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- JP2021501786A5 JP2021501786A5 JP2020524813A JP2020524813A JP2021501786A5 JP 2021501786 A5 JP2021501786 A5 JP 2021501786A5 JP 2020524813 A JP2020524813 A JP 2020524813A JP 2020524813 A JP2020524813 A JP 2020524813A JP 2021501786 A5 JP2021501786 A5 JP 2021501786A5
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| BR112020018642A2 (pt) | 2018-03-14 | 2020-12-29 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Composto da fórmula i, composição farmacêutica, método de tratamento de câncer em um sujeito em necessidade, método de eliminação de uma célula tumoral em um sujeito |
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| TWI877863B (zh) | 2018-10-11 | 2025-03-21 | 美商嘉來克生命科學有限責任公司 | 整合應激路徑之前藥調節劑 |
| KR102195348B1 (ko) | 2018-11-15 | 2020-12-24 | 에이치케이이노엔 주식회사 | 단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물 |
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| US12091392B2 (en) | 2019-02-13 | 2024-09-17 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| MA54953A (fr) | 2019-02-13 | 2021-12-22 | Denali Therapeutics Inc | Composés, compositions et procédés |
| CA3137213A1 (en) | 2019-04-23 | 2020-10-29 | Evotec International Gmbh | Modulators of the integrated stress response pathway |
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| AR118836A1 (es) * | 2019-04-30 | 2021-11-03 | Calico Life Sciences Llc | Moduladores de la vía de tensión integrada |
| JP2022536663A (ja) | 2019-06-12 | 2022-08-18 | プラクシス バイオテック エルエルシー | 統合的ストレス応答経路のモジュレーター |
| WO2021092240A1 (en) * | 2019-11-05 | 2021-05-14 | Dermira, Inc. | Mrgprx2 antagonists for the treatment of inflammatory disorders |
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| CN113754541B (zh) * | 2020-06-02 | 2025-01-03 | 深圳湾实验室 | 靶向eb病毒核抗原蛋白的小分子抑制剂、制备方法及其应用 |
| MX2023004623A (es) | 2020-10-22 | 2023-05-12 | Evotec Int Gmbh | Moduladores de la via integrada de respuesta al estres. |
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| JP2023546224A (ja) | 2020-10-22 | 2023-11-01 | エヴォテック・インターナショナル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 統合ストレス応答経路のモジュレーター |
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| CN119013017A (zh) * | 2022-02-15 | 2024-11-22 | 治纳辅医药科技有限公司 | 包含抗癌剂和对前列腺素e2受体具有抑制活性的新化合物的用于治疗癌症的药物组合物 |
| CN114614096B (zh) * | 2022-02-24 | 2024-03-08 | 复旦大学 | 一种快充型电解液及其在锂离子电池中的应用 |
| CR20240463A (es) * | 2022-03-30 | 2025-02-05 | Escient Pharmaceuticals Inc | Derivados de quinolina como moduladores del receptor x2 de la proteína g relacionados con mas y productos relacionados |
| WO2023211854A1 (en) * | 2022-04-25 | 2023-11-02 | Praxis Precision Medicines, Inc. | Kcnt1 inhibitors comprising a thiazole core and methods of use |
| KR20250016137A (ko) * | 2022-04-25 | 2025-02-03 | 프락시스 프리시젼 메디신즈, 인크. | 피라졸 코어를 포함하는 kcnt1 억제제 및 사용 방법 |
| CN115368263B (zh) * | 2022-09-01 | 2024-05-17 | 南开大学 | 一种肉桂酸酰胺衍生物的合成及其制药应用 |
| CN121263408A (zh) * | 2023-07-14 | 2026-01-02 | 深圳众格生物科技有限公司 | 一种化合物、包含其的药物组合物及其用途 |
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| CN104364239B (zh) * | 2012-06-13 | 2017-08-25 | 霍夫曼-拉罗奇有限公司 | 二氮杂螺环烷烃和氮杂螺环烷烃 |
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