JP2021528384A5 - - Google Patents
Info
- Publication number
- JP2021528384A5 JP2021528384A5 JP2020567941A JP2020567941A JP2021528384A5 JP 2021528384 A5 JP2021528384 A5 JP 2021528384A5 JP 2020567941 A JP2020567941 A JP 2020567941A JP 2020567941 A JP2020567941 A JP 2020567941A JP 2021528384 A5 JP2021528384 A5 JP 2021528384A5
- Authority
- JP
- Japan
- Prior art keywords
- acylated
- item
- active agent
- acid
- preketone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023184635A JP7592140B2 (ja) | 2018-06-05 | 2023-10-27 | 代謝障害および非アルコール性脂肪肝疾患の治療のための活性薬剤およびその使用方法 |
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862680977P | 2018-06-05 | 2018-06-05 | |
| US201862680976P | 2018-06-05 | 2018-06-05 | |
| US62/680,976 | 2018-06-05 | ||
| US62/680,977 | 2018-06-05 | ||
| US201862776455P | 2018-12-06 | 2018-12-06 | |
| US201862776448P | 2018-12-06 | 2018-12-06 | |
| US62/776,455 | 2018-12-06 | ||
| US62/776,448 | 2018-12-06 | ||
| US201962828958P | 2019-04-03 | 2019-04-03 | |
| US62/828,958 | 2019-04-03 | ||
| PCT/US2019/035680 WO2019236775A1 (en) | 2018-06-05 | 2019-06-05 | Active agents and methods of their use for the treatment of metabolic disorders and nonalcoholic fatty liver disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023184635A Division JP7592140B2 (ja) | 2018-06-05 | 2023-10-27 | 代謝障害および非アルコール性脂肪肝疾患の治療のための活性薬剤およびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021528384A JP2021528384A (ja) | 2021-10-21 |
| JP2021528384A5 true JP2021528384A5 (enExample) | 2022-06-13 |
| JP7377220B2 JP7377220B2 (ja) | 2023-11-09 |
Family
ID=68769573
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020567941A Active JP7377220B2 (ja) | 2018-06-05 | 2019-06-05 | 代謝障害および非アルコール性脂肪肝疾患の治療のための活性薬剤およびその使用方法 |
| JP2023184635A Active JP7592140B2 (ja) | 2018-06-05 | 2023-10-27 | 代謝障害および非アルコール性脂肪肝疾患の治療のための活性薬剤およびその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023184635A Active JP7592140B2 (ja) | 2018-06-05 | 2023-10-27 | 代謝障害および非アルコール性脂肪肝疾患の治療のための活性薬剤およびその使用方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10953027B2 (enExample) |
| EP (1) | EP3801496A4 (enExample) |
| JP (2) | JP7377220B2 (enExample) |
| KR (1) | KR20210016407A (enExample) |
| CN (1) | CN112367987A (enExample) |
| AU (1) | AU2019282691A1 (enExample) |
| BR (1) | BR112020024695A2 (enExample) |
| CA (1) | CA3102404A1 (enExample) |
| IL (1) | IL279161A (enExample) |
| MX (1) | MX2020013104A (enExample) |
| PH (1) | PH12020552060A1 (enExample) |
| SG (1) | SG11202011698VA (enExample) |
| WO (1) | WO2019236775A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3801496A4 (en) | 2018-06-05 | 2022-07-06 | Flagship Pioneering Innovations V, Inc. | SUBSTANCES AND METHODS OF USE FOR THE TREATMENT OF METABOLIC DISEASES AND NON-ALCOHOL FATTY LIVER |
