JP2021113210A5 - - Google Patents
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- JP2021113210A5 JP2021113210A5 JP2021070121A JP2021070121A JP2021113210A5 JP 2021113210 A5 JP2021113210 A5 JP 2021113210A5 JP 2021070121 A JP2021070121 A JP 2021070121A JP 2021070121 A JP2021070121 A JP 2021070121A JP 2021113210 A5 JP2021113210 A5 JP 2021113210A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- cytotoxic agent
- linker
- solution
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 238000000034 method Methods 0.000 claims 19
- 229940127089 cytotoxic agent Drugs 0.000 claims 9
- 239000002254 cytotoxic agent Substances 0.000 claims 9
- 231100000599 cytotoxic agent Toxicity 0.000 claims 9
- 239000003153 chemical reaction reagent Substances 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- -1 taxane compound Chemical class 0.000 claims 5
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims 2
- 102000050554 Eph Family Receptors Human genes 0.000 claims 2
- 108091008815 Eph receptors Proteins 0.000 claims 2
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 claims 1
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims 1
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 1
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 1
- 101150013553 CD40 gene Proteins 0.000 claims 1
- 102100032912 CD44 antigen Human genes 0.000 claims 1
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims 1
- 102100025012 Dipeptidyl peptidase 4 Human genes 0.000 claims 1
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical class O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 1
- 102000051096 EphA2 Receptor Human genes 0.000 claims 1
- 108010055196 EphA2 Receptor Proteins 0.000 claims 1
- 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 claims 1
- 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 claims 1
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims 1
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 1
- 101000908391 Homo sapiens Dipeptidyl peptidase 4 Proteins 0.000 claims 1
- 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 claims 1
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 1
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 101000874179 Homo sapiens Syndecan-1 Proteins 0.000 claims 1
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 1
- 102100031586 Leukocyte antigen CD37 Human genes 0.000 claims 1
- 108090000015 Mesothelin Proteins 0.000 claims 1
- 102000003735 Mesothelin Human genes 0.000 claims 1
- 101100369076 Mus musculus Tdgf1 gene Proteins 0.000 claims 1
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 1
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 claims 1
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims 1
- 102100035721 Syndecan-1 Human genes 0.000 claims 1
- 229940123237 Taxane Drugs 0.000 claims 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 1
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 1
- 238000005377 adsorption chromatography Methods 0.000 claims 1
- 108010044540 auristatin Proteins 0.000 claims 1
- 230000001588 bifunctional effect Effects 0.000 claims 1
- 229940127093 camptothecin Drugs 0.000 claims 1
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical group C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 229960000975 daunorubicin Drugs 0.000 claims 1
- 238000000502 dialysis Methods 0.000 claims 1
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims 1
