JP2021523934A5 - - Google Patents
Info
- Publication number
- JP2021523934A5 JP2021523934A5 JP2021506391A JP2021506391A JP2021523934A5 JP 2021523934 A5 JP2021523934 A5 JP 2021523934A5 JP 2021506391 A JP2021506391 A JP 2021506391A JP 2021506391 A JP2021506391 A JP 2021506391A JP 2021523934 A5 JP2021523934 A5 JP 2021523934A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- salt
- phenyl
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862660880P | 2018-04-20 | 2018-04-20 | |
| US62/660,880 | 2018-04-20 | ||
| PCT/US2019/028560 WO2019204819A1 (en) | 2018-04-20 | 2019-04-22 | Aminopyrazines and related compounds useful as mitochondrial uncouplers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021523934A JP2021523934A (ja) | 2021-09-09 |
| JP2021523934A5 true JP2021523934A5 (enExample) | 2022-04-25 |
Family
ID=67139787
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021506390A Pending JP2021523933A (ja) | 2018-04-20 | 2019-04-22 | ミトコンドリア脱共役剤として有用なイミダゾピリジン |
| JP2021506388A Pending JP2021522327A (ja) | 2018-04-20 | 2019-04-22 | ミトコンドリア脱共役剤として有用なオキサジアゾロピラジンおよびオキサジアゾロピリジン |
| JP2021506391A Pending JP2021523934A (ja) | 2018-04-20 | 2019-04-22 | ミトコンドリア脱共役剤として有用なアミノピラジンおよび関連化合物 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021506390A Pending JP2021523933A (ja) | 2018-04-20 | 2019-04-22 | ミトコンドリア脱共役剤として有用なイミダゾピリジン |
| JP2021506388A Pending JP2021522327A (ja) | 2018-04-20 | 2019-04-22 | ミトコンドリア脱共役剤として有用なオキサジアゾロピラジンおよびオキサジアゾロピリジン |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20210253538A1 (enExample) |
| EP (4) | EP3781567B1 (enExample) |
| JP (3) | JP2021523933A (enExample) |
| KR (3) | KR20210003831A (enExample) |
| CN (3) | CN112262146A (enExample) |
| AU (2) | AU2019256722A1 (enExample) |
| BR (2) | BR112020021466A2 (enExample) |
| CA (2) | CA3097752A1 (enExample) |
| IL (2) | IL278069A (enExample) |
| MX (2) | MX2020011049A (enExample) |
| WO (3) | WO2019204813A1 (enExample) |
| ZA (2) | ZA202006296B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3781567B1 (en) | 2018-04-20 | 2022-08-24 | Virginia Tech Intellectual Properties, Inc. | Imidazopyridines useful as mitochondrial uncouplers |
| WO2020191503A1 (en) * | 2019-03-27 | 2020-10-01 | Algernon Pharmaceuticals Inc. | Methods and uses of bromantane and derivatives thereof for treating lung disease, fatty liver disease, and kidney disorders |
| EP4178955A1 (en) | 2020-07-11 | 2023-05-17 | Pfizer Inc. | Antiviral heteroaryl ketone derivatives |
| US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
| EP4482494A4 (en) * | 2022-02-21 | 2026-02-25 | Univ Colorado Regents | RE-SENSITIZATION OF MULTI-DRUG-RESISTANT GRAM-NEGATIVE (MDR) BACTERIA TO COLISTIN USING IONOPHORES |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2501680A1 (fr) | 1981-03-12 | 1982-09-17 | Elf Aquitaine | Synthese de tetra mercaptides stanniques |
| US4472840A (en) | 1981-09-21 | 1984-09-25 | Jefferies Steven R | Method of inducing osseous formation by implanting bone graft material |
| US4559157A (en) | 1983-04-21 | 1985-12-17 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing |
