|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
US5892019A
(en)
|
1987-07-15 |
1999-04-06 |
The United States Of America, As Represented By The Department Of Health And Human Services |
Production of a single-gene-encoded immunoglobulin
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
DE69120146T2
(de)
|
1990-01-12 |
1996-12-12 |
Cell Genesys Inc |
Erzeugung xenogener antikörper
|
|
GB9015908D0
(en)
|
1990-07-19 |
1990-09-05 |
Celltech Ltd |
Multivalent immunoglobulin
|
|
US6277969B1
(en)
|
1991-03-18 |
2001-08-21 |
New York University |
Anti-TNF antibodies and peptides of human tumor necrosis factor
|
|
WO1993023550A2
(en)
|
1992-05-18 |
1993-11-25 |
Genentech, Inc. |
Activation of oligomerizing receptors by using fused receptor ligands
|
|
DE69427928T3
(de)
|
1993-03-05 |
2012-05-10 |
Bayer Healthcare Llc |
Humane monoklonale anti-TNF alpha Antikörper
|
|
CA2139385C
(en)
|
1994-02-04 |
2001-12-25 |
Gottfried Alber |
Products containing g-csf and tnf binding protein
|
|
AU697387C
(en)
|
1994-09-16 |
2006-03-02 |
Austin Research Institute Cancer and Anti-inflammatory Syndicate No 1 |
Polypeptides with Fc binding ability
|
|
US8791237B2
(en)
|
1994-11-08 |
2014-07-29 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for treatment of non-hodgkins lymphoma
|
|
KR100475492B1
(ko)
|
1995-01-26 |
2005-03-14 |
바이오겐 아이덱 엠에이 인코포레이티드 |
항종양제로서의 림프독소-α/β 복합체 및항-림프독소-β수용체 항체
|
|
IL116784A
(en)
|
1996-01-16 |
2000-01-31 |
Hadasit Med Res Service |
Device for examining viscoelasticity of a living or artificial tissue
|
|
US8212004B2
(en)
|
1999-03-02 |
2012-07-03 |
Human Genome Sciences, Inc. |
Neutrokine-alpha fusion proteins
|
|
US6342369B1
(en)
|
1997-05-15 |
2002-01-29 |
Genentech, Inc. |
Apo-2-receptor
|
|
US20060269558A1
(en)
|
1998-04-27 |
2006-11-30 |
Murphy Gerald P |
Nr-CAM gene, nucleic acids and nucleic acid products for therapeutic and diagnostic uses for tumors
|
|
SI1642972T1
(sl)
|
1999-01-07 |
2010-05-31 |
Zymogenetics Inc |
Terapevtske uporabe BR X topnih receptorjev
|
|
JP2003512020A
(ja)
|
1999-03-04 |
2003-04-02 |
ヒューマン ジノーム サイエンシーズ， インコーポレイテッド |
腫瘍壊死因子レセプター６αおよび腫瘍壊死因子レセプター６β
|
|
AU3623700A
(en)
|
1999-03-11 |
2000-09-28 |
Reinhard Ebner |
Apoptosis inducing molecule ii and methods of use
|
|
DE19963859A1
(de)
|
1999-12-30 |
2001-07-12 |
Apotech Res & Dev Ltd |
Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen
|
|
US7262005B1
(en)
|
2000-02-04 |
2007-08-28 |
Aurora Biosciences Corporation |
Methods of protein destabilization and uses thereof
|
|
JP2003531588A
(ja)
|
2000-04-11 |
2003-10-28 |
ジェネンテック・インコーポレーテッド |
多価抗体とその用途
|
|
TWI318983B
(en)
|
2000-05-02 |
2010-01-01 |
Uab Research Foundation |
An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof
|
|
EP1360290A2
(en)
|
2000-06-23 |
2003-11-12 |
Maxygen, Inc. |
Co-stimulatory molecules
|
|
IL153853A0
(en)
|
2000-07-10 |
2003-07-31 |
Novartis Ag |
Bifunctional molecules and vectors complexed therewith for targeted gene delivery
|
|
WO2002102303A2
(en)
|
2001-05-01 |
2002-12-27 |
Medimmune, Inc. |
Crystals and structure of synagis fab
|
|
US7115717B2
(en)
|
2001-05-18 |
2006-10-03 |
Kirin Beer Kabushiki Kaisha |
Anti-TRAIL-R antibodies
|
|
US20050214210A1
(en)
*
|
2001-05-25 |
2005-09-29 |
Human Genome Sciences, Inc. |
Antibodies that immunospecifically bind to TRAIL receptors
|
|
WO2002097046A2
