BR102019014802A2 - difluorometil-fenil triazóis - Google Patents
difluorometil-fenil triazóis Download PDFInfo
- Publication number
- BR102019014802A2 BR102019014802A2 BR102019014802A BR102019014802A BR102019014802A2 BR 102019014802 A2 BR102019014802 A2 BR 102019014802A2 BR 102019014802 A BR102019014802 A BR 102019014802A BR 102019014802 A BR102019014802 A BR 102019014802A BR 102019014802 A2 BR102019014802 A2 BR 102019014802A2
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- group
- pain
- petition
- disorders
- Prior art date
Links
- 0 *c(cc1)nnc1Cl Chemical compound *c(cc1)nnc1Cl 0.000 description 6
- VLDFEHKWNXRLPE-UHFFFAOYSA-N CC(C)(C)OC(CCC1N=C(C)C(S2OC(C)(C)C(C)(C)O2)=C1C)=O Chemical compound CC(C)(C)OC(CCC1N=C(C)C(S2OC(C)(C)C(C)(C)O2)=C1C)=O VLDFEHKWNXRLPE-UHFFFAOYSA-N 0.000 description 1
- LGONRINVMHBPHF-UHFFFAOYSA-N Cc1c(CO)[n](-c2ccc(C(F)F)cc2)nn1 Chemical compound Cc1c(CO)[n](-c2ccc(C(F)F)cc2)nn1 LGONRINVMHBPHF-UHFFFAOYSA-N 0.000 description 1
- TYZLDUJNKWBTIZ-UHFFFAOYSA-N Cc1c(COc(cc2)nnc2-[n]2cnc(C(N(C)C)O)c2)[n](-c2ccc(C(F)F)cc2)nn1 Chemical compound Cc1c(COc(cc2)nnc2-[n]2cnc(C(N(C)C)O)c2)[n](-c2ccc(C(F)F)cc2)nn1 TYZLDUJNKWBTIZ-UHFFFAOYSA-N 0.000 description 1
- UADAWIGKTXVIEH-UHFFFAOYSA-N Cc1c(COc(cc2)nnc2-[n]2cnc(C(OC)=O)c2)[n](C2C=CC(C(F)F)=CC2)nn1 Chemical compound Cc1c(COc(cc2)nnc2-[n]2cnc(C(OC)=O)c2)[n](C2C=CC(C(F)F)=CC2)nn1 UADAWIGKTXVIEH-UHFFFAOYSA-N 0.000 description 1
- FJJRIFYQALEIBA-UHFFFAOYSA-N Cc1c(COc(cc2)nnc2-c2c[n](C3CC3)nc2)[n](-c2ccc(C(F)F)cc2)nn1 Chemical compound Cc1c(COc(cc2)nnc2-c2c[n](C3CC3)nc2)[n](-c2ccc(C(F)F)cc2)nn1 FJJRIFYQALEIBA-UHFFFAOYSA-N 0.000 description 1
- BBDZUDRCNGHJBP-UHFFFAOYSA-N Cc1c(COc2ccc(-[n]3ncc(C(F)(F)F)c3)nn2)[n](-c2ccc(C(F)F)cc2)nn1 Chemical compound Cc1c(COc2ccc(-[n]3ncc(C(F)(F)F)c3)nn2)[n](-c2ccc(C(F)F)cc2)nn1 BBDZUDRCNGHJBP-UHFFFAOYSA-N 0.000 description 1
- GUSWJGOYDXFJSI-UHFFFAOYSA-N Clc(cc1)nnc1Cl Chemical compound Clc(cc1)nnc1Cl GUSWJGOYDXFJSI-UHFFFAOYSA-N 0.000 description 1
- XDTUAEOZICQUGM-UHFFFAOYSA-N O=S1(C(c2cnc[nH]2)=CC=C1)=O Chemical compound O=S1(C(c2cnc[nH]2)=CC=C1)=O XDTUAEOZICQUGM-UHFFFAOYSA-N 0.000 description 1
- LWRYDHOHXNQTSK-UHFFFAOYSA-N O=S1C=CC=C1 Chemical compound O=S1C=CC=C1 LWRYDHOHXNQTSK-UHFFFAOYSA-N 0.000 description 1
- LFXRMLCGXKNJPN-UHFFFAOYSA-N OC(c(nc1)c[n]1-c(nn1)ccc1Cl)=O Chemical compound OC(c(nc1)c[n]1-c(nn1)ccc1Cl)=O LFXRMLCGXKNJPN-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18184716 | 2018-07-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR102019014802A2 true BR102019014802A2 (pt) | 2020-02-04 |
Family
ID=63014393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR102019014802A BR102019014802A2 (pt) | 2018-07-20 | 2019-07-18 | difluorometil-fenil triazóis |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10941137B2 (enExample) |
| EP (1) | EP3823967B1 (enExample) |
| JP (1) | JP7311583B2 (enExample) |
| CN (1) | CN112424197B (enExample) |
| AR (1) | AR117615A1 (enExample) |
| BR (1) | BR102019014802A2 (enExample) |
| TW (1) | TW202019915A (enExample) |
| WO (1) | WO2020016443A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI901650B (zh) * | 2020-03-26 | 2025-10-21 | 匈牙利商羅特格登公司 | 啶及吡啶并〔３，４－ｃ〕嗒衍生物 |
| CN115461337A (zh) * | 2020-05-13 | 2022-12-09 | 豪夫迈·罗氏有限公司 | 作为GABA A α5 PAM的新型三唑基衍生物 |
