JP2021501786A5 - - Google Patents

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Publication number
JP2021501786A5
JP2021501786A5 JP2020524813A JP2020524813A JP2021501786A5 JP 2021501786 A5 JP2021501786 A5 JP 2021501786A5 JP 2020524813 A JP2020524813 A JP 2020524813A JP 2020524813 A JP2020524813 A JP 2020524813A JP 2021501786 A5 JP2021501786 A5 JP 2021501786A5
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JP
Japan
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alkyl
och
disease
independently
halo
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Pending
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JP2020524813A
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English (en)
Japanese (ja)
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JP2021501786A (ja
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Priority claimed from PCT/US2018/058957 external-priority patent/WO2019090076A1/en
Publication of JP2021501786A publication Critical patent/JP2021501786A/ja
Publication of JP2021501786A5 publication Critical patent/JP2021501786A5/ja
Pending legal-status Critical Current

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JP2020524813A 2017-11-02 2018-11-02 統合的ストレス経路の調節剤 Pending JP2021501786A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762580742P 2017-11-02 2017-11-02
US62/580,742 2017-11-02
US201862643063P 2018-03-14 2018-03-14
US62/643,063 2018-03-14
PCT/US2018/058957 WO2019090076A1 (en) 2017-11-02 2018-11-02 Modulators of the integrated stress pathway

Publications (2)

Publication Number Publication Date
JP2021501786A JP2021501786A (ja) 2021-01-21
JP2021501786A5 true JP2021501786A5 (https=) 2021-12-09

Family

ID=64564980

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020524813A Pending JP2021501786A (ja) 2017-11-02 2018-11-02 統合的ストレス経路の調節剤

Country Status (20)

Country Link
US (2) US20200345727A1 (https=)
EP (1) EP3710428B1 (https=)
JP (1) JP2021501786A (https=)
KR (1) KR20200096522A (https=)
CN (1) CN112204009B (https=)
AU (2) AU2018360857A1 (https=)
BR (1) BR112020008839A2 (https=)
CA (1) CA3080806A1 (https=)
CL (1) CL2020001167A1 (https=)
CO (1) CO2020006248A2 (https=)
EC (1) ECSP20026381A (https=)
IL (1) IL274369B2 (https=)
MX (1) MX2020004555A (https=)
PE (1) PE20210396A1 (https=)
PH (1) PH12020550523A1 (https=)
RU (1) RU2020117900A (https=)
SG (1) SG11202003982QA (https=)
TW (1) TWI797186B (https=)
UY (1) UY37957A (https=)
WO (1) WO2019090076A1 (https=)

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CA3071024A1 (en) 2017-08-09 2019-02-14 Denali Therapeutics Inc. Compounds, compositions and methods
CN111201245B (zh) 2017-09-01 2024-04-05 戴纳立制药公司 化合物、组合物和方法
KR20190043437A (ko) 2017-10-18 2019-04-26 씨제이헬스케어 주식회사 단백질 키나제 억제제로서의 헤테로고리 화합물
WO2019090088A1 (en) 2017-11-02 2019-05-09 Calico Life Sciences Llc Modulators of the integrated stress pathway
CN111757739A (zh) 2017-12-13 2020-10-09 普拉西斯生物技术有限责任公司 整合应激反应路径抑制剂
BR112020018642A2 (pt) 2018-03-14 2020-12-29 H. Lee Moffitt Cancer Center And Research Institute, Inc. Composto da fórmula i, composição farmacêutica, método de tratamento de câncer em um sujeito em necessidade, método de eliminação de uma célula tumoral em um sujeito
AU2019282253A1 (en) 2018-06-05 2020-11-26 Altos Labs, Inc. Inhibitors of integrated stress response pathway
TW202545902A (zh) 2018-10-11 2025-12-01 美商嘉來克生命科學有限責任公司 整合應激路徑之前藥調節劑
KR102195348B1 (ko) 2018-11-15 2020-12-24 에이치케이이노엔 주식회사 단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물
AU2020209216A1 (en) 2019-01-18 2021-08-26 Astrazeneca Ab PCSK9 inhibitors and methods of use thereof
SG11202107614PA (en) 2019-01-18 2021-08-30 Astrazeneca Ab Pcsk9 inhibitors and methods of use thereof
EP3924341A4 (en) 2019-02-13 2022-11-02 Denali Therapeutics Inc. Compounds, compositions and methods
SG11202108552QA (en) 2019-02-13 2021-09-29 Denali Therapeutics Inc Compounds, compositions and methods
EP3959198A1 (en) 2019-04-23 2022-03-02 Evotec International GmbH Modulators of the integrated stress response pathway
MX2021012904A (es) 2019-04-23 2022-01-18 Evotec Int Gmbh Moduladores de la via de respuesta al estres integrada.
SG11202111970WA (en) * 2019-04-30 2021-11-29 Calico Life Sciences Llc Substituted cyclolakyls as modulators of the integrated stress pathway
WO2020252207A1 (en) 2019-06-12 2020-12-17 Praxis Biotech LLC Modulators of integrated stress response pathway
CN114845709B (zh) * 2019-11-05 2024-10-01 德米拉公司 用于治疗炎性病症的mrgprx2拮抗剂
JP7699595B2 (ja) 2020-01-28 2025-06-27 エヴォテック・インターナショナル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 統合的ストレス応答経路の調節因子
CN115190813B (zh) 2020-03-11 2024-10-15 埃沃特克国际有限责任公司 整合应激反应途径的调节剂
CN113754541B (zh) * 2020-06-02 2025-01-03 深圳湾实验室 靶向eb病毒核抗原蛋白的小分子抑制剂、制备方法及其应用
EP4232153A1 (en) 2020-10-22 2023-08-30 Evotec International GmbH Modulators of the integrated stress response pathway
RS66455B1 (sr) 2020-10-22 2025-02-28 Evotec Int Gmbh Modulatori puta integrisanog odgovora na stres
EP4232447A1 (en) 2020-10-22 2023-08-30 Evotec International GmbH Modulators of the integrated stress response pathway
WO2023107705A1 (en) 2021-12-10 2023-06-15 Incyte Corporation Bicyclic amines as cdk12 inhibitors
CN119013017A (zh) * 2022-02-15 2024-11-22 治纳辅医药科技有限公司 包含抗癌剂和对前列腺素e2受体具有抑制活性的新化合物的用于治疗癌症的药物组合物
CN114614096B (zh) * 2022-02-24 2024-03-08 复旦大学 一种快充型电解液及其在锂离子电池中的应用
CA3245969A1 (en) * 2022-03-30 2023-10-05 Escient Pharmaceuticals, Inc. QUINOLINE DERIVATIVES AS MRGPRX2 RECEIVER MODULATORS AND RELATED PRODUCTS
IL316283A (en) * 2022-04-25 2024-12-01 Praxis Prec Medicines Inc KCNT1 inhibitors comprising a pyrazole core and methods of use
WO2023211854A1 (en) * 2022-04-25 2023-11-02 Praxis Precision Medicines, Inc. Kcnt1 inhibitors comprising a thiazole core and methods of use
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AU2024291624A1 (en) * 2023-07-14 2025-11-20 Shenzhen Zhongge Biological Technology Co., Ltd. Compound, pharmaceutical composition comprising same, and use thereof

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