(en)
|
2001-05-25 |
2002-12-05 |
Amgen, Inc. |
B7 related protein-2 molecules and uses thereof
|
|
AU2002318364A1
(en)
|
2001-06-14 |
2003-01-02 |
Bristol-Myers Squibb Company |
Novel human histone deacetylases
|
|
AU2002361784A1
(en)
|
2001-12-20 |
2003-07-09 |
Human Genome Sciences, Inc. |
Antibodies that immunospecifically bind to trail receptors
|
|
DK2314629T4
(da)
|
2002-07-18 |
2023-02-06 |
Merus Nv |
Rekombinant produktion af blandinger af antistoffer
|
|
GB0220205D0
(en)
|
2002-08-30 |
2002-10-09 |
Chiron Spa |
Neisseria toxin
|
|
KR20090046973A
(ko)
|
2002-11-27 |
2009-05-11 |
아이알엠 엘엘씨 |
암세포에서 세포자멸사를 유도하기 위한 방법 및 조성물
|
|
AU2003303889A1
(en)
|
2003-01-07 |
2004-08-30 |
Biomerieux |
Polypeptides f' of the hepatitis c virus, epitopes, and the diagnostic and therapeutic applications thereof
|
|
DE602004030451D1
(de)
|
2003-07-15 |
2011-01-20 |
Chugai Pharmaceutical Co Ltd |
Produktion von igm durch transformierte zellen und verfahren zur quantifizierung dieser igm-produktion
|
|
EP1656151B1
(en)
|
2003-08-01 |
2007-09-26 |
Enhan Technology Holdings International Co., Ltd. |
Effects of sporoderm-broken germination activated ganoderma spores on treatment of spinal cord injury and proliferation and/or differentiation of neural stem cells in injured spinal cord
|
|
CN100427505C
(zh)
|
2004-08-19 |
2008-10-22 |
中国医学科学院基础医学研究所 |
抗人肿瘤坏死因子相关凋亡诱导配体的受体dr5单克隆抗体（ad5-10）及其制法与用途
|
|
DK1814913T3
(en)
|
2004-11-05 |
2015-09-28 |
Univ Leland Stanford Junior |
ANTIBODY-INDUCED CELL membrane damage.
|
|
EP1833848A2
(en)
|
2004-12-09 |
2007-09-19 |
Lajolla Institute for Allergy and Immunology |
Novel tnf receptor regulatory domain
|
|
NZ556651A
(en)
|
2005-01-21 |
2010-05-28 |
Epitopix Llc |
Yersinia spp. polypeptides and methods of use
|
|
US8029783B2
(en)
*
|
2005-02-02 |
2011-10-04 |
Genentech, Inc. |
DR5 antibodies and articles of manufacture containing same
|
|
US20060269556A1
(en)
|
2005-04-18 |
2006-11-30 |
Karl Nocka |
Mast cell activation using siglec 6 antibodies
|
|
JO3058B1
(ar)
|
2005-04-29 |
2017-03-15 |
Applied Molecular Evolution Inc |
الاجسام المضادة لمضادات -اي ال-6,تركيباتها طرقها واستعمالاتها
|
|
US8088908B2
(en)
|
2005-05-10 |
2012-01-03 |
City Of Hope |
Humanized anti-prostate stem cell antigen monoclonal antibody
|
|
US20060269567A1
(en)
|
2005-05-16 |
2006-11-30 |
Liu Yuen |
Universal detoxifying composition
|
|
US20060269569A1
(en)
|
2005-05-16 |
2006-11-30 |
Liu Yuen |
Universal antioncotic and pain relieving ointment
|
|
AU2006249992B2
(en)
|
2005-05-24 |
2010-09-02 |
The United States Of America As Represented By The Secretary Of The Navy |
Anti-adhesin based passive immunoprophylactic
|
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
PE20071101A1
(es)
|
2005-08-31 |
2007-12-21 |
Amgen Inc |
Polipeptidos y anticuerpos
|
|
TW200732350A
(en)
|
2005-10-21 |
2007-09-01 |
Amgen Inc |
Methods for generating monovalent IgG
|
|
TWI461436B
(zh)
|
2005-11-25 |
2014-11-21 |
Kyowa Hakko Kirin Co Ltd |
人類ｃｄ１３４（ｏｘ４０）之人類單株抗體及其製造及使用方法
|
|
CA2635599C
(en)
|
2006-01-13 |
2014-06-17 |
Irm Llc |
Antibodies against thymic stromal lymphopoietin receptor for treating allergic diseases
|
|
CN101074261A
(zh)
|
2006-04-30 |
2007-11-21 |
北京同为时代生物技术有限公司 |
Trail受体1和/或trail受体2特异性抗体及其应用
|
|
US8268635B2
(en)
|
2006-05-19 |
2012-09-18 |
Antonio Ferrante |
