JP2020526534A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020526534A5 JP2020526534A5 JP2020500862A JP2020500862A JP2020526534A5 JP 2020526534 A5 JP2020526534 A5 JP 2020526534A5 JP 2020500862 A JP2020500862 A JP 2020500862A JP 2020500862 A JP2020500862 A JP 2020500862A JP 2020526534 A5 JP2020526534 A5 JP 2020526534A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutical composition
- composition according
- multiple myeloma
- activator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 61
- 208000034578 Multiple myelomas Diseases 0.000 claims description 34
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 34
- 239000008194 pharmaceutical composition Substances 0.000 claims description 31
- 238000000034 method Methods 0.000 claims description 27
- 239000012190 activator Substances 0.000 claims description 22
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims description 10
- 229960003957 dexamethasone Drugs 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 9
- 229940125782 compound 2 Drugs 0.000 claims description 8
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 6
- 229960001467 bortezomib Drugs 0.000 claims description 6
- GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- AICOOMRHRUFYCM-ZRRPKQBOSA-N oxazine, 1 Chemical compound C([C@@H]1[C@H](C(C[C@]2(C)[C@@H]([C@H](C)N(C)C)[C@H](O)C[C@]21C)=O)CC1=CC2)C[C@H]1[C@@]1(C)[C@H]2N=C(C(C)C)OC1 AICOOMRHRUFYCM-ZRRPKQBOSA-N 0.000 claims description 6
- 229960004942 lenalidomide Drugs 0.000 claims description 5
- GOTYRUGSSMKFNF-UHFFFAOYSA-N lenalidomide Chemical compound C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O GOTYRUGSSMKFNF-UHFFFAOYSA-N 0.000 claims description 5
- 229960000688 pomalidomide Drugs 0.000 claims description 5
- UVSMNLNDYGZFPF-UHFFFAOYSA-N pomalidomide Chemical compound O=C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O UVSMNLNDYGZFPF-UHFFFAOYSA-N 0.000 claims description 5
- 230000000306 recurrent effect Effects 0.000 claims description 5
- 229940125904 compound 1 Drugs 0.000 claims description 4
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 claims 3
- 101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 claims 3
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims 3
- 229960002204 daratumumab Drugs 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 208000034951 Genetic Translocation Diseases 0.000 claims 2
- -1 MMset Proteins 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 230000000711 cancerogenic effect Effects 0.000 claims 2
- 231100000315 carcinogenic Toxicity 0.000 claims 2
- 229960002438 carfilzomib Drugs 0.000 claims 2
- BLMPQMFVWMYDKT-NZTKNTHTSA-N carfilzomib Chemical group C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)[C@]1(C)OC1)NC(=O)CN1CCOCC1)CC1=CC=CC=C1 BLMPQMFVWMYDKT-NZTKNTHTSA-N 0.000 claims 2
- 108010021331 carfilzomib Proteins 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 2
- 229960004528 vincristine Drugs 0.000 claims 2
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 2
- PKYIMGFMRFVOMB-LDLOPFEMSA-N (2R)-2-[5-[3-chloro-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy]phenyl]propanoic acid Chemical compound COc1ccccc1-c1nccc(COc2ccccc2C[C@@H](Oc2ncnc3sc(c(-c4ccc(OCCN5CCN(C)CC5)c(Cl)c4C)c23)-c2ccc(F)cc2)C(O)=O)n1 PKYIMGFMRFVOMB-LDLOPFEMSA-N 0.000 claims 1