| LU84979A1 (fr) | 1983-08-30 | 1985-04-24 | Oreal | Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux |
| US4820508A (en) | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
| US5606019A (en) | 1987-10-29 | 1997-02-25 | Protien Polymer Technologies, Inc. | Synthetic protein as implantables |
| JP2668259B2 (ja) * | 1988-02-18 | 1997-10-27 | 塩野義製薬株式会社 | 複素環化合物および抗潰瘍剤 |
| GB2215209B (en) | 1988-03-14 | 1992-08-26 | Osmed Inc | Method and apparatus for biodegradable, osteogenic, bone graft substitute device |
| US4992478A (en) | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| JPH0327172A (ja) | 1989-06-19 | 1991-02-05 | Nissan Chem Ind Ltd | 布の漂白方法 |
| US5645591A (en) | 1990-05-29 | 1997-07-08 | Stryker Corporation | Synthetic bone matrix |
| JPH0741461A (ja) * | 1993-05-27 | 1995-02-10 | Eisai Co Ltd | スルホン酸エステル誘導体 |
| WO2000052001A1 (en) * | 1999-03-03 | 2000-09-08 | Samjin Pharmaceutical Co., Ltd. | Piperazine derivatives and process for the preparation thereof |
| ATE307121T1 (de) * | 2000-02-16 | 2005-11-15 | Neurogen Corp | Substituierte arylpyrazine |
| US6777446B2 (en) * | 2000-09-05 | 2004-08-17 | Tularik, Inc. | FXR modulators |
| WO2004007472A1 (ja) * | 2002-07-10 | 2004-01-22 | Ono Pharmaceutical Co., Ltd. | Ｃｃｒ４アンタゴニストおよびその医薬用途 |
| EP1529531A1 (en) | 2003-11-04 | 2005-05-11 | 4Sc Ag | Oxadiazolopyrazine derivatives as pharmaceutically active compounds |
| WO2005044270A1 (en) | 2003-11-04 | 2005-05-19 | 4Sc Ag | Oxadiazolopyrazine derivatives as pharmaceutically active compounds |
| JP2008515979A (ja) * | 2004-10-14 | 2008-05-15 | コンパス ファーマシューティカルズ リミティド ライアビリティ カンパニー | フラザノ‘３，４−ビピラジン（ｂｉｐｙｒａｚｉｎｅ）及び抗腫瘍剤としてのその使用 |
| WO2006124874A2 (en) | 2005-05-12 | 2006-11-23 | Kalypsys, Inc. | Inhibitors of b-raf kinase |
| ES2270715B1 (es) | 2005-07-29 | 2008-04-01 | Laboratorios Almirall S.A. | Nuevos derivados de pirazina. |
| ES2412007T3 (es) * | 2005-12-21 | 2013-07-09 | Janssen Pharmaceutica, N.V. | Derivados de pirazinona sustituida novedosos para uso en enfermedades mediadas por MCH-1 |
| EP2017277A1 (en) | 2007-06-29 | 2009-01-21 | 4Sc Ag | Thiophene-imidazopyridines |
| AU2008345225A1 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| PL2424530T3 (pl) * | 2009-04-30 | 2016-07-29 | Univ Midwestern | Sposób i kompozycja do leczenia cukrzycowej kwasicy ketonowej |
| WO2012020742A1 (ja) * | 2010-08-10 | 2012-02-16 | 塩野義製薬株式会社 | 新規複素環誘導体およびそれらを含有する医薬組成物 |
| KR20140077963A (ko) * | 2011-10-20 | 2014-06-24 | 글락소스미스클라인 엘엘씨 | 시르투인 조절제로서의 치환된 비시클릭 아자-헤테로사이클 및 유사체 |
| KR101481952B1 (ko) * | 2012-04-13 | 2015-01-22 | 한국과학기술연구원 | 신경보호제로서의 유레아 유도체 |
| US9492448B2 (en) | 2012-06-20 | 2016-11-15 | University Of Virginia Patent Foundation | Compositions and methods for regulating glucose homeostasis and insulin action |
| TW201441203A (zh) | 2012-11-05 | 2014-11-01 | Medeia Therapeutics Ltd | Ｎ－取代４－胺苯酚及對應醌亞胺 |
| WO2015000715A1 (en) * | 2013-07-02 | 2015-01-08 | Syngenta Participations Ag | Pesticidally active bi- or tricyclic heterocycles with sulfur containing substituents |