- 108010087914 epidermal growth factor receptor VIII Proteins 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 238000002523 gelfiltration Methods 0.000 claims 1
- 102000006495 integrins Human genes 0.000 claims 1
- 108010044426 integrins Proteins 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- 229960002087 pertuzumab Drugs 0.000 claims 1
- NMHMNPHRMNGLLB-UHFFFAOYSA-N phloretic acid Chemical group OC(=O)CCC1=CC=C(O)C=C1 NMHMNPHRMNGLLB-UHFFFAOYSA-N 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- YUOCYTRGANSSRY-UHFFFAOYSA-N pyrrolo[2,3-i][1,2]benzodiazepine Chemical class C1=CN=NC2=C3C=CN=C3C=CC2=C1 YUOCYTRGANSSRY-UHFFFAOYSA-N 0.000 claims 1
- 229960004641 rituximab Drugs 0.000 claims 1
- 229950008684 sibrotuzumab Drugs 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
- 229960000575 trastuzumab Drugs 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023029131A JP7481521B2 (ja) | 2009-06-03 | 2023-02-28 | 抱合方法 |
| JP2024071095A JP2024099722A (ja) | 2009-06-03 | 2024-04-25 | 抱合方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18377409P | 2009-06-03 | 2009-06-03 | |
| US61/183,774 | 2009-06-03 | ||
| JP2019084898A JP6873184B2 (ja) | 2009-06-03 | 2019-04-26 | 抱合方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019084898A Division JP6873184B2 (ja) | 2009-06-03 | 2019-04-26 | 抱合方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023029131A Division JP7481521B2 (ja) | 2009-06-03 | 2023-02-28 | 抱合方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021113210A JP2021113210A (ja) | 2021-08-05 |
| JP2021113210A5 true JP2021113210A5 (enExample) | 2021-09-30 |
| JP7262507B2 JP7262507B2 (ja) | 2023-04-21 |
Family
ID=43298108
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012514074A Active JP5784592B2 (ja) | 2009-06-03 | 2010-06-02 | 抱合方法 |
| JP2015144521A Active JP6114783B2 (ja) | 2009-06-03 | 2015-07-22 | 抱合方法 |
| JP2017052321A Pending JP2017128590A (ja) | 2009-06-03 | 2017-03-17 | 抱合方法 |
| JP2019084898A Active JP6873184B2 (ja) | 2009-06-03 | 2019-04-26 | 抱合方法 |
| JP2021070121A Active JP7262507B2 (ja) | 2009-06-03 | 2021-04-19 | 抱合方法 |
| JP2023029131A Active JP7481521B2 (ja) | 2009-06-03 | 2023-02-28 | 抱合方法 |
| JP2024071095A Pending JP2024099722A (ja) | 2009-06-03 | 2024-04-25 | 抱合方法 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012514074A Active JP5784592B2 (ja) | 2009-06-03 | 2010-06-02 | 抱合方法 |
| JP2015144521A Active JP6114783B2 (ja) | 2009-06-03 | 2015-07-22 | 抱合方法 |
| JP2017052321A Pending JP2017128590A (ja) | 2009-06-03 | 2017-03-17 | 抱合方法 |
| JP2019084898A Active JP6873184B2 (ja) | 2009-06-03 | 2019-04-26 | 抱合方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023029131A Active JP7481521B2 (ja) | 2009-06-03 | 2023-02-28 | 抱合方法 |
| JP2024071095A Pending JP2024099722A (ja) | 2009-06-03 | 2024-04-25 | 抱合方法 |
Country Status (27)
| Country | Link |
|---|---|
| US (8) | US8624003B2 (enExample) |
| EP (2) | EP2437790B1 (enExample) |
| JP (7) | JP5784592B2 (enExample) |
| KR (4) | KR101947176B1 (enExample) |
| CN (2) | CN102448500A (enExample) |
| AU (1) | AU2010256659B2 (enExample) |
| BR (1) | BRPI1010620B8 (enExample) |
| CA (1) | CA2761959C (enExample) |
| CY (1) | CY1121992T1 (enExample) |
| DK (1) | DK2437790T3 (enExample) |
| ES (1) | ES2726945T3 (enExample) |
| HK (1) | HK1216508A1 (enExample) |
| HR (1) | HRP20190898T1 (enExample) |
| HU (1) | HUE043645T2 (enExample) |
| IL (7) | IL300840A (enExample) |
| LT (1) | LT2437790T (enExample) |
| ME (1) | ME03479B (enExample) |
| MX (3) | MX2011012794A (enExample) |
| PL (1) | PL2437790T3 (enExample) |
| PT (1) | PT2437790T (enExample) |
