|
US4737462A
(en)
|
1982-10-19 |
1988-04-12 |
Cetus Corporation |
Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β
|
|
US4518584A
(en)
|
1983-04-15 |
1985-05-21 |
Cetus Corporation |
Human recombinant interleukin-2 muteins
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
WO1988007089A1
(en)
|
1987-03-18 |
1988-09-22 |
Medical Research Council |
Altered antibodies
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US6172197B1
(en)
|
1991-07-10 |
2001-01-09 |
Medical Research Council |
Methods for producing members of specific binding pairs
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
ATE300615T1
(de)
|
1990-08-29 |
2005-08-15 |
Genpharm Int |
Transgene mäuse fähig zur produktion heterologer antikörper
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US6277969B1
(en)
|
1991-03-18 |
2001-08-21 |
New York University |
Anti-TNF antibodies and peptides of human tumor necrosis factor
|
|
EP1400536A1
(en)
|
1991-06-14 |
2004-03-24 |
Genentech Inc. |
Method for making humanized antibodies
|
|
ES2341666T3
(es)
|
1991-12-02 |
2010-06-24 |
Medimmune Limited |
Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
|
|
GB9325182D0
(en)
|
1993-12-08 |
1994-02-09 |
T Cell Sciences Inc |
Humanized antibodies or binding proteins thereof specific for t cell subpopulations exhibiting select beta chain variable regions
|
|
US6599719B2
(en)
|
1994-11-07 |
2003-07-29 |
Human Genome Sciences, Inc. |
Nucleic acid molecules encoding tumor necrosis factor-gamma-alpha
|
|
US6824767B2
(en)
|
1994-11-07 |
2004-11-30 |
Human Genome Sciences, Inc. |
Tumor necrosis factor-gamma
|
|
WO2000066608A1
(en)
|
1999-04-30 |
2000-11-09 |
Human Genome Sciences, Inc. |
Tumor necrosis factor-gamma
|
|
US7597886B2
(en)
|
1994-11-07 |
2009-10-06 |
Human Genome Sciences, Inc. |
Tumor necrosis factor-gamma
|
|
US7820798B2
(en)
|
1994-11-07 |
2010-10-26 |
Human Genome Sciences, Inc. |
Tumor necrosis factor-gamma
|
|
US20030198640A1
(en)
|
1994-11-07 |
2003-10-23 |
Human Genome Sciences, Inc. |
Methods and compositions for treating inflammatory bowel diseases relating to human tumor necrosis factor-gamma-beta
|
|
JP4046349B2
(ja)
|
1994-11-07 |
2008-02-13 |
ヒューマン ジノーム サイエンシーズ, インコーポレイテッド |
腫瘍壊死因子−γ
|
|
US20030129189A1
(en)
|
1994-11-07 |
2003-07-10 |
Guo-Liang Yu |
Tumor necrosis factor-gamma
|
|
AU725609C
(en)
|
1995-08-18 |
2002-01-03 |
Morphosys Ag |
Protein/(poly)peptide libraries
|
|
US6696248B1
(en)
|
1995-08-18 |
2004-02-24 |
Morphosys Ag |
Protein/(poly)peptide libraries
|
|
US6632976B1
(en)
|
1995-08-29 |
2003-10-14 |
Kirin Beer Kabushiki Kaisha |
Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene
|
|
US7357927B2
(en)
|
1996-03-12 |
2008-04-15 |
Human Genome Sciences, Inc. |
Death domain containing receptors
|
|
ES2375931T3
(es)
|
1997-12-05 |
2012-03-07 |
The Scripps Research Institute |
Humanización de anticuerpo murino.
