JP2021501787A5 - - Google Patents

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JP2021501787A5
JP2021501787A5 JP2020524825A JP2020524825A JP2021501787A5 JP 2021501787 A5 JP2021501787 A5 JP 2021501787A5 JP 2020524825 A JP2020524825 A JP 2020524825A JP 2020524825 A JP2020524825 A JP 2020524825A JP 2021501787 A5 JP2021501787 A5 JP 2021501787A5
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JP
Japan
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alkyl
formula
compound
disease
halo
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JP2020524825A
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English (en)
Japanese (ja)
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JP7324196B2 (ja
JP2021501787A (ja
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Priority claimed from PCT/US2018/058965 external-priority patent/WO2019090082A1/en
Publication of JP2021501787A publication Critical patent/JP2021501787A/ja
Publication of JP2021501787A5 publication Critical patent/JP2021501787A5/ja
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JP2020524825A 2017-11-02 2018-11-02 統合的ストレス経路の調節剤 Active JP7324196B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762580802P 2017-11-02 2017-11-02
US62/580,802 2017-11-02
US201862643073P 2018-03-14 2018-03-14
US62/643,073 2018-03-14
PCT/US2018/058965 WO2019090082A1 (en) 2017-11-02 2018-11-02 Modulators of the integrated stress pathway

Publications (3)

Publication Number Publication Date
JP2021501787A JP2021501787A (ja) 2021-01-21
JP2021501787A5 true JP2021501787A5 (https=) 2021-12-09
JP7324196B2 JP7324196B2 (ja) 2023-08-09

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ID=64661438

Family Applications (1)

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JP2020524825A Active JP7324196B2 (ja) 2017-11-02 2018-11-02 統合的ストレス経路の調節剤

Country Status (9)

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US (1) US20210205277A1 (https=)
EP (1) EP3704096B1 (https=)
JP (1) JP7324196B2 (https=)
CN (1) CN112204012B (https=)
AU (1) AU2018358157B2 (https=)
BR (1) BR112020008825A2 (https=)
CA (1) CA3080964A1 (https=)
MX (1) MX2020004519A (https=)
WO (1) WO2019090082A1 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118239937A (zh) 2017-08-09 2024-06-25 戴纳立制药公司 化合物、组合物及方法
DK3676297T3 (da) 2017-09-01 2023-08-14 Denali Therapeutics Inc Forbindelser, sammensætninger og fremgangsmåder
US11939320B2 (en) 2017-11-02 2024-03-26 Abbvie Inc. Modulators of the integrated stress pathway
WO2019118785A2 (en) 2017-12-13 2019-06-20 Praxis Biotech LLC Inhibitors of integrated stress response pathway
WO2019236710A1 (en) 2018-06-05 2019-12-12 Praxis Biotech LLC Inhibitors of integrated stress response pathway
TWI877863B (zh) 2018-10-11 2025-03-21 美商嘉來克生命科學有限責任公司 整合應激路徑之前藥調節劑
US12091392B2 (en) 2019-02-13 2024-09-17 Denali Therapeutics Inc. Compounds, compositions and methods
MA54953A (fr) 2019-02-13 2021-12-22 Denali Therapeutics Inc Composés, compositions et procédés
MX2021012904A (es) 2019-04-23 2022-01-18 Evotec Int Gmbh Moduladores de la via de respuesta al estres integrada.
CA3137213A1 (en) 2019-04-23 2020-10-29 Evotec International Gmbh Modulators of the integrated stress response pathway
JP2022536663A (ja) 2019-06-12 2022-08-18 プラクシス バイオテック エルエルシー 統合的ストレス応答経路のモジュレーター
AU2021213289A1 (en) 2020-01-28 2022-07-07 Evotec International Gmbh Modulators of the integrated stress response pathway
MX2022011143A (es) 2020-03-11 2022-10-13 Evotec Int Gmbh Moduladores de la via de respuesta integrada al estres.
JP2023546224A (ja) 2020-10-22 2023-11-01 エヴォテック・インターナショナル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 統合ストレス応答経路のモジュレーター
MX2023004623A (es) 2020-10-22 2023-05-12 Evotec Int Gmbh Moduladores de la via integrada de respuesta al estres.
US20230391763A1 (en) 2020-10-22 2023-12-07 Evotec International Gmbh Modulators of the integrated stress response pathway
EP4247811A1 (en) * 2020-11-19 2023-09-27 F. Hoffmann-La Roche AG Bicyclo[1.1.1]pentane compounds for the treatment and prophylaxis of hepatitis b virus infection
CN115453012B (zh) * 2022-10-21 2023-05-12 山东百诺医药股份有限公司 一种同时测定氢溴酸伏硫西汀中多个位置异构体的反相hplc方法
WO2024109736A1 (zh) * 2022-11-21 2024-05-30 深圳众格生物科技有限公司 一种化合物、包含其的药物组合物及其合成方法和用途

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Publication number Priority date Publication date Assignee Title
US5212A (en) 1847-07-31 Richard m
US162A (en) 1837-04-17 Island
US4911920A (en) 1986-07-30 1990-03-27 Alcon Laboratories, Inc. Sustained release, comfort formulation for glaucoma therapy
FR2588189B1 (fr) 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
JP2594486B2 (ja) 1991-01-15 1997-03-26 アルコン ラボラトリーズ インコーポレイテッド 局所的眼薬組成物
JO2397B1 (en) * 2002-12-20 2007-06-17 ميرك شارب اند دوم كوربوريشن Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors
CN101475538A (zh) * 2002-12-20 2009-07-08 默克公司 用作11-β-羟基类固醇脱氢酶-1抑制剂的三唑衍生物
WO2011087758A1 (en) * 2009-12-22 2011-07-21 H. Lundbeck A/S Adamantyl amide derivatives and uses of same
JP6806562B2 (ja) * 2013-03-15 2021-01-06 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア eIF2α経路の調節因子
US20160318856A1 (en) * 2013-09-11 2016-11-03 The Brigham And Women's Hospital, Inc. Substituted Urea eIF2alpha Kinase Activators
JP2015199722A (ja) * 2014-04-02 2015-11-12 大日本住友製薬株式会社 イミダゾール誘導体からなる医薬
TW201722958A (zh) * 2015-09-15 2017-07-01 葛蘭素史克智慧財產(第二)有限公司 化學化合物
TW201808914A (zh) * 2016-05-05 2018-03-16 嘉來克生命科學有限責任公司 整合應激途徑之調節劑

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