| JP2021528385A (ja) | 2018-06-05 | 2021-10-21 | フラッグシップ パイオニアリング イノベーションズ ブイ, インコーポレイテッド | 自己免疫障害を治療するためのアシル化活性剤およびその使用方法 |
| WO2020037009A1 (en) | 2018-08-13 | 2020-02-20 | Flagship Pioneering Innovations V, Inc. | Conjugates and methods of using the same |
| EP4069209A4 (en) * | 2019-12-05 | 2024-04-10 | Flagship Pioneering Innovations V, Inc. | ACYLATED ACTIVE AGENTS AND METHODS OF USE THEREOF FOR THE TREATMENT OF METABOLIC DISEASES AND NON-ALCOHOLIC FATTY LIVER DISEASE |
| JP7737231B2 (ja) * | 2020-03-31 | 2025-09-10 | 大阪瓦斯株式会社 | ジオール化合物およびその重合体ならびにそれらの製造方法 |
| WO2021222702A1 (en) * | 2020-05-01 | 2021-11-04 | Flagship Pioneering Innovations V, Inc. | Crystalline forms, compositions containing them, and methods of their use |
| RU2742414C1 (ru) * | 2020-06-16 | 2021-02-05 | Владимир Сергеевич Понамарёв | Препарат комплексный с гепатопротекторной активностью для крупного рогатого скота |
| CA3187310A1 (en) | 2020-06-26 | 2021-12-30 | Durect Corporation | Use of oxygenated cholesterol sulfates for treating autoimmune conditions |
| WO2022140580A1 (en) * | 2020-12-24 | 2022-06-30 | Orn Almarsson | Xanthophyll derivatives |
| JP2024502909A (ja) * | 2020-12-24 | 2024-01-23 | アルマルソン、オーン | キサントフィル誘導体 |
| CN113244208B (zh) * | 2021-05-20 | 2022-07-12 | 云南中医药大学 | Hpa在制备治疗非酒精性脂肪性肝病药物中的应用 |
| WO2023280750A1 (en) * | 2021-07-09 | 2023-01-12 | Dsm Ip Assets B.V. | Synthesis of butyrate compounds |
| JP7401156B1 (ja) | 2022-11-08 | 2023-12-19 | ミヤリサン製薬株式会社 | 子宮、卵管および卵巣における炎症の予防および/または治療剤 |
| WO2024102902A1 (en) * | 2022-11-10 | 2024-05-16 | Temple University-Of The Commonwealth System Of Higher Education | Methods of treating or preventing liver diseases or disorders |
| CA3215648C (en) * | 2023-04-26 | 2026-03-31 | Cavaleri Health, Inc. | Short chain fatty acids & gallates compositions |
| CN118580213B (zh) * | 2024-08-05 | 2024-10-11 | 中国农业大学 | 一种黄酮衍生物及其在制备治疗糖尿病药物中的用途 |
| CN118834192A (zh) * | 2024-08-20 | 2024-10-25 | 江南大学 | 一种4'-羟基-3, 5, 7, 3', 5'-五甲氧基黄酮、其酶法生物合成、分离制备方法及降脂活性提升研究 |
Family Cites Families (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RO87311B (ro) * | 1983-10-04 | 1985-12-01 | Nicolaie Oita | Medicament cu actiune metabolica complexa si procedeu de obtinere a acestuia |
| JPS6081127A (ja) | 1983-10-13 | 1985-05-09 | Chugai Pharmaceut Co Ltd | 食欲抑制剤 |
| US5385938B1 (en) | 1986-12-23 | 1997-07-15 | Tristrata Inc | Method of using glycolic acid for treating wrinkles |
| IT1244647B (it) * | 1991-02-05 | 1994-08-08 | Salvatore Mancuso | Prodotto farmaceutico per la terapia dei tumori, in particolare di quelli ovarici e del sistema emopoietico, contenente quercitina come principio attivo. |
| JP3165279B2 (ja) * | 1993-03-29 | 2001-05-14 | 三井農林株式会社 | 3−アシル化カテキンを含有する油溶性抗酸化剤 |
| CN1315473C (zh) * | 1997-03-17 | 2007-05-16 | 英国技术集团国际有限公司 | 治疗组合物 |
