JPWO2020122034A5 - - Google Patents

Info

Publication number

JPWO2020122034A5

JPWO2020122034A5 JP2020560106A JP2020560106A JPWO2020122034A5 JP WO2020122034 A5 JPWO2020122034 A5 JP WO2020122034A5 JP 2020560106 A JP2020560106 A JP 2020560106A JP 2020560106 A JP2020560106 A JP 2020560106A JP WO2020122034 A5 JPWO2020122034 A5 JP WO2020122034A5

Authority

JP

Japan

Prior art keywords

antibody

pharmaceutical composition

amino acid

seq

composition according

Prior art date

2019-12-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000008194 pharmaceutical composition Substances 0.000 claims 43
• 125000003275 alpha amino acid group Chemical group 0.000 claims 22
• 150000001413 amino acids Chemical class 0.000 claims 18
• 239000000611 antibody drug conjugate Substances 0.000 claims 17
• 229940049595 antibody-drug conjugate Drugs 0.000 claims 17
• 239000012661 PARP inhibitor Substances 0.000 claims 8
• 229940121906 Poly ADP ribose polymerase inhibitor Drugs 0.000 claims 8
• 229940079593 drug Drugs 0.000 claims 7
• 239000003814 drug Substances 0.000 claims 7
• 150000003839 salts Chemical class 0.000 claims 6
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 5
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
• 206010006187 Breast cancer Diseases 0.000 claims 3
• 208000026310 Breast neoplasm Diseases 0.000 claims 3
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
• 206010033128 Ovarian cancer Diseases 0.000 claims 2
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
• 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
• HWGQMRYQVZSGDQ-HZPDHXFCSA-N chembl3137320 Chemical compound CN1N=CN=C1[C@H]([C@H](N1)C=2C=CC(F)=CC=2)C2=NNC(=O)C3=C2C1=CC(F)=C3 HWGQMRYQVZSGDQ-HZPDHXFCSA-N 0.000 claims 2
• 206010017758 gastric cancer Diseases 0.000 claims 2
• 201000005202 lung cancer Diseases 0.000 claims 2
• 208000020816 lung neoplasm Diseases 0.000 claims 2
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
• PCHKPVIQAHNQLW-CQSZACIVSA-N niraparib Chemical compound N1=C2C(C(=O)N)=CC=CC2=CN1C(C=C1)=CC=C1[C@@H]1CCCNC1 PCHKPVIQAHNQLW-CQSZACIVSA-N 0.000 claims 2
• 229950011068 niraparib Drugs 0.000 claims 2
• FAQDUNYVKQKNLD-UHFFFAOYSA-N olaparib Chemical group FC1=CC=C(CC2=C3[CH]C=CC=C3C(=O)N=N2)C=C1C(=O)N(CC1)CCN1C(=O)C1CC1 FAQDUNYVKQKNLD-UHFFFAOYSA-N 0.000 claims 2
• 229960000572 olaparib Drugs 0.000 claims 2
• 201000002528 pancreatic cancer Diseases 0.000 claims 2
• 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
• HMABYWSNWIZPAG-UHFFFAOYSA-N rucaparib Chemical compound C1=CC(CNC)=CC=C1C(N1)=C2CCNC(=O)C3=C2C1=CC(F)=C3 HMABYWSNWIZPAG-UHFFFAOYSA-N 0.000 claims 2
• 229950004707 rucaparib Drugs 0.000 claims 2
• 201000011549 stomach cancer Diseases 0.000 claims 2
• 229950004550 talazoparib Drugs 0.000 claims 2
• JNAHVYVRKWKWKQ-CYBMUJFWSA-N veliparib Chemical compound N=1C2=CC=CC(C(N)=O)=C2NC=1[C@@]1(C)CCCN1 JNAHVYVRKWKWKQ-CYBMUJFWSA-N 0.000 claims 2
• 229950011257 veliparib Drugs 0.000 claims 2
• 206010005003 Bladder cancer Diseases 0.000 claims 1
• 206010009944 Colon cancer Diseases 0.000 claims 1
• 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
• 206010051066 Gastrointestinal stromal tumour Diseases 0.000 claims 1
• 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
• 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
• 208000010191 Osteitis Deformans Diseases 0.000 claims 1
• 208000027868 Paget disease Diseases 0.000 claims 1
• 206010060862 Prostate cancer Diseases 0.000 claims 1
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
• 206010038389 Renal cancer Diseases 0.000 claims 1
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• 201000009036 biliary tract cancer Diseases 0.000 claims 1
• 208000020790 biliary tract neoplasm Diseases 0.000 claims 1
• 208000011892 carcinosarcoma of the corpus uteri Diseases 0.000 claims 1
• 208000029742 colonic neoplasm Diseases 0.000 claims 1
• 201000004101 esophageal cancer Diseases 0.000 claims 1
• 238000009472 formulation Methods 0.000 claims 1
• 201000007492 gastroesophageal junction adenocarcinoma Diseases 0.000 claims 1
• 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims 1
• 201000010536 head and neck cancer Diseases 0.000 claims 1
• 208000014829 head and neck neoplasm Diseases 0.000 claims 1
• 201000010982 kidney cancer Diseases 0.000 claims 1
• 201000000062 kidney sarcoma Diseases 0.000 claims 1
• 208000027202 mammary Paget disease Diseases 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 201000005112 urinary bladder cancer Diseases 0.000 claims 1
• 201000005290 uterine carcinosarcoma Diseases 0.000 claims 1