|
JPS4934761B1
(https=)
|
1969-03-10 |
1974-09-18 |
|
|
|
US5080898A
(en)
|
1982-05-12 |
1992-01-14 |
The University Hospital |
Enzymatically active toxin coupled to a cell-specific ligand
|
|
US5668255A
(en)
|
1984-06-07 |
1997-09-16 |
Seragen, Inc. |
Hybrid molecules having translocation region and cell-binding region
|
|
US6022950A
(en)
|
1984-06-07 |
2000-02-08 |
Seragen, Inc. |
Hybrid molecules having translocation region and cell-binding region
|
|
US5091178A
(en)
|
1986-02-21 |
1992-02-25 |
Oncogen |
Tumor therapy with biologically active anti-tumor antibodies
|
|
US7838216B1
(en)
|
1986-03-05 |
2010-11-23 |
The United States Of America, As Represented By The Department Of Health And Human Services |
Human gene related to but distinct from EGF receptor gene
|
|
US6893625B1
(en)
|
1986-10-27 |
2005-05-17 |
Royalty Pharma Finance Trust |
Chimeric antibody with specificity to human B cell surface antigen
|
|
IL85035A0
(en)
|
1987-01-08 |
1988-06-30 |
Int Genetic Eng |
Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
|
|
JP3040121B2
(ja)
|
1988-01-12 |
2000-05-08 |
ジェネンテク，インコーポレイテッド |
増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法
|
|
US5506126A
(en)
|
1988-02-25 |
1996-04-09 |
The General Hospital Corporation |
Rapid immunoselection cloning method
|
|
US4861579A
(en)
|
1988-03-17 |
1989-08-29 |
American Cyanamid Company |
Suppression of B-lymphocytes in mammals by administration of anti-B-lymphocyte antibodies
|
|
US5135736A
(en)
|
1988-08-15 |
1992-08-04 |
Neorx Corporation |
Covalently-linked complexes and methods for enhanced cytotoxicity and imaging
|
|
DE69031120T2
(de)
|
1989-05-19 |
1998-01-15 |
Genentech, Inc., South San Francisco, Calif. |
Her2 extrazellulare domäne
|
|
WO1991009871A1
(en)
|
1989-12-22 |
1991-07-11 |
Seragen Incorporated |
Hybrid molecules having translocation region and cell-binding region
|
|
US5578482A
(en)
|
1990-05-25 |
1996-11-26 |
Georgetown University |
Ligand growth factors that bind to the erbB-2 receptor protein and induce cellular responses
|
|
US5635384A
(en)
|
1990-06-11 |
1997-06-03 |
Dowelanco |
Ribosome-inactivating proteins, inactive precursor forms thereof, a process for making and a method of using
|
|
IL101943A0
(en)
|
1991-05-24 |
1992-12-30 |
Genentech Inc |
Structure,production and use of heregulin
|
|
US5834229A
(en)
|
1991-05-24 |
1998-11-10 |
Genentech, Inc. |
Nucleic acids vectors and host cells encoding and expressing heregulin 2-α
|
|
EP1400536A1
(en)
|
1991-06-14 |
2004-03-24 |
Genentech Inc. |
Method for making humanized antibodies
|
|
US6146850A
(en)
|
1991-11-04 |
2000-11-14 |
Xoma Corporation |
Proteins encoding gelonin sequences
|
|
US5621083A
(en)
|
1991-11-04 |
1997-04-15 |
Xoma Corporation |
Immunotoxins comprising ribosome-inactivating proteins
|
|
WO1994026910A1
(en)
|
1993-05-12 |
1994-11-24 |
Xoma Corporation |
Immunotoxins comprising gelonin and an antibody
|
|
US5552144A
(en)
*
|
1992-01-22 |
1996-09-03 |
Microcarb, Inc. |
Immunogenic shiga-like toxin II variant mutants
|
|
AU4025193A
(en)
|
1992-04-08 |
1993-11-18 |
Cetus Oncology Corporation |
Humanized C-erbB-2 specific antibodies
|
|
ATE311895T1
(de)
|
1992-05-26 |
2005-12-15 |
Immunex Corp |
Neue zytokine die cd30 binden
|
|
AU687346B2
(en)
|
1992-06-30 |
1998-02-26 |
Oncologix, Inc. |
A combination of anti-erbB-2 monoclonal antibodies and method of using
|
|
DK0752248T3
(da)
|
1992-11-13 |
2000-11-13 |
Idec Pharma Corp |
Terapeutisk anvendelse af kimæriske og radioaktivt mærkede antistoffer mod humant B-lymfocytbegrænset differentieringsantig
|
|
US5736137A
(en)
|
1992-11-13 |
1998-04-07 |
Idec Pharmaceuticals Corporation |
Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
|
|
US5869445A
(en)
|
1993-03-17 |
1999-02-09 |
University Of Washington |
Methods for eliciting or enhancing reactivity to HER-2/neu protein
|
|
US5484892A
(en)
|
1993-05-21 |
1996-01-16 |
Dana-Farber Cancer Institute, Inc. |
Monoclonal antibodies that block ligand binding to the CD22 receptor in mature B cells
|
|
US5417972A
(en)
|
1993-08-02 |
1995-05-23 |
The Board Of Trustees Of The Leland Stanford Junior University |
Method of killing B-cells in a complement independent and an ADCC independent manner using antibodies which specifically bind CDIM