| JPH11199598A (ja) | 1998-01-08 | 1999-07-27 | Yokohama Kokusai Bio Kenkyusho:Kk | ウルソデオキシコール酸誘導体とその製造法 |
| DE19860698A1 (de) * | 1998-12-30 | 2000-07-06 | Hexal Ag | Neue pharmazeutische Zusammensetzung |
| AU7365900A (en) | 1999-09-08 | 2001-04-10 | Nitromed, Inc. | Methods of treating and preventing congestive heart failure with hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate |
| JP2002145875A (ja) * | 2000-11-06 | 2002-05-22 | Fancl Corp | キサンチンオキシダーゼ阻害剤 |
| US20040033480A1 (en) | 2002-08-15 | 2004-02-19 | Wong Norman C.W. | Use of resveratrol to regulate expression of apolipoprotein A1 |
| WO2004105779A2 (en) | 2003-05-27 | 2004-12-09 | Cesare Montecucco | Green tea and oplyphenol inhibitors of bacterial proteases |
| DE10335725A1 (de) | 2003-08-05 | 2005-03-03 | Bayer Cropscience Gmbh | Safener auf Basis aromatisch-aliphatischer Carbonsäuredarivate |
| US20070082944A1 (en) | 2003-09-12 | 2007-04-12 | Robert Fish | Antimicrobial compositions and methods of use |
| KR100592796B1 (ko) * | 2004-03-19 | 2006-06-26 | 삼아약품 주식회사 | 녹차카테킨을 유효성분으로 포함하는 고지혈증 예방 및치료제 |
| CN1946706B (zh) | 2004-04-26 | 2012-03-21 | 帝斯曼知识产权资产管理有限公司 | 用于制造生育酚酰化产物的方法 |
| ES2641759T3 (es) * | 2004-07-05 | 2017-11-13 | Suntory Holdings Limited | Inhibidores de lipasa |
| GB0415181D0 (en) | 2004-07-06 | 2004-08-11 | School Of Pharmacy The Univers | Compounds for use in the treatment of infection |
| US7544816B2 (en) | 2004-08-19 | 2009-06-09 | The Hong Kong Polytechnic University | (−)-Epigallocatechin gallate derivatives for inhibiting proteasome |
| GB0425658D0 (en) | 2004-11-22 | 2004-12-22 | Stanford Rook Ltd | Immunotherapeutic agent |
| CA2491763A1 (en) * | 2005-01-06 | 2006-07-06 | Tassos P. Anastassiades | Blood glucose control with n-acylated glucosamines |
| JP2006249056A (ja) * | 2005-03-07 | 2006-09-21 | Mitsui Norin Co Ltd | 子宮癌抑制剤 |
| US20100040558A1 (en) | 2005-04-26 | 2010-02-18 | University Of South Florida | Green tea polyphenol alpha secretase enhancers and methods of use |
| WO2007006308A1 (en) | 2005-07-07 | 2007-01-18 | Aditech Pharma Ab | Novel glucopyranose esters and glucofuranose esters of alkyl- fu marates and their pharmaceutical use |
| WO2007021789A1 (en) | 2005-08-11 | 2007-02-22 | Medical College Of Georgia Research Institute | Modified green tea polyphenol formulations |
| MX2009004337A (es) * | 2006-11-01 | 2009-05-22 | Pronova Biopharma Norge As | Compuestos lipidos omega-3. |
| WO2008093984A1 (en) * | 2007-01-29 | 2008-08-07 | Hanall Pharmaceutical Company. Ltd | N, n- dimethyl imidodicarbonimidic diamide acetate, method for producing the same and pharmaceutical compositions comprising the same |
| US8026285B2 (en) | 2007-09-04 | 2011-09-27 | Bezwada Biomedical, Llc | Control release of biologically active compounds from multi-armed oligomers |
