CN112424197B - 作为gaba受体调节剂的二氟甲基-苯基三唑类 - Google Patents

作为gaba受体调节剂的二氟甲基-苯基三唑类 Download PDF

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Publication number
CN112424197B
CN112424197B CN201980047952.XA CN201980047952A CN112424197B CN 112424197 B CN112424197 B CN 112424197B CN 201980047952 A CN201980047952 A CN 201980047952A CN 112424197 B CN112424197 B CN 112424197B
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China
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alkyl
pain
disorder
group
halogen
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Chinese (zh)
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CN112424197A (zh
Inventor
J·S·拉森
F·宾德尔
Y·崔
O·胡克
R·利平斯基
F·蒙特尔
M·奥斯特迈尔
A·佩雷拉
S·彼得斯
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Boehringer Ingelheim International GmbH
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Boehringer Ingelheim International GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201980047952.XA 2018-07-20 2019-07-19 作为gaba受体调节剂的二氟甲基-苯基三唑类 Active CN112424197B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18184716 2018-07-20
EP18184716.1 2018-07-20
PCT/EP2019/069593 WO2020016443A1 (en) 2018-07-20 2019-07-19 Difluoromethyl-phenyl triazoles as gaba receptor modulators

Publications (2)

Publication Number Publication Date
CN112424197A CN112424197A (zh) 2021-02-26
CN112424197B true CN112424197B (zh) 2025-04-22

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CN201980047952.XA Active CN112424197B (zh) 2018-07-20 2019-07-19 作为gaba受体调节剂的二氟甲基-苯基三唑类

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Country Link
US (2) US10941137B2 (enExample)
EP (1) EP3823967B1 (enExample)
JP (1) JP7311583B2 (enExample)
CN (1) CN112424197B (enExample)
AR (1) AR117615A1 (enExample)
BR (1) BR102019014802A2 (enExample)
TW (1) TW202019915A (enExample)
WO (1) WO2020016443A1 (enExample)

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US12649738B2 (en) 2020-03-26 2026-06-09 Richter Gedeon Nyrt. 1,3-dihydro-2H-pyrrolo[3,4-c]pyridine derivatives as GABAA α5 receptor modulators
TWI901650B (zh) * 2020-03-26 2025-10-21 匈牙利商羅特格登公司 啶及吡啶并〔３，４－ｃ〕嗒衍生物
EP4149933B1 (en) * 2020-05-13 2024-06-12 F. Hoffmann-La Roche AG New triazolyl derivatives as gaba a alpha5 pam
EP3971179A1 (en) * 2020-09-22 2022-03-23 Boehringer Ingelheim International GmbH Difluoromethyl-pyridin-2-yl triazoles
TWI915398B (zh) * 2020-08-05 2026-02-21 丹麥商薩尼奧納有限責任公司 二氟甲基-吡啶-2-基三唑
EP3992188A1 (en) * 2020-10-29 2022-05-04 Boehringer Ingelheim International GmbH Difluoromethyl-pyridin-2-yl triazoles
EP3950683A1 (en) * 2020-08-05 2022-02-09 Boehringer Ingelheim International GmbH Difluoromethyl-pyridin-2-yl triazoles
IL310708A (en) * 2021-08-12 2024-04-01 Shanghai Simr Biotechnology Co Ltd The history of converted triazole, a method for its preparation, its pharmaceutical preparation and its use
HU231691B1 (hu) 2021-09-29 2025-10-28 Richter Gedeon Nyrt GABAA ALFA5 receptor modulátor hatású biciklusos aminszármazékok
CN116462664B (zh) * 2022-03-08 2025-07-01 上海赛默罗生物科技有限公司 吡唑环类化合物、其制备方法、组合物及应用
CN116854680A (zh) * 2022-03-28 2023-10-10 上海赛默罗生物科技有限公司 异噁唑-杂环类衍生物、药物组合物和用途
WO2024251133A1 (zh) * 2023-06-05 2024-12-12 武汉人福创新药物研发中心有限公司 作为α5-GABAA受体调节剂的杂环化合物及其用途

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CN101868458A (zh) * 2007-12-04 2010-10-20 弗·哈夫曼-拉罗切有限公司 异*唑并-哒嗪衍生物
WO2014001278A1 (en) * 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex

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CN101277952B (zh) 2005-10-11 2011-09-28 弗·哈夫曼-拉罗切有限公司 异*唑衍生物
DE602006014185D1 (de) 2005-11-09 2010-06-17 Hoffmann La Roche 3-arylisoxazol-4-carbonylbenzofuranderivative
RU2426731C2 (ru) 2005-12-23 2011-08-20 Ф. Хоффманн-Ля Рош Аг Производные арил-изоксазоло-4-ил-оксадиазола
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ATE537171T1 (de) 2005-12-27 2011-12-15 Hoffmann La Roche Aryl-isoxazol-4-yl-imidazoä1,5-aüpyridin-deriva e
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KR101119365B1 (ko) 2006-05-31 2012-03-07 에프. 호프만-라 로슈 아게 아릴-4-에틴일-아이속사졸 유도체
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US8742097B2 (en) * 2010-11-09 2014-06-03 Hoffmann-La Roche Inc. Triazole compounds I
RU2582337C2 (ru) * 2010-11-09 2016-04-27 Ф.Хоффманн-Ля Рош Аг Производные триазола в качестве лигандов рецепторов гамк
JP2014122161A (ja) 2011-03-31 2014-07-03 Astellas Pharma Inc ピラゾール化合物
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EP2885290B1 (en) 2012-06-26 2017-10-18 Saniona A/S A phenyl triazole derivative and its use for modulating the gabaa receptor complex
WO2014001280A1 (en) * 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
MA48594B1 (fr) 2016-12-08 2022-05-31 Hoffmann La Roche Nouveaux dérivés d'éther d'isoxazolyle en tant que pam alpha5 gaba a

Patent Citations (2)

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CN101868458A (zh) * 2007-12-04 2010-10-20 弗·哈夫曼-拉罗切有限公司 异*唑并-哒嗪衍生物
WO2014001278A1 (en) * 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex

Also Published As

Publication number Publication date
CN112424197A (zh) 2021-02-26
EP3823967A1 (en) 2021-05-26
TW202019915A (zh) 2020-06-01
BR102019014802A2 (pt) 2020-02-04
JP2021531291A (ja) 2021-11-18
US20200024261A1 (en) 2020-01-23
US20210147393A1 (en) 2021-05-20
WO2020016443A1 (en) 2020-01-23
AR117615A1 (es) 2021-08-18
US10941137B2 (en) 2021-03-09
JP7311583B2 (ja) 2023-07-19
EP3823967B1 (en) 2022-08-31

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