|
|
US6297367B1
(en)
|
1997-12-30 |
2001-10-02 |
Chiron Corporation |
Polynucleotide encoding TNFL1
|
|
WO1999045959A1
(en)
|
1998-03-13 |
1999-09-16 |
Dana-Farber Cancer Institute, Inc. |
Humanized antibody and uses thereof
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
ATE482275T1
(de)
|
1999-07-02 |
2010-10-15 |
Morphosys Ag |
Erzeugung spezifischer bindungspartner die an von genomischen dns-fragmenten oder ests kodierten (poly)peptiden binden
|
|
US6399857B1
(en)
*
|
1999-09-22 |
2002-06-04 |
Paradigm Genetics, Inc. |
Modified nucleotide sequence encoding a LexA DNA binding domain optimized for arabidopsis species
|
|
US20110131679A2
(en)
|
2000-04-19 |
2011-06-02 |
Thomas La Rosa |
Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
|
|
US6571638B2
(en)
|
2000-06-30 |
2003-06-03 |
Sawtek, Inc. |
Surface-acoustic-wave pressure sensor and associated methods
|
|
AU2001277857A1
(en)
|
2000-07-07 |
2002-01-21 |
Human Genome Sciences, Inc. |
Tumor necrosis factor-gamma
|
|
US6824989B1
(en)
|
2000-09-01 |
2004-11-30 |
Upstate Biotechnology, Inc. |
Recombinant monoclonal antibody to phosphotyrosine-containing proteins
|
|
CA2391711A1
(en)
|
2001-06-26 |
2002-12-26 |
University Of Guelph |
Non-radioactive assay of lipopolysaccharide kinases
|
|
KR101033196B1
(ko)
*
|
2002-02-14 |
2011-05-09 |
이뮤노메딕스, 인코오포레이티드 |
항-cd20 항체 및 그 융합 단백질 및 이들의 이용방법
|
|
US7314974B2
(en)
*
|
2002-02-21 |
2008-01-01 |
Monsanto Technology, Llc |
Expression of microbial proteins in plants for production of plants with improved properties
|
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
US20090042291A1
(en)
|
2002-03-01 |
2009-02-12 |
Xencor, Inc. |
Optimized Fc variants
|
|
SI2301965T1
(sl)
|
2002-10-16 |
2015-07-31 |
Purdue Pharma L.P. |
Protitelesa, ki vežejo celično- povezan CA 125 / O722P in metode uporabe le-teh
|
|
WO2004050836A2
(en)
|
2002-11-27 |
2004-06-17 |
Biogen Idec Ma Inc. |
Humanized antibodies against monocyte chemotactic proteins
|
|
US20090010920A1
(en)
|
2003-03-03 |
2009-01-08 |
Xencor, Inc. |
Fc Variants Having Decreased Affinity for FcyRIIb
|
|
US20050101889A1
(en)
|
2003-11-06 |
2005-05-12 |
Freeman Gary A. |
Using chest velocity to process physiological signals to remove chest compression artifacts
|
|
AU2005271892A1
(en)
*
|
2004-07-10 |
2006-02-16 |
Alexion Pharmaceuticals, Inc. |
Methods for discovering antibodies specific to cancer cells and antibodies discovered thereby
|
|
KR100596277B1
(ko)
|
2004-08-20 |
2006-07-03 |
동부일렉트로닉스 주식회사 |
반도체 소자 및 그의 절연막 형성 방법
|
|
TWI309240B
(en)
|
2004-09-17 |
2009-05-01 |
Hoffmann La Roche |
Anti-ox40l antibodies
|
|
CN102321174B
(zh)
|
2005-05-06 |
2013-10-16 |
津莫吉尼蒂克斯公司 |
Il-31单克隆抗体及使用方法
|
|
JP5339901B2
(ja)
|
2005-05-10 |
2013-11-13 |
バイオジェン・アイデック・エムエイ・インコーポレイテッド |
炎症傷害の処置および評価
|
|
US20090317388A1
(en)
|
2005-05-25 |
2009-12-24 |
Linda Burkly |
Tl1a in treatment of disease
|
|
CN103145839A
(zh)
*
|
2005-06-30 |
2013-06-12 |
Abbvie公司 |