|
|
US5595721A
(en)
|
1993-09-16 |
1997-01-21 |
Coulter Pharmaceutical, Inc. |
Radioimmunotherapy of lymphoma using anti-CD20
|
|
US20020164788A1
(en)
|
1994-12-02 |
2002-11-07 |
The Wellcome Foundation Limited |
Humanized antibodies to CD38
|
|
GB9424449D0
(en)
|
1994-12-02 |
1995-01-18 |
Wellcome Found |
Antibodies
|
|
ATE186745T1
(de)
|
1995-01-18 |
1999-12-15 |
Roche Diagnostics Gmbh |
Antikörper gegen cd30, die proteolytische spaltung und abgabe des membrangebundenen cd30 antigens verhindern
|
|
CA2218601A1
(en)
*
|
1995-03-24 |
1996-10-03 |
Ophidian Pharmaceuticals, Inc. |
Treatment for verotoxin-producing escherichia coli
|
|
US5667786A
(en)
*
|
1995-06-07 |
1997-09-16 |
Novavax, Inc. |
Method for treating tumors with a toxin
|
|
US5977322A
(en)
|
1995-06-14 |
1999-11-02 |
The Regents Of The University Of California |
High affinity human antibodies to tumor antigens
|
|
WO1997007797A1
(en)
|
1995-08-25 |
1997-03-06 |
Dana-Farber Cancer Institute |
Treatment of human prostate disease with beta-lapachone derivatives
|
|
US5783186A
(en)
|
1995-12-05 |
1998-07-21 |
Amgen Inc. |
Antibody-induced apoptosis
|
|
US5858682A
(en)
|
1996-08-02 |
1999-01-12 |
Pharmingen |
E2A/pbx1 fusion protein specific monoclonal antibodies
|
|
AU723268B2
(en)
|
1996-09-09 |
2000-08-24 |
Zealand Pharma A/S |
Improved solid-phase peptide synthesis and agent for use in such synthesis
|
|
JP2001500730A
(ja)
|
1996-09-10 |
2001-01-23 |
ヘンリー エム ジャクソン ファンデーション フォージ アドバンスメント オブ ミリタリー メディシン |
ヒスチジン―タグ付き志賀毒素およびトキソイド、該毒素およびトキソイドとの融合タンパク質ならびにそれらの精製及び調製方法
|
|
US5770380A
(en)
|
1996-09-13 |
1998-06-23 |
University Of Pittsburgh |
Synthetic antibody mimics--multiple peptide loops attached to a molecular scaffold
|
|
KR20060079258A
(ko)
|
1996-10-18 |
2006-07-05 |
제넨테크, 인크. |
항-ＥｒｂＢ２ 항체
|
|
US7541034B1
(en)
|
1997-03-20 |
2009-06-02 |
The United States Of America As Represented By The Department Of Health And Human Services |
Recombinant antibodies and immunoconjugates targeted to CD-22 bearing cells and tumors
|
|
US6306393B1
(en)
|
1997-03-24 |
2001-10-23 |
Immunomedics, Inc. |
Immunotherapy of B-cell malignancies using anti-CD22 antibodies
|
|
AU6919798A
(en)
|
1997-04-24 |
1998-11-13 |
Crisplant A/S |
A conveyor unit for use in a closed loop conveyor system and a conveyor system
|
|
US6171586B1
(en)
|
1997-06-13 |
2001-01-09 |
Genentech, Inc. |
Antibody formulation
|
|
ES2244066T3
(es)
|
1997-06-24 |
2005-12-01 |
Genentech, Inc. |
Procedimiento y composiciones de glicoproteinas galactosiladas.
|
|
US6368596B1
(en)
|
1997-07-08 |
2002-04-09 |
Board Of Regents, The University Of Texas System |
Compositions and methods for homoconjugates of antibodies which induce growth arrest or apoptosis of tumor cells
|
|
FR2766193B1
(fr)
|
1997-07-18 |
2001-09-14 |
Inst Curie |
Polypeptide chimerique comprenant le fragment b de la toxine shiga et des peptides d'interet therapeutique
|
|
AU759779B2
(en)
|
1997-10-31 |
2003-05-01 |
Genentech Inc. |
Methods and compositions comprising glycoprotein glycoforms
|
|
CA2222993A1
(en)
|
1998-02-04 |
1999-08-04 |
The Ontario Cancer Institute |
A method for using a ribosome-inactivating protein complex as a structural template and a molecular search engine in the design, construction and screening of combinatorial protein libraries
|
|
US6242195B1
(en)
|
1998-04-02 |
2001-06-05 |
Genentech, Inc. |
Methods for determining binding of an analyte to a receptor
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
US6528624B1
(en)
|
1998-04-02 |
2003-03-04 |
Genentech, Inc. |
Polypeptide variants
|
|
WO1999062526A2
(en)
|
1998-06-05 |
1999-12-09 |
Mayo Foundation For Medical Education And Research |
Use of genetically engineered antibodies to cd38 to treat multiple myeloma
|
|
DE69910216T2
(de)
|
1998-07-22 |
2004-02-19 |
Osprey Pharmaceuticals Ltd., Calgary |
Konjugate zur behandlung von entzündungskrankheiten und von assozierter gewebeschädigung
|
|
US7157418B1
(en)
*
|
1998-07-22 |
2007-01-02 |
Osprey Pharmaceuticals, Ltd. |
Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders
|
|
US6770456B1
(en)
|
1998-07-29 |
2004-08-03 |
Ludwig Institute For Cancer Research |