| FR2923717B1 (fr) | 2007-11-15 | 2015-01-16 | Caudalie | Compositions de derives polyphenoliques stilbeniques et leurs applications pour lutter contre les pathologies et le veillissement des organismes vivants |
| WO2009089144A1 (en) * | 2008-01-04 | 2009-07-16 | Isis Innovation Limited | Ketone bodies and ketone body esters as blood lipid lowering agents |
| ITRM20080214A1 (it) | 2008-04-21 | 2009-10-22 | Uni Degli Studi Di Napoli Federico Ii | Derivati dell'acido butirrico somministrabili per via orale, formulazioni che li contengono e loro uso clinico. |
| KR100918776B1 (ko) * | 2009-04-20 | 2009-09-24 | 계명대학교 산학협력단 | 폴리에틸렌 글리콜과 갈레이트 카테킨을 이용한 혈당상승 억제 조성물 |
| ES2343773B1 (es) | 2008-11-07 | 2011-06-24 | Consejo Superior De Investigaciones Cientificas (Csic) | Procedimiento enzimatico para la acilacion en posicion 3- del resveratrol. |
| DK2473045T3 (en) | 2009-09-01 | 2016-12-12 | Catabasis Pharmaceuticals Inc | Niacin-FATTY ACID CONJUGATES AND THEIR USES |
| EP2619194A4 (en) * | 2010-04-08 | 2014-09-10 | Genesis Group Inc | CATECHIN FATTY ACID DERIVATIVES AND METHODS OF USE |
| KR101212612B1 (ko) * | 2010-10-12 | 2012-12-14 | 전남대학교산학협력단 | 항산화활성 및 과산화물생성억제활성 중 하나 이상의 활성을 갖는 신규 화합물 및 퉁퉁마디로부터의 상기 신규 화합물 분리방법 |
| JP2014523413A (ja) * | 2011-06-16 | 2014-09-11 | ザ ロイヤル インスティテューション フォー ザ アドバンスメント オブ ラーニング/マクギル ユニバーシティ | 合成没食子酸エピガロカテキン(egcg)類似体 |
| JP2014521702A (ja) * | 2011-08-05 | 2014-08-28 | カーデロ セラピューティクス インコーポレイテッド | フラボノイド化合物 |
| WO2013115742A1 (en) * | 2012-01-31 | 2013-08-08 | Mahmut Bilgic | Pharmaceutical composition comprising alpha-glucosidase inhibitor |
| SK50062012A3 (sk) * | 2012-02-29 | 2013-09-03 | Ustav Experimentalnej Farmakologie A Toxikologie Sav | Quercetin derivatives, pharmaceutical compositions comprising them and their use |
| PT2866804T (pt) | 2012-06-27 | 2023-12-18 | Amazentis Sa | Melhoria da autofagia ou aumento da longevidade por administração de urolitinas ou seus precursores |
| US9713603B2 (en) | 2012-08-20 | 2017-07-25 | The Hong Kong Polytechnic University | Prodrug of green tea epigallocatechin-3-gallate (Pro-EGCG) for use in the treatment of endometriosis |
| KR101480600B1 (ko) * | 2013-01-22 | 2015-01-08 | 경북대학교 산학협력단 | 레스베라트롤 유도체의 피부미백 용도 |
| EP2981260B1 (en) | 2013-04-04 | 2021-01-13 | Sphaera Pharma Pvt. Ltd. | Novel analogues of epicatechin and related polyphenols |
| US9764019B2 (en) | 2013-07-09 | 2017-09-19 | Vedanta Biosciences, Inc. | Compositions containing combinations of bioactive molecules derived from microbiota for treatment of disease |
| WO2015019193A2 (en) | 2013-08-08 | 2015-02-12 | Dalhousie University | Acylated derivatives of phloridzin and isoquercetrin as anticancer therapeutics and methods of use thereof |
