JP2024105360A5 - - Google Patents
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- JP2024105360A5 JP2024105360A5 JP2024071962A JP2024071962A JP2024105360A5 JP 2024105360 A5 JP2024105360 A5 JP 2024105360A5 JP 2024071962 A JP2024071962 A JP 2024071962A JP 2024071962 A JP2024071962 A JP 2024071962A JP 2024105360 A5 JP2024105360 A5 JP 2024105360A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formula
- compound
- nhc
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361792812P | 2013-03-15 | 2013-03-15 | |
| US61/792,812 | 2013-03-15 | ||
| JP2019032014A JP6936823B2 (ja) | 2013-03-15 | 2019-02-25 | 抗癌活性及び抗増殖活性を呈する２−アミノピリミジン−６−オン及び類似体 |
| JP2021138625A JP7169412B2 (ja) | 2013-03-15 | 2021-08-27 | 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体 |
| JP2022173722A JP7536064B2 (ja) | 2013-03-15 | 2022-10-28 | 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022173722A Division JP7536064B2 (ja) | 2013-03-15 | 2022-10-28 | 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024105360A JP2024105360A (ja) | 2024-08-06 |
| JP2024105360A5 true JP2024105360A5 (https=) | 2025-01-21 |
Family
ID=51529950
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503185A Active JP6165314B2 (ja) | 2013-03-15 | 2014-03-14 | 抗癌活性及び抗増殖活性を呈する２−アミノピリミジン−６−オン及び類似体 |
| JP2017120849A Pending JP2017193567A (ja) | 2013-03-15 | 2017-06-20 | 抗癌活性及び抗増殖活性を呈する２−アミノピリミジン−６−オン及び類似体 |
| JP2019032014A Active JP6936823B2 (ja) | 2013-03-15 | 2019-02-25 | 抗癌活性及び抗増殖活性を呈する２−アミノピリミジン−６−オン及び類似体 |
| JP2021138625A Active JP7169412B2 (ja) | 2013-03-15 | 2021-08-27 | 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体 |
| JP2022173722A Active JP7536064B2 (ja) | 2013-03-15 | 2022-10-28 | 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体 |
| JP2024071962A Pending JP2024105360A (ja) | 2013-03-15 | 2024-04-25 | 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体 |
Family Applications Before (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503185A Active JP6165314B2 (ja) | 2013-03-15 | 2014-03-14 | 抗癌活性及び抗増殖活性を呈する２−アミノピリミジン−６−オン及び類似体 |
| JP2017120849A Pending JP2017193567A (ja) | 2013-03-15 | 2017-06-20 | 抗癌活性及び抗増殖活性を呈する２−アミノピリミジン−６−オン及び類似体 |
| JP2019032014A Active JP6936823B2 (ja) | 2013-03-15 | 2019-02-25 | 抗癌活性及び抗増殖活性を呈する２−アミノピリミジン−６−オン及び類似体 |
| JP2021138625A Active JP7169412B2 (ja) | 2013-03-15 | 2021-08-27 | 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体 |
| JP2022173722A Active JP7536064B2 (ja) | 2013-03-15 | 2022-10-28 | 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9181223B2 (https=) |
| EP (1) | EP2968286B1 (https=) |
| JP (6) | JP6165314B2 (https=) |
| KR (5) | KR20240013846A (https=) |
| CN (2) | CN105120864B (https=) |
| AU (5) | AU2014233411B2 (https=) |
| BR (1) | BR112015022288B1 (https=) |
| CA (1) | CA2903285C (https=) |
| DK (1) | DK2968286T3 (https=) |
| ES (1) | ES2651165T3 (https=) |
| IL (4) | IL241000B (https=) |
| MX (1) | MX365574B (https=) |
| NL (1) | NL301373I2 (https=) |
| PH (1) | PH12015502114B1 (https=) |
| PT (1) | PT2968286T (https=) |
| RU (1) | RU2015143717A (https=) |
| SG (1) | SG11201507660TA (https=) |
| WO (1) | WO2014145025A2 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| CA2903285C (en) * | 2013-03-15 | 2021-05-11 | Deciphera Pharmaceuticals, Llc | 2-aminopyrimidin-6-ones and analogs exhibiting anti-cancer and anti-proliferative activities |
