JP2022058402A5 - - Google Patents
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- JP2022058402A5 JP2022058402A5 JP2021210002A JP2021210002A JP2022058402A5 JP 2022058402 A5 JP2022058402 A5 JP 2022058402A5 JP 2021210002 A JP2021210002 A JP 2021210002A JP 2021210002 A JP2021210002 A JP 2021210002A JP 2022058402 A5 JP2022058402 A5 JP 2022058402A5
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- Prior art keywords
- reagent
- analyte
- ribosome protein
- capture
- nucleic acid
- Prior art date
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- 239000003153 chemical reaction reagent Substances 0.000 claims 69
- 238000000034 method Methods 0.000 claims 36
- 238000001514 detection method Methods 0.000 claims 34
- 239000012491 analyte Substances 0.000 claims 33
- 108091034117 Oligonucleotide Proteins 0.000 claims 27
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims 18
- 239000002853 nucleic acid probe Substances 0.000 claims 18
- 102000004169 proteins and genes Human genes 0.000 claims 16
- 108090000623 proteins and genes Proteins 0.000 claims 16
- 210000001808 exosome Anatomy 0.000 claims 12
- 239000000523 sample Substances 0.000 claims 12
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 11
- -1 antibodies Substances 0.000 claims 8
- 239000002245 particle Substances 0.000 claims 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 4
- 108091023037 Aptamer Proteins 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 230000000295 complement effect Effects 0.000 claims 3
- 238000005259 measurement Methods 0.000 claims 3
- 238000003752 polymerase chain reaction Methods 0.000 claims 3
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 2
- HLXHCNWEVQNNKA-UHFFFAOYSA-N 5-methoxy-2,3-dihydro-1h-inden-2-amine Chemical compound COC1=CC=C2CC(N)CC2=C1 HLXHCNWEVQNNKA-UHFFFAOYSA-N 0.000 claims 2
- 108700037654 Acyl carrier protein (ACP) Proteins 0.000 claims 2
- 102000048456 Acyl carrier protein (ACP) Human genes 0.000 claims 2
- 108091093088 Amplicon Proteins 0.000 claims 2
- 108090001008 Avidin Proteins 0.000 claims 2
- 102100025222 CD63 antigen Human genes 0.000 claims 2
- 102100027221 CD81 antigen Human genes 0.000 claims 2
- 102100037904 CD9 antigen Human genes 0.000 claims 2
- 101100507655 Canis lupus familiaris HSPA1 gene Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 2
- 101000934368 Homo sapiens CD63 antigen Proteins 0.000 claims 2
- 101000914479 Homo sapiens CD81 antigen Proteins 0.000 claims 2
- 101000738354 Homo sapiens CD9 antigen Proteins 0.000 claims 2
- 102000006992 Interferon-alpha Human genes 0.000 claims 2
- 108010047761 Interferon-alpha Proteins 0.000 claims 2
- 108090000174 Interleukin-10 Proteins 0.000 claims 2
- 102000013691 Interleukin-17 Human genes 0.000 claims 2
- 108050003558 Interleukin-17 Proteins 0.000 claims 2
- 108010002350 Interleukin-2 Proteins 0.000 claims 2
- 102100030703 Interleukin-22 Human genes 0.000 claims 2
- 108090000978 Interleukin-4 Proteins 0.000 claims 2
- 108010002616 Interleukin-5 Proteins 0.000 claims 2
- 108090001005 Interleukin-6 Proteins 0.000 claims 2
- 108010068204 Peptide Elongation Factors Proteins 0.000 claims 2
- 102000002508 Peptide Elongation Factors Human genes 0.000 claims 2
- 101710132632 Protein C4 Proteins 0.000 claims 2
- 101710132684 Protein L5 Proteins 0.000 claims 2
- 108010090804 Streptavidin Proteins 0.000 claims 2
- 108700030796 Tsg101 Proteins 0.000 claims 2
- 101150072717 Tsg101 gene Proteins 0.000 claims 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
- 230000003321 amplification Effects 0.000 claims 2
- 229960002685 biotin Drugs 0.000 claims 2
- 235000020958 biotin Nutrition 0.000 claims 2
- 239000011616 biotin Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000002414 glycolytic effect Effects 0.000 claims 2
- 108010074109 interleukin-22 Proteins 0.000 claims 2
- 238000007834 ligase chain reaction Methods 0.000 claims 2
- OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 claims 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims 2
- 108010025591 ribosomal protein L16 Proteins 0.000 claims 2
