JP2021501779A5 - - Google Patents

Download PDF

Info

Publication number
JP2021501779A5
JP2021501779A5 JP2020524769A JP2020524769A JP2021501779A5 JP 2021501779 A5 JP2021501779 A5 JP 2021501779A5 JP 2020524769 A JP2020524769 A JP 2020524769A JP 2020524769 A JP2020524769 A JP 2020524769A JP 2021501779 A5 JP2021501779 A5 JP 2021501779A5
Authority
JP
Japan
Prior art keywords
disease
syndrome
diseases
renal
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020524769A
Other languages
English (en)
Japanese (ja)
Other versions
JP7184889B2 (ja
JP2021501779A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/058960 external-priority patent/WO2019090078A1/en
Publication of JP2021501779A publication Critical patent/JP2021501779A/ja
Publication of JP2021501779A5 publication Critical patent/JP2021501779A5/ja
Application granted granted Critical
Publication of JP7184889B2 publication Critical patent/JP7184889B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020524769A 2017-11-02 2018-11-02 統合的ストレス経路の調節剤 Active JP7184889B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762580805P 2017-11-02 2017-11-02
US62/580,805 2017-11-02
US201862643067P 2018-03-14 2018-03-14
US62/643,067 2018-03-14
PCT/US2018/058960 WO2019090078A1 (en) 2017-11-02 2018-11-02 Modulators of the integrated stress pathway

Publications (3)

Publication Number Publication Date
JP2021501779A JP2021501779A (ja) 2021-01-21
JP2021501779A5 true JP2021501779A5 (https=) 2021-12-09
JP7184889B2 JP7184889B2 (ja) 2022-12-06

Family

ID=64572457

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020524769A Active JP7184889B2 (ja) 2017-11-02 2018-11-02 統合的ストレス経路の調節剤

Country Status (9)

Country Link
US (3) US20200361881A1 (https=)
EP (1) EP3704098B1 (https=)
JP (1) JP7184889B2 (https=)
CN (1) CN112154142B (https=)
AU (1) AU2018360847B2 (https=)
BR (1) BR112020008827A2 (https=)
CA (1) CA3080808A1 (https=)
MX (1) MX2020004537A (https=)
WO (1) WO2019090078A1 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118239937A (zh) 2017-08-09 2024-06-25 戴纳立制药公司 化合物、组合物及方法
DK3676297T3 (da) 2017-09-01 2023-08-14 Denali Therapeutics Inc Forbindelser, sammensætninger og fremgangsmåder
US11939320B2 (en) 2017-11-02 2024-03-26 Abbvie Inc. Modulators of the integrated stress pathway
WO2019118785A2 (en) 2017-12-13 2019-06-20 Praxis Biotech LLC Inhibitors of integrated stress response pathway
WO2019236710A1 (en) 2018-06-05 2019-12-12 Praxis Biotech LLC Inhibitors of integrated stress response pathway
TWI877863B (zh) 2018-10-11 2025-03-21 美商嘉來克生命科學有限責任公司 整合應激路徑之前藥調節劑
MA54953A (fr) 2019-02-13 2021-12-22 Denali Therapeutics Inc Composés, compositions et procédés
US12091392B2 (en) 2019-02-13 2024-09-17 Denali Therapeutics Inc. Compounds, compositions and methods
CA3137213A1 (en) 2019-04-23 2020-10-29 Evotec International Gmbh Modulators of the integrated stress response pathway
MX2021012904A (es) 2019-04-23 2022-01-18 Evotec Int Gmbh Moduladores de la via de respuesta al estres integrada.
JP7805788B2 (ja) 2019-05-23 2026-01-26 ヤンセン バイオテツク,インコーポレーテツド Il-23及びtnfアルファに対する抗体の併用療法による炎症性腸疾患の治療方法
JP2022536663A (ja) 2019-06-12 2022-08-18 プラクシス バイオテック エルエルシー 統合的ストレス応答経路のモジュレーター
AU2021213289A1 (en) 2020-01-28 2022-07-07 Evotec International Gmbh Modulators of the integrated stress response pathway
MX2022011143A (es) 2020-03-11 2022-10-13 Evotec Int Gmbh Moduladores de la via de respuesta integrada al estres.
IL298389A (en) * 2020-05-21 2023-01-01 Janssen Biotech Inc Method of treating inflammatory bowel disease with a combination therapy of antibodies to il-23 and tnf alpha
MX2023004623A (es) 2020-10-22 2023-05-12 Evotec Int Gmbh Moduladores de la via integrada de respuesta al estres.
JP2023546224A (ja) 2020-10-22 2023-11-01 エヴォテック・インターナショナル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 統合ストレス応答経路のモジュレーター
US20230391763A1 (en) 2020-10-22 2023-12-07 Evotec International Gmbh Modulators of the integrated stress response pathway
CN113979963B (zh) * 2021-12-24 2022-03-11 凯思凯旭(上海)医药科技有限公司 一种作为甲状腺激素β受体激动剂的化合物及其用途
WO2025259779A1 (en) * 2024-06-12 2025-12-18 Insmed Incorporated Uses of certain carboxamides as dpp1 inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4911920A (en) 1986-07-30 1990-03-27 Alcon Laboratories, Inc. Sustained release, comfort formulation for glaucoma therapy
FR2588189B1 (fr) 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
JP2594486B2 (ja) 1991-01-15 1997-03-26 アルコン ラボラトリーズ インコーポレイテッド 局所的眼薬組成物
US5212162A (en) 1991-03-27 1993-05-18 Alcon Laboratories, Inc. Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
JO2397B1 (en) * 2002-12-20 2007-06-17 ميرك شارب اند دوم كوربوريشن Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors
JP6806562B2 (ja) * 2013-03-15 2021-01-06 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア eIF2α経路の調節因子
US20160318856A1 (en) * 2013-09-11 2016-11-03 The Brigham And Women's Hospital, Inc. Substituted Urea eIF2alpha Kinase Activators
TW201808914A (zh) * 2016-05-05 2018-03-16 嘉來克生命科學有限責任公司 整合應激途徑之調節劑