| AR109179A1 (es) | 2016-08-19 | 2018-11-07 | Pfizer | Inhibidores de diacilglicerol aciltransferasa 2 |
| EP3632906B1 (en) * | 2017-05-24 | 2023-12-13 | Abbisko Therapeutics Co., Ltd. | Azaaryl derivative, preparation method therefor, and application thereof for use in pharmacy |
| US11180495B2 (en) | 2017-06-19 | 2021-11-23 | Abbisko Therapeutics Co., Ltd. | Nitrogen heteroaryl derivative having CSF1R inhibitory activity, and preparation method therefor and application thereof |
| IL276398B2 (en) | 2018-01-31 | 2026-03-01 | Deciphera Pharmaceuticals Llc | Combination therapy for mastocytosis |
| KR102708177B1 (ko) | 2018-01-31 | 2024-09-23 | 데시페라 파마슈티칼스, 엘엘씨. | 위장관 기질 종양의 치료를 위한 병용 요법 |
| CN110845476B (zh) * | 2018-08-21 | 2022-11-18 | 上海和誉生物医药科技有限公司 | 一种高选择性csf1r抑制剂、其制备方法和在药学上的应用 |
| SMT202500389T1 (it) | 2018-12-28 | 2025-11-10 | Deciphera Pharmaceuticals Llc | Inibitori di csf1r per l'uso nel trattamento di tumori tenosinoviali a cellule giganti |
| EP3938363A1 (en) | 2019-03-11 | 2022-01-19 | Teva Pharmaceuticals International GmbH | Solid state forms of ripretinib |
| MX2021013662A (es) | 2019-05-10 | 2022-03-11 | Deciphera Pharmaceuticals Llc | Inhibidores de la autofagia de heteroarilaminopirimidina amida y metodos de uso de estos. |
| EP3966207B1 (en) | 2019-05-10 | 2023-11-01 | Deciphera Pharmaceuticals, LLC | Phenylaminopyrimidine amide autophagy inhibitors and methods of use thereof |
| IL325201A (en) | 2019-06-17 | 2026-02-01 | Deciphera Pharmaceuticals Llc | Aminopyrimidine amide autophagy inhibitors and methods of using them |
| LT4013412T (lt) | 2019-08-12 | 2026-03-25 | Deciphera Pharmaceuticals, Llc | Ripretinibas, skirtas virškinamojo trakto stromos navikų gydymui |
| PT4013412T (pt) | 2019-08-12 | 2026-03-18 | Deciphera Pharmaceuticals Llc | Ripretinib para o tratamento de tumores estromais gastrointestinais |
| CN115243681B (zh) | 2019-12-30 | 2024-08-16 | 德西费拉制药有限责任公司 | 1-(4-溴-5-(1-乙基-7-(甲氨基)-2-侧氧基-1,2-二氢-1,6-萘啶-3-基)-2-氟苯基)-3-苯基脲的组合物 |
| HRP20231699T1 (hr) | 2019-12-30 | 2024-05-10 | Deciphera Pharmaceuticals, Llc | Formulacije inhibitora amorfne kinaze i postupci njihove primjene |
| MX2023005747A (es) | 2020-11-18 | 2023-07-28 | Deciphera Pharmaceuticals Llc | Inhibidores de gcn2 y perk quinasas y metodos de uso de los mismos. |
| CN115385896B (zh) * | 2021-05-24 | 2024-11-15 | 上海和誉生物医药科技有限公司 | 一种csf-1r抑制剂中间体或其酸式盐的制备方法 |
| CN113880812A (zh) * | 2021-11-17 | 2022-01-04 | 上海皓元生物医药科技有限公司 | 一种csf-ir抑制剂的制备方法 |
| KR20240113496A (ko) | 2021-12-03 | 2024-07-22 | 데시페라 파마슈티칼스, 엘엘씨. | Gcn2 및 perk 키나아제 억제제로서의 헤테로고리 화합물 |
| US12319655B2 (en) | 2021-12-09 | 2025-06-03 | Deciphera Pharmaceuticals, Llc | RAF kinase inhibitors and methods of use thereof |
| CN118434727A (zh) * | 2021-12-31 | 2024-08-02 | 上海海雁医药科技有限公司 | 取代的嘧啶酮衍生物、其药物组合物及医药上的用途 |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
| CN117624132B (zh) * | 2023-11-28 | 2026-04-21 | 上海相辉医药科技有限公司 | 一种CSF-1R激酶抑制剂Vimseltinib(DCC-3014)的制备方法 |
| WO2025122952A1 (en) * | 2023-12-08 | 2025-06-12 | Deciphera Pharmaceuticals, Llc | Formulations of vimseltinib |
| US20250206720A1 (en) | 2023-12-08 | 2025-06-26 | Deciphera Pharmaceuticals, Llc | Solid forms of an ulk inhibitor |
| WO2025231106A1 (en) | 2024-05-01 | 2025-11-06 | Deciphera Pharmaceuticals, Llc | Csf-1r inhibitors and methods of use thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080255155A1 (en) * | 2006-10-18 | 2008-10-16 | Stephane Raeppel | Kinase inhibitors and uses thereof |
