CL2022002837A1 - Conjugados anticuerpo-fármaco que comprenden agonistas de sting (divisional 202202711) - Google Patents
Conjugados anticuerpo-fármaco que comprenden agonistas de sting (divisional 202202711)Info
- Publication number
- CL2022002837A1 CL2022002837A1 CL2022002837A CL2022002837A CL2022002837A1 CL 2022002837 A1 CL2022002837 A1 CL 2022002837A1 CL 2022002837 A CL2022002837 A CL 2022002837A CL 2022002837 A CL2022002837 A CL 2022002837A CL 2022002837 A1 CL2022002837 A1 CL 2022002837A1
- Authority
- CL
- Chile
- Prior art keywords
- antibody
- drug conjugates
- divisional
- sting agonists
- sting
- Prior art date
Links
- 239000000611 antibody drug conjugate Substances 0.000 title abstract 4
- 229940049595 antibody-drug conjugate Drugs 0.000 title abstract 4
- 229940044665 STING agonist Drugs 0.000 title 1
- 108010050904 Interferons Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
Classifications
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La divulgación presente provee andamiajes y conjugados anticuerpo-fármaco (ADCs, por sus siglas en inglés) que comprenden un estimulante de los genes de interferón (STING). La divulgación presente también provee usos de los ADCs para tratamiento, por ejemplo, para el tratamiento del cáncer.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US202063004108P | 2020-04-02 | 2020-04-02 | |
US202063040755P | 2020-06-18 | 2020-06-18 | |
US202063111820P | 2020-11-10 | 2020-11-10 |
Publications (1)
Publication Number | Publication Date |
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CL2022002837A1 true CL2022002837A1 (es) | 2023-06-16 |
Family
ID=75660370
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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CL2022002711A CL2022002711A1 (es) | 2020-04-02 | 2022-10-03 | Conjugados de anticuerpo-fármaco que comprenden agonistas de sting |
CL2022002837A CL2022002837A1 (es) | 2020-04-02 | 2022-10-14 | Conjugados anticuerpo-fármaco que comprenden agonistas de sting (divisional 202202711) |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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CL2022002711A CL2022002711A1 (es) | 2020-04-02 | 2022-10-03 | Conjugados de anticuerpo-fármaco que comprenden agonistas de sting |
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CN114174285B (zh) * | 2019-07-25 | 2023-10-31 | 上海济煜医药科技有限公司 | 杂环酰胺类化合物及其制备方法和应用 |
TW202120500A (zh) | 2019-08-02 | 2021-06-01 | 美商梅爾莎納醫療公司 | 干擾素基因刺激蛋白(sting)激動劑化合物及用途 |
US11964024B2 (en) | 2021-01-04 | 2024-04-23 | Mersana Therapeutics, Inc. | B7H4-targeted antibody-drug conjugates and methods of use thereof |
WO2022272039A1 (en) * | 2021-06-25 | 2022-12-29 | Bolt Biotherapeutics, Inc. | Bis-benzimidazole sting agonist immunoconjugates, and uses thereof |
TW202334238A (zh) | 2021-11-30 | 2023-09-01 | 日商第一三共股份有限公司 | 蛋白酶分解性遮蔽抗體 |
TW202342105A (zh) * | 2021-12-17 | 2023-11-01 | 大陸商北京加科思新藥研發有限公司 | 包含可用作sting激動劑的化合物的化合物-連接基構建體及其用途 |
WO2023136589A1 (en) * | 2022-01-11 | 2023-07-20 | Bisichem Co., Ltd. | Fused heteroaryl hydroxamates as sting agonists |
TW202400241A (zh) * | 2022-03-07 | 2024-01-01 | 美商梅爾莎納醫療公司 | 包含sting促效劑之抗體藥物共軛物、組合及使用方法 |
WO2023215740A1 (en) * | 2022-05-06 | 2023-11-09 | Seagen Inc. | Immunomodulatory antibody-drug conjugates |
