JP2021531291A5 - - Google Patents
Info
- Publication number
- JP2021531291A5 JP2021531291A5 JP2021503007A JP2021503007A JP2021531291A5 JP 2021531291 A5 JP2021531291 A5 JP 2021531291A5 JP 2021503007 A JP2021503007 A JP 2021503007A JP 2021503007 A JP2021503007 A JP 2021503007A JP 2021531291 A5 JP2021531291 A5 JP 2021531291A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- pain
- substituted
- substituents independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18184716 | 2018-07-20 | ||
| EP18184716.1 | 2018-07-20 | ||
| PCT/EP2019/069593 WO2020016443A1 (en) | 2018-07-20 | 2019-07-19 | Difluoromethyl-phenyl triazoles as gaba receptor modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021531291A JP2021531291A (ja) | 2021-11-18 |
| JP2021531291A5 true JP2021531291A5 (enExample) | 2022-07-27 |
| JP7311583B2 JP7311583B2 (ja) | 2023-07-19 |
Family
ID=63014393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021503007A Active JP7311583B2 (ja) | 2018-07-20 | 2019-07-19 | Ｇａｂａ受容体モジュレーターとしてのジフルオロメチル－フェニルトリアゾール |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10941137B2 (enExample) |
| EP (1) | EP3823967B1 (enExample) |
| JP (1) | JP7311583B2 (enExample) |
| CN (1) | CN112424197B (enExample) |
| AR (1) | AR117615A1 (enExample) |
| BR (1) | BR102019014802A2 (enExample) |
| TW (1) | TW202019915A (enExample) |
| WO (1) | WO2020016443A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12649738B2 (en) | 2020-03-26 | 2026-06-09 | Richter Gedeon Nyrt. | 1,3-dihydro-2H-pyrrolo[3,4-c]pyridine derivatives as GABAA α5 receptor modulators |
| TWI901650B (zh) * | 2020-03-26 | 2025-10-21 | 匈牙利商羅特格登公司 | 啶及吡啶并〔３，４－ｃ〕嗒衍生物 |
| EP4149933B1 (en) * | 2020-05-13 | 2024-06-12 | F. Hoffmann-La Roche AG | New triazolyl derivatives as gaba a alpha5 pam |
| EP3971179A1 (en) * | 2020-09-22 | 2022-03-23 | Boehringer Ingelheim International GmbH | Difluoromethyl-pyridin-2-yl triazoles |
| TWI915398B (zh) * | 2020-08-05 | 2026-02-21 | 丹麥商薩尼奧納有限責任公司 | 二氟甲基-吡啶-2-基三唑 |
| EP3992188A1 (en) * | 2020-10-29 | 2022-05-04 | Boehringer Ingelheim International GmbH | Difluoromethyl-pyridin-2-yl triazoles |
| EP3950683A1 (en) * | 2020-08-05 | 2022-02-09 | Boehringer Ingelheim International GmbH | Difluoromethyl-pyridin-2-yl triazoles |
| IL310708A (en) * | 2021-08-12 | 2024-04-01 | Shanghai Simr Biotechnology Co Ltd | The history of converted triazole, a method for its preparation, its pharmaceutical preparation and its use |
| HU231691B1 (hu) | 2021-09-29 | 2025-10-28 | Richter Gedeon Nyrt | GABAA ALFA5 receptor modulátor hatású biciklusos aminszármazékok |
| CN116462664B (zh) * | 2022-03-08 | 2025-07-01 | 上海赛默罗生物科技有限公司 | 吡唑环类化合物、其制备方法、组合物及应用 |
| CN116854680A (zh) * | 2022-03-28 | 2023-10-10 | 上海赛默罗生物科技有限公司 | 异噁唑-杂环类衍生物、药物组合物和用途 |
| WO2024251133A1 (zh) * | 2023-06-05 | 2024-12-12 | 武汉人福创新药物研发中心有限公司 | 作为α5-GABAA受体调节剂的杂环化合物及其用途 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009508905A (ja) | 2005-09-19 | 2009-03-05 | エフ．ホフマン−ラ ロシュ アーゲー | ＧＡＢＡＡα５逆アゴニストとしてのイソオキサゾロ誘導体 |
| CN101277952B (zh) | 2005-10-11 | 2011-09-28 | 弗·哈夫曼-拉罗切有限公司 | 异*唑衍生物 |
| DE602006014185D1 (de) | 2005-11-09 | 2010-06-17 | Hoffmann La Roche | 3-arylisoxazol-4-carbonylbenzofuranderivative |
| RU2426731C2 (ru) | 2005-12-23 | 2011-08-20 | Ф. Хоффманн-Ля Рош Аг | Производные арил-изоксазоло-4-ил-оксадиазола |
| PL1968973T3 (pl) | 2005-12-27 | 2012-03-30 | Hoffmann La Roche | Pochodne aryloizoksazol-4-iloimidazolu |
| ATE537171T1 (de) | 2005-12-27 | 2011-12-15 | Hoffmann La Roche | Aryl-isoxazol-4-yl-imidazoä1,5-aüpyridin-deriva e |
| ES2340221T3 (es) | 2006-05-24 | 2010-05-31 | Eli Lilly And Company | Compuestos y procedimientos para modular fxr. |