Methods of identifying agents that selectively activate p38 and/or NKkB signaling
|
|
NZ573646A
(en)
|
2006-06-12 |
2012-04-27 |
Wyeth Llc |
Single-chain multivalent binding proteins with effector function
|
|
KR100847010B1
(ko)
|
2006-07-05 |
2008-07-17 |
아주대학교산학협력단 |
세포사멸 수용체 5 (ｄｒ5)에 특이적으로 결합하는 항체 및이를 포함하는 암 예방 또는 치료용 조성물
|
|
EP1894940A1
(en)
|
2006-08-28 |
2008-03-05 |
Apogenix GmbH |
TNF superfamily fusion proteins
|
|
JP2010502224A
(ja)
|
2006-09-08 |
2010-01-28 |
アボット・ラボラトリーズ |
インターロイキン１３結合タンパク質
|
|
GB0620894D0
(en)
|
2006-10-20 |
2006-11-29 |
Univ Southampton |
Human immune therapies using a CD27 agonist alone or in combination with other immune modulators
|
|
KR20090105913A
(ko)
|
2006-11-02 |
2009-10-07 |
다니엘 제이 카폰 |
이동 부분을 갖는 하이브리드 면역글로불린
|
|
EP2195342A1
(en)
|
2007-09-07 |
2010-06-16 |
Ablynx N.V. |
Binding molecules with multiple binding sites, compositions comprising the same and uses thereof
|
|
CA2706700A1
(en)
|
2007-11-08 |
2009-05-14 |
Cytimmune Sciences, Inc. |
Compositions and methods for generating antibodies
|
|
EP2254592B1
(en)
|
2008-02-28 |
2019-06-05 |
Dako Denmark A/S |
Mhc multimers in borrelia diagnostics and disease
|
|
CN105169389A
(zh)
|
2008-08-01 |
2015-12-23 |
阿克西斯股份有限公司 |
骨关节炎治疗剂及预防剂
|
|
WO2010037402A1
(en)
|
2008-10-02 |
2010-04-08 |
Dako Denmark A/S |
Molecular vaccines for infectious disease
|
|
CA2785907A1
(en)
|
2009-12-29 |
2011-07-28 |
Emergent Product Development Seattle, Llc |
Ron binding constructs and methods of use thereof
|
|
WO2011116387A1
(en)
|
2010-03-19 |
2011-09-22 |
Tetragenetics, Inc. |
Production of aglycosylated monoclonal antibodies in ciliates
|
|
KR20130010123A
(ko)
|
2010-04-07 |
2013-01-25 |
아비에 인코포레이티드 |
ＴＮＦ-α 결합 단백질
|
|
MX337040B
(es)
|
2010-09-09 |
2016-02-09 |
Pfizer |
Moleculas de union a 4-1bb.
|
|
PH12013500845A1
(en)
|
2010-10-29 |
2013-06-24 |
Daiichi Sankyo Co Ltd |
Novel anti-dr5 antibody
|
|
UY33826A
(es)
|
2010-12-22 |
2012-07-31 |
Abbott Lab |
Proteínas de unión con dominios trivariables y sus usos
|
|
HUE038848T2
(hu)
|
2011-04-21 |
2018-11-28 |
Bristol Myers Squibb Co |
CD40-antagonista antitest polipeptidek
|
|
GB201115280D0
(en)
|
2011-09-05 |
2011-10-19 |
Alligator Bioscience Ab |
Antibodies, uses and methods
|
|
GB201116092D0
(en)
|
2011-09-16 |
2011-11-02 |
Bioceros B V |
Antibodies and uses thereof
|
|
US9382319B2
(en)
*
|
2011-09-26 |
2016-07-05 |
Jn Biosciences Llc |
Hybrid constant regions
|
|
EP2760891B1
(en)
*
|
2011-09-26 |
2018-11-07 |
JN Biosciences LLC |
Hybrid constant regions
|
|
RU2014121043A
(ru)
|
2011-10-24 |
2015-12-10 |
Эббви Инк. |
Биспецифические иммуносвязывающие средства, направленные против tnf и il-17
|
|
WO2013120012A2
(en)
|
2012-02-08 |
2013-08-15 |
Igm Biosciences Inc. |
Cdim binding proteins and uses thereof
|
|
EP2684896A1
(en)
|
2012-07-09 |
2014-01-15 |
International-Drug-Development-Biotech |
Anti-DR5 family antibodies, bispecific or multivalent anti-DR5 family antibodies and methods of use thereof
|
|
AU2013296425B2
(en)
*
|
2012-08-01 |
2018-06-07 |
Nationwide Children's Hospital |
Intrathecal delivery of recombinant adeno-associated virus 9
|
|
JP2015524821A
(ja)
|
2012-08-02 |
2015-08-27 |
ジェイエヌ バイオサイエンシーズ エルエルシー |
システイン変異及びμ尾部を介して多量体化した抗体又は融合タンパク質
|
|
WO2014063368A1
(zh)
|
2012-10-26 |
2014-05-01 |
中国医学科学院基础医学研究所 |
抗人死亡受体5胞外区的人源化单克隆抗体
|
|
US9487773B2
(en)
|
2013-03-01 |
2016-11-08 |