| US20150056194A1 (en) * | 2013-08-21 | 2015-02-26 | Georgia Regents Research Institute, Inc. | Modified green tea polyphenols and methods thereof for treating liver disease |
| CA2948605C (en) * | 2014-05-20 | 2019-12-24 | Fuji Chemical Industries Co., Ltd. | Carotenoid derivative, pharmaceutically acceptable salt thereof, or pharmaceutically acceptable ester or amide thereof |
| WO2016013654A1 (ja) | 2014-07-24 | 2016-01-28 | 株式会社プロテクティア | アレルゲン活性の抑制剤およびその用途 |
| CA2958090A1 (en) | 2014-08-13 | 2016-02-18 | The Regents Of The University Of California | Biodegradable trehalose glycopolymers |
| WO2016026139A1 (zh) * | 2014-08-22 | 2016-02-25 | 财团法人国防教育研究基金会 | 用于治疗非酒精性脂肪肝疾病的药物及应用 |
| WO2016086453A1 (zh) * | 2014-12-04 | 2016-06-09 | 中国药科大学 | 五环三萜类胆固醇酯转运蛋白抑制剂、其药物组合物及医药用途 |
| KR101702076B1 (ko) | 2015-02-25 | 2017-02-02 | 주식회사 휴메딕스 | 지방산 컨쥬게이션된 7-데하이드로콜레스테롤 유도체 |
| CN104940181B (zh) * | 2015-06-29 | 2018-02-16 | 齐锦生 | β‑羟丁酸或其药学上可接受的盐的用途 |
| US9545419B1 (en) * | 2015-11-24 | 2017-01-17 | Elorac Inc | Method and compositions for treating chronic inflammatory disorders |
| JP7382716B2 (ja) * | 2015-12-31 | 2023-11-17 | 北京谷神生命健康科技有限公司 | 非アルコール性脂肪性肝疾患(nafld)の予防または治療用医薬の調製におけるトリアセチル-3-ヒドロキシフェニルアデノシンの使用 |
| JP6830580B2 (ja) | 2016-01-13 | 2021-02-17 | 国立大学法人富山大学 | セラミド含量増加剤 |
| WO2017132775A1 (en) | 2016-02-05 | 2017-08-10 | Viteava Pharmaceuticals Inc. | Novel compositions and methods for the treatment of leiomyoma |
| CN106995474B (zh) * | 2017-04-25 | 2019-11-05 | 中国海洋大学 | 双半乳糖基二酰基甘油酯及其制备方法与用途 |
| CN110869024A (zh) | 2017-06-05 | 2020-03-06 | 旗舰创业创新五公司 | 多生物剂及其使用方法 |
| WO2019236765A1 (en) | 2018-06-05 | 2019-12-12 | Flagship Pioneering Innovations V, Inc. | Acylated catechin polyphenols and methods of their use for the treatment of cancer |
| EP3801496A4 (en) | 2018-06-05 | 2022-07-06 | Flagship Pioneering Innovations V, Inc. | SUBSTANCES AND METHODS OF USE FOR THE TREATMENT OF METABOLIC DISEASES AND NON-ALCOHOL FATTY LIVER |
| JP2021528385A (ja) * | 2018-06-05 | 2021-10-21 | フラッグシップ パイオニアリング イノベーションズ ブイ, インコーポレイテッド | 自己免疫障害を治療するためのアシル化活性剤およびその使用方法 |
| WO2020037009A1 (en) | 2018-08-13 | 2020-02-20 | Flagship Pioneering Innovations V, Inc. | Conjugates and methods of using the same |
| WO2021222702A1 (en) * | 2020-05-01 | 2021-11-04 | Flagship Pioneering Innovations V, Inc. | Crystalline forms, compositions containing them, and methods of their use |
-
2019
- 2019-06-05 EP EP19815045.0A patent/EP3801496A4/en active Pending
- 2019-06-05 KR KR1020207037346A patent/KR20210016407A/ko not_active Ceased
- 2019-06-05 AU AU2019282691A patent/AU2019282691A1/en not_active Abandoned
- 2019-06-05 WO PCT/US2019/035680 patent/WO2019236775A1/en not_active Ceased
- 2019-06-05 MX MX2020013104A patent/MX2020013104A/es unknown