- QRDAPCMJAOQZSU-KQQUZDAGSA-N (e)-3-[4-[(e)-3-(3-fluorophenyl)-3-oxoprop-1-enyl]-1-methylpyrrol-2-yl]-n-hydroxyprop-2-enamide Chemical compound C1=C(\C=C\C(=O)NO)N(C)C=C1\C=C\C(=O)C1=CC=CC(F)=C1 QRDAPCMJAOQZSU-KQQUZDAGSA-N 0.000 claims 1
- VLIUIBXPEDFJRF-UHFFFAOYSA-N 2-(n-(2-chlorophenyl)anilino)-n-[7-(hydroxyamino)-7-oxoheptyl]pyrimidine-5-carboxamide Chemical group N1=CC(C(=O)NCCCCCCC(=O)NO)=CN=C1N(C=1C(=CC=CC=1)Cl)C1=CC=CC=C1 VLIUIBXPEDFJRF-UHFFFAOYSA-N 0.000 claims 1
- AAAQFGUYHFJNHI-SFHVURJKSA-N 2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide Chemical compound N([C@H](C1=NN=C(C)N1C1=CC=C(OC)C=C11)CC(=O)NCC)=C1C1=CC=C(Cl)C=C1 AAAQFGUYHFJNHI-SFHVURJKSA-N 0.000 claims 1
- VMOBEAUQUPPPON-UHFFFAOYSA-N 3-fluoro-4-piperazin-1-ylbenzonitrile Chemical compound FC1=CC(C#N)=CC=C1N1CCNCC1 VMOBEAUQUPPPON-UHFFFAOYSA-N 0.000 claims 1
- UWZAJPITKGWMFJ-UHFFFAOYSA-N 4-[2-(cyclopropylmethoxy)-5-methylsulfonylphenyl]-2-methylisoquinolin-1-one Chemical compound Cn1cc(-c2cc(ccc2OCC2CC2)S(C)(=O)=O)c2ccccc2c1=O UWZAJPITKGWMFJ-UHFFFAOYSA-N 0.000 claims 1
- 239000012664 BCL-2-inhibitor Substances 0.000 claims 1
- 229940123711 Bcl2 inhibitor Drugs 0.000 claims 1
- JQNINBDKGLWYMU-GEAQBIRJSA-N CO[C@H]1\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)C2=CC3=C(OC[C@]4(CCCC5=C4C=CC(Cl)=C5)CN3C[C@@H]3CC[C@@H]13)C=C2 Chemical compound CO[C@H]1\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)C2=CC3=C(OC[C@]4(CCCC5=C4C=CC(Cl)=C5)CN3C[C@@H]3CC[C@@H]13)C=C2 JQNINBDKGLWYMU-GEAQBIRJSA-N 0.000 claims 1
- 102000003910 Cyclin D Human genes 0.000 claims 1
- 108090000259 Cyclin D Proteins 0.000 claims 1
- 102000006311 Cyclin D1 Human genes 0.000 claims 1
- 108010058546 Cyclin D1 Proteins 0.000 claims 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 1
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 1
- 102100027842 Fibroblast growth factor receptor 3 Human genes 0.000 claims 1
- 101710182396 Fibroblast growth factor receptor 3 Proteins 0.000 claims 1
- 101001056180 Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1 Proteins 0.000 claims 1
- 101000979190 Homo sapiens Transcription factor MafB Proteins 0.000 claims 1
- 102100026539 Induced myeloid leukemia cell differentiation protein Mcl-1 Human genes 0.000 claims 1
- 229940123628 Lysine (K)-specific demethylase 1A inhibitor Drugs 0.000 claims 1
- 229940079156 Proteasome inhibitor Drugs 0.000 claims 1
- 102100023234 Transcription factor MafB Human genes 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 229940124660 anti-multiple myeloma Drugs 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 229940125763 bromodomain inhibitor Drugs 0.000 claims 1
- 238000009108 consolidation therapy Methods 0.000 claims 1
- 229960004397 cyclophosphamide Drugs 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 229910052805 deuterium Inorganic materials 0.000 claims 1
- 229960004679 doxorubicin Drugs 0.000 claims 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 1
- 229960005420 etoposide Drugs 0.000 claims 1
- 238000009093 first-line therapy Methods 0.000 claims 1
- 229940121372 histone deacetylase inhibitor Drugs 0.000 claims 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 238000009115 maintenance therapy Methods 0.000 claims 1