| RS (1) | RS58810B1 (enExample) |
| RU (2) | RU2765240C2 (enExample) |
| SG (2) | SG10201810743WA (enExample) |
| SI (1) | SI2437790T1 (enExample) |
| SM (1) | SMT201900284T1 (enExample) |
| TR (1) | TR201907573T4 (enExample) |
| WO (1) | WO2010141566A1 (enExample) |
Families Citing this family (76)
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| US7276497B2 (en) * | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
| US20110166319A1 (en) * | 2005-02-11 | 2011-07-07 | Immunogen, Inc. | Process for preparing purified drug conjugates |
| NZ595430A (en) | 2005-08-24 | 2013-05-31 | Immunogen Inc | Process for preparing maytansinoid antibody conjugates |
| AR076284A1 (es) | 2009-04-29 | 2011-06-01 | Bayer Schering Pharma Ag | Inmunoconjugados de antimesotelina y usos de los mismos |
| KR101947176B1 (ko) | 2009-06-03 | 2019-02-12 | 이뮤노젠 아이엔씨 | 접합 방법 |
| CA2818583A1 (en) * | 2010-11-19 | 2012-05-24 | Venus Remedies Limited | Novel conjugates for targeted drug delivery |
| EA201991268A3 (ru) | 2011-03-29 | 2020-01-31 | Иммуноджен, Инк. | Получение конъюгатов "майтансиноид-антитело" одностадийным способом |
| BR112013032928A2 (pt) | 2011-06-21 | 2017-01-24 | Immunogen Inc | "derivados de maitansinoide com ligante de peptídeo e conjugados dos mesmos, composição farmacêutica que os compreende e uso dos mesmos" |
| SG11201400275YA (en) * | 2011-08-31 | 2014-08-28 | Nikolai Vladimirovich Bovin | Facile laboratory method for localising biomolecules to the surface of cells and viruses |
| KR20140107418A (ko) * | 2011-12-13 | 2014-09-04 | 이뮤노젠 아이엔씨 | 접합체 안정성을 개선하기 위한 n-하이드록시숙신이미드의 용도 |
| EP3486248B1 (en) | 2012-09-26 | 2021-04-07 | ImmunoGen, Inc. | Improved methods for the acylation of maytansinol |
| HK1213288A1 (zh) | 2012-10-04 | 2016-06-30 | Immunogen, Inc. | 使用pvdf膜純化細胞結合劑細胞毒性劑綴合物 |
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| CN108939059B (zh) | 2013-06-14 | 2022-05-10 | 康思葆（北京）生物技术有限公司 | 蛋白-细胞偶联物、其制备方法和用途 |
| US10208125B2 (en) | 2013-07-15 | 2019-02-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Anti-mucin 1 binding agents and uses thereof |
| JP2016538283A (ja) | 2013-11-13 | 2016-12-08 | ザイムワークス，インコーポレイテッド | Ｅｇｆｒ及び／またはｈｅｒ２を標的にする一価抗原結合性構築物及びその使用 |
| ES3030987T3 (en) | 2013-11-27 | 2025-07-03 | Zymeworks Bc Inc | Bispecific antigen-binding constructs targeting her2 |
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| JP2017510548A (ja) * | 2014-01-29 | 2017-04-13 | シャンハイ ヘンルイ ファーマスーティカル カンパニー リミテッドＳｈａｎｇｈａｉ Ｈｅｎｇｒｕｉ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． | リガンド‐細胞傷害性薬物抱合体、その製造方法、およびその用途 |
| WO2016001485A1 (en) | 2014-06-30 | 2016-01-07 | Glykos Finland Oy | Saccharide derivative of a toxic payload and antibody conjugates thereof |
| US9982045B2 (en) | 2014-08-12 | 2018-05-29 | Novartis Ag | Anti-CDH6 antibody drug conjugates |
| GB201416960D0 (en) * | 2014-09-25 | 2014-11-12 | Antikor Biopharma Ltd | Biological materials and uses thereof |
| US10428143B2 (en) | 2014-09-28 | 2019-10-01 | The Regents Of The University Of California | Modulation of stimulatory and non-stimulatory myeloid cells |
| GB201419184D0 (en) * | 2014-10-28 | 2014-12-10 | Adc Biotechnology Ltd | Method of synthesising biomolecule-effector/reporter-conjugates using affinity resins |
| CN107592813A (zh) * | 2014-11-19 | 2018-01-16 | 伊缪诺金公司 | 用于制备细胞结合剂‑细胞毒性剂缀合物的方法 |
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| US11535634B2 (en) | 2019-06-05 | 2022-12-27 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
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