Technophage, Investigacao E Desenvolvimento Em Biotecnologia, Sa |
Cell-based methods for coupling protein interactions and binding molecule selection
|
|
UA118028C2
(uk)
|
2013-04-03 |
2018-11-12 |
Рош Глікарт Аг |
Біспецифічне антитіло, специфічне щодо fap і dr5, антитіло, специфічне щодо dr5, і спосіб їх застосування
|
|
WO2014180754A1
(en)
|
2013-05-07 |
2014-11-13 |
F. Hoffmann-La Roche Ag |
Trimeric antigen binding molecules
|
|
US20150038682A1
(en)
|
2013-08-02 |
2015-02-05 |
Jn Biosciences Llc |
Antibodies or fusion proteins multimerized via homomultimerizing peptide
|
|
CA2922830A1
(en)
|
2013-09-05 |
2015-04-16 |
Igm Biosciences, Inc. |
Constant chain modified bispecific, penta- and hexavalent ig-m antibodies
|
|
WO2015037000A1
(en)
|
2013-09-11 |
2015-03-19 |
Compugen Ltd |
Vstm5 polypeptides and uses thereof as a drug for treatment of cancer, infectious diseases and immune related diseases
|
|
US10519251B2
(en)
|
2013-12-30 |
2019-12-31 |
Epimab Biotherapeutics, Inc. |
Fabs-in-tandem immunoglobulin and uses thereof
|
|
US10167333B2
(en)
|
2014-01-16 |
2019-01-01 |
Mario Umberto Francesco Mondelli |
Neutralizing human monoclonal antibodies against hepatitis B virus surface antigen
|
|
EP3105250B1
(en)
|
2014-02-10 |
2020-08-05 |
IGM Biosciences, Inc. |
Iga multi-specific binding molecules
|
|
AU2015237864B2
(en)
|
2014-03-24 |
2020-12-03 |
Cancer Research Technology Limited |
Modified antibodies containing modified IgG2 domains which elicit agonist or antagonistic properties and use thereof
|
|
PL3560954T3
(pl)
|
2014-04-03 |
2021-12-13 |
Igm Biosciences, Inc. |
Zmodyfikowany łańcuch J
|
|
JP6810687B2
(ja)
|
2014-10-08 |
2021-01-06 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
Ｆａｐ及びｄｒ５に特異的な二重特異性抗体と化学療法剤との併用療法
|
|
IL308212A
(en)
|
2015-01-20 |
2024-01-01 |
Igm Biosciences Inc |
Tumor necrosis factor-α receptor binding molecules and their uses
|
|
RU2017129236A
(ru)
|
2015-01-26 |
2019-03-07 |
Макродженикс, Инк. |
Мультивалентные молекулы, содержащие dr5-связывающие домены
|
|
EP3957738A1
(en)
|
2015-03-04 |
2022-02-23 |
IGM Biosciences, Inc. |
Cd20 binding molecules and uses thereof
|
|
WO2016154593A1
(en)
|
2015-03-25 |
2016-09-29 |
Igm Biosciences, Inc. |
Multi-valent hepatitis b virus antigen binding molecules and uses thereof
|
|
CN107847591B
(zh)
|
2015-04-17 |
2023-07-28 |
Igm生物科学股份有限公司 |
多价人免疫缺陷病毒抗原结合分子及其应用
|
|
KR102669985B1
(ko)
|
2015-06-30 |
2024-05-29 |
샌포드 번햄 프레비즈 메디컬 디스커버리 인스티튜트 |
Btla 융합 단백질 작용제 및 이의 용도
|
|
NZ739830A
(en)
|
2015-07-12 |
2021-12-24 |
Hangzhou Dac Biotech Co Ltd |
Bridge linkers for conjugation of cell-binding molecules
|
|
EP3355913B1
(en)
|
2015-09-30 |
2024-10-30 |
IGM Biosciences, Inc. |
Binding molecules with modified j-chain
|
|
EP3356401B1
(en)
|
2015-09-30 |
2020-06-24 |
IGM Biosciences, Inc. |
Binding molecules with modified j-chain
|
|
SG11201809336QA
(en)
|
2016-05-09 |
2018-11-29 |
Igm Biosciences Inc |
Anti-pd-l1 antibodies
|
|
AU2017299608A1
(en)
|
2016-07-20 |
2019-02-07 |
Igm Biosciences, Inc. |
Multimeric CD137/4-1BB binding molecules and uses thereof
|
|
EP3496536A4
(en)
|
2016-07-20 |
2020-02-12 |
IGM Biosciences, Inc. |
MULTIMERE CD40-BINDING MOLECULES AND USES THEREOF
|
|
MX2019000799A
(es)
|
2016-07-20 |
2019-06-03 |
Igm Biosciences Inc |
Moleculas de union a gitr multimericas y usos de las mismas.
