JP2025037925A5 - - Google Patents

Info

Publication number
JP2025037925A5
JP2025037925A5 JP2024203859A JP2024203859A JP2025037925A5 JP 2025037925 A5 JP2025037925 A5 JP 2025037925A5 JP 2024203859 A JP2024203859 A JP 2024203859A JP 2024203859 A JP2024203859 A JP 2024203859A JP 2025037925 A5 JP2025037925 A5 JP 2025037925A5
Authority
JP
Japan
Prior art keywords
alkyl
compound
haloalkyl
pharmaceutically acceptable
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024203859A
Other languages
English (en)
Japanese (ja)
Other versions
JP2025037925A (ja
Filing date
Publication date
Priority claimed from JP2021535755A external-priority patent/JP7721052B2/ja
Application filed filed Critical
Publication of JP2025037925A publication Critical patent/JP2025037925A/ja
Publication of JP2025037925A5 publication Critical patent/JP2025037925A5/ja
Pending legal-status Critical Current

Links

JP2024203859A 2018-12-21 2024-11-22 協同的結合に関与する化合物及びその使用 Pending JP2025037925A (ja)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201862783816P 2018-12-21 2018-12-21
US62/783,816 2018-12-21
US201962894493P 2019-08-30 2019-08-30
US62/894,493 2019-08-30
US201962930489P 2019-11-04 2019-11-04
US62/930,489 2019-11-04
JP2021535755A JP7721052B2 (ja) 2018-12-21 2019-12-20 協同的結合に関与する化合物及びその使用
PCT/US2019/068100 WO2020132597A1 (en) 2018-12-21 2019-12-20 Compounds that participate in cooperative binding and uses thereof

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2021535755A Division JP7721052B2 (ja) 2018-12-21 2019-12-20 協同的結合に関与する化合物及びその使用

Publications (2)

Publication Number Publication Date
JP2025037925A JP2025037925A (ja) 2025-03-18
JP2025037925A5 true JP2025037925A5 (https=) 2025-10-08

Family

ID=71099011

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021535755A Active JP7721052B2 (ja) 2018-12-21 2019-12-20 協同的結合に関与する化合物及びその使用
JP2024203859A Pending JP2025037925A (ja) 2018-12-21 2024-11-22 協同的結合に関与する化合物及びその使用

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2021535755A Active JP7721052B2 (ja) 2018-12-21 2019-12-20 協同的結合に関与する化合物及びその使用

Country Status (14)