- 2019-06-05 JP JP2020567941A patent/JP7377220B2/ja active Active
- 2019-06-05 BR BR112020024695-6A patent/BR112020024695A2/pt not_active Application Discontinuation
- 2019-06-05 CA CA3102404A patent/CA3102404A1/en active Pending
- 2019-06-05 SG SG11202011698VA patent/SG11202011698VA/en unknown
- 2019-06-05 CN CN201980037671.6A patent/CN112367987A/zh active Pending
-
2020
- 2020-02-27 US US16/803,411 patent/US10953027B2/en active Active
- 2020-11-17 US US16/950,120 patent/US11813272B2/en active Active
- 2020-12-01 PH PH12020552060A patent/PH12020552060A1/en unknown
- 2020-12-02 IL IL279161A patent/IL279161A/en unknown
-
2023
- 2023-10-26 US US18/495,450 patent/US20240180941A1/en not_active Abandoned
- 2023-10-27 JP JP2023184635A patent/JP7592140B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6777366B2 (ja) | スルホラファンとシリマリン及び/又はシリビニンを含有してなるオオアザミ抽出物または粉末を含む組成物 | |
| JP2020522514A5 (enExample) | ||
| EP2730286B1 (en) | Composition for maintaining bone health and for treating osteoarthritis and osteoarthrosis of the joints | |
| JP2018021079A5 (enExample) | ||
| ES2585066T3 (es) | Composiciones para el tratamiento de trastornos neurológicos | |
| FR3027228A1 (fr) | Composition comprenant un melange d'extraits vegetaux et utilisation pour agir sur le metabolisme glucidique et/ou lipidique | |
| WO2009082459A2 (en) | Anti-aging composition containing resveratrol and method of administration | |
| AU2015320975A1 (en) | Combination treatment of SGLT2 inhibitors and dopamine agonists for preventing metabolic disorders in equine animals | |
| KR101380140B1 (ko) | 트리아세틸-3-히드록실페닐아데노신 및 혈지조절에 대한 용도 | |
| Jangra et al. | Ameliorative effect of fermentable fibres on adiposity and insulin resistance in C57BL/6 mice fed a high-fat and sucrose diet | |
| JP2009007313A (ja) | 筋萎縮抑制剤 | |
| CN104379214A (zh) | 用于治疗代谢紊乱的野葛和植物甾醇 | |
| US20150147411A1 (en) | Composition for preventing or treating colitis comprising s-allyl-l-cysteine as active ingredient, and medical preparation comprising same | |
| WO2018102914A1 (en) | Use of medium-chain triglycerides for the management of metabolic conditions | |
| CN112386601B (zh) | 维生素d补充制剂及其应用 | |
| JP2017052747A (ja) | ウロプラキン発現促進剤 | |
| JP2019147772A (ja) | ヘプシジン発現抑制剤、並びに鉄欠乏性貧血改善及び/又は予防用飲食品 | |
| US20070066567A1 (en) | Use of phospholipid arachidonic acids for increasing muscle mass in humans | |
| KR20240141767A (ko) | 미토콘드리아 질량 및 기능 증가를 촉진하기 위한 용도 및 방법 | |
| KR100771322B1 (ko) | 항비만제 및 건강식품 | |
| AU2019350801B2 (en) | Fat accumulation inhibitor and blood lipid level improving agent | |
| JP6018800B2 (ja) | 経口投与組成物 | |
| RU2020142587A (ru) | Активные средства и способы их применения для лечения метаболических нарушений и неалкогольной жировой болезни печени | |
| JP2021535210A5 (enExample) | ||
| JP2023505233A5 (enExample) |