BR112022003584A2 - Compostos de pirrolopirimidina inibidores de perk - Google Patents
Compostos de pirrolopirimidina inibidores de perkInfo
- Publication number
- BR112022003584A2 BR112022003584A2 BR112022003584A BR112022003584A BR112022003584A2 BR 112022003584 A2 BR112022003584 A2 BR 112022003584A2 BR 112022003584 A BR112022003584 A BR 112022003584A BR 112022003584 A BR112022003584 A BR 112022003584A BR 112022003584 A2 BR112022003584 A2 BR 112022003584A2
- Authority
- BR
- Brazil
- Prior art keywords
- pyrrolopyrimidine compounds
- perk inhibitor
- perk
- compounds
- inhibitor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
compostos de pirrolopirimidina inibidores de perk. são providos aqui compostos de fórmula (i), composições e métodos úteis para inibir perk e para tratar condições, doenças e distúrbios relacionados.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962893528P | 2019-08-29 | 2019-08-29 | |
PCT/US2020/048621 WO2021041975A1 (en) | 2019-08-29 | 2020-08-28 | Perk inhibiting pyrrolopyrimidine compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022003584A2 true BR112022003584A2 (pt) | 2022-05-24 |
Family
ID=72470610
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022003584A BR112022003584A2 (pt) | 2019-08-29 | 2020-08-28 | Compostos de pirrolopirimidina inibidores de perk |
Country Status (11)
Country | Link |
---|---|
US (1) | US20220356186A1 (pt) |
EP (1) | EP4021908A1 (pt) |
JP (1) | JP2022546414A (pt) |
KR (1) | KR20220066290A (pt) |
CN (1) | CN114710956A (pt) |
AU (1) | AU2020336975A1 (pt) |
BR (1) | BR112022003584A2 (pt) |
CA (1) | CA3152508A1 (pt) |
IL (1) | IL290889A (pt) |
MX (1) | MX2022002446A (pt) |
WO (1) | WO2021041975A1 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022261352A1 (en) * | 2021-06-09 | 2022-12-15 | Icahn School Of Medicine At Mount Sinai | Perfluoroalkane substituted pyrazolo[3,4-d]pyrimidin and pyrrolo[2,3-d]pyrimidin compounds and uses thereof |
WO2023025912A1 (en) | 2021-08-25 | 2023-03-02 | Alesta Therapeutics BV | Use of gcn2 inhibitors in treating cancer |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3903297A (en) | 1973-11-01 | 1975-09-02 | Upjohn Co | Method of treatment and prophylaxis of gastric hypersecretion and gastric and duodenal ulcers using prostaglandin analogs |
US7863444B2 (en) * | 1997-03-19 | 2011-01-04 | Abbott Laboratories | 4-aminopyrrolopyrimidines as kinase inhibitors |
IL131582A0 (en) * | 1997-03-19 | 2001-01-28 | Basf Ag | Pyrrolo [2,3d] pyrimidines and their use as tyrosine kinase inhibitors |
CA2794153C (en) | 2010-03-25 | 2018-01-02 | Glaxosmithkline Llc | Substituted indoline derivatives as perk inhibitors |
ES2685661T3 (es) * | 2013-11-08 | 2018-10-10 | Ono Pharmaceutical Co., Ltd. | Derivado de pirrolopirimidina |
WO2016004254A1 (en) | 2014-07-01 | 2016-01-07 | The Regents Of The University Of California | Combined modulation of ire1 |
WO2016085160A2 (ko) * | 2014-11-28 | 2016-06-02 | (주)네오팜 | 발모촉진용 또는 탈모방지용 조성물 |
GB201508747D0 (en) * | 2015-05-21 | 2015-07-01 | Univ Edinburgh | Compounds |
CN109153680B (zh) * | 2016-07-07 | 2021-04-23 | 株式会社大熊制药 | 4-氨基吡唑并[3,4-d]嘧啶基氮杂双环衍生物及含其的药物组合物 |
CN110831927B (zh) * | 2017-04-18 | 2023-07-14 | 礼来公司 | 苯基-2-羟基-乙酰氨基-2-甲基-苯基化合物 |
-
2020
- 2020-08-28 BR BR112022003584A patent/BR112022003584A2/pt unknown
- 2020-08-28 CN CN202080073530.2A patent/CN114710956A/zh active Pending
- 2020-08-28 MX MX2022002446A patent/MX2022002446A/es unknown
- 2020-08-28 US US17/639,279 patent/US20220356186A1/en active Pending
- 2020-08-28 JP JP2022513164A patent/JP2022546414A/ja active Pending
- 2020-08-28 EP EP20771405.6A patent/EP4021908A1/en not_active Withdrawn
- 2020-08-28 KR KR1020227010197A patent/KR20220066290A/ko unknown
- 2020-08-28 WO PCT/US2020/048621 patent/WO2021041975A1/en active Application Filing
- 2020-08-28 AU AU2020336975A patent/AU2020336975A1/en active Pending
- 2020-08-28 CA CA3152508A patent/CA3152508A1/en active Pending
-
2022
- 2022-02-24 IL IL290889A patent/IL290889A/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2021041975A1 (en) | 2021-03-04 |
CA3152508A1 (en) | 2021-03-04 |
MX2022002446A (es) | 2022-06-02 |
CN114710956A (zh) | 2022-07-05 |
EP4021908A1 (en) | 2022-07-06 |
JP2022546414A (ja) | 2022-11-04 |
IL290889A (en) | 2022-04-01 |
KR20220066290A (ko) | 2022-05-24 |
US20220356186A1 (en) | 2022-11-10 |
AU2020336975A1 (en) | 2022-03-31 |
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