CL2022002711A1 - Conjugados de anticuerpo-fármaco que comprenden agonistas de sting - Google Patents

Conjugados de anticuerpo-fármaco que comprenden agonistas de sting

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Publication number
CL2022002711A1
CL2022002711A1 CL2022002711A CL2022002711A CL2022002711A1 CL 2022002711 A1 CL2022002711 A1 CL 2022002711A1 CL 2022002711 A CL2022002711 A CL 2022002711A CL 2022002711 A CL2022002711 A CL 2022002711A CL 2022002711 A1 CL2022002711 A1 CL 2022002711A1
Authority
CL
Chile
Prior art keywords
antibody
drug conjugates
sting agonists
sting
adcs
Prior art date
Application number
CL2022002711A
Other languages
English (en)
Inventor
R Duvall Jeremy
W Bentley Keith
A Bukhalid Raghida
Cetinbas Naniye
I Damelin Marc
W Kelleher Eugene
B Lowinger Timothy
D Thomas Joshua
Toader Dorin
Xu Ling
Yang Liping
Original Assignee
Mersana Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mersana Therapeutics Inc filed Critical Mersana Therapeutics Inc
Publication of CL2022002711A1 publication Critical patent/CL2022002711A1/es

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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La divulgación presente provee andamiajes y conjugados anticuerpo-fármaco (ADCs, por sus siglas en inglés) que comprenden un estimulante de los genes de interferón (STING). La divulgación presente también provee usos de los ADCs para tratamiento, por ejemplo, para el tratamiento del cáncer.
CL2022002711A 2020-04-02 2022-10-03 Conjugados de anticuerpo-fármaco que comprenden agonistas de sting CL2022002711A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063004108P 2020-04-02 2020-04-02
US202063040755P 2020-06-18 2020-06-18
US202063111820P 2020-11-10 2020-11-10

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