JP2021501789A5 - - Google Patents

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JP2021501789A5
JP2021501789A5 JP2020524864A JP2020524864A JP2021501789A5 JP 2021501789 A5 JP2021501789 A5 JP 2021501789A5 JP 2020524864 A JP2020524864 A JP 2020524864A JP 2020524864 A JP2020524864 A JP 2020524864A JP 2021501789 A5 JP2021501789 A5 JP 2021501789A5
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disease
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halo
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JP2020524864A
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JP7337790B2 (ja
JP2021501789A (ja
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Priority claimed from PCT/US2018/058949 external-priority patent/WO2019090069A1/en
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JP2020524864A 2017-11-02 2018-11-02 統合的ストレス経路の調節剤 Active JP7337790B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762580726P 2017-11-02 2017-11-02
US62/580,726 2017-11-02
US201862643059P 2018-03-14 2018-03-14
US62/643,059 2018-03-14
PCT/US2018/058949 WO2019090069A1 (en) 2017-11-02 2018-11-02 Modulators of the integrated stress pathway

Publications (3)

Publication Number Publication Date
JP2021501789A JP2021501789A (ja) 2021-01-21
JP2021501789A5 true JP2021501789A5 (https=) 2021-12-09
JP7337790B2 JP7337790B2 (ja) 2023-09-04

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JP2020524864A Active JP7337790B2 (ja) 2017-11-02 2018-11-02 統合的ストレス経路の調節剤

Country Status (21)

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US (2) US20200361941A1 (https=)
EP (1) EP3704094B1 (https=)
JP (1) JP7337790B2 (https=)
KR (1) KR20200096918A (https=)
CN (1) CN112189008A (https=)
AU (2) AU2018358346A1 (https=)
BR (1) BR112020008841A2 (https=)
CA (1) CA3080801A1 (https=)
CL (1) CL2020001184A1 (https=)
CO (1) CO2020006227A2 (https=)
CR (1) CR20200243A (https=)
EC (1) ECSP20027553A (https=)
IL (1) IL274368B2 (https=)
MX (1) MX2020004551A (https=)
PE (1) PE20210040A1 (https=)
PH (1) PH12020550524A1 (https=)
RU (1) RU2020117927A (https=)
SG (1) SG11202003985YA (https=)
TW (1) TWI818929B (https=)
UY (1) UY37956A (https=)
WO (1) WO2019090069A1 (https=)

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EP3512839A4 (en) 2016-09-18 2020-03-25 H. Lee Moffitt Cancer Center And Research Institute, Inc. AGAINST INTERACTION OF YAP1 WITH YCT1 INHIBITORS
CN118239937A (zh) 2017-08-09 2024-06-25 戴纳立制药公司 化合物、组合物及方法
DK3676297T3 (da) 2017-09-01 2023-08-14 Denali Therapeutics Inc Forbindelser, sammensætninger og fremgangsmåder
US11939320B2 (en) 2017-11-02 2024-03-26 Abbvie Inc. Modulators of the integrated stress pathway
WO2019118785A2 (en) 2017-12-13 2019-06-20 Praxis Biotech LLC Inhibitors of integrated stress response pathway
BR112020018642A2 (pt) 2018-03-14 2020-12-29 H. Lee Moffitt Cancer Center And Research Institute, Inc. Composto da fórmula i, composição farmacêutica, método de tratamento de câncer em um sujeito em necessidade, método de eliminação de uma célula tumoral em um sujeito
WO2019236710A1 (en) 2018-06-05 2019-12-12 Praxis Biotech LLC Inhibitors of integrated stress response pathway
JP2021529814A (ja) * 2018-07-09 2021-11-04 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited 化学化合物
TWI877863B (zh) * 2018-10-11 2025-03-21 美商嘉來克生命科學有限責任公司 整合應激路徑之前藥調節劑
MA54953A (fr) 2019-02-13 2021-12-22 Denali Therapeutics Inc Composés, compositions et procédés
US12091392B2 (en) 2019-02-13 2024-09-17 Denali Therapeutics Inc. Compounds, compositions and methods
CA3137213A1 (en) 2019-04-23 2020-10-29 Evotec International Gmbh Modulators of the integrated stress response pathway
MX2021012904A (es) 2019-04-23 2022-01-18 Evotec Int Gmbh Moduladores de la via de respuesta al estres integrada.
AR118836A1 (es) * 2019-04-30 2021-11-03 Calico Life Sciences Llc Moduladores de la vía de tensión integrada
JP2022536663A (ja) 2019-06-12 2022-08-18 プラクシス バイオテック エルエルシー 統合的ストレス応答経路のモジュレーター
IL291665B2 (en) * 2019-09-27 2025-07-01 Univ Texas Inhibitors of receptor interacting protein kinase i for the treatment of disease
AU2021213289A1 (en) 2020-01-28 2022-07-07 Evotec International Gmbh Modulators of the integrated stress response pathway
MX2022011143A (es) 2020-03-11 2022-10-13 Evotec Int Gmbh Moduladores de la via de respuesta integrada al estres.
WO2021211742A1 (en) * 2020-04-14 2021-10-21 The General Hospital Corporation Use of gcn2 inhibitors in treating mitochondrial myopathies and diseases associated with mitochondrial dysfunction
CN116547287B (zh) * 2020-08-26 2025-09-26 弗特克斯药品有限公司 Apol1的抑制剂及其使用方法
US20230391763A1 (en) 2020-10-22 2023-12-07 Evotec International Gmbh Modulators of the integrated stress response pathway
MX2023004623A (es) 2020-10-22 2023-05-12 Evotec Int Gmbh Moduladores de la via integrada de respuesta al estres.
JP2023546224A (ja) * 2020-10-22 2023-11-01 エヴォテック・インターナショナル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 統合ストレス応答経路のモジュレーター
CN118146172A (zh) * 2022-12-06 2024-06-07 帕潘纳(北京)科技有限公司 7-氟-6-氨基-2h-1,4-苯并恶嗪-3(4h)-酮的制备方法
CN121263408A (zh) * 2023-07-14 2026-01-02 深圳众格生物科技有限公司 一种化合物、包含其的药物组合物及其用途
KR20250122004A (ko) * 2024-02-05 2025-08-13 재단법인 대구경북첨단의료산업진흥재단 신규한 eIF2B 작용제 및 이를 포함하는 대사질환 예방 또는 치료용 조성물
US12303604B1 (en) 2024-10-16 2025-05-20 Currax Pharmaceuticals Llc Pharmaceutical formulations comprising naltrexone and/or bupropion

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FR2588189B1 (fr) 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
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