| KR101119365B1 (ko) | 2006-05-31 | 2012-03-07 | 에프. 호프만-라 로슈 아게 | 아릴-4-에틴일-아이속사졸 유도체 |
| EP1894928A1 (en) | 2006-08-29 | 2008-03-05 | PheneX Pharmaceuticals AG | Heterocyclic fxr binding compounds |
| EP1894924A1 (en) | 2006-08-29 | 2008-03-05 | Phenex Pharmaceuticals AG | Heterocyclic FXR binding compounds |
| CN101965344B (zh) | 2007-06-22 | 2013-03-06 | 弗·哈夫曼-拉罗切有限公司 | 异*唑-咪唑衍生物 |
| US7943619B2 (en) | 2007-12-04 | 2011-05-17 | Hoffmann-La Roche Inc. | Isoxazolo-pyridazine derivatives |
| US7618973B2 (en) | 2007-12-04 | 2009-11-17 | Hoffmann-La Roche Inc. | Isoxazolo-pyrazine derivatives |
| JP5301557B2 (ja) | 2007-12-04 | 2013-09-25 | エフ．ホフマン−ラ ロシュ アーゲー | イソオキサゾロ−ピリジン誘導体 |
| EP2128158A1 (en) | 2008-05-26 | 2009-12-02 | Phenex Pharmaceuticals AG | Heterocyclic cyclopropyl-substituted FXR binding compounds |
| US8389550B2 (en) | 2009-02-25 | 2013-03-05 | Hoffmann-La Roche Inc. | Isoxazoles / O-pyridines with ethyl and ethenyl linker |
| US8222246B2 (en) | 2009-04-02 | 2012-07-17 | Hoffmann-La Roche Inc. | Substituted isoxazoles |
| US8227461B2 (en) | 2009-04-30 | 2012-07-24 | Hoffmann-La Roche Inc. | Isoxazoles |
| BRPI1013762A2 (pt) | 2009-05-05 | 2015-08-25 | Hoffmann La Roche | "derivados isoxazol-piridazina" |
| BRPI1014454A2 (pt) | 2009-05-05 | 2016-04-05 | Hoffmann La Roche | derivados de isoxazol-pirazol |
| US8415379B2 (en) | 2009-05-05 | 2013-04-09 | Hoffmann-La Roche Inc. | Pyridines |
| ES2601181T3 (es) | 2009-05-05 | 2017-02-14 | F. Hoffmann-La Roche Ag | Derivados de isoxazol-tiazol como agonistas inversos del receptor GABA A para su uso en el tratamiento de trastornos cognitivos |
| KR101354416B1 (ko) | 2009-05-07 | 2014-02-19 | 에프. 호프만-라 로슈 아게 | 감마-아미노부티르산 조절제로서 이속사졸-피리딘 유도체 |
| EP2289883A1 (en) | 2009-08-19 | 2011-03-02 | Phenex Pharmaceuticals AG | Novel FXR (NR1H4) binding and activity modulating compounds |
| CN103189062B (zh) | 2010-11-05 | 2016-03-23 | 霍夫曼-拉罗奇有限公司 | 活性药物化合物用于治疗中枢神经系统病症的用途 |
| US8742097B2 (en) * | 2010-11-09 | 2014-06-03 | Hoffmann-La Roche Inc. | Triazole compounds I |
| RU2582337C2 (ru) * | 2010-11-09 | 2016-04-27 | Ф.Хоффманн-Ля Рош Аг | Производные триазола в качестве лигандов рецепторов гамк |
| JP2014122161A (ja) | 2011-03-31 | 2014-07-03 | Astellas Pharma Inc | ピラゾール化合物 |
| WO2014001278A1 (en) * | 2012-06-26 | 2014-01-03 | Aniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
| MX357504B (es) | 2012-06-26 | 2018-07-12 | Saniona Aps | Derivado de feniltriazol y su uso para modular complejo del receptor gabaa. |
| EP2885290B1 (en) | 2012-06-26 | 2017-10-18 | Saniona A/S | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
| WO2014001280A1 (en) * | 2012-06-26 | 2014-01-03 | Aniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
| MA48594B1 (fr) | 2016-12-08 | 2022-05-31 | Hoffmann La Roche | Nouveaux dérivés d'éther d'isoxazolyle en tant que pam alpha5 gaba a |
-
2019
- 2019-07-18 BR BR102019014802A patent/BR102019014802A2/pt not_active Application Discontinuation
- 2019-07-19 AR ARP190102039A patent/AR117615A1/es not_active Application Discontinuation
- 2019-07-19 TW TW108125527A patent/TW202019915A/zh unknown
- 2019-07-19 JP JP2021503007A patent/JP7311583B2/ja active Active
- 2019-07-19 CN CN201980047952.XA patent/CN112424197B/zh active Active
- 2019-07-19 US US16/516,398 patent/US10941137B2/en active Active
- 2019-07-19 WO PCT/EP2019/069593 patent/WO2020016443A1/en not_active Ceased
- 2019-07-19 EP EP19742592.9A patent/EP3823967B1/en active Active
-
2021
- 2021-01-27 US US17/160,285 patent/US20210147393A1/en not_active Abandoned
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