JP2021501789A5 - - Google Patents

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JP2021501789A5
JP2021501789A5 JP2020524864A JP2020524864A JP2021501789A5 JP 2021501789 A5 JP2021501789 A5 JP 2021501789A5 JP 2020524864 A JP2020524864 A JP 2020524864A JP 2020524864 A JP2020524864 A JP 2020524864A JP 2021501789 A5 JP2021501789 A5 JP 2021501789A5
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disease
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JP2020524864A
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JP7337790B2 (ja
JP2021501789A (ja
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Priority claimed from PCT/US2018/058949 external-priority patent/WO2019090069A1/en
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JP2020524864A 2017-11-02 2018-11-02 統合的ストレス経路の調節剤 Active JP7337790B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762580726P 2017-11-02 2017-11-02
US62/580,726 2017-11-02
US201862643059P 2018-03-14 2018-03-14
US62/643,059 2018-03-14
PCT/US2018/058949 WO2019090069A1 (en) 2017-11-02 2018-11-02 Modulators of the integrated stress pathway

Publications (3)

Publication Number Publication Date
JP2021501789A JP2021501789A (ja) 2021-01-21
JP2021501789A5 true JP2021501789A5 (https=) 2021-12-09
JP7337790B2 JP7337790B2 (ja) 2023-09-04

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JP2020524864A Active JP7337790B2 (ja) 2017-11-02 2018-11-02 統合的ストレス経路の調節剤

Country Status (21)

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US (2) US20200361941A1 (https=)
EP (1) EP3704094B1 (https=)
JP (1) JP7337790B2 (https=)
KR (1) KR20200096918A (https=)
CN (1) CN112189008A (https=)
AU (2) AU2018358346A1 (https=)
BR (1) BR112020008841A2 (https=)
CA (1) CA3080801A1 (https=)
CL (1) CL2020001184A1 (https=)
CO (1) CO2020006227A2 (https=)
CR (1) CR20200243A (https=)
EC (1) ECSP20027553A (https=)
IL (1) IL274368B2 (https=)
MX (1) MX2020004551A (https=)
PE (1) PE20210040A1 (https=)
PH (1) PH12020550524A1 (https=)
RU (1) RU2020117927A (https=)
SG (1) SG11202003985YA (https=)
TW (1) TWI818929B (https=)
UY (1) UY37956A (https=)
WO (1) WO2019090069A1 (https=)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019530678A (ja) 2016-09-18 2019-10-24 エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド Yap1のoct4との相互作用を標的とするyap1阻害剤
CA3071024A1 (en) 2017-08-09 2019-02-14 Denali Therapeutics Inc. Compounds, compositions and methods
CN111201245B (zh) 2017-09-01 2024-04-05 戴纳立制药公司 化合物、组合物和方法
WO2019090088A1 (en) 2017-11-02 2019-05-09 Calico Life Sciences Llc Modulators of the integrated stress pathway
CN111757739A (zh) 2017-12-13 2020-10-09 普拉西斯生物技术有限责任公司 整合应激反应路径抑制剂
BR112020018642A2 (pt) 2018-03-14 2020-12-29 H. Lee Moffitt Cancer Center And Research Institute, Inc. Composto da fórmula i, composição farmacêutica, método de tratamento de câncer em um sujeito em necessidade, método de eliminação de uma célula tumoral em um sujeito
AU2019282253A1 (en) 2018-06-05 2020-11-26 Altos Labs, Inc. Inhibitors of integrated stress response pathway
WO2020012339A1 (en) * 2018-07-09 2020-01-16 Glaxosmithkline Intellectual Property Development Limited Chemical compounds
TW202545902A (zh) 2018-10-11 2025-12-01 美商嘉來克生命科學有限責任公司 整合應激路徑之前藥調節劑
EP3924341A4 (en) 2019-02-13 2022-11-02 Denali Therapeutics Inc. Compounds, compositions and methods
SG11202108552QA (en) 2019-02-13 2021-09-29 Denali Therapeutics Inc Compounds, compositions and methods
EP3959198A1 (en) 2019-04-23 2022-03-02 Evotec International GmbH Modulators of the integrated stress response pathway
MX2021012904A (es) 2019-04-23 2022-01-18 Evotec Int Gmbh Moduladores de la via de respuesta al estres integrada.
SG11202111970WA (en) * 2019-04-30 2021-11-29 Calico Life Sciences Llc Substituted cyclolakyls as modulators of the integrated stress pathway
WO2020252207A1 (en) 2019-06-12 2020-12-17 Praxis Biotech LLC Modulators of integrated stress response pathway
IL291665B2 (en) * 2019-09-27 2025-07-01 Univ Texas Inhibitors of receptor interacting protein kinase i for the treatment of disease
JP7699595B2 (ja) 2020-01-28 2025-06-27 エヴォテック・インターナショナル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 統合的ストレス応答経路の調節因子
CN115190813B (zh) 2020-03-11 2024-10-15 埃沃特克国际有限责任公司 整合应激反应途径的调节剂
WO2021211742A1 (en) * 2020-04-14 2021-10-21 The General Hospital Corporation Use of gcn2 inhibitors in treating mitochondrial myopathies and diseases associated with mitochondrial dysfunction
IL300298B2 (en) * 2020-08-26 2025-06-01 Vertex Pharma Inhibitors of apol1 and methods of using same
EP4232447A1 (en) 2020-10-22 2023-08-30 Evotec International GmbH Modulators of the integrated stress response pathway
RS66455B1 (sr) 2020-10-22 2025-02-28 Evotec Int Gmbh Modulatori puta integrisanog odgovora na stres
EP4232153A1 (en) * 2020-10-22 2023-08-30 Evotec International GmbH Modulators of the integrated stress response pathway
CN118146172A (zh) * 2022-12-06 2024-06-07 帕潘纳(北京)科技有限公司 7-氟-6-氨基-2h-1,4-苯并恶嗪-3(4h)-酮的制备方法
AU2024291624A1 (en) * 2023-07-14 2025-11-20 Shenzhen Zhongge Biological Technology Co., Ltd. Compound, pharmaceutical composition comprising same, and use thereof
KR20250122004A (ko) * 2024-02-05 2025-08-13 재단법인 대구경북첨단의료산업진흥재단 신규한 eIF2B 작용제 및 이를 포함하는 대사질환 예방 또는 치료용 조성물
US12303604B1 (en) 2024-10-16 2025-05-20 Currax Pharmaceuticals Llc Pharmaceutical formulations comprising naltrexone and/or bupropion