- 101710150697 Inositol monophosphatase 1 Proteins 0.000 claims 1
- 101710126181 Insulin-like growth factor 2 mRNA-binding protein 1 Proteins 0.000 claims 1
- 102000003960 Ligases Human genes 0.000 claims 1
- 108090000364 Ligases Proteins 0.000 claims 1
- 102100029083 Minor histocompatibility antigen H13 Human genes 0.000 claims 1
- 102000006382 Ribonucleases Human genes 0.000 claims 1
- 108010083644 Ribonucleases Proteins 0.000 claims 1
- 238000002835 absorbance Methods 0.000 claims 1
- 238000000149 argon plasma sintering Methods 0.000 claims 1
- 239000012131 assay buffer Substances 0.000 claims 1
- 230000029918 bioluminescence Effects 0.000 claims 1
- 238000005415 bioluminescence Methods 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 238000011901 isothermal amplification Methods 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 239000006174 pH buffer Substances 0.000 claims 1
- 238000004094 preconcentration Methods 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 239000000376 reactant Substances 0.000 claims 1
- 238000005096 rolling process Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023059022A JP7575516B2 (ja) | 2014-05-15 | 2023-03-31 | 改善されたアッセイ方法 |
| JP2024181465A JP2025020158A (ja) | 2014-05-15 | 2024-10-17 | 改善されたアッセイ方法 |
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461993581P | 2014-05-15 | 2014-05-15 | |
| US61/993,581 | 2014-05-15 | ||
| US201462013823P | 2014-06-18 | 2014-06-18 | |
| US62/013,823 | 2014-06-18 | ||
| US201462048489P | 2014-09-10 | 2014-09-10 | |
| US62/048,489 | 2014-09-10 | ||
| US201462049520P | 2014-09-12 | 2014-09-12 | |
| US62/049,520 | 2014-09-12 | ||
| US201462055093P | 2014-09-25 | 2014-09-25 | |
| US62/055,093 | 2014-09-25 | ||
| JP2020075171A JP7000493B2 (ja) | 2014-05-15 | 2020-04-21 | 改善されたアッセイ方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020075171A Division JP7000493B2 (ja) | 2014-05-15 | 2020-04-21 | 改善されたアッセイ方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023059022A Division JP7575516B2 (ja) | 2014-05-15 | 2023-03-31 | 改善されたアッセイ方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022058402A JP2022058402A (ja) | 2022-04-12 |
| JP2022058402A5 true JP2022058402A5 (enExample) | 2022-07-21 |
| JP7256860B2 JP7256860B2 (ja) | 2023-04-12 |
Family
ID=54480726
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016567814A Active JP6695280B2 (ja) | 2014-05-15 | 2015-05-15 | 改善されたアッセイ方法 |
| JP2020075171A Active JP7000493B2 (ja) | 2014-05-15 | 2020-04-21 | 改善されたアッセイ方法 |
| JP2021210002A Active JP7256860B2 (ja) | 2014-05-15 | 2021-12-23 | 改善されたアッセイ方法 |
| JP2023059022A Active JP7575516B2 (ja) | 2014-05-15 | 2023-03-31 | 改善されたアッセイ方法 |
| JP2024181465A Pending JP2025020158A (ja) | 2014-05-15 | 2024-10-17 | 改善されたアッセイ方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016567814A Active JP6695280B2 (ja) | 2014-05-15 | 2015-05-15 | 改善されたアッセイ方法 |
| JP2020075171A Active JP7000493B2 (ja) | 2014-05-15 | 2020-04-21 | 改善されたアッセイ方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023059022A Active JP7575516B2 (ja) | 2014-05-15 | 2023-03-31 | 改善されたアッセイ方法 |
| JP2024181465A Pending JP2025020158A (ja) | 2014-05-15 | 2024-10-17 | 改善されたアッセイ方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US10408823B2 (enExample) |
| EP (1) | EP3143401A4 (enExample) |
| JP (5) | JP6695280B2 (enExample) |
| KR (3) | KR20250011724A (enExample) |
| CN (3) | CN112239774B (enExample) |
| AU (3) | AU2015259048B2 (enExample) |
| CA (1) | CA2948547A1 (enExample) |
| WO (1) | WO2015175856A1 (enExample) |
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| CN108290058B (zh) | 2015-09-17 | 2023-05-16 | 美国安进公司 | 使用il23途径生物标志物预测il23拮抗剂的临床应答 |
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| CN113557309A (zh) | 2018-10-31 | 2021-10-26 | 斯坦福大学托管董事会 | 用于使用寡核苷酸缀合抗体检测细胞的方法和试剂盒 |
| CN120098057A (zh) | 2019-03-01 | 2025-06-06 | 中尺度技术有限责任公司 | 用于免疫方法的被电化学发光标记的探针、使用这类探针的方法和包含这类探针的试剂盒 |
| IL300973A (en) | 2020-09-02 | 2023-04-01 | Meso Scale Technologies Llc | Kits for detecting one or more target analytes in a sample and methods for making and using the same |
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