Country Link
US (2) US20200197391A1 (https=)
EP (1) EP3897644A4 (https=)
JP (2) JP7721052B2 (https=)
KR (1) KR20210116479A (https=)
CN (1) CN113498342A (https=)
AU (2) AU2019401466B2 (https=)
BR (1) BR112021012057A2 (https=)
CA (1) CA3123869A1 (https=)
IL (2) IL284210B2 (https=)
MX (2) MX2021007468A (https=)
SA (1) SA521422304B1 (https=)
SG (1) SG11202106605VA (https=)
TW (1) TW202600561A (https=)
WO (1) WO2020132597A1 (https=)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201629069A (zh) * 2015-01-09 2016-08-16 霍普驅動生物科技股份有限公司 參與協同結合之化合物及其用途
EP4302834A3 (en) 2016-07-12 2024-07-17 Revolution Medicines, Inc. 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors
JP7240319B2 (ja) 2017-01-23 2023-03-15 レヴォリューション・メディスンズ,インコーポレイテッド アロステリックshp2阻害剤としての二環式化合物
KR20190110588A (ko) 2017-01-23 2019-09-30 레볼루션 메디슨즈, 인크. 알로스테릭 shp2 억제제로서의 피리딘 화합물
TW201930292A (zh) 2017-10-12 2019-08-01 美商銳新醫藥公司 作為變構shp2抑制劑的吡啶、吡嗪和三嗪化合物
JP7361693B2 (ja) 2017-12-15 2023-10-16 レヴォリューション・メディスンズ,インコーポレイテッド アロステリックshp2阻害剤としての多環式化合物
BR112021012057A2 (pt) * 2018-12-21 2021-10-19 Revolution Medicines, Inc. Compostos que participam de ligação cooperativa e usos dos mesmos
AU2020377925A1 (en) 2019-11-04 2022-05-05 Revolution Medicines, Inc. Ras inhibitors
TW202132316A (zh) * 2019-11-04 2021-09-01 美商銳新醫藥公司 Ras抑制劑
IL322454A (en) * 2019-11-04 2025-09-01 Revolution Medicines Inc ras inhibitors
US20210322405A1 (en) * 2020-04-15 2021-10-21 Washington University Compositions and methods for treating cancer
IL299131A (en) 2020-06-18 2023-02-01 Revolution Medicines Inc Methods for delaying, preventing and treating acquired resistance to RAS inhibitors
US20250195521A1 (en) 2020-09-03 2025-06-19 Revolution Medicines, Inc. Use of sos1 inhibitors to treat malignancies with shp2 mutations
CA3194067A1 (en) 2020-09-15 2022-03-24 Revolution Medicines, Inc. Ras inhibitors
WO2022133037A1 (en) * 2020-12-17 2022-06-23 Blossomhill Therapeutics, Inc. Macrocycles and their use
CN116635076A (zh) * 2020-12-17 2023-08-22 荣山医药股份有限公司 大环化合物及其用途
MX2023011608A (es) * 2021-04-02 2023-12-14 Massachusetts Gen Hospital Metodos para inhibir ras.
US20240217960A1 (en) * 2021-04-09 2024-07-04 Universität Basel Triazine derivative as covalent inhibitors of pi3k
KR20240017811A (ko) * 2021-05-05 2024-02-08 레볼루션 메디슨즈, 인크. 암의 치료를 위한 ras 억제제
JP2024516450A (ja) 2021-05-05 2024-04-15 レボリューション メディシンズ インコーポレイテッド 共有結合性ras阻害剤及びその使用
TW202309052A (zh) 2021-05-05 2023-03-01 美商銳新醫藥公司 Ras抑制劑
AU2022281343A1 (en) 2021-05-25 2023-11-30 Revolution Medicines, Inc. Methods for inhibiting ras
US12280055B2 (en) 2021-05-27 2025-04-22 Mirati Therapeutics, Inc. Combination therapies
WO2023015559A1 (en) * 2021-08-13 2023-02-16 Nutshell Biotech (Shanghai) Co., Ltd. Macrocycle compounds as inhibitors of ras
AR126854A1 (es) 2021-08-27 2023-11-22 Hoffmann La Roche Compuestos macrocíclicos para el tratamiento de cáncer
AR127308A1 (es) 2021-10-08 2024-01-10 Revolution Medicines Inc Inhibidores ras
CN119212994A (zh) 2021-12-17 2024-12-27 建新公司 作为shp2抑制剂的吡唑并吡嗪化合物
EP4227307A1 (en) 2022-02-11 2023-08-16 Genzyme Corporation Pyrazolopyrazine compounds as shp2 inhibitors
JP2025510572A (ja) 2022-03-08 2025-04-15 レボリューション メディシンズ インコーポレイテッド 免疫不応性肺癌を治療するための方法
CN119156393A (zh) * 2022-04-25 2024-12-17 翰森生物有限责任公司 环状化合物及其制备方法和医药用途
JP2025519199A (ja) 2022-06-01 2025-06-24 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト がんの治療のためのハロインドール大環状化合物
WO2023240263A1 (en) 2022-06-10 2023-12-14 Revolution Medicines, Inc. Macrocyclic ras inhibitors
EP4582426A4 (en) * 2022-09-19 2025-12-24 Adlai Nortye Biopharma Co Ltd PAN-KRAS INHIBITOR COMPOUND
KR20250085767A (ko) 2022-09-29 2025-06-12 광조우 조요 파마테크 컴퍼니 리미티드 거대고리 유도체 및 이의 적용
WO2024153028A1 (zh) * 2023-01-20 2024-07-25 深圳晶蛋生物医药科技有限公司 大环类化合物、其药物组合物及其应用
CN120813588A (zh) 2023-02-14 2025-10-17 豪夫迈·罗氏有限公司 用于治疗癌症的三环化合物
AU2024241633A1 (en) 2023-03-30 2025-11-06 Revolution Medicines, Inc. Compositions for inducing ras gtp hydrolysis and uses thereof
AR132338A1 (es) 2023-04-07 2025-06-18 Revolution Medicines Inc Inhibidores de ras
CR20250420A (es) 2023-04-07 2025-11-20 Revolution Medicines Inc Inhibidores macrocíclicos de ras
CN121464140A (zh) 2023-04-14 2026-02-03 锐新医药公司 Ras抑制剂的结晶形式、含有其的组合物及其使用方法
CN121100123A (zh) 2023-04-14 2025-12-09 锐新医药公司 Ras抑制剂的结晶形式
CN116284045A (zh) * 2023-05-18 2023-06-23 西南交通大学 一种手性吲哚单元取代的四氢异喹啉化合物及其合成方法
KR20260027943A (ko) * 2023-05-26 2026-03-03 레볼루션 메디슨즈, 인크. Ras 억제제
CN116570599B (zh) * 2023-07-04 2023-10-20 四川大学华西医院 Vs6766联合ly3009120的应用及药物组合物
US20250049810A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
AU2024360465A1 (en) 2023-10-12 2026-04-09 Revolution Medicines, Inc. Macrocyclic ras inhibitors
WO2025090809A1 (en) * 2023-10-25 2025-05-01 Kumquat Biosciences Inc. Macrocyclic heterocycles and uses thereof
CN117567483B (zh) * 2023-11-23 2025-10-21 济南市中心医院 一种通过金催化的不对称环加成反应及动力学拆分合成手性氮杂八元环类化合物的方法
WO2025162395A1 (zh) * 2024-02-01 2025-08-07 山东先声生物制药有限公司 吲哚衍生物作为ras抑制剂及其应用
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025214350A1 (en) * 2024-04-08 2025-10-16 Sunrise Oncology (Hong Kong) Limited Macrocyclic compounds as ras inhibitors for the treatment of cancer
WO2025217307A1 (en) 2024-04-09 2025-10-16 Revolution Medicines, Inc. Methods for predicting response to a ras(on) inhibitor and combination therapies
TW202547461A (zh) 2024-05-17 2025-12-16 美商銳新醫藥公司 Ras抑制劑
WO2025255438A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026050446A1 (en) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Ras inhibitors
WO2026046393A1 (zh) * 2024-09-02 2026-03-05 山东先声再明生物制药有限公司 吲哚类衍生物的制备及其应用
WO2026072904A2 (en) 2024-09-26 2026-04-02 Revolution Medicines, Inc. Compositions and methods for treating lung cancer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7601852B2 (en) * 2006-05-11 2009-10-13 Kosan Biosciences Incorporated Macrocyclic kinase inhibitors
US9119853B2 (en) * 2010-02-09 2015-09-01 Neurovive Pharmaceutical Ab Sanglifehrin based compounds
PL2710018T3 (pl) * 2011-05-19 2022-04-04 Fundación Del Sector Público Estatal Centro Nacional De Investigaciones Oncológicas Carlos III (F.S.P. CNIO) Związki makrocykliczne jako inhibitory kinaz białkowych
AR091279A1 (es) * 2012-06-08 2015-01-21 Gilead Sciences Inc Inhibidores macrociclicos de virus flaviviridae
IL269779B2 (en) * 2017-04-05 2026-04-01 Revolution Medicines Inc Methods and reagents for the analysis of protein-protein interfaces
BR112021012057A2 (pt) * 2018-12-21 2021-10-19 Revolution Medicines, Inc. Compostos que participam de ligação cooperativa e usos dos mesmos