Endogenous retrovirus tumor associated nucleic acids and antigens
|
|
PT1974747E
(pt)
|
1998-08-11 |
2012-09-05 |
Biogen Idec Inc |
Terapias de combinação para linfomas de células b compreendendo a administração de anticorpo anti-cd20
|
|
AU5963699A
(en)
|
1998-10-02 |
2000-04-26 |
Mcmaster University |
Spliced form of (erb)b-2/neu oncogene
|
|
US6224866B1
(en)
|
1998-10-07 |
2001-05-01 |
Biocrystal Ltd. |
Immunotherapy of B cell involvement in progression of solid, nonlymphoid tumors
|
|
HK1041811A1
(zh)
|
1998-11-09 |
2002-07-26 |
Idec药物公司 |
接受bmt或pbsc移植患者的抗cd20嵌合抗体治疗
|
|
ES2543819T3
(es)
|
1998-11-09 |
2015-08-24 |
Biogen Inc. |
Tratamiento de neoplasias hematológicas asociadas con células tumorales circulantes utilizando anticuerpo quimérico dirigido contra CD20
|
|
PL209392B1
(pl)
|
1999-01-15 |
2011-08-31 |
Genentech Inc |
Przeciwciało, komórka gospodarza, sposób wytwarzania przeciwciała oraz zastosowanie przeciwciała
|
|
US7625859B1
(en)
|
2000-02-16 |
2009-12-01 |
Oregon Health & Science University |
HER-2 binding antagonists
|
|
US6897044B1
(en)
|
1999-01-28 |
2005-05-24 |
Biogen Idec, Inc. |
Production of tetravalent antibodies
|
|
CA2361292C
(en)
*
|
1999-03-16 |
2012-05-29 |
Edward A. Berger |
A novel chimeric protein for prevention and treatment of hiv infection
|
|
WO2000067796A1
(en)
|
1999-05-07 |
2000-11-16 |
Genentech, Inc. |
Treatment of autoimmune diseases with antagonists which bind to b cell surface markers
|
|
US7527787B2
(en)
|
2005-10-19 |
2009-05-05 |
Ibc Pharmaceuticals, Inc. |
Multivalent immunoglobulin-based bioactive assemblies
|
|
US7312318B2
(en)
|
2002-03-01 |
2007-12-25 |
Immunomedics, Inc. |
Internalizing anti-CD74 antibodies and methods of use
|
|
US7144991B2
(en)
|
1999-06-07 |
2006-12-05 |
Aletheon Pharmaceuticals, Inc. |
Streptavidin expressed gene fusions and methods of use thereof
|
|
DE60042785D1
(de)
|
1999-06-09 |
2009-10-01 |
Immunomedics Inc |
Immuntherapie von autoimmunerkrankungen durch die verwendung von b-zell spezifischen antikörpern
|
|
ITMI991299A1
(it)
|
1999-06-11 |
2000-12-11 |
Consiglio Nazionale Ricerche |
Uso di anticorpi contro antigeni di superficie per il trattamento della malattia trapianto contro ospite
|
|
US6949245B1
(en)
|
1999-06-25 |
2005-09-27 |
Genentech, Inc. |
Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
|
|
AU779612C
(en)
|
1999-07-02 |
2005-12-15 |
Genentech Inc. |
Peptide compounds that bind HER2
|
|
DE19930748C2
(de)
|
1999-07-02 |
2001-05-17 |
Infineon Technologies Ag |
Verfahren zur Herstellung von EEPROM- und DRAM-Grabenspeicherzellbereichen auf einem Chip
|
|
KR20020027490A
(ko)
|
1999-07-12 |
2002-04-13 |
제넨테크, 인크. |
Ｃｄ20에 결합하는 길항제를 사용한 외래 항원에 대한면역 반응 차단 방법
|
|
US6451284B1
(en)
|
1999-08-11 |
2002-09-17 |
Idec Pharmaceuticals Corporation |
Clinical parameters for determining hematologic toxicity prior to radioimmunotheraphy
|
|
AU784971B2
(en)
|
1999-08-11 |
2006-08-10 |
Biogen Inc. |
Treatment of patients having non-Hodgkins lymphoma with bone marrow involvement with anti-CD20 antibodies
|
|
US8557244B1
(en)
|
1999-08-11 |
2013-10-15 |
Biogen Idec Inc. |
Treatment of aggressive non-Hodgkins lymphoma with anti-CD20 antibody
|
|
AU6929100A
(en)
|
1999-08-23 |
2001-03-19 |
Biocrystal Limited |
Methods and compositions for immunotherapy of b cell involvement in promotion ofa disease condition comprising multiple sclerosis
|
|
US6492498B1
(en)
|
1999-11-15 |
2002-12-10 |
Regents Of The University Of Minnesota |
Multimeric immunotoxins
|
|
US20010031485A1
(en)
|
2000-03-22 |
2001-10-18 |
Sibtech, Inc. |
Recombinant proteins containing Shiga-like toxin and vascular endothelial growth factor fragments
|
|
US7267973B2
(en)
|
2000-03-22 |
2007-09-11 |
Sibtech, Inc. |
Nucleic acids encoding recombinant proteins containing Shiga-like toxin and vascular endothelial growth factor
|
|
JP2003528155A
(ja)
|
2000-03-24 |
2003-09-24 |
カイロン コーポレイション |
Ｃｄ２０に対する抗体とインターロイキン−２との組み合わせを用いる非ホジキンリンパ腫の治療方法
|
|
JP2003531588A
(ja)
|
2000-04-11 |
2003-10-28 |
ジェネンテック・インコーポレーテッド |
多価抗体とその用途
|
|
AU2001259142C1
(en)
|
2000-04-25 |
2006-11-23 |
Biogen Idec Inc. |
Intrathecal administration of rituximab for treatment of central nervous system lymphomas
