|
US20080070981A1
(en)
|
2000-02-23 |
2008-03-20 |
Henryk Borowy-Borowski |
Water-soluble compositions of bioactive lipophilic compounds
|
|
PE20010306A1
(es)
|
1999-07-02 |
2001-03-29 |
Agouron Pharma |
Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
|
|
GB0018891D0
(en)
|
2000-08-01 |
2000-09-20 |
Novartis Ag |
Organic compounds
|
|
AU2002234755A1
(en)
|
2001-02-26 |
2002-09-12 |
Pharma Pacific Pty Ltd |
Interferon-alpha induced gene
|
|
US7595048B2
(en)
|
2002-07-03 |
2009-09-29 |
Ono Pharmaceutical Co., Ltd. |
Method for treatment of cancer by inhibiting the immunosuppressive signal induced by PD-1
|
|
WO2004056875A1
(en)
|
2002-12-23 |
2004-07-08 |
Wyeth |
Antibodies against pd-1 and uses therefor
|
|
EP1591527B1
(en)
|
2003-01-23 |
2015-08-26 |
Ono Pharmaceutical Co., Ltd. |
Substance specific to human pd-1
|
|
DK2161336T4
(en)
|
2005-05-09 |
2017-04-24 |
Ono Pharmaceutical Co |
Human monoclonal antibodies for programmed death 1 (PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapies
|
|
US8367065B2
(en)
|
2006-09-15 |
2013-02-05 |
Enzon Pharmaceuticals, Inc. |
Targeted polymeric prodrugs containing multifunctional linkers
|
|
NZ582150A
(en)
|
2007-06-18 |
2012-08-31 |
Msd Oss Bv |
Antibodies to human programmed death receptor pd-1
|
|
WO2009002993A1
(en)
|
2007-06-25 |
2008-12-31 |
Endocyte, Inc. |
Conjugates containing hydrophilic spacer linkers
|
|
WO2009097128A1
(en)
|
2008-01-29 |
2009-08-06 |
Ludwig Institute For Cancer Research Ltd. |
Membrane transporter napi2b (slc34a2) epitope for antibody therapy, antibodies directed thereto, and target for cancer therapy
|
|
WO2009114335A2
(en)
|
2008-03-12 |
2009-09-17 |
Merck & Co., Inc. |
Pd-1 binding proteins
|
|
CN102203125A
(zh)
|
2008-08-25 |
2011-09-28 |
安普利穆尼股份有限公司 |
Pd-1拮抗剂及其使用方法
|
|
MX2011003195A
(es)
|
2008-09-26 |
2011-08-12 |
Dana Farber Cancer Inst Inc |
Anticuerpos anti-pd-1, pd-l1 y pd-l2 humanos y usos de los mismos.
|
|
HRP20170908T1
(hr)
|
2008-12-09 |
2017-09-22 |
F. Hoffmann - La Roche Ag |
Protutijela anti-pd-l1 i njihova uporaba za poboljšanje funkcije t-stanice
|
|
JP2013512251A
(ja)
|
2009-11-24 |
2013-04-11 |
アンプリミューン、インコーポレーテッド |
Pd−l1/pd−l2の同時阻害
|
|
AU2012290121B2
(en)
|
2011-08-01 |
2015-11-26 |
Genentech, Inc. |
Methods of treating cancer using PD-1 axis binding antagonists and MEK inhibitors
|
|
EP2908818A4
(en)
|
2012-10-16 |
2016-07-13 |
Endocyte Inc |
CONJUGATES OF DRUG DELIVERY CONTAINING ARTIFICIAL AMINO ACIDS AND METHODS OF USE
|
|
AU2013358892B2
(en)
|
2012-12-13 |
2018-06-21 |
Aduro Biotech, Inc. |
Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use
|
|
JP6400082B2
(ja)
|
2013-05-18 |
2018-10-03 |
アデュロ バイオテック,インコーポレイテッド |
「インターフェロン遺伝子の刺激因子」依存性シグナル伝達を抑制するための組成物および方法
|
|
DK2996473T3
(da)
|
2013-05-18 |
2019-11-04 |
Aduro Biotech Inc |
Sammensætninger og fremgangsmåder til aktivering af "stimulator af interferon-gen"-afhængig signalering
|
|
KR102538993B1
(ko)
|
2013-10-15 |
2023-06-02 |
씨젠 인크. |
개선된 리간드-약물 컨쥬게이트 약물동력학을 위한 peg화된 약물-링커
|
|
EP3498301A1
(en)
*
|
2014-04-25 |
2019-06-19 |
Pierre Fabre Medicament |
Kit comprising igf-1r antibody-drug-conjugate and its use for the treatment of cancer
|
|
CA2950033A1
(en)
|
2014-06-04 |
2015-12-10 |
Glaxosmithkline Intellectual Property Development Limited |
Cyclic di-nucleotides as modulators of sting
|
|
TWI695011B
(zh)
|
2014-06-18 |
2020-06-01 |
美商梅爾莎納醫療公司 |
抗her2表位之單株抗體及其使用之方法
|
|
PL3233882T3
(pl)
|
2014-12-16 |
2020-04-30 |
Kayla Therapeutics |
Fluorowane cykliczne dinukleotydy do indukcji cytokin
|
|
US20170340658A1
(en)
|
2014-12-16 |
2017-11-30 |
Invivogen |
Combined use of a chemotherapeutic agent and a cyclic dinucleotide for cancer treatment
|
|
GB201501462D0
(en)
|
2015-01-29 |
2015-03-18 |
Glaxosmithkline Ip Dev Ltd |
Novel compounds
|
|
MX2018001814A
(es)
|
2015-08-13 |
2018-05-07 |
Merck Sharp & Dohme |
Compuestos dinucleotidos ciclicos como agonistas del estimulador de genes de interferon.
