JP2021501787A5 - - Google Patents

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Publication number
JP2021501787A5
JP2021501787A5 JP2020524825A JP2020524825A JP2021501787A5 JP 2021501787 A5 JP2021501787 A5 JP 2021501787A5 JP 2020524825 A JP2020524825 A JP 2020524825A JP 2020524825 A JP2020524825 A JP 2020524825A JP 2021501787 A5 JP2021501787 A5 JP 2021501787A5
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JP
Japan
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alkyl
formula
compound
disease
halo
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JP2020524825A
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English (en)
Japanese (ja)
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JP2021501787A (ja
JP7324196B2 (ja
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Priority claimed from PCT/US2018/058965 external-priority patent/WO2019090082A1/en
Publication of JP2021501787A publication Critical patent/JP2021501787A/ja
Publication of JP2021501787A5 publication Critical patent/JP2021501787A5/ja
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Publication of JP7324196B2 publication Critical patent/JP7324196B2/ja
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JP2020524825A 2017-11-02 2018-11-02 統合的ストレス経路の調節剤 Active JP7324196B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762580802P 2017-11-02 2017-11-02
US62/580,802 2017-11-02
US201862643073P 2018-03-14 2018-03-14
US62/643,073 2018-03-14
PCT/US2018/058965 WO2019090082A1 (en) 2017-11-02 2018-11-02 Modulators of the integrated stress pathway

Publications (3)

Publication Number Publication Date
JP2021501787A JP2021501787A (ja) 2021-01-21
JP2021501787A5 true JP2021501787A5 (https=) 2021-12-09
JP7324196B2 JP7324196B2 (ja) 2023-08-09

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ID=64661438

Family Applications (1)

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JP2020524825A Active JP7324196B2 (ja) 2017-11-02 2018-11-02 統合的ストレス経路の調節剤

Country Status (9)

Country Link
US (1) US20210205277A1 (https=)
EP (1) EP3704096B1 (https=)
JP (1) JP7324196B2 (https=)
CN (1) CN112204012B (https=)
AU (1) AU2018358157B2 (https=)
BR (1) BR112020008825A2 (https=)
CA (1) CA3080964A1 (https=)
MX (1) MX2020004519A (https=)
WO (1) WO2019090082A1 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3071024A1 (en) 2017-08-09 2019-02-14 Denali Therapeutics Inc. Compounds, compositions and methods
CN111201245B (zh) 2017-09-01 2024-04-05 戴纳立制药公司 化合物、组合物和方法
WO2019090088A1 (en) 2017-11-02 2019-05-09 Calico Life Sciences Llc Modulators of the integrated stress pathway
CN111757739A (zh) 2017-12-13 2020-10-09 普拉西斯生物技术有限责任公司 整合应激反应路径抑制剂
AU2019282253A1 (en) 2018-06-05 2020-11-26 Altos Labs, Inc. Inhibitors of integrated stress response pathway
TW202545902A (zh) 2018-10-11 2025-12-01 美商嘉來克生命科學有限責任公司 整合應激路徑之前藥調節劑
EP3924341A4 (en) 2019-02-13 2022-11-02 Denali Therapeutics Inc. Compounds, compositions and methods
SG11202108552QA (en) 2019-02-13 2021-09-29 Denali Therapeutics Inc Compounds, compositions and methods
MX2021012904A (es) 2019-04-23 2022-01-18 Evotec Int Gmbh Moduladores de la via de respuesta al estres integrada.
EP3959198A1 (en) 2019-04-23 2022-03-02 Evotec International GmbH Modulators of the integrated stress response pathway
WO2020252207A1 (en) 2019-06-12 2020-12-17 Praxis Biotech LLC Modulators of integrated stress response pathway
JP7699595B2 (ja) * 2020-01-28 2025-06-27 エヴォテック・インターナショナル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 統合的ストレス応答経路の調節因子
CN115190813B (zh) 2020-03-11 2024-10-15 埃沃特克国际有限责任公司 整合应激反应途径的调节剂
EP4232153A1 (en) 2020-10-22 2023-08-30 Evotec International GmbH Modulators of the integrated stress response pathway
RS66455B1 (sr) 2020-10-22 2025-02-28 Evotec Int Gmbh Modulatori puta integrisanog odgovora na stres
EP4232447A1 (en) 2020-10-22 2023-08-30 Evotec International GmbH Modulators of the integrated stress response pathway
EP4247811A1 (en) * 2020-11-19 2023-09-27 F. Hoffmann-La Roche AG Bicyclo[1.1.1]pentane compounds for the treatment and prophylaxis of hepatitis b virus infection
CN115453012B (zh) * 2022-10-21 2023-05-12 山东百诺医药股份有限公司 一种同时测定氢溴酸伏硫西汀中多个位置异构体的反相hplc方法
AU2023384649A1 (en) * 2022-11-21 2025-05-22 Shenzhen Zhongge Biological Technology Co., Ltd. Compound, pharmaceutical composition containing same, synthesis method therefor and use thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5212A (en) 1847-07-31 Richard m
US162A (en) 1837-04-17 Island
US4911920A (en) 1986-07-30 1990-03-27 Alcon Laboratories, Inc. Sustained release, comfort formulation for glaucoma therapy
FR2588189B1 (fr) 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
ATE141502T1 (de) 1991-01-15 1996-09-15 Alcon Lab Inc Verwendung von karrageenan in topischen ophthalmologischen zusammensetzungen
UA80459C2 (en) * 2002-12-20 2007-09-25 Merck & Co Inc Triazole derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1
JO2397B1 (en) * 2002-12-20 2007-06-17 ميرك شارب اند دوم كوربوريشن Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors
WO2011087758A1 (en) * 2009-12-22 2011-07-21 H. Lundbeck A/S Adamantyl amide derivatives and uses of same
CA2904794C (en) * 2013-03-15 2021-11-23 Peter Walter Modulators of the eif2alpha pathway
US20160318856A1 (en) * 2013-09-11 2016-11-03 The Brigham And Women's Hospital, Inc. Substituted Urea eIF2alpha Kinase Activators
JP2015199722A (ja) * 2014-04-02 2015-11-12 大日本住友製薬株式会社 イミダゾール誘導体からなる医薬
TW201722958A (zh) * 2015-09-15 2017-07-01 葛蘭素史克智慧財產(第二)有限公司 化學化合物
TW201808914A (zh) * 2016-05-05 2018-03-16 嘉來克生命科學有限責任公司 整合應激途徑之調節劑

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