Il-12/p40结合蛋白
|
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
JP5164167B2
(ja)
|
2005-08-30 |
2013-03-13 |
ユニバーシティー オブ マイアミ |
免疫調節性腫瘍壊死因子受容体25(tnfr25)のアゴニスト、アンタゴニスト及び免疫毒素
|
|
WO2007146968A2
(en)
|
2006-06-12 |
2007-12-21 |
Trubion Pharmaceuticals, Inc. |
Single-chain multivalent binding proteins with effector function
|
|
US7691980B2
(en)
|
2007-01-09 |
2010-04-06 |
Bio-Rad Laboratories, Inc. |
Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
|
|
US20110217310A1
(en)
|
2007-01-10 |
2011-09-08 |
Siegel Richard M |
Blockade of tl1a-dr3 interactions to ameliorate t cell mediated disease pathology
|
|
US9896511B2
(en)
|
2007-01-10 |
2018-02-20 |
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services |
Antibodies that bind to TL1A and methods of treating inflammatory or autoimmune disease comprising administering such antibodies
|
|
US20100055700A1
(en)
|
2007-02-28 |
2010-03-04 |
Cedars-Sinai Medical Center |
Role of il-12, il-23 and il-17 receptors in inflammatory bowel disease
|
|
UA104132C2
(en)
*
|
2007-11-13 |
2014-01-10 |
Тева Биофармасьютикалз Юесей, Инк. |
Humanized antibodies against tl1a
|
|
CN101469270B
(zh)
|
2007-12-27 |
2012-08-22 |
牛斌 |
工业连续化塑料裂解器
|
|
EP2275431A3
(en)
|
2008-01-18 |
2011-05-25 |
Bio-Rad Laboratories, Inc. |
Enhanced fractionation of phosphorylated and nonphosphorylated biomolecules by apatite chromotography
|
|
JP5581323B2
(ja)
|
2008-09-29 |
2014-08-27 |
ロシュ グリクアート アクチェンゲゼルシャフト |
ヒトil17に対する抗体およびその使用
|
|
EP2411412B1
(en)
|
2009-03-24 |
2015-05-27 |
Teva Biopharmaceuticals USA, Inc. |
Humanized antibodies against light and uses thereof
|
|
JP2013501057A
(ja)
|
2009-08-03 |
2013-01-10 |
ユニバーシティー・オブ・マイアミ |
制御性t細胞のinvivoにおける増殖
|
|
WO2011106707A2
(en)
|
2010-02-26 |
2011-09-01 |
Human Genome Sciences, Inc. |
Antibodies that specifically bind to dr3
|
|
JP5813114B2
(ja)
|
2010-08-25 |
2015-11-17 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
Il−18r1に対する抗体およびその使用
|
|
CN103249742B
(zh)
|
2010-09-16 |
2017-04-12 |
巴利奥医药股份公司 |
抗人肿瘤坏死因子1型受体抗体
|
|
US8766034B2
(en)
|
2010-09-22 |
2014-07-01 |
Cedars-Sinai Medical Center |
TL1A model of inflammation fibrosis and autoimmunity
|
|
JO3375B1
(ar)
|
2010-11-08 |
2019-03-13 |
Regeneron Pharma |
أجسام مضادة بشرية للجين a1 الشبيه بعامل النخر الورمي (tl1a)
|
|
US9902996B2
(en)
|
2011-02-11 |
2018-02-27 |
Cedars-Sinai Medical Center |
Methods of predicting the need for surgery in crohn's disease
|
|
KR20140104344A
(ko)
|
2011-05-20 |
2014-08-28 |
더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 시크리터리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비시스 |
T 세포 매개성 질병의 병증을 개선하기 위한 tl1a-dr3의 상호작용의 차단 및 그것의 항체
|
|
SG195253A1
(en)
|
2011-06-03 |
2013-12-30 |
Xoma Technology Ltd |
Antibodies specific for tgf-beta
|
|
CN109517059B
(zh)
|
2011-06-30 |
2023-03-28 |
中外制药株式会社 |
异源二聚化多肽
|
|
MX2014003689A
(es)
|
2011-09-30 |
2014-12-05 |
Teva Pharmaceuticals Australia Pty Ltd |
Anticuerpos contra tl1a y sus usos.