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1026506A (en) * 1962-10-17 1966-04-20 Du Pont Bicyclodiamines and preparation thereof
US3264351A (en) * 1964-07-08 1966-08-02 American Home Prod 1, 4-diaminobicyclo [2.2.2] octanes
US3301827A (en) * 1965-05-07 1967-01-31 Du Pont Polymers from polycyclic reactants having functional substituents on bridgehead carbon atoms
US4911920A (en) 1986-07-30 1990-03-27 Alcon Laboratories, Inc. Sustained release, comfort formulation for glaucoma therapy
FR2588189B1 (fr) 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
ATE141502T1 (de) 1991-01-15 1996-09-15 Alcon Lab Inc Verwendung von karrageenan in topischen ophthalmologischen zusammensetzungen
US5212162A (en) 1991-03-27 1993-05-18 Alcon Laboratories, Inc. Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
TWI538905B (zh) * 2010-12-22 2016-06-21 H 朗德貝克公司 雙環[3.2.1]辛基醯胺衍生物及其用途
CA2904794C (en) * 2013-03-15 2021-11-23 Peter Walter Modulators of the eif2alpha pathway
US20160318856A1 (en) * 2013-09-11 2016-11-03 The Brigham And Women's Hospital, Inc. Substituted Urea eIF2alpha Kinase Activators
TWI763668B (zh) * 2016-05-05 2022-05-11 美商嘉來克生命科學有限責任公司 整合應激途徑之調節劑
TW201808903A (zh) * 2016-05-05 2018-03-16 嘉來克生命科學有限責任公司 整合應激途徑之調節劑
TW201808888A (zh) * 2016-05-05 2018-03-16 嘉來克生命科學有限責任公司 整合應激途徑之調節劑
CN106349130B (zh) * 2016-08-25 2018-01-23 潍坊大有生物化工有限公司 一种新的氟苯尼考的合成方法

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