| EP2125781A2 (en) * | 2006-12-20 | 2009-12-02 | Amgen Inc. | Substituted heterocycles and methods of use |
| CN102256493A (zh) * | 2008-10-29 | 2011-11-23 | 迪赛孚尔制药有限公司 | 表现出抗癌活性和抗增殖活性的环丙烷酰胺及其类似物 |
| US9193719B2 (en) | 2013-03-15 | 2015-11-24 | Deciphera Pharmaceuticals, Llc | 1,2,4-triazol-5-ones and analogs exhibiting anti-cancer and anti-proliferative activities |
| CA2903285C (en) * | 2013-03-15 | 2021-05-11 | Deciphera Pharmaceuticals, Llc | 2-aminopyrimidin-6-ones and analogs exhibiting anti-cancer and anti-proliferative activities |
| US9133183B2 (en) * | 2013-03-15 | 2015-09-15 | Deciphera Pharmaceuticals, Llc | Imidazolidinones and analogs exhibiting anti-cancer and anti-proliferative activities |
-
2014
- 2014-03-14 CA CA2903285A patent/CA2903285C/en active Active
- 2014-03-14 SG SG11201507660TA patent/SG11201507660TA/en unknown
- 2014-03-14 ES ES14764032.0T patent/ES2651165T3/es active Active
- 2014-03-14 US US14/214,171 patent/US9181223B2/en active Active
- 2014-03-14 BR BR112015022288-9A patent/BR112015022288B1/pt active IP Right Grant
- 2014-03-14 PT PT147640320T patent/PT2968286T/pt unknown
- 2014-03-14 KR KR1020247001621A patent/KR20240013846A/ko not_active Ceased
- 2014-03-14 JP JP2016503185A patent/JP6165314B2/ja active Active
- 2014-03-14 MX MX2015012736A patent/MX365574B/es active IP Right Grant
- 2014-03-14 WO PCT/US2014/029661 patent/WO2014145025A2/en not_active Ceased
- 2014-03-14 DK DK14764032.0T patent/DK2968286T3/en active
- 2014-03-14 KR KR1020267005630A patent/KR20260042557A/ko active Pending
- 2014-03-14 KR KR1020227016381A patent/KR102628583B1/ko active Active
- 2014-03-14 KR KR1020217026183A patent/KR102399891B1/ko active Active
- 2014-03-14 CN CN201480021743.5A patent/CN105120864B/zh active Active
- 2014-03-14 CN CN201710265111.9A patent/CN107311981B/zh active Active
- 2014-03-14 AU AU2014233411A patent/AU2014233411B2/en active Active
- 2014-03-14 EP EP14764032.0A patent/EP2968286B1/en active Active
- 2014-03-14 RU RU2015143717A patent/RU2015143717A/ru not_active Application Discontinuation
- 2014-03-14 KR KR1020157029134A patent/KR102293086B1/ko active Active
-
2015
- 2015-09-01 IL IL241000A patent/IL241000B/en active IP Right Grant
- 2015-09-14 PH PH12015502114A patent/PH12015502114B1/en unknown
-
2017
- 2017-06-20 JP JP2017120849A patent/JP2017193567A/ja active Pending
-
2018
- 2018-07-09 IL IL260502A patent/IL260502B/en active IP Right Grant
- 2018-11-28 AU AU2018271293A patent/AU2018271293B2/en active Active
-
2019
- 2019-02-25 JP JP2019032014A patent/JP6936823B2/ja active Active
-
2020
- 2020-06-16 IL IL275422A patent/IL275422B/en unknown
- 2020-07-15 AU AU2020205294A patent/AU2020205294B2/en active Active
-
2021
- 2021-08-27 JP JP2021138625A patent/JP7169412B2/ja active Active
-
2022
- 2022-01-04 IL IL289629A patent/IL289629B2/en unknown
- 2022-06-15 AU AU2022204166A patent/AU2022204166C1/en active Active
- 2022-10-28 JP JP2022173722A patent/JP7536064B2/ja active Active
-
2024
- 2024-04-02 AU AU2024202088A patent/AU2024202088A1/en active Pending
- 2024-04-25 JP JP2024071962A patent/JP2024105360A/ja active Pending
-
2026
- 2026-03-16 NL NL301373C patent/NL301373I2/nl unknown
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