|
|
JP6124800B2
(ja)
|
2011-11-30 |
2017-05-10 |
中外製薬株式会社 |
免疫複合体を形成する細胞内への運搬体(キャリア)を含む医薬
|
|
GB201203051D0
(en)
|
2012-02-22 |
2012-04-04 |
Ucb Pharma Sa |
Biological products
|
|
BR112015002091A2
(pt)
|
2012-08-02 |
2017-12-12 |
Hoffmann La Roche |
método para a produção de um polipeptídeo, polipeptídeo, uso de um polipeptídeo e composição
|
|
CN104508132B
(zh)
|
2012-08-02 |
2017-09-15 |
弗·哈夫曼-拉罗切有限公司 |
用于产生作为与惰性免疫球蛋白Fc区Fc融合的可溶FcR的方法及其用途
|
|
WO2014051109A1
(ja)
*
|
2012-09-28 |
2014-04-03 |
協和発酵キリン株式会社 |
抗ヒトbmp9抗体および該抗体を有効成分とする異所性骨化疾患の治療剤
|
|
US10766960B2
(en)
|
2012-12-27 |
2020-09-08 |
Chugai Seiyaku Kabushiki Kaisha |
Heterodimerized polypeptide
|
|
EA201591153A1
(ru)
|
2013-01-02 |
2016-01-29 |
Гленмарк Фармасьютикалс С.А. |
Антитела, связывающиеся с tl1a, и их применение
|
|
FI2970398T3
(fi)
|
2013-03-13 |
2024-08-06 |
Us Health |
Rsv f -prefuusioproteiineja ja niiden käyttö
|
|
ES2699599T3
(es)
|
2013-03-15 |
2019-02-11 |
Abbvie Biotherapeutics Inc |
Variantes de Fc
|
|
BR112015023752B1
(pt)
|
2013-03-15 |
2023-11-14 |
Zyngenia, Inc. |
Domínio de reconhecimento modular (mrd), complexo compreendendo mrd e cetuximabe, usos do complexo para inibir a angiogênese e tratar câncer e composição farmacêutica compreendendo o dito complexo
|
|
SG11201509982UA
(https=)
*
|
2013-06-06 |
2016-04-28 |
Igenica Biotherapeutics Inc |
|
|
WO2015010108A1
(en)
|
2013-07-19 |
2015-01-22 |
Cedars-Sinai Medical Center |
Signature of tl1a (tnfsf15) signaling pathway
|
|
EA034666B1
(ru)
|
2013-09-13 |
2020-03-04 |
Бейджин Свитзерланд Гмбх |
Антитело против pd-1 и его применение для лечения рака или вирусной инфекции и фрагмент антитела
|
|
MX388027B
(es)
*
|
2013-11-13 |
2025-03-19 |
Pfizer |
Anticuerpos específicos para el ligando 1a tipo factor de necrosis tumoral y composiciones y usos de los mismos.
|
|
EP3131917B1
(en)
*
|
2014-04-18 |
2020-06-17 |
The Board of Trustees of the Leland Stanford Junior University |
Humanized and chimeric monoclonal antibodies to cd99
|
|
TW201622727A
(zh)
|
2014-05-02 |
2016-07-01 |
泰瓦藥品工業有限公司 |
以延遲釋放型6-巰基嘌呤治療克隆氏症
|
|
ES2936810T3
(es)
|
2014-05-16 |
2023-03-22 |
Pfizer |
Anticuerpos biespecíficos con interfaces CH1-CL de ingeniería
|
|
US10160805B2
(en)
|
2014-07-11 |
2018-12-25 |
New York University |
Methods of treating inflammatory bowel disease by administering tumor necrosis factor-like ligand 1A or an agonistic death-domain receptor 3 antibody
|
|
CR20170194A
(es)
|
2014-11-14 |
2017-07-10 |
Hoffmann La Roche |
Moleculas de unión a antígeno que comprenden un trímero de ligando de la familia de tnf
|
|
MA41460A
(fr)
|
2015-02-03 |
2017-12-12 |
Oncomed Pharm Inc |
Agents de liaison à la tnfrsf et leurs utilisations
|
|
WO2016156291A1
(en)
|
2015-03-31 |
2016-10-06 |
F. Hoffmann-La Roche Ag |
Antigen binding molecules comprising a trimeric tnf family ligand
|
|
EP3280439A1
(en)
*
|
2015-04-07 |
2018-02-14 |
INSERM - Institut National de la Santé et de la Recherche Médicale |
Anti-pd-l1 immunotoxin for use in therapy
|
|
US10647756B2
(en)
|
2015-05-18 |
2020-05-12 |
Pfizer Inc. |
Humanized antibodies