WO2024083926A1 (en) * | 2022-10-18 | 2024-04-25 | Tubulis Gmbh | Novel antibody drug conjugates with novel napi2b antibodies, therapeutic methods and uses thereof |
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US20080070981A1 (en) | 2000-02-23 | 2008-03-20 | Henryk Borowy-Borowski | Water-soluble compositions of bioactive lipophilic compounds |
US8367065B2 (en) | 2006-09-15 | 2013-02-05 | Enzon Pharmaceuticals, Inc. | Targeted polymeric prodrugs containing multifunctional linkers |
EP2250201B1 (en) | 2008-01-29 | 2014-04-30 | Ludwig Institute for Cancer Research Ltd. | Membrane transporter napi2b (slc34a2) epitope for antibody therapy, antibodies directed thereto, and target for cancer therapy |
AU2013331440A1 (en) | 2012-10-16 | 2015-04-30 | Endocyte, Inc. | Drug delivery conjugates containing unnatural amino acids and methods for using |
MX2021008464A (es) | 2013-10-15 | 2023-03-03 | Seattle Genetics Inc | Farmaco-enlazadores modificados con polietilenglicol para la farmacocinetica mejorada de conjugados de ligando-farmaco. |
TWI695011B (zh) | 2014-06-18 | 2020-06-01 | 美商梅爾莎納醫療公司 | 抗her2表位之單株抗體及其使用之方法 |
US20170158772A1 (en) * | 2015-12-07 | 2017-06-08 | Opi Vi - Ip Holdco Llc | Compositions of antibody construct - agonist conjugates and methods of use thereof |
US10947317B2 (en) | 2016-03-15 | 2021-03-16 | Mersana Therapeutics, Inc. | NaPi2b-targeted antibody-drug conjugates and methods of use thereof |
IL295649A (en) | 2016-04-07 | 2022-10-01 | Glaxosmithkline Ip Dev Ltd | Heterocyclic amides are useful as protein modulators |
US10225009B2 (en) | 2016-07-01 | 2019-03-05 | Adtran, Inc. | Broadband access devices having a radio link |
US11135307B2 (en) * | 2016-11-23 | 2021-10-05 | Mersana Therapeutics, Inc. | Peptide-containing linkers for antibody-drug conjugates |
US20180271996A1 (en) * | 2017-02-28 | 2018-09-27 | Mersana Therapeutics, Inc. | Combination therapies of her2-targeted antibody-drug conjugates |
AR113224A1 (es) * | 2017-04-28 | 2020-02-19 | Novartis Ag | Conjugados de anticuerpo que comprenden un agonista de sting |
EP3691640A1 (en) * | 2017-10-05 | 2020-08-12 | GlaxoSmithKline Intellectual Property Development Limited | Methods for administering sting agonists |
TW202120500A (zh) * | 2019-08-02 | 2021-06-01 | 美商梅爾莎納醫療公司 | 干擾素基因刺激蛋白(sting)激動劑化合物及用途 |
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CN116196435A (zh) | 2023-06-02 |
AU2021248635A1 (en) | 2022-10-27 |
CL2022002711A1 (es) | 2023-06-16 |
EP4218826A3 (en) | 2023-10-25 |
CA3174297A1 (en) | 2021-10-07 |
WO2021202984A1 (en) | 2021-10-07 |
MX2022014230A (es) | 2023-01-04 |
AU2022259796A1 (en) | 2022-12-01 |
KR20230005189A (ko) | 2023-01-09 |
TW202203977A (zh) | 2022-02-01 |
BR122022020762A2 (pt) | 2023-04-11 |
US20230172910A1 (en) | 2023-06-08 |
AR127344A2 (es) | 2024-01-31 |
CO2022015650A2 (es) | 2022-12-09 |
IL297859A (en) | 2023-01-01 |
IL296901A (en) | 2022-12-01 |
MX2022012304A (es) | 2022-11-30 |
US20230321048A1 (en) | 2023-10-12 |
CN115768485A (zh) | 2023-03-07 |
EP4126065A1 (en) | 2023-02-08 |
JP2023520513A (ja) | 2023-05-17 |
JP2023070678A (ja) | 2023-05-19 |
EP4218826A2 (en) | 2023-08-02 |
KR20230004896A (ko) | 2023-01-06 |
US20220378749A1 (en) | 2022-12-01 |
TW202317202A (zh) | 2023-05-01 |
BR112022019919A2 (pt) | 2023-02-14 |
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