| EP3950683A1 (en) * | 2020-08-05 | 2022-02-09 | Boehringer Ingelheim International GmbH | Difluoromethyl-pyridin-2-yl triazoles |
| EP3971179A1 (en) * | 2020-09-22 | 2022-03-23 | Boehringer Ingelheim International GmbH | Difluoromethyl-pyridin-2-yl triazoles |
| US20230286946A1 (en) | 2020-08-05 | 2023-09-14 | Boehringer Ingelheim International Gmbh | Difluoromethyl-pyridin-2-yl triazoles |
| EP3992188A1 (en) * | 2020-10-29 | 2022-05-04 | Boehringer Ingelheim International GmbH | Difluoromethyl-pyridin-2-yl triazoles |
| AU2022327398A1 (en) * | 2021-08-12 | 2024-03-21 | Shanghai SIMR Biotechnology Co., Ltd | Substituted triazole derivative, preparation method therefor, pharmaceutical composition thereof, and use thereof |
| HU231691B1 (hu) | 2021-09-29 | 2025-10-28 | Richter Gedeon Nyrt | GABAA ALFA5 receptor modulátor hatású biciklusos aminszármazékok |
| CN116462664B (zh) * | 2022-03-08 | 2025-07-01 | 上海赛默罗生物科技有限公司 | 吡唑环类化合物、其制备方法、组合物及应用 |
| CN116854680A (zh) * | 2022-03-28 | 2023-10-10 | 上海赛默罗生物科技有限公司 | 异噁唑-杂环类衍生物、药物组合物和用途 |
| CN119080754A (zh) * | 2023-06-05 | 2024-12-06 | 武汉人福创新药物研发中心有限公司 | 作为α5-GABAA受体调节剂的杂环化合物及其用途 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1931661B1 (en) | 2005-09-19 | 2008-11-19 | F.Hoffmann-La Roche Ag | Isoxazolo derivatives as gaba a alpha5 inverse agonists |
| WO2007042420A1 (en) | 2005-10-11 | 2007-04-19 | F. Hoffmann-La Roche Ag | Isoxazole derivatives |
| KR101103129B1 (ko) | 2005-11-09 | 2012-01-04 | 에프. 호프만-라 로슈 아게 | 3-아릴-아이속사졸-4-카본일-벤조퓨란 유도체 |
| RU2426731C2 (ru) | 2005-12-23 | 2011-08-20 | Ф. Хоффманн-Ля Рош Аг | Производные арил-изоксазоло-4-ил-оксадиазола |
| BRPI0620773A2 (pt) | 2005-12-27 | 2011-11-22 | Hoffmann La Roche | derivados de aril-isoxazol-4-il-imidazol |
| JP4864982B2 (ja) | 2005-12-27 | 2012-02-01 | エフ．ホフマン−ラ ロシュ アーゲー | アリール−イソオキサゾール−４−イル−イミダゾ［１，５−ａ］ピリジン誘導体 |
| US8106077B2 (en) | 2006-05-24 | 2012-01-31 | Eli Lilly And Company | Compounds and methods for modulating FXR |
| MX2008014796A (es) | 2006-05-31 | 2008-12-02 | Hoffmann La Roche | Derivados de aril-4-etinil-isoxazol. |
| EP1894928A1 (en) | 2006-08-29 | 2008-03-05 | PheneX Pharmaceuticals AG | Heterocyclic fxr binding compounds |
| EP1894924A1 (en) | 2006-08-29 | 2008-03-05 | Phenex Pharmaceuticals AG | Heterocyclic FXR binding compounds |
| JP5416103B2 (ja) | 2007-06-22 | 2014-02-12 | エフ．ホフマン−ラ ロシュ アーゲー | イソオキサゾール−イミダゾール誘導体 |
| UA100132C2 (en) | 2007-12-04 | 2012-11-26 | Ф. Хоффманн-Ля Рош Аг | Isoxazolo-pyridine derivatives |
| US7943619B2 (en) | 2007-12-04 | 2011-05-17 | Hoffmann-La Roche Inc. | Isoxazolo-pyridazine derivatives |
| WO2009071464A1 (en) | 2007-12-04 | 2009-06-11 | F. Hoffmann-La Roche Ag | Isoxazolo-pyrazine derivatives |
| EP2128158A1 (en) | 2008-05-26 | 2009-12-02 | Phenex Pharmaceuticals AG | Heterocyclic cyclopropyl-substituted FXR binding compounds |
| US8389550B2 (en) | 2009-02-25 | 2013-03-05 | Hoffmann-La Roche Inc. | Isoxazoles / O-pyridines with ethyl and ethenyl linker |
| US8222246B2 (en) | 2009-04-02 | 2012-07-17 | Hoffmann-La Roche Inc. | Substituted isoxazoles |
| US8227461B2 (en) | 2009-04-30 | 2012-07-24 | Hoffmann-La Roche Inc. | Isoxazoles |
