Inspection of network traffic on accelerated platforms
|
|
WO2022086853A1
(en)
|
2020-10-19 |
2022-04-28 |
Avidea Technologies, Inc. |
Star polymer drug conjugates
|
|
JP2024501894A
(ja)
|
2021-01-04 |
2024-01-16 |
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