|
|
TW201726700A
(zh)
|
2015-10-28 |
2017-08-01 |
艾杜諾生物科技公司 |
用於活化「干擾素基因刺激子」依賴性訊號之組合物及方法
|
|
NZ738202A
(en)
|
2015-12-03 |
2019-07-26 |
Glaxosmithkline Ip Dev Ltd |
Cyclic purine dinucleotides as modulators of sting
|
|
EP3386536A4
(en)
|
2015-12-07 |
2019-07-31 |
Opi Vi- IP Holdco LLC |
COMPOSITION OF ANTIBODY CONSTRUCT AGONIST CONJUGATES AND METHOD FOR USE THEREOF
|
|
US20170158772A1
(en)
*
|
2015-12-07 |
2017-06-08 |
Opi Vi - Ip Holdco Llc |
Compositions of antibody construct - agonist conjugates and methods of use thereof
|
|
CA3016474A1
(en)
|
2016-03-15 |
2017-09-21 |
Mersana Therapeutics, Inc. |
Napi2b-targeted antibody-drug conjugates and methods of use thereof
|
|
CN109563081A
(zh)
|
2016-04-07 |
2019-04-02 |
葛兰素史克知识产权开发有限公司 |
可用作蛋白调节剂的杂环酰胺类
|
|
SI3440076T1
(sl)
|
2016-04-07 |
2022-09-30 |
Glaxosmithkline Intellectual Property Development Limited |
Heterociklični amidi uporabni kot proteinski modulatorji
|
|
US10225009B2
(en)
|
2016-07-01 |
2019-03-05 |
Adtran, Inc. |
Broadband access devices having a radio link
|
|
WO2018009466A1
(en)
|
2016-07-05 |
2018-01-11 |
Aduro Biotech, Inc. |
Locked nucleic acid cyclic dinucleotide compounds and uses thereof
|
|
GEP20217285B
(en)
|
2016-10-04 |
2021-08-10 |
Merck Sharp & Dohme |
BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS
|
|
US11135307B2
(en)
*
|
2016-11-23 |
2021-10-05 |
Mersana Therapeutics, Inc. |
Peptide-containing linkers for antibody-drug conjugates
|
|
CA3049791A1
(en)
|
2017-01-27 |
2018-08-02 |
Silverback Therapeutics, Inc. |
Tumor targeting conjugates and methods of use thereof
|
|
TW201834697A
(zh)
*
|
2017-02-28 |
2018-10-01 |
美商梅爾莎納醫療公司 |
Her2標靶抗體-藥物結合物之組合療法
|
|
AR113224A1
(es)
*
|
2017-04-28 |
2020-02-19 |
Novartis Ag |
Conjugados de anticuerpo que comprenden un agonista de sting
|
|
CA3065919A1
(en)
|
2017-06-07 |
2018-12-13 |
Silverback Therapeutics, Inc. |
Antibody construct conjugates
|
|
US11285131B2
(en)
|
2017-08-04 |
2022-03-29 |
Merck Sharp & Dohme Corp. |
Benzo[b]thiophene STING agonists for cancer treatment
|
|
JP2020529421A
(ja)
|
2017-08-04 |
2020-10-08 |
メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. |
がんの処置のためのPD−1アンタゴニストおよびベンゾ[b]チオフェンSTINGアゴニストの組み合わせ
|
|
IL273252B2
(en)
|
2017-09-20 |
2024-03-01 |
Mersana Therapeutics Inc |
Compositions and methods for predicting response to napi2b-targeted therapy
|
|
JP2020536106A
(ja)
|
2017-10-05 |
2020-12-10 |
グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited |
Hivの処置に有用なインターフェロン遺伝子の刺激物質(sting)の調節物質
|
|
EP3691640A1
(en)
*
|
2017-10-05 |
2020-08-12 |