| WO2010127976A1 (en) | 2009-05-05 | 2010-11-11 | F. Hoffmann-La Roche Ag | Isoxazole-pyridine derivatives |
| MX2011011490A (es) | 2009-05-05 | 2011-11-18 | Hoffmann La Roche | Derivados de isoxazol-tiazol como agonistas inversos del receptor de acido gamma-aminobutirico a (gaba a), para usarse en el tratamiento de trastornos cognitivos. |
| EP2427458B1 (en) | 2009-05-05 | 2014-05-07 | F.Hoffmann-La Roche Ag | Isoxazole-pyridazine derivatives |
| AU2010244552A1 (en) | 2009-05-05 | 2011-09-29 | F. Hoffmann-La Roche Ag | Isoxazole-pyrazole derivatives |
| MX2011011484A (es) | 2009-05-07 | 2011-11-18 | Hoffmann La Roche | Derivados de isoxazol-piridina como moduladores del acido gamma-aminobutirico. |
| EP2289883A1 (en) | 2009-08-19 | 2011-03-02 | Phenex Pharmaceuticals AG | Novel FXR (NR1H4) binding and activity modulating compounds |
| MX341471B (es) | 2010-11-05 | 2016-08-22 | Hoffmann La Roche | Uso de compuestos farmaceuticos activos para el tratamiento de estados patologicos del sistema nervioso central. |
| US8742097B2 (en) * | 2010-11-09 | 2014-06-03 | Hoffmann-La Roche Inc. | Triazole compounds I |
| EP2638035B1 (en) * | 2010-11-09 | 2014-12-17 | F.Hoffmann-La Roche Ag | Triazole derivatives as ligands for Gaba receptors |
| JP2014122161A (ja) | 2011-03-31 | 2014-07-03 | Astellas Pharma Inc | ピラゾール化合物 |
| US9475797B2 (en) * | 2012-06-26 | 2016-10-25 | Saniona A/S | Phenyl triazole derivative and its use for modulating the GABAA receptor complex |
| WO2014001280A1 (en) * | 2012-06-26 | 2014-01-03 | Aniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
| WO2014001278A1 (en) * | 2012-06-26 | 2014-01-03 | Aniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
| CA2876778A1 (en) | 2012-06-26 | 2014-01-03 | Saniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
| ES2910110T3 (es) | 2016-12-08 | 2022-05-11 | Hoffmann La Roche | Nuevos derivados de isoxazolil-éter como PAM de alfa 5 GABA A |
-
2019
- 2019-07-18 BR BR102019014802A patent/BR102019014802A2/pt not_active Application Discontinuation
- 2019-07-19 EP EP19742592.9A patent/EP3823967B1/en active Active
- 2019-07-19 AR ARP190102039A patent/AR117615A1/es not_active Application Discontinuation
- 2019-07-19 TW TW108125527A patent/TW202019915A/zh unknown
- 2019-07-19 US US16/516,398 patent/US10941137B2/en active Active
- 2019-07-19 JP JP2021503007A patent/JP7311583B2/ja active Active
- 2019-07-19 CN CN201980047952.XA patent/CN112424197B/zh active Active
- 2019-07-19 WO PCT/EP2019/069593 patent/WO2020016443A1/en not_active Ceased
-
2021
- 2021-01-27 US US17/160,285 patent/US20210147393A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020016443A1 (en) | 2020-01-23 |
| EP3823967A1 (en) | 2021-05-26 |
| US20210147393A1 (en) | 2021-05-20 |
| US20200024261A1 (en) | 2020-01-23 |
| CN112424197B (zh) | 2025-04-22 |
| JP2021531291A (ja) | 2021-11-18 |
| CN112424197A (zh) | 2021-02-26 |
| US10941137B2 (en) | 2021-03-09 |
| AR117615A1 (es) | 2021-08-18 |
| TW202019915A (zh) | 2020-06-01 |
| EP3823967B1 (en) | 2022-08-31 |
| JP7311583B2 (ja) | 2023-07-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B03A | Publication of a patent application or of a certificate of addition of invention [chapter 3.1 patent gazette] | ||
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |