DE60313156D1 - Amonafidsalze - Google Patents

Amonafidsalze

Info

Publication number
DE60313156D1
DE60313156D1 DE60313156T DE60313156T DE60313156D1 DE 60313156 D1 DE60313156 D1 DE 60313156D1 DE 60313156 T DE60313156 T DE 60313156T DE 60313156 T DE60313156 T DE 60313156T DE 60313156 D1 DE60313156 D1 DE 60313156D1
Authority
DE
Germany
Prior art keywords
sup
sub
independently
alkyl group
hr6r7
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60313156T
Other languages
English (en)
Other versions
DE60313156T2 (de
Inventor
Alfred M Ajami
David Barlow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xanthus Pharmaceuticals Inc Canada
Original Assignee
Xanthus Life Sciences Inc Canada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xanthus Life Sciences Inc Canada filed Critical Xanthus Life Sciences Inc Canada
Application granted granted Critical
Publication of DE60313156D1 publication Critical patent/DE60313156D1/de
Publication of DE60313156T2 publication Critical patent/DE60313156T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Lubricants (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
DE60313156T 2002-04-22 2003-04-22 Amonafidsalze Expired - Lifetime DE60313156T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/128,129 US6693198B2 (en) 2002-04-22 2002-04-22 Amonafide salts
US128129 2002-04-22
PCT/US2003/012619 WO2003089415A1 (en) 2002-04-22 2003-04-22 Amonafide salts

Publications (2)

Publication Number Publication Date
DE60313156D1 true DE60313156D1 (de) 2007-05-24
DE60313156T2 DE60313156T2 (de) 2007-12-13

Family

ID=29248438

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60313156T Expired - Lifetime DE60313156T2 (de) 2002-04-22 2003-04-22 Amonafidsalze

Country Status (9)

Country Link
US (2) US6693198B2 (de)
EP (1) EP1499595B1 (de)
JP (2) JP4630518B2 (de)
AT (1) ATE359273T1 (de)
AU (1) AU2003221771B2 (de)
CA (1) CA2482445A1 (de)
DE (1) DE60313156T2 (de)
ES (1) ES2287463T3 (de)
WO (1) WO2003089415A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050239816A1 (en) * 2002-04-22 2005-10-27 Xanthus Life Sciences, Inc. Amonafide salts
US6693198B2 (en) 2002-04-22 2004-02-17 Xanthus Life Sciences, Inc. Amonafide salts
EP1539150A4 (de) * 2002-07-08 2006-10-11 Chemgenex Pharmaceuticals Inc Naphthalimidsynthese, einschliesslich amonafid-synthese, und pharmazeutische zubereitungen daraus
AU2005209845A1 (en) * 2004-01-30 2005-08-18 Chemgenex Pharmaceuticals, Inc. Naphthalimide dosing by N-acetyl transferase genotyping
BRPI0510719A (pt) * 2004-05-05 2007-11-20 Unibioscreen Sa derivados de naftalimida, composição farmacêutica, uso e método de preparação dos mesmos
CA2569279A1 (en) * 2004-06-04 2005-12-15 Chemgenex Pharmaceuticals, Inc. Methods of treating cellular proliferative disease using naphthalimide and parp-1 inhibitors
FR2898902B1 (fr) * 2006-03-24 2010-09-10 Oreal Colorants particuliers de type naphtalimide, composition tinctoriale comprenant au moins un tel colorant, procede de mise en oeuvre et utilisations
ES2338193B8 (es) * 2008-02-25 2011-07-19 Centro Atlantico Del Medicamento, S.A. Nuevas sales de amonafide.
CA2995880C (en) 2009-01-16 2021-01-05 Exelixis, Inc. Processes for preparing n-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
CN102718709A (zh) * 2011-03-30 2012-10-10 北京德众万全药物技术开发有限公司 一种制备氨萘非特的新方法
CN109490291B (zh) * 2018-11-20 2021-05-11 上海应用技术大学 基于吸电子基取代的1,8-萘酰亚胺类化合物作为氟离子的显色试剂的用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES459497A1 (es) * 1977-06-04 1978-04-16 Made Labor Sa Un metodo para la preparacion industrial de naftalimidas y sus derivados.
US4614820A (en) * 1983-04-01 1986-09-30 Warner-Lambert Co. 3,6-disubstituted-1,8-naphthalimides
US4499266A (en) * 1983-04-01 1985-02-12 Warner-Lambert Company 3,6-Dinitro-1,8-naphthalimides
US5183821A (en) 1983-09-19 1993-02-02 Laboratories Knoll, S.A. Method for treating leukemias using N-(2-dimethylaminoethyl)-3-amino-1,8-naphthalimide for treating leukemias and solid tumors
US4665071A (en) 1984-02-21 1987-05-12 Warner-Lambert Company 3,6-disubstituted-1,8-naphthalimides and methods for their production and use
DE3614414A1 (de) * 1986-04-29 1987-11-05 Knoll Ag Neue benzo(de)isochinolin-1,3-dione, ihre herstellung und verwendung
DE3635711A1 (de) * 1986-10-21 1988-04-28 Knoll Ag 5-nitrobenzo(de)isochinolin-1,3-dione, ihre herstellung und verwendung
US5420137A (en) 1989-07-11 1995-05-30 Knoll Ag Amonafide salts
DE3922771A1 (de) * 1989-07-11 1991-01-24 Knoll Ag Amonafide-salze
DE4106122A1 (de) * 1991-02-27 1992-09-03 Bayer Ag Neue naphthalimide, diese enthaltende toner und die verwendung der neuen naphthalimide als additive fuer toner
AU760136B2 (en) * 1998-11-25 2003-05-08 Merck Patent Gmbh Substituted benzo(DE)isoquinoline-1,3-diones
US6630173B2 (en) 2000-04-12 2003-10-07 Chemgenex Therapeutics, Inc. Naphthalimide compositions and uses thereof
US6693198B2 (en) 2002-04-22 2004-02-17 Xanthus Life Sciences, Inc. Amonafide salts

Also Published As

Publication number Publication date
US6693198B2 (en) 2004-02-17
US20030203932A1 (en) 2003-10-30
DE60313156T2 (de) 2007-12-13
EP1499595B1 (de) 2007-04-11
AU2003221771B2 (en) 2007-02-15
JP2003321452A (ja) 2003-11-11
AU2003221771A1 (en) 2003-11-03
WO2003089415A1 (en) 2003-10-30
CA2482445A1 (en) 2003-10-30
EP1499595A1 (de) 2005-01-26
US6989390B2 (en) 2006-01-24
JP4630518B2 (ja) 2011-02-09
JP2010006831A (ja) 2010-01-14
ATE359273T1 (de) 2007-05-15
US20040132763A1 (en) 2004-07-08
ES2287463T3 (es) 2007-12-16

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: XANTHUS PHARMACEUTICALS, INC., MONTREAL, QUEBE, CA

8364 No opposition during term of opposition