GlaxoSmithKline Intellectual Property Development Limited |
Methods for administering sting agonists
|
|
WO2019069270A1
(en)
|
2017-10-05 |
2019-04-11 |
Glaxosmithkline Intellectual Property Development Limited |
GENERATOR STIMULATOR MODULATORS (STING) INTERFERON
|
|
WO2019084060A1
(en)
|
2017-10-24 |
2019-05-02 |
Silverback Therapeutics, Inc. |
CONJUGATES AND METHODS OF USE FOR THE SELECTIVE DELIVERY OF IMMUNOMODULATORY AGENTS
|
|
CA3080857A1
(en)
|
2017-11-07 |
2019-05-16 |
Regeneron Pharmaceuticals, Inc. |
Hydrophilic linkers for antibody drug conjugates
|
|
CN110016021B
(zh)
|
2018-01-08 |
2021-05-07 |
成都先导药物开发股份有限公司 |
一种免疫调节剂
|
|
CN110016025B
(zh)
|
2018-01-08 |
2021-08-06 |
成都先导药物开发股份有限公司 |
一种免疫调节剂
|
|
EP3774765A4
(en)
|
2018-04-03 |
2021-12-29 |
Merck Sharp & Dohme Corp. |
Aza-benzothiophene compounds as sting agonists
|
|
JP7326319B2
(ja)
|
2018-04-03 |
2023-08-15 |
メルク・シャープ・アンド・ドーム・エルエルシー |
Stingアゴニストとしてのベンゾチオフェン類及び関連する化合物
|
|
ES2929415T3
(es)
|
2018-05-25 |
2022-11-29 |
Incyte Corp |
Compuestos heterocíclicos tricíclicos como activadores de STING
|
|
WO2019236567A2
(en)
|
2018-06-04 |
2019-12-12 |
Trustees Of Tufts College |
Tumor microenvironment-activated drug-binder conjugated, and uses related thereto
|
|
TW202016081A
(zh)
|
2018-06-21 |
2020-05-01 |
英商克拉德夫製藥有限公司 |
人類sting之小分子調節劑、結合物及治療應用
|
|
US11535633B2
(en)
|
2018-06-28 |
2022-12-27 |
Jiangsu Hengrui Medicine Co., Ltd. |
Fused tricyclic heterocycle compounds and therapeutic uses thereof
|
|
WO2020010451A1
(en)
*
|
2018-07-10 |
2020-01-16 |
Trillium Therapeutics Inc. |
Heteroaromatic-fused imidazolyl amides, compositions and uses thereof as sting agonists
|
|
US10875872B2
(en)
|
2018-07-31 |
2020-12-29 |
Incyte Corporation |
Heteroaryl amide compounds as sting activators
|
|
CN112552314B
(zh)
|
2018-08-24 |
2022-03-04 |
杭州阿诺生物医药科技有限公司 |
Sting激动剂小分子抗肿瘤化合物及其应用
|
|
CN111655682B
(zh)
|
2018-08-29 |
2024-05-31 |
杭州阿诺生物医药科技有限公司 |
一种高活性sting蛋白激动剂化合物
|
|
CA3111784A1
(en)
|
2018-09-12 |
2020-03-19 |
Silverback Therapeutics, Inc. |
Methods and compositions for the treatment of disease with immune stimulatory conjugates
|
|
CN110963997A
(zh)
|
2018-09-28 |
2020-04-07 |
四川科伦博泰生物医药股份有限公司 |
杂环酰胺类化合物、包含其的药物组合物及其制备方法和用途
|
|
ES2959804T3
(es)
|
2018-12-06 |
2024-02-28 |
Glaxosmithkline Ip Dev Ltd |
Nueva formulación farmacéutica que comprende un modulador de STING
|
|
WO2020132566A1
(en)
|
2018-12-21 |
2020-06-25 |
Nimbus Titan, Inc. |
Sting pyrazole agonists and uses thereof
|
|
WO2020132582A1
(en)
*
|
2018-12-21 |
2020-06-25 |
Nimbus Titan, Inc. |
Sting agonists and uses thereof
|
|
WO2020132549A1
(en)
|