| KR101428622B1 (ko) | 2014-01-07 | 2014-08-13 | 국방과학연구소 | 옥사디아졸로 피라진기를 포함하는 화합물 또는 염을 포함하는 리튬 이차 전지용 전극 및 이를 포함하는 리튬 이차 전지 |
| CN107108521A (zh) * | 2014-10-28 | 2017-08-29 | 盐野义制药株式会社 | 具有ampk活化作用的杂环衍生物 |
| HK1243636A1 (zh) | 2014-11-18 | 2018-07-20 | Rutgers, The State University Of New Jersey | 用於治疗代谢疾病和癌症的新的线粒体解偶联剂 |
| WO2017151063A1 (en) | 2016-03-03 | 2017-09-08 | Agency For Science, Technology And Research | Use of furazano[3,4-b]pyrazine derivatives for chemotherapy |
| TWI754702B (zh) * | 2016-12-28 | 2022-02-11 | 德商Ｕｃｂ製藥有限公司 | （氮雜）吲哚－和苯並呋喃－３－磺醯胺類 |
| EP3630115B1 (en) | 2017-05-22 | 2025-12-10 | University Of Virginia Patent Foundation | Compositions and methods for preparing and using mitochondrial uncouplers |
| EP3781567B1 (en) * | 2018-04-20 | 2022-08-24 | Virginia Tech Intellectual Properties, Inc. | Imidazopyridines useful as mitochondrial uncouplers |
-
2019
- 2019-04-22 EP EP19735421.0A patent/EP3781567B1/en active Active
- 2019-04-22 CN CN201980038732.0A patent/CN112262146A/zh active Pending
- 2019-04-22 CN CN201980038852.0A patent/CN112261941A/zh active Pending
- 2019-04-22 BR BR112020021466-3A patent/BR112020021466A2/pt not_active Application Discontinuation
- 2019-04-22 WO PCT/US2019/028544 patent/WO2019204813A1/en not_active Ceased
- 2019-04-22 KR KR1020207033297A patent/KR20210003831A/ko not_active Withdrawn
- 2019-04-22 CA CA3097752A patent/CA3097752A1/en active Pending
- 2019-04-22 WO PCT/US2019/028560 patent/WO2019204819A1/en not_active Ceased
- 2019-04-22 US US17/049,145 patent/US20210253538A1/en not_active Abandoned
- 2019-04-22 US US17/048,897 patent/US12655156B2/en active Active
- 2019-04-22 EP EP26175958.3A patent/EP4763834A3/en active Pending
- 2019-04-22 AU AU2019256722A patent/AU2019256722A1/en not_active Abandoned
- 2019-04-22 EP EP19735420.2A patent/EP3781572B1/en active Active
- 2019-04-22 KR KR1020207033356A patent/KR102900692B1/ko active Active
- 2019-04-22 MX MX2020011049A patent/MX2020011049A/es unknown
- 2019-04-22 AU AU2019256719A patent/AU2019256719A1/en not_active Abandoned
- 2019-04-22 JP JP2021506390A patent/JP2021523933A/ja active Pending
- 2019-04-22 KR KR1020207033337A patent/KR102913366B1/ko active Active
- 2019-04-22 BR BR112020021469-8A patent/BR112020021469A2/pt not_active Application Discontinuation
- 2019-04-22 JP JP2021506388A patent/JP2021522327A/ja active Pending
- 2019-04-22 US US17/049,232 patent/US11708376B2/en active Active
- 2019-04-22 MX MX2020011050A patent/MX2020011050A/es unknown
- 2019-04-22 CA CA3097751A patent/CA3097751A1/en active Pending
- 2019-04-22 CN CN201980038722.7A patent/CN112262141A/zh active Pending
- 2019-04-22 EP EP19789309.2A patent/EP3781165A4/en not_active Withdrawn
- 2019-04-22 JP JP2021506391A patent/JP2021523934A/ja active Pending
- 2019-04-22 WO PCT/US2019/028555 patent/WO2019204816A1/en not_active Ceased
-
2020
- 2020-10-09 ZA ZA2020/06296A patent/ZA202006296B/en unknown
- 2020-10-09 ZA ZA2020/06295A patent/ZA202006295B/en unknown
- 2020-10-15 IL IL278069A patent/IL278069A/en unknown
- 2020-10-15 IL IL278070A patent/IL278070A/en unknown
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