|
|
JP2019530640A
(ja)
|
2016-07-20 |
2019-10-24 |
アイジーエム バイオサイエンシズ インコーポレイテッド |
多量体ｏｘ４０結合分子及びその使用
|
|
ES2981272T3
(es)
|
2016-09-23 |
2024-10-08 |
Merus Nv |
Moléculas de unión que modulan una actividad biológica expresada por una célula
|
|
MX2019011986A
(es)
|
2017-04-07 |
2019-11-07 |
Igm Biosciences Inc |
Regiones constantes de igm humana modificadas para la modulacion de la funcion efectora de la citolisis dependiente de complemento referencia cruzada a solicitudes relacionadas.
|
|
EP3759229A4
(en)
|
2018-02-26 |
2021-12-29 |
IGM Biosciences Inc. |
Use of a multimeric anti-dr5 binding molecule in combination with a chemotherapeutic agent for treating cancer
|
|
MX2020009069A
(es)
|
2018-03-01 |
2020-10-08 |
Igm Biosciences Inc |
Mutaciones de fc de igm y de la cadena j que afectan la semivida de igm en suero.
|
|
US20210380701A1
(en)
|
2018-10-23 |
2021-12-09 |
Igm Biosciences, Inc. |
MULTIVALENT IgM- AND IgA-Fc-BASED BINDING MOLECULES
|
|
US20220106398A1
(en)
|
2019-02-08 |
2022-04-07 |
Igm Biosciences, Inc. |
Anti-gitr antigen-binding domains and uses thereof
|
|
JP2022544405A
(ja)
|
2019-08-15 |
2022-10-18 |
アイジーエム バイオサイエンシズ インコーポレイテッド |
免疫刺激性多量体型結合分子
|
|
KR20220045030A
(ko)
|
2019-08-17 |
2022-04-12 |
아이쥐엠 바이오사이언스 인코포레이티드 |
다량체성 이중특이적 항-cd123 결합 분자 및 이의 용도
|
|
US20220306760A1
(en)
|
2019-08-23 |
2022-09-29 |
Igm Biosciences, Inc. |
Igm glycovariants
|
|
AU2020351205A1
(en)
|
2019-09-19 |
2022-04-14 |
Igm Biosciences, Inc. |
Multimeric antibodies with enhanced selectivity for cells with high target density
|
|
BR112022013071A2
(pt)
|
2020-01-06 |
2022-09-20 |
Igm Biosciences Inc |
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|
|
EP4139362A2
(en)
|
2020-04-22 |
2023-03-01 |
IGM Biosciences Inc. |
Pd-1 agonist multimeric binding molecules
|
|
JP2023526224A
(ja)
|
2020-05-12 |
2023-06-21 |
アイジーエム バイオサイエンシズ インコーポレイテッド |
がんを治療するための、がん治療薬との組合せでの多量体抗ｄｒ５結合分子の使用
|
|
WO2022026475A2
(en)
|
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2022-02-03 |
Igm Biosciences, Inc. |
Multimeric coronavirus binding molecules and uses thereof
|
|
WO2022109023A1
(en)
|
2020-11-17 |
2022-05-27 |
Igm Biosciences, Inc. |
Uses of effector cell engaging molecules with moieties of differing potencies
|
|
WO2022177870A1
(en)
|
2021-02-17 |
2022-08-25 |
The Board Of Regents Of The University Of Texas System |
Multimeric sars-cov-2 binding molecules and uses thereof
|
|
US20240076392A1
(en)
|
2021-02-17 |
2024-03-07 |
Igm Biosciences, Inc. |
Anti-cd123 binding molecules and uses thereof
|