JP7608164B2 - 抗体－薬物コンジュゲートとｐａｒｐ阻害剤の組み合わせ - Google Patents

抗体－薬物コンジュゲートとｐａｒｐ阻害剤の組み合わせ Download PDF

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JP7608164B2
JP7608164B2 JP2020560106A JP2020560106A JP7608164B2 JP 7608164 B2 JP7608164 B2 JP 7608164B2 JP 2020560106 A JP2020560106 A JP 2020560106A JP 2020560106 A JP2020560106 A JP 2020560106A JP 7608164 B2 JP7608164 B2 JP 7608164B2
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antibody
amino acid
seq
acid sequence
set forth
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JPWO2020122034A1 (ja
JPWO2020122034A5 (enExample
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祐輔 扇谷
大祐 岡嶌
悠里 橋本
宏和 鈴木
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Daiichi Sankyo Co Ltd
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes

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  • Organic Chemistry (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
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  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020560106A 2018-12-11 2019-12-10 抗体－薬物コンジュゲートとｐａｒｐ阻害剤の組み合わせ Active JP7608164B2 (ja)

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JP2024221344A JP2025041725A (ja) 2018-12-11 2024-12-18 抗体－薬物コンジュゲートとｐａｒｐ阻害剤の組み合わせ

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JP2018231948 2018-12-11
JP2018231948 2018-12-11
PCT/JP2019/048171 WO2020122034A1 (ja) 2018-12-11 2019-12-10 抗体－薬物コンジュゲートとｐａｒｐ阻害剤の組み合わせ

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JP2024221344A Pending JP2025041725A (ja) 2018-12-11 2024-12-18 抗体－薬物コンジュゲートとｐａｒｐ阻害剤の組み合わせ

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US (1) US20220023436A1 (enExample)
EP (1) EP3909580A4 (enExample)
JP (2) JP7608164B2 (enExample)
CN (1) CN113271942A (enExample)
AU (1) AU2019396895B2 (enExample)
BR (1) BR112021011119A2 (enExample)
EA (1) EA202191641A1 (enExample)
SG (1) SG11202106248XA (enExample)
TW (1) TW202034959A (enExample)
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Families Citing this family (17)

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Publication number Priority date Publication date Assignee Title
AU2020285681A1 (en) * 2019-05-29 2022-01-27 Daiichi Sankyo Company, Limited Dosage of an antibody-drug conjugate
WO2022074617A1 (en) * 2020-10-09 2022-04-14 Astrazeneca Uk Limited Combination of antibody-drug conjugate and parp1 selective inhibitor
WO2022248268A1 (en) * 2021-05-28 2022-12-01 Adc Therapeutics Sa Combination therapy
US11806405B1 (en) 2021-07-19 2023-11-07 Zeno Management, Inc. Immunoconjugates and methods
CN118414173A (zh) 2021-11-18 2024-07-30 阿斯利康(英国)有限公司 抗体-药物缀合物和parp1选择性抑制剂的组合
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