|
|
US7306801B2
(en)
|
2000-05-15 |
2007-12-11 |
Health Research, Inc. |
Methods of therapy for cancers characterized by overexpression of the HER2 receptor protein
|
|
JP2004512262A
(ja)
|
2000-06-20 |
2004-04-22 |
アイデック ファーマスーティカルズ コーポレイション |
非放射性抗ｃｄ２０抗体／放射標識抗ｃｄ２２抗体の組合せ
|
|
EP1174440A1
(en)
|
2000-07-19 |
2002-01-23 |
U-BISys B.V. |
A selectively-expressed epitope on the human CD38 molecule detected by a phage display library-derived human scFv antibody fragment
|
|
US20020127247A1
(en)
*
|
2000-11-17 |
2002-09-12 |
Allergen Sales, Inc. |
Modified clostridial neurotoxins with altered biological persistence
|
|
US20040018194A1
(en)
|
2000-11-28 |
2004-01-29 |
Francisco Joseph A. |
Recombinant anti-CD30 antibodies and uses thereof
|
|
US7090843B1
(en)
|
2000-11-28 |
2006-08-15 |
Seattle Genetics, Inc. |
Recombinant anti-CD30 antibodies and uses thereof
|
|
DE10063048A1
(de)
|
2000-12-18 |
2002-07-11 |
Deutsches Krebsforsch |
Einzelketten-Antikörper mit verbesserter Stabilität
|
|
US7829084B2
(en)
|
2001-01-17 |
2010-11-09 |
Trubion Pharmaceuticals, Inc. |
Binding constructs and methods for use thereof
|
|
WO2002096948A2
(en)
|
2001-01-29 |
2002-12-05 |
Idec Pharmaceuticals Corporation |
Engineered tetravalent antibodies and methods of use
|
|
NZ527283A
(en)
|
2001-01-29 |
2006-03-31 |
Biogen Idec Inc |
Modified antibodies and methods of use
|
|
AU2002307037B2
(en)
|
2001-04-02 |
2008-08-07 |
Biogen Idec Inc. |
Recombinant antibodies coexpressed with GnTIII
|
|
WO2003061694A1
(en)
|
2001-05-10 |
2003-07-31 |
Seattle Genetics, Inc. |
Immunosuppression of the humoral immune response by anti-cd20 antibodies
|
|
JP2005515161A
(ja)
|
2001-06-14 |
2005-05-26 |
インターミューン インコーポレイテッド |
γ−インターフェロンおよびＢ細胞特異的抗体の併用療法
|
|
US7321026B2
(en)
|
2001-06-27 |
2008-01-22 |
Skytech Technology Limited |
Framework-patched immunoglobulins
|
|
WO2003055439A2
(en)
|
2001-07-18 |
2003-07-10 |
The Regents Of The University Of California |
Her2/neu target antigen and use of same to stimulate an immune response
|
|
US7355012B2
(en)
|
2001-09-26 |
2008-04-08 |
United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Mutated anti-CD22 antibodies with increased affinity to CD22-expressing leukemia cells
|
|
IL162835A0
(en)
|
2002-01-09 |
2005-11-20 |
Medarex Inc |
Human monoclonal antibodies against cd30
|
|
AU2003208097A1
(en)
|
2002-02-04 |
2003-09-02 |
Hideo Yoshida |
Anticancer agents using vero toxin variants
|
|
WO2003072736A2
(en)
|
2002-02-21 |
2003-09-04 |
Duke University |
Reagents and treatment methods for autoimmune diseases
|
|
AU2003213580A1
(en)
*
|
2002-02-26 |
2003-09-09 |
Genencor International, Inc. |
Subtilisin carlsberg proteins with reduced immunogenicity
|
|
US20040248151A1
(en)
|
2002-04-05 |
2004-12-09 |
Ventana Medical Systems, Inc. |
Method for predicting the response to HER2-directed therapy
|
|
EP2289942B1
(en)
|
2002-04-10 |
2013-07-31 |
Genentech, Inc. |
Anti-HER2 antibody variants
|
|
US7449480B2
(en)
|
2002-05-14 |
2008-11-11 |
Baylor College Of Medicine |
Small molecule inhibitors of HER2 expression
|
|
US7019017B2
(en)
|
2002-05-14 |
2006-03-28 |
Baylor College Of Medicine |
Small molecule inhibitors of HER2 expression
|
|
US20050180972A1
(en)
|
2002-07-31 |
2005-08-18 |
Wahl Alan F. |
Anti-CD20 antibody-drug conjugates for the treatment of cancer and immune disorders
|
|
TWI335821B
(en)
|
2002-12-16 |
2011-01-11 |
Genentech Inc |
Immunoglobulin variants and uses thereof
|
|
AU2003303374A1
(en)
|
2002-12-20 |
2004-07-22 |
The Johns Hopkins University |
Treatment of metastatic cancer with the b-subunit of shiga toxin
|
|
EP1583833A1
(en)
|
2003-01-03 |
2005-10-12 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. |
Rhesus her2/neu, nucleotides encoding same, and uses thereof
|
|
CN1802388B
(zh)
|
2003-05-09 |
2011-01-05 |
杜克大学 |
Cd20特异抗体及使用它们的方法
|
|
AR044388A1
(es)
|
2003-05-20 |
2005-09-07 |
Applied Molecular Evolution |
Moleculas de union a cd20
|
|
WO2005000902A1
(en)
|
2003-06-30 |
2005-01-06 |
Mu-Hyeon Choe |
The dimer of chimeric recombinant binding domain-functional group fusion formed via disulfide-bond-bridge and the processes for producing the same
|
|
CA2531238C
(en)
|
2003-07-04 |
2015-02-24 |