|
|
JP6932700B2
(ja)
|
2015-09-15 |
2021-09-08 |
アムジエン・インコーポレーテツド |
4価の二重特異性抗原結合タンパク質及び4価の四重特異性抗原結合タンパク質、ならびにそれらの使用
|
|
TWI703158B
(zh)
|
2015-09-18 |
2020-09-01 |
美商希佛隆公司 |
特異性結合tl1a之抗體
|
|
PE20240096A1
(es)
|
2015-10-02 |
2024-01-18 |
Hoffmann La Roche |
Anticuerpos biespecificos especificos para un receptor de tnf coestimulador
|
|
US20180319889A1
(en)
|
2015-11-02 |
2018-11-08 |
La Jolla Institute For Allergy & Immunology |
Method and medicament for treating airway and/or lung diseases
|
|
ITUB20155097A1
(it)
*
|
2015-11-05 |
2017-05-05 |
Biouniversa Srl |
Anticorpi umanizzati anti-BAG3
|
|
CR20180365A
(es)
|
2015-12-16 |
2018-09-28 |
Amgen Inc |
PROTEÍNAS DE UNIÓN AL ANTÍGENO BISPECÍFICO DE ANTI-TL1A/ANTI-TNF-a Y SUS USOS
|
|
AU2017258492B2
(en)
|
2016-04-29 |
2023-12-07 |
Pfizer Inc. |
Interferon beta antibodies and uses thereof
|
|
KR102417687B1
(ko)
|
2016-05-09 |
2022-07-07 |
브리스톨-마이어스 스큅 컴퍼니 |
Tl1a 항체 및 그의 용도
|
|
US10688412B2
(en)
|
2016-07-25 |
2020-06-23 |
Cehpalon, Inc. |
Affinity chromatography wash buffer
|
|
MY191324A
(en)
|
2016-10-26 |
2022-06-15 |
Cedars Sinai Medical Center |
Neutralizing anti-tl1a monoclonal antibodies
|
|
EP3554342B1
(en)
|
2016-12-14 |
2024-07-24 |
Biora Therapeutics, Inc. |
Treatment of a disease of the gastrointestinal tract with a tnf inhibitor
|
|
CA3078800A1
(en)
|
2017-10-10 |
2019-04-18 |
Sanofi |
Anti-cd38 antibodies and methods of use
|
|
WO2019121906A1
(en)
|
2017-12-19 |
2019-06-27 |
F-Star Beta Limited |
Specific pd-l1 binding sequences inserted in a ch3 domain
|
|
JP7332627B2
(ja)
|
2018-04-25 |
2023-08-23 |
プロメテウス バイオサイエンシーズ,インク. |
最適化された抗tl1a抗体
|
|
GB201811450D0
(en)
|
2018-07-12 |
2018-08-29 |
F Star Delta Ltd |
Mesothelin and CD137 binding molecules
|
|
GB201811408D0
(en)
|
2018-07-12 |
2018-08-29 |
F Star Beta Ltd |
CD137 Binding Molecules
|
|
GB201811415D0
(en)
|
2018-07-12 |
2018-08-29 |
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Anti-Mesothelin Anti bodies
|
|
PL3820569T3
(pl)
|
2018-07-12 |
2025-07-14 |
Invox Pharma Limited |
Cząsteczki przeciwciał, które wiążą PD-L1 oraz CD137
|
|
GB201811404D0
(en)
|
2018-07-12 |
2018-08-29 |
F Star Beta Ltd |
Anti-CD137 Antibodies
|
|
BR112021000282A2
(pt)
|
2018-07-12 |
2021-04-06 |
F-Star Beta Limited |
Moléculas de anticorpo que se ligam a cd137 e ox40
|
|
GB201811410D0
(en)
|
2018-07-12 |
2018-08-29 |
F Star Beta Ltd |
OX40 Binding molecules
|
|
CA3115679A1
(en)
|
2018-10-09 |
2020-04-16 |
Sanofi |
Trispecific anti-cd38, anti-cd28, and anti-cd3 binding proteins and methods of use for treating viral infection
|
|
AU2019366956B2
(en)
|
2018-10-23 |
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Heterodimeric Fc-fused proteins
|
|
KR20220103721A
(ko)
|
2019-10-24 |
2022-07-22 |
프로메테우스 바이오사이언시즈, 인크. |
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|
|
WO2021081365A1
(en)
|
2019-10-24 |
2021-04-29 |
Prometheus Biosciences, Inc. |
Humanized antibodies to tnf-like ligand 1a (tl1a) and uses thereof
|
|
CN116322762A
(zh)
|
2020-06-26 |
2023-06-23 |
辉瑞公司 |
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|