2018-12-21 |
2020-06-25 |
Nimbus Titan, Inc. |
Sting heterocycle agonists and uses thereof
|
|
CN111393404B
(zh)
|
2019-01-02 |
2023-02-17 |
中国科学院上海药物研究所 |
一类苯并噻吩类化合物及其药物组合物及应用
|
|
CN111393405B
(zh)
|
2019-01-02 |
2022-11-25 |
中国科学院上海药物研究所 |
一类含氟取代的苯并噻吩类化合物及其药物组合物及应用
|
|
US12129267B2
(en)
|
2019-01-07 |
2024-10-29 |
Incyte Corporation |
Heteroaryl amide compounds as sting activators
|
|
CN111471056B
(zh)
|
2019-01-23 |
2021-07-02 |
成都先导药物开发股份有限公司 |
一种大环类免疫调节剂
|
|
CN111499617B
(zh)
|
2019-01-31 |
2021-08-06 |
成都先导药物开发股份有限公司 |
一种免疫调节剂
|
|
CN113645977A
(zh)
|
2019-03-05 |
2021-11-12 |
F-星治疗公司 |
化合物、组合物和疾病治疗方法
|
|
US20220144852A1
(en)
|
2019-03-28 |
2022-05-12 |
Lupin Limited |
Macrocyclic compounds as sting agonists
|
|
TW202104214A
(zh)
|
2019-04-05 |
2021-02-01 |
英商葛蘭素史密斯克藍智慧財產發展有限公司 |
化合物
|
|
JP2022529183A
(ja)
|
2019-04-17 |
2022-06-17 |
アヴィディア テクノロジーズ, インコーポレイテッド |
リガンド提示および/または薬物送達のためのスターポリマーを製造する組成物および方法
|
|
KR102885020B1
(ko)
|
2019-04-30 |
2025-11-11 |
쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드 |
벤조티오펜 화합물, 이의 제조 방법 및 용도
|
|
CN111848573B
(zh)
|
2019-04-30 |
2023-04-07 |
四川科伦博泰生物医药股份有限公司 |
苯并噻吩酰胺类化合物及其制备方法和用途
|
|
MA55805A
(fr)
|
2019-05-03 |
2022-03-09 |
Flagship Pioneering Innovations V Inc |
Métodes de modulation de l'activité immunitaire
|
|
WO2021000770A1
(zh)
|
2019-07-02 |
2021-01-07 |
凯复制药有限公司 |
可增强免疫活性的杂环化合物、其制备方法及其在医药上的应用
|
|
GB201910305D0
(en)
|
2019-07-18 |
2019-09-04 |
Ctxt Pty Ltd |
Compounds
|
|
KR20220035955A
(ko)
|
2019-07-22 |
2022-03-22 |
루핀 리미티드 |
Sting 작용제로서의 거대고리 화합물 및 이의 방법 및 용도
|
|
US20220267364A1
(en)
|
2019-07-25 |
2022-08-25 |
Shanghai Jemincare Pharmaceuticals Co., Ltd. |
Heterocyclic amide compound, preparation method therefor and use thereof
|
|
US11155567B2
(en)
|
2019-08-02 |
2021-10-26 |
Mersana Therapeutics, Inc. |
Sting agonist compounds and methods of use
|
|
WO2021113679A1
(en)
|
2019-12-06 |
2021-06-10 |
Mersana Therapeutics, Inc. |
Dimeric compounds as sting agonists
|
|
CN113248475B
(zh)
|
2020-02-11 |
2023-03-17 |
中国科学院上海药物研究所 |
一类杂环取代的苯并咪唑二聚体或其药学上可接受的盐、组合物及其用途
|
|
MY210304A
(en)
|
2020-04-02 |
2025-09-10 |
Mersana Therapeutics Inc |
Antibody drug conjugates comprising sting agonists
|
|
CA3203721A1
(en)
|
2021-01-04 |
2022-07-07 |
Timothy B. Lowinger |
B7h4-targeted antibody-drug conjugates and methods of use thereof
|
|
CN112898286A
(zh)
|
2021-01-28 |
2021-06-04 |
中国药科大学 |
苯并噻吩类化合物或其可药用的盐、异构体及其制备方法、药物组合物和用途
|
|
US20230398229A1
(en)
|
2022-03-07 |
2023-12-14 |
Mersana Therapeutics, Inc. |
Antibody drug conjugates comprising sting agonists, combinations and methods of use
|