Affibody Ab |
Polypeptides having binding affinity for her2
|
|
CA2534639C
(en)
|
2003-07-31 |
2013-07-30 |
Immunomedics, Inc. |
Anti-cd19 antibodies
|
|
US7674460B2
(en)
|
2003-08-01 |
2010-03-09 |
A&G Pharmaceutical, Inc. |
Compositions and methods for restoring sensitivity to treatment with HER2 antagonists
|
|
US8147832B2
(en)
|
2003-08-14 |
2012-04-03 |
Merck Patent Gmbh |
CD20-binding polypeptide compositions and methods
|
|
US7982011B2
(en)
|
2003-11-25 |
2011-07-19 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Mutated anti-cd22 antibodies and immunoconjugates
|
|
EP1687016A4
(en)
|
2003-11-25 |
2009-07-29 |
Anjin Corp |
GENETIC VARIANT OF DIPHTHERIC TOXIN
|
|
KR20140066259A
(ko)
|
2004-02-06 |
2014-05-30 |
모르포시스 아게 |
항-ｃｄ３８ 인간 항체 및 그의 용도
|
|
AU2005235811B2
(en)
|
2004-02-06 |
2011-11-03 |
Morphosys Ag |
Anti-CD38 human antibodies and uses therefor
|
|
EP1727827B1
(en)
|
2004-03-26 |
2010-05-12 |
Molecular Templates, Inc. |
Library of toxin mutants, and methods of using same
|
|
US9228008B2
(en)
|
2004-05-28 |
2016-01-05 |
Idexx Laboratories, Inc. |
Canine anti-CD20 antibodies
|
|
DK1771482T3
(da)
|
2004-07-22 |
2014-10-20 |
Genentech Inc |
HER2-antistofsammensætning
|
|
JP5225069B2
(ja)
|
2005-03-23 |
2013-07-03 |
ゲンマブ エー／エス |
多発性骨髄腫の治療のためのｃｄ３８に対する抗体
|
|
CA2603414C
(en)
|
2005-03-31 |
2012-09-18 |
Biomedics Inc. |
Anti-cd20 monoclonal antibody
|
|
WO2007040653A2
(en)
|
2005-05-16 |
2007-04-12 |
The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services National Institutes Of Health |
Anti-cd30 antibodies that bind to intact cd30 but not soluble cd30
|
|
US7771955B2
(en)
|
2005-06-09 |
2010-08-10 |
University Of Maryland |
Affinity membrane for capture of a target biomolecule and formation thereof by site-directed immobilization of a capture biomolecule
|
|
PT1907424E
(pt)
|
2005-07-01 |
2015-10-09 |
Squibb & Sons Llc |
Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1)
|
|
FI20055417A0
(fi)
|
2005-07-20 |
2005-07-20 |
Glykos Finland Oy |
Syöpäpesifiset glykaanit ja niiden käyttö
|
|
RU2421242C2
(ru)
|
2005-07-25 |
2011-06-20 |
Трабьон Фармасьютикалз, Инк. |
Применение однократной дозы cd20-специфических связывающих молекул
|
|
EP1945660B1
(en)
|
2005-09-26 |
2014-05-07 |
Molecular Templates, Inc. |
Library from toxin mutants, and methods of using same
|
|
WO2007071061A1
(en)
|
2005-12-23 |
2007-06-28 |
Viventia Biotech Inc. |
Methods for generating and screening fusion protein libraries and uses thereof
|
|
ES2532985T3
(es)
|
2006-02-16 |
2015-04-06 |
The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. |
Proteínas quiméricas de toxoide de Shiga
|
|
US7373982B2
(en)
|
2006-03-21 |
2008-05-20 |
Halliburton Energy Services, Inc. |
Cements for use across formations containing gas hydrates
|
|
WO2008073160A2
(en)
*
|
2006-08-17 |
2008-06-19 |
The Trustees Of Columbia University In The City Of New York |
Methods for converting or inducing protective immunity
|
|
US8257706B2
(en)
|
2006-08-25 |
2012-09-04 |
Seattle Genetics, Inc. |
CD30 binding agents and uses thereof
|
|
EP1914242A1
(en)
|
2006-10-19 |
2008-04-23 |
Sanofi-Aventis |
Novel anti-CD38 antibodies for the treatment of cancer
|
|
US8481683B2
(en)
|
2006-12-01 |
2013-07-09 |
Medarex, Inc. |
Human antibodies that bind CD22 and uses thereof
|
|
CN101622352A
(zh)
*
|
2006-12-29 |
2010-01-06 |
美国奥斯普瑞医药公司 |
选择和产生修饰的毒素、含有修饰的毒素的缀合物的方法及其应用
|
|
EP2097529A4
(en)
|
2006-12-29 |
2010-03-24 |
Osprey Pharmaceuticals Usa Inc |
METHOD FOR SELECTION AND PRODUCTION OF MODIFIED TOXINS, MODIFIED TOXINE CONJUGATES AND USES THEREOF
|
|
CA2689602A1
(en)
|
2007-06-06 |
2008-12-18 |
Avi Biopharma, Inc. |
Soluble her2 and her3 splice variant proteins, splice-switching oligonucleotides, and their use in the treatment of disease
|
|
AU2008279550B2
(en)
|
2007-06-21 |
2012-08-09 |
Angelica Therapeutics, Inc. |
Modified toxins
|
|
US7887801B2
(en)
|
2007-07-13 |
2011-02-15 |
Topotarget Germany Ag |
Optimized DNA and protein sequence of an antibody to improve quality and yield of bacterially expressed antibody fusion proteins
|
|
MX2010000970A
(es)
|
2007-07-31 |
2010-03-09 |
Regeneron Pharma |
Anticuerpos humanos contra cd20 humano y metodo para utilizarlos.
