JP2021501780A5 - - Google Patents

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Publication number
JP2021501780A5
JP2021501780A5 JP2020524776A JP2020524776A JP2021501780A5 JP 2021501780 A5 JP2021501780 A5 JP 2021501780A5 JP 2020524776 A JP2020524776 A JP 2020524776A JP 2020524776 A JP2020524776 A JP 2020524776A JP 2021501780 A5 JP2021501780 A5 JP 2021501780A5
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JP
Japan
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alkyl
halo
group
disease
cyano
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JP2020524776A
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English (en)
Japanese (ja)
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JP2021501780A (ja
JP7307057B2 (ja
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Priority claimed from PCT/US2018/058974 external-priority patent/WO2019090090A1/en
Publication of JP2021501780A publication Critical patent/JP2021501780A/ja
Publication of JP2021501780A5 publication Critical patent/JP2021501780A5/ja
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Publication of JP7307057B2 publication Critical patent/JP7307057B2/ja
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JP2020524776A 2017-11-02 2018-11-02 統合的ストレス経路の調節剤 Active JP7307057B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762580820P 2017-11-02 2017-11-02
US62/580,820 2017-11-02
US201862643079P 2018-03-14 2018-03-14
US62/643,079 2018-03-14
PCT/US2018/058974 WO2019090090A1 (en) 2017-11-02 2018-11-02 Modulators of the integrated stress pathway

Publications (3)

Publication Number Publication Date
JP2021501780A JP2021501780A (ja) 2021-01-21
JP2021501780A5 true JP2021501780A5 (https=) 2021-12-09
JP7307057B2 JP7307057B2 (ja) 2023-07-11

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ID=64572461

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020524776A Active JP7307057B2 (ja) 2017-11-02 2018-11-02 統合的ストレス経路の調節剤

Country Status (9)

Country Link
US (1) US20230192712A1 (https=)
EP (1) EP3704125B1 (https=)
JP (1) JP7307057B2 (https=)
CN (1) CN112218869A (https=)
AU (1) AU2018360854B2 (https=)
BR (1) BR112020008836A2 (https=)
CA (1) CA3080948A1 (https=)
MX (1) MX2020004556A (https=)
WO (1) WO2019090090A1 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118239937A (zh) 2017-08-09 2024-06-25 戴纳立制药公司 化合物、组合物及方法
DK3676297T3 (da) 2017-09-01 2023-08-14 Denali Therapeutics Inc Forbindelser, sammensætninger og fremgangsmåder
SG11202004009TA (en) * 2017-11-02 2020-05-28 Calico Life Sciences Llc Modulators of the integrated stress pathway
US11939320B2 (en) 2017-11-02 2024-03-26 Abbvie Inc. Modulators of the integrated stress pathway
WO2019118785A2 (en) 2017-12-13 2019-06-20 Praxis Biotech LLC Inhibitors of integrated stress response pathway
WO2019236710A1 (en) 2018-06-05 2019-12-12 Praxis Biotech LLC Inhibitors of integrated stress response pathway
TWI877863B (zh) 2018-10-11 2025-03-21 美商嘉來克生命科學有限責任公司 整合應激路徑之前藥調節劑
US12091392B2 (en) 2019-02-13 2024-09-17 Denali Therapeutics Inc. Compounds, compositions and methods
MA54953A (fr) 2019-02-13 2021-12-22 Denali Therapeutics Inc Composés, compositions et procédés
MX2021012904A (es) 2019-04-23 2022-01-18 Evotec Int Gmbh Moduladores de la via de respuesta al estres integrada.
CA3137213A1 (en) 2019-04-23 2020-10-29 Evotec International Gmbh Modulators of the integrated stress response pathway
US20220168270A1 (en) * 2019-06-11 2022-06-02 Yale University Compositions for pathogenesis-directed therapy and treatments of skin diseases and disorders
JP2022536663A (ja) 2019-06-12 2022-08-18 プラクシス バイオテック エルエルシー 統合的ストレス応答経路のモジュレーター
IL291665B2 (en) 2019-09-27 2025-07-01 Univ Texas Inhibitors of receptor interacting protein kinase i for the treatment of disease
AU2021213289A1 (en) 2020-01-28 2022-07-07 Evotec International Gmbh Modulators of the integrated stress response pathway
MX2022011143A (es) 2020-03-11 2022-10-13 Evotec Int Gmbh Moduladores de la via de respuesta integrada al estres.
US20230391763A1 (en) 2020-10-22 2023-12-07 Evotec International Gmbh Modulators of the integrated stress response pathway
JP2023546224A (ja) * 2020-10-22 2023-11-01 エヴォテック・インターナショナル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 統合ストレス応答経路のモジュレーター
MX2023004623A (es) 2020-10-22 2023-05-12 Evotec Int Gmbh Moduladores de la via integrada de respuesta al estres.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4911920A (en) 1986-07-30 1990-03-27 Alcon Laboratories, Inc. Sustained release, comfort formulation for glaucoma therapy
FR2588189B1 (fr) 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
JP2594486B2 (ja) 1991-01-15 1997-03-26 アルコン ラボラトリーズ インコーポレイテッド 局所的眼薬組成物
US5212162A (en) 1991-03-27 1993-05-18 Alcon Laboratories, Inc. Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
AU675730B2 (en) * 1993-07-16 1997-02-13 Merck & Co., Inc. Substituted piperazinylcamphor derivatives as oxytocin antagonists
EP1717225A4 (en) * 2004-02-18 2009-10-21 Kyorin Seiyaku Kk BICYCLIC AMID DERIVATIVES
JP6806562B2 (ja) 2013-03-15 2021-01-06 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア eIF2α経路の調節因子

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