CO2024006278A2 - Inhibidores de moléculas pequeñas de la proteasa específica de ubiquitina 1 (usp1) y sus usos - Google Patents

Inhibidores de moléculas pequeñas de la proteasa específica de ubiquitina 1 (usp1) y sus usos

Info

Publication number
CO2024006278A2
CO2024006278A2 CONC2024/0006278A CO2024006278A CO2024006278A2 CO 2024006278 A2 CO2024006278 A2 CO 2024006278A2 CO 2024006278 A CO2024006278 A CO 2024006278A CO 2024006278 A2 CO2024006278 A2 CO 2024006278A2
Authority
CO
Colombia
Prior art keywords
usp1
ubiquitin
specific protease
small molecule
molecule inhibitors
Prior art date
Application number
CONC2024/0006278A
Other languages
English (en)
Inventor
Jianping Wu
Luoheng Qin
Jinxin Liu
Original Assignee
Insilico Medicine Ip Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Insilico Medicine Ip Ltd filed Critical Insilico Medicine Ip Ltd
Publication of CO2024006278A2 publication Critical patent/CO2024006278A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

RESUMEN En la presente se proporcionan compuestos inhibidores de moléculas pequeñas de la proteasa específica de ubiquitina 1 (USP1) y composiciones que los comprenden. En la presente se proporcionan, además, métodos para dirigirse a la proteasa específica de ubiquitina 1 (USP1) y métodos para tratar enfermedades o trastornos relacionados con USP1, tales como el cáncer.
CONC2024/0006278A 2021-11-12 2024-05-17 Inhibidores de moléculas pequeñas de la proteasa específica de ubiquitina 1 (usp1) y sus usos CO2024006278A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2021130284 2021-11-12
CN2022123821 2022-10-08
PCT/CN2022/131290 WO2023083285A1 (en) 2021-11-12 2022-11-11 Small molecule inhibitors of ubiquitin specific protease 1 (usp1) and uses thereof

Publications (1)

Publication Number Publication Date
CO2024006278A2 true CO2024006278A2 (es) 2024-05-30

Family

ID=86335132

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2024/0006278A CO2024006278A2 (es) 2021-11-12 2024-05-17 Inhibidores de moléculas pequeñas de la proteasa específica de ubiquitina 1 (usp1) y sus usos

Country Status (4)

Country Link
AU (1) AU2022387669A1 (es)
CA (1) CA3235603A1 (es)
CO (1) CO2024006278A2 (es)
WO (1) WO2023083285A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3235765A1 (en) 2021-11-12 2023-05-19 Jianping Wu Small molecule inhibitors of ubiquitin specific protease 1 (usp1) and uses thereof
WO2024022266A1 (en) * 2022-07-25 2024-02-01 Guangdong Newopp Biopharmaceuticals Co., Ltd. Heteroaryl compounds as inhibitors of usp1
WO2024032647A1 (zh) * 2022-08-09 2024-02-15 上海济煜医药科技有限公司 含氮杂环化合物作为泛素-特异性蛋白酶1抑制剂的制备方法、应用及其用途
WO2024061213A1 (zh) * 2022-09-20 2024-03-28 正大天晴药业集团股份有限公司 用作泛素-特异性蛋白酶抑制剂的羰基稠合杂环衍生物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3377493B1 (en) * 2015-11-20 2020-04-08 Forma Therapeutics, Inc. Purinones as ubiquitin-specific protease 1 inhibitors
WO2020132269A1 (en) * 2018-12-20 2020-06-25 KSQ Therapeutics, Inc. Substituted pyrazolopyrimidines and substituted purines and their use as ubiquitin-specific-processing protease 1 (usp1) inhibitors
AU2021218805A1 (en) * 2020-02-14 2022-09-01 KSQ Therapeutics, Inc. Therapeutic combinations comprising ubiquitin-specific-processing protease 1 (USP1) inhibitors and poly (ADP-ribose) polymerase (PARP) inhibitors
KR20230098186A (ko) * 2020-10-30 2023-07-03 케이에스큐 세러퓨틱스 인코포레이티드 치환된 피라졸로피리미딘의 고체 상태 형태 및 이의 용도
EP4291559A1 (en) * 2021-02-15 2023-12-20 Tango Therapeutics, Inc. Pyrrolo[3,2-d]pyrimidine compounds and methods of use in the treatment of cancer
BR112023018799A2 (pt) * 2021-03-17 2023-12-12 Medivir Ab Derivados de purina como agentes anticâncer
WO2022199652A1 (en) * 2021-03-24 2022-09-29 Impact Therapeutics (Shanghai) , Inc Five-membered heteroaryl-pyrimidine compounds as usp1 inhibitors and the use thereof
BR112023019075A2 (pt) * 2021-04-07 2023-10-17 Forma Therapeutics Inc Inibição de protease 1 específica de ubiquitina (usp1)

Also Published As

Publication number Publication date
AU2022387669A1 (en) 2024-05-16
CA3235603A1 (en) 2023-05-19
WO2023083285A1 (en) 2023-05-19

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