|
|
EP2187971A2
(en)
|
2007-08-01 |
2010-05-26 |
The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services |
A fold-back diabody diphtheria toxin immunotoxin and methods of use
|
|
WO2009032954A1
(en)
|
2007-09-04 |
2009-03-12 |
The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services |
Deletions in domain ii of pseudomonas exotoxin a that reduce non-specific toxicity
|
|
US20110263825A1
(en)
|
2007-09-06 |
2011-10-27 |
Osaka University |
Anti-cd20 monoclonal antibodies
|
|
US20100298238A1
(en)
|
2007-10-08 |
2010-11-25 |
Rutgers, The State University |
Nontoxic shiga-like toxin mutant compositions and methods
|
|
CA2705289A1
(en)
|
2007-11-13 |
2009-05-22 |
The Scripps Research Institute |
Production of cytotoxic antibody-toxin fusion in eukaryotic algae
|
|
EP2650311A3
(en)
|
2007-11-27 |
2014-06-04 |
Ablynx N.V. |
Amino acid sequences directed against heterodimeric cytokines and/or their receptors and polypeptides comprising the same
|
|
US8315343B2
(en)
|
2007-12-17 |
2012-11-20 |
Telefonaktiebolaget Lm Ericsson (Publ) |
Multi-antenna receiver interference cancellation method and apparatus
|
|
EP2072525A1
(en)
|
2007-12-21 |
2009-06-24 |
Affibody AB |
New polypeptides having affinity for HER2
|
|
TWI472339B
(zh)
|
2008-01-30 |
2015-02-11 |
Genentech Inc |
包含結合至ｈｅｒ２結構域ii之抗體及其酸性變異體的組合物
|
|
WO2009110944A1
(en)
|
2008-02-29 |
2009-09-11 |
Angelica Therapeutics, Inc. |
Modified toxins
|
|
ES2342646B1
(es)
|
2008-06-02 |
2011-04-26 |
Institut De Recerca Hospital Universitari Vall Hebron |
Metodo de diagnostico de canceres que expresan el receptor her-2 o sus variantes truncadas.
|
|
CN102159243B
(zh)
|
2008-07-21 |
2015-08-19 |
免疫医疗公司 |
用于改良的治疗特征的抗体的结构变体
|
|
US20100093563A1
(en)
|
2008-09-22 |
2010-04-15 |
Robert Anthony Williamson |
Methods and vectors for display of molecules and displayed molecules and collections
|
|
US8552154B2
(en)
|
2008-09-26 |
2013-10-08 |
Emory University |
Anti-PD-L1 antibodies and uses therefor
|
|
WO2010085539A1
(en)
|
2009-01-23 |
2010-07-29 |
The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. |
Methods and compositions based on shiga toxin type 2 protein
|
|
AU2010240569A1
(en)
|
2009-04-20 |
2011-10-20 |
Pfizer Inc. |
Control of protein glycosylation and compositions and methods relating thereto
|
|
JP2012533587A
(ja)
|
2009-07-22 |
2012-12-27 |
セニックス バイオサイエンス ゲーエムベーハー |
自然に存在する細胞内輸送経路を介して化合物を送達するための送達システム及びコンジュゲート
|
|
US9174169B2
(en)
|
2009-08-14 |
2015-11-03 |
Unifrax I Llc |
Mounting mat for exhaust gas treatment device
|
|
US9616120B2
(en)
|
2010-03-04 |
2017-04-11 |
Vet Therapeutics, Inc. |
Monoclonal antibodies directed to CD20
|
|
EP2371864A1
(en)
|
2010-03-23 |
2011-10-05 |
Ganymed Pharmaceuticals AG |
Monoclonal antibodies for treatment of cancer
|
|
WO2011130580A1
(en)
|
2010-04-15 |
2011-10-20 |
Alper Biotech, Llc |
Monoclonal antibodies against her2 antigens, and uses therefor
|
|
EP2576621B1
(en)
|
2010-05-27 |
2019-04-10 |
Genmab A/S |
Monoclonal antibodies against her2
|
|
GB201013989D0
(en)
|
2010-08-20 |
2010-10-06 |
Univ Southampton |
Biological materials and methods of using the same
|
|
CN101948546B
(zh)
*
|
2010-09-25 |
2012-11-07 |
中国人民解放军军事医学科学院微生物流行病研究所 |
融合蛋白SAmB及其编码基因与应用
|
|
US20120141505A1
(en)
|
2010-11-01 |
2012-06-07 |
Fatih M. Uckun |
Cd19-ligand and use
|
|
PH12013501201A1
(en)
|
2010-12-09 |
2013-07-29 |
Univ Pennsylvania |
Use of chimeric antigen receptor-modified t cells to treat cancer