Similar Documents

Publication Publication Date Title
JP2025037925A5 (https=)
JP2013542218A5 (https=)
JP2007523139A5 (https=)
RU2013116924A (ru) N1/n2-лактамные ингибиторы ацетил-коа-карбоксилаз
JP2019104748A5 (https=)
JP2021513534A5 (https=)
JP2015510886A5 (https=)
JP2008523069A5 (https=)
JP2009536221A5 (https=)
JP2010529036A5 (https=)
JP2010501478A5 (https=)
JP2014500861A5 (https=)
JP2012149045A5 (ja) ベンゾ[b]ナフト[1,2−d]フラン化合物
RU2014140735A (ru) ПРОИЗВОДНЫЕ ПИРАЗОЛО[1, 5-a]ПИРИМИДИНА, КОМПОЗИЦИИ, СОДЕРЖАЩИЕ УКАЗАННЫЕ СОЕДИНЕНИЯ, И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
JP2018135343A5 (https=)
JP2009529540A5 (https=)
JP2011037841A5 (https=)
JP2010510976A5 (https=)
JP2008515852A5 (https=)
CA2679232A1 (en) Substituted 4-aryl-1,4-dihydro-1,6-naphthyridinamides and use thereof
JP2006505543A5 (https=)
JP2015501820A5 (https=)
JP2007508362A5 (https=)
NO20080738L (no) Fremgangsmater for neurobeskyttelse
RU2017144050A (ru) Способ синтеза производных рапамицина