Similar Documents

Publication Publication Date Title
JP2021501779A5 (https=)
JP2021501789A5 (https=)
JP2021501790A5 (https=)
JP2021501787A5 (https=)
JP2021501785A5 (https=)
JP2021501786A5 (https=)
JP2021501780A5 (https=)
JP2021501781A5 (https=)
JP2021501788A5 (https=)
JP2022530647A5 (https=)
JP2022504638A5 (https=)
RU2020117927A (ru) Модуляторы интегрированного стресса
RU2020117900A (ru) Модуляторы интегрированного стресса
CA3103664A1 (en) Methods of treating or selecting a treatment for a subject resistant to tnf inhibitor using a nlrp3 antagonist
JP2022501060A (ja) 遺伝子の発現のための変異体リバーステトラサイクリントランスアクチベーター
BR112016009488B1 (pt) piperidil-etil-pirimidina substituída, seus usos, e composição farmacêutica
WO2017047769A1 (ja) トール様受容体7またはトール様受容体9の活性化阻害剤
JP2026053628A (ja) 抗炎症剤に連結されたecm親和性ペプチドを用いて炎症性状態および自己免疫状態を処置するための方法および組成物
Wen et al. SDF-1α and CXCR4 as therapeutic targets in cardiovascular disease
JP6462151B2 (ja) グレリンo−アシルトランスフェラーゼ阻害剤
JP2018507899A (ja) 補体関連疾患の治療のための組成物および治療方法
TW202015693A (zh) 治療pi3k 相關病症之給藥方案
CN112194726B (zh) 用于病理性蛋白聚集物清除的嵌合抗原受体及其应用
van Grotel et al. Hypereosinophilic syndrome in children
JP2025081327A (ja) 異所性骨形成副作用の軽減で治療効果が増進した骨形成タンパク質-9、10の変異体及びこれを含む薬学的組成物