|
|
JOP20210044A1
(ar)
|
2010-12-30 |
2017-06-16 |
Takeda Pharmaceuticals Co |
الأجسام المضادة لـ cd38
|
|
PL219845B1
(pl)
|
2011-01-05 |
2015-07-31 |
Adamed Spółka Z Ograniczoną Odpowiedzialnością |
Przeciwnowotworowe białko fuzyjne
|
|
US20140065172A1
(en)
|
2011-01-26 |
2014-03-06 |
Cenix Bioscience Gmbh |
Delivery system and conjugates for compound delivery via naturally occurring intracellular transport routes
|
|
WO2012104344A1
(en)
|
2011-02-01 |
2012-08-09 |
Genmab A/S |
Human antibodies and antibody-drug conjugates against cd74
|
|
US8895006B2
(en)
|
2011-03-04 |
2014-11-25 |
Rutgers, The State University Of New Jersey |
Ricin ribosome binding protein compositions and methods of use thereof
|
|
SG194787A1
(en)
|
2011-05-06 |
2013-12-30 |
Us Gov Health & Human Serv |
Recombinant immunotoxin targeting mesothelin
|
|
WO2012170785A1
(en)
|
2011-06-08 |
2012-12-13 |
The Regents Of The University Of California |
Anti-cd22 antigen binding molecules to treat lung cancer and prostate cancer
|
|
MX368257B
(es)
|
2011-08-01 |
2019-09-26 |
Genentech Inc |
Antagonistas de unión al eje pd-1e inhibidores de mek y sus usos en el tratamiento de cáncer.
|
|
PL397167A1
(pl)
*
|
2011-11-28 |
2013-06-10 |
Adamed Spólka Z Ograniczona Odpowiedzialnoscia |
Przeciwnowotworowe bialko fuzyjne
|
|
CA2865243A1
(en)
|
2012-02-23 |
2013-08-29 |
President And Fellows Of Harvard College |
Modified microbial toxin receptor for delivering agents into cells
|
|
CA2891764A1
(en)
|
2012-11-19 |
2014-05-22 |
Baliopharm Ag |
Recombinant bispecific antibody binding to cd20 and cd95
|
|
EP2740493A1
(en)
*
|
2012-12-05 |
2014-06-11 |
Institut Curie |
Conjugates of the B-subunit of Shiga toxin for anticancer therapies
|
|
EP3666795A1
(en)
|
2013-03-12 |
2020-06-17 |
Molecular Templates, Inc. |
Cytotoxic proteins comprising cell-targeting binding regions and shiga toxin a subunit regions for selective killing of specific cell types
|
|
EP2778173A1
(en)
*
|
2013-03-15 |
2014-09-17 |
Laboratoire Français du Fractionnement et des Biotechnologies |
Antibody directed against anthrax toxins and its uses
|
|
JP6090020B2
(ja)
|
2013-07-10 |
2017-03-08 |
富士ゼロックス株式会社 |
画像形成システム
|
|
CN105940102B
(zh)
|
2013-08-26 |
2020-02-18 |
海瑞克·亚柏坎 |
抗cd30嵌合抗原受体及其用途
|
|
GB2519786A
(en)
|
2013-10-30 |
2015-05-06 |
Sergej Michailovic Kiprijanov |
Multivalent antigen-binding protein molecules
|
|
US20150118251A1
(en)
|
2013-10-31 |
2015-04-30 |
Sanofi |
Specific anti-cd38 antibodies for treating human cancers
|
|
US20160177284A1
(en)
|
2014-01-27 |
2016-06-23 |
Molecular Templates, Inc. |
Cell-targeted molecules comprising amino-terminus proximal or amino-terminal shiga toxin a subunit effector regions
|
|
US20210138076A2
(en)
|
2014-01-27 |
2021-05-13 |
Molecular Templates, Inc. |
Cell-targeting molecules comprising shiga toxin a subunit effectors and cd8+ t-cell epitopes
|
|
CN112851769A
(zh)
|
2014-01-27 |
2021-05-28 |
分子模板公司 |
用于哺乳动物中的去免疫化志贺毒素a亚基效应子多肽
|
|
WO2015120058A2
(en)
|
2014-02-05 |
2015-08-13 |
Molecular Templates, Inc. |
Methods of screening, selecting, and identifying cytotoxic recombinant polypeptides based on an interim diminution of ribotoxicity
|
|
US11142584B2
(en)
|
2014-03-11 |
2021-10-12 |
Molecular Templates, Inc. |
CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same
|
|
JP6935195B2
(ja)
|
2014-03-11 |
2021-09-15 |
モレキュラー テンプレーツ, インク.Molecular Templates, Inc. |
