CN112424197B - 作为gaba受体调节剂的二氟甲基-苯基三唑类 - Google Patents

作为gaba受体调节剂的二氟甲基-苯基三唑类 Download PDF

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Publication number
CN112424197B
CN112424197B CN201980047952.XA CN201980047952A CN112424197B CN 112424197 B CN112424197 B CN 112424197B CN 201980047952 A CN201980047952 A CN 201980047952A CN 112424197 B CN112424197 B CN 112424197B
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China
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alkyl
pain
disorder
group
halogen
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Chinese (zh)
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CN112424197A (zh
Inventor
J·S·拉森
F·宾德尔
Y·崔
O·胡克
R·利平斯基
F·蒙特尔
M·奥斯特迈尔
A·佩雷拉
S·彼得斯
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Boehringer Ingelheim International GmbH
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Boehringer Ingelheim International GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201980047952.XA 2018-07-20 2019-07-19 作为gaba受体调节剂的二氟甲基-苯基三唑类 Active CN112424197B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18184716 2018-07-20
EP18184716.1 2018-07-20
PCT/EP2019/069593 WO2020016443A1 (en) 2018-07-20 2019-07-19 Difluoromethyl-phenyl triazoles as gaba receptor modulators

Publications (2)

Publication Number Publication Date
CN112424197A CN112424197A (zh) 2021-02-26
CN112424197B true CN112424197B (zh) 2025-04-22

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US (2) US10941137B2 (enExample)
EP (1) EP3823967B1 (enExample)
JP (1) JP7311583B2 (enExample)
CN (1) CN112424197B (enExample)
AR (1) AR117615A1 (enExample)
BR (1) BR102019014802A2 (enExample)
TW (1) TW202019915A (enExample)
WO (1) WO2020016443A1 (enExample)

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TWI901650B (zh) * 2020-03-26 2025-10-21 匈牙利商羅特格登公司 啶及吡啶并〔３，４－ｃ〕嗒衍生物
CN115461337A (zh) * 2020-05-13 2022-12-09 豪夫迈·罗氏有限公司 作为GABA A α5 PAM的新型三唑基衍生物
EP3950683A1 (en) * 2020-08-05 2022-02-09 Boehringer Ingelheim International GmbH Difluoromethyl-pyridin-2-yl triazoles
EP3971179A1 (en) * 2020-09-22 2022-03-23 Boehringer Ingelheim International GmbH Difluoromethyl-pyridin-2-yl triazoles
US20230286946A1 (en) 2020-08-05 2023-09-14 Boehringer Ingelheim International Gmbh Difluoromethyl-pyridin-2-yl triazoles
EP3992188A1 (en) * 2020-10-29 2022-05-04 Boehringer Ingelheim International GmbH Difluoromethyl-pyridin-2-yl triazoles
AU2022327398A1 (en) * 2021-08-12 2024-03-21 Shanghai SIMR Biotechnology Co., Ltd Substituted triazole derivative, preparation method therefor, pharmaceutical composition thereof, and use thereof
HU231691B1 (hu) 2021-09-29 2025-10-28 Richter Gedeon Nyrt GABAA ALFA5 receptor modulátor hatású biciklusos aminszármazékok
CN116462664B (zh) * 2022-03-08 2025-07-01 上海赛默罗生物科技有限公司 吡唑环类化合物、其制备方法、组合物及应用
CN116854680A (zh) * 2022-03-28 2023-10-10 上海赛默罗生物科技有限公司 异噁唑-杂环类衍生物、药物组合物和用途
CN119080754A (zh) * 2023-06-05 2024-12-06 武汉人福创新药物研发中心有限公司 作为α5-GABAA受体调节剂的杂环化合物及其用途

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WO2014001278A1 (en) * 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex

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WO2007042420A1 (en) 2005-10-11 2007-04-19 F. Hoffmann-La Roche Ag Isoxazole derivatives
KR101103129B1 (ko) 2005-11-09 2012-01-04 에프. 호프만-라 로슈 아게 3-아릴-아이속사졸-4-카본일-벤조퓨란 유도체
RU2426731C2 (ru) 2005-12-23 2011-08-20 Ф. Хоффманн-Ля Рош Аг Производные арил-изоксазоло-4-ил-оксадиазола
BRPI0620773A2 (pt) 2005-12-27 2011-11-22 Hoffmann La Roche derivados de aril-isoxazol-4-il-imidazol
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JP5416103B2 (ja) 2007-06-22 2014-02-12 エフ．ホフマン−ラ ロシュ アーゲー イソオキサゾール−イミダゾール誘導体
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CN101868458A (zh) * 2007-12-04 2010-10-20 弗·哈夫曼-拉罗切有限公司 异*唑并-哒嗪衍生物
WO2014001278A1 (en) * 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex

Also Published As

Publication number Publication date
WO2020016443A1 (en) 2020-01-23
EP3823967A1 (en) 2021-05-26
US20210147393A1 (en) 2021-05-20
US20200024261A1 (en) 2020-01-23
JP2021531291A (ja) 2021-11-18
CN112424197A (zh) 2021-02-26
US10941137B2 (en) 2021-03-09
AR117615A1 (es) 2021-08-18
TW202019915A (zh) 2020-06-01
BR102019014802A2 (pt) 2020-02-04
EP3823967B1 (en) 2022-08-31
JP7311583B2 (ja) 2023-07-19

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