結合領域、志賀毒素ａサブユニットのエフェクター領域、及びカルボキシ末端小胞体局在化シグナルモチーフを含むタンパク質
|
|
ES2809729T3
(es)
|
2014-03-11 |
2021-03-05 |
Molecular Templates Inc |
Proteínas que comprenden regiones efectoras de la subunidad A de la toxina Shiga próximas al extremo amino terminal y regiones de unión de tipo inmunoglobulina de reconocimiento celular capaces de unirse específicamente a HER2/neu/ErbB2
|
|
TWI674257B
(zh)
|
2014-03-14 |
2019-10-11 |
日商拉夸里亞創藥股份有限公司 |
作為ｔｒｐｍ８拮抗劑之氮雜螺衍生物
|
|
CN106604934A
(zh)
|
2014-06-11 |
2017-04-26 |
分子模板公司 |
耐受蛋白酶切割的志贺毒素a亚基效应子多肽和包含其的细胞靶向分子
|
|
WO2015191883A1
(en)
|
2014-06-12 |
2015-12-17 |
Dophen Biomedical |
Homogenous antibody drug conjugates via enzymatic methods
|
|
ES2806776T3
(es)
|
2014-06-18 |
2021-02-18 |
Chemotherapeutisches Forschungsinstitut Georg Speyer Haus |
Células NK-92 que expresan CAR como agentes terapéuticos celulares
|
|
CN105713087B
(zh)
|
2014-11-12 |
2020-05-08 |
北京康乐卫士生物技术股份有限公司 |
人乳头瘤病毒58型单克隆抗体及其应用
|
|
EP3253799B1
(en)
|
2015-02-05 |
2020-12-02 |
Molecular Templates, Inc. |
Multivalent cd20-binding molecules comprising shiga toxin a subunit effector regions and enriched compositions thereof
|
|
EP3957738A1
(en)
|
2015-03-04 |
2022-02-23 |
IGM Biosciences, Inc. |
Cd20 binding molecules and uses thereof
|
|
EP3303373B1
(en)
|
2015-05-30 |
2020-04-08 |
Molecular Templates, Inc. |
De-immunized, shiga toxin a subunit scaffolds and cell-targeting molecules comprising the same
|
|
KR20180030085A
(ko)
|
2015-07-26 |
2018-03-21 |
몰레큘러 템플레이츠, 인코퍼레이션. |
시가 독소 a 서브유닛 작동체 및 cd8+ t-세포 에피토프를 포함하는 세포-표적화 분자
|
|
ES2883297T3
(es)
|
2016-03-29 |
2021-12-07 |
Stcube Inc |
Anticuerpos de función doble específicos para PD-L1 glucosilado y métodos de uso de los mismos
|
|
EP3448874A4
(en)
|
2016-04-29 |
2020-04-22 |
Voyager Therapeutics, Inc. |
COMPOSITIONS FOR TREATING A DISEASE
|
|
WO2018080812A1
(en)
|
2016-10-30 |
2018-05-03 |
Henlix, Inc. |
Anti-pd-l1 antibodies and variants
|
|
WO2018106895A1
(en)
|
2016-12-07 |
2018-06-14 |
Molecular Templates, Inc. |
Shiga toxin a subunit effector polypeptides, shiga toxin effector scaffolds, and cell-targeting molecules for site-specific conjugation
|
|
EP3434693A4
(en)
|
2016-12-26 |
2019-10-02 |
Dankook University Cheonan Campus Industry Academic Cooperation Foundation |
COMPOSITION FOR THE DIFFERENTIATION OF DENTAL STRAIN CELLS IN ODONTOBLAST FIELD CELLS AND MONOCLONAL IGG OR IGM-TYPE ANTIBODIES WITH SPECIFIC BINDING TO SURFACES OF ODOBOBLAST FIELD CELLS
|
|
MX2019008840A
(es)
|
2017-01-25 |
2019-09-09 |
Molecular Templates Inc |
Moleculas con direccion hacia las celulas que comprenden efectores de la sub-unidad a de la toxina shiga desinmunizados y epitopos de las celulas t cd8+.
|
|
WO2018159615A1
(en)
|
2017-02-28 |
2018-09-07 |
Chugai Seiyaku Kabushiki Kaisha |
Protein purification with protein l
|
|
DK3592769T3
(da)
|
2017-03-09 |
2024-08-12 |
Genmab As |
Antistoffer mod pd-l1
|
|
EP3689893A4
(en)
|
2017-09-25 |
2021-12-15 |
JSR Corporation |
IMMUNOGLOBULIN-BINDING PROTEIN AND AFFINITY CARRIERS THEREFORE
|
|
WO2020081493A1
(en)
|
2018-10-16 |
2020-04-23 |
Molecular Templates, Inc. |
Pd-l1 binding proteins
|
|
WO2020154475A1
(en)
|
2019-01-23 |
2020-07-30 |
Molecular Templates, Inc. |
Proteins comprising modified immunoglobulin variable light chains
|
|
MX2022003195A
(es)
|
2019-09-18 |
2022-04-11 |
Molecular Templates Inc |
Moleculas de union a pd-l1 que comprenden andamios de la subunidad a de la toxina shiga.
|