- GVOISEJVFFIGQE-YCZSINBZSA-N n-[(1r,2s,5r)-5-[methyl(propan-2-yl)amino]-2-[(3s)-2-oxo-3-[[6-(trifluoromethyl)quinazolin-4-yl]amino]pyrrolidin-1-yl]cyclohexyl]acetamide Chemical compound CC(=O)N[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1N1C(=O)[C@@H](NC=2C3=CC(=CC=C3N=CN=2)C(F)(F)F)CC1 GVOISEJVFFIGQE-YCZSINBZSA-N 0.000 claims 1
- 229960005184 panobinostat Drugs 0.000 claims 1
- FWZRWHZDXBDTFK-ZHACJKMWSA-N panobinostat Chemical compound CC1=NC2=CC=C[CH]C2=C1CCNCC1=CC=C(\C=C\C(=O)NO)C=C1 FWZRWHZDXBDTFK-ZHACJKMWSA-N 0.000 claims 1
- 239000003207 proteasome inhibitor Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 229940125327 trotabresib Drugs 0.000 claims 1
- LQBVNQSMGBZMKD-UHFFFAOYSA-N venetoclax Chemical compound C=1C=C(Cl)C=CC=1C=1CC(C)(C)CCC=1CN(CC1)CCN1C(C=C1OC=2C=C3C=CNC3=NC=2)=CC=C1C(=O)NS(=O)(=O)C(C=C1[N+]([O-])=O)=CC=C1NCC1CCOCC1 LQBVNQSMGBZMKD-UHFFFAOYSA-N 0.000 claims 1
- 229960001183 venetoclax Drugs 0.000 claims 1
- 239000000126 substance Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762530778P | 2017-07-10 | 2017-07-10 | |
| US62/530,778 | 2017-07-10 | ||
| US201762593185P | 2017-11-30 | 2017-11-30 | |
| US62/593,185 | 2017-11-30 | ||
| US201862675581P | 2018-05-23 | 2018-05-23 | |
| US62/675,581 | 2018-05-23 | ||
| PCT/US2018/041230 WO2019014100A1 (en) | 2017-07-10 | 2018-07-09 | ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2020526534A JP2020526534A (ja) | 2020-08-31 |
| JP2020526534A5 true JP2020526534A5 (enExample) | 2021-09-02 |
| JPWO2019014100A5 JPWO2019014100A5 (enExample) | 2022-11-02 |
| JP7258009B2 JP7258009B2 (ja) | 2023-04-14 |
Family
ID=63036419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020500862A Active JP7258009B2 (ja) | 2017-07-10 | 2018-07-09 | 抗増殖化合物及びその使用方法 |
Country Status (28)
| Country | Link |
|---|---|
| US (5) | US10357489B2 (enExample) |
| EP (2) | EP4467143A3 (enExample) |
| JP (1) | JP7258009B2 (enExample) |
| KR (1) | KR102656934B1 (enExample) |
| CN (1) | CN110869021B (enExample) |
| AU (2) | AU2018301335B2 (enExample) |
| CA (1) | CA3069138A1 (enExample) |
| CL (1) | CL2020000060A1 (enExample) |
| CO (1) | CO2020000193A2 (enExample) |
| DK (1) | DK3651766T3 (enExample) |
| EC (1) | ECSP20001149A (enExample) |
| ES (1) | ES2992913T3 (enExample) |
| FI (1) | FI3651766T3 (enExample) |
| HR (1) | HRP20241553T1 (enExample) |
| HU (1) | HUE069137T2 (enExample) |
| IL (1) | IL271889B2 (enExample) |
| LT (1) | LT3651766T (enExample) |
| MX (1) | MX2023000085A (enExample) |
| PL (1) | PL3651766T3 (enExample) |
| PT (1) | PT3651766T (enExample) |
| RS (1) | RS66162B1 (enExample) |
| SA (1) | SA520411007B1 (enExample) |
| SG (1) | SG11202000143PA (enExample) |
| SI (1) | SI3651766T1 (enExample) |
| SM (1) | SMT202400470T1 (enExample) |
| TW (2) | TWI830576B (enExample) |
| WO (1) | WO2019014100A1 (enExample) |
| ZA (1) | ZA202000157B (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10357489B2 (en) * | 2017-07-10 | 2019-07-23 | Celgene Corporation | Antiproliferative compounds and methods of use thereof |
| KR20210018199A (ko) | 2018-03-26 | 2021-02-17 | 씨4 테라퓨틱스, 인코포레이티드 | 이카로스의 분해를 위한 세레블론 결합제 |
| EP4272737A3 (en) | 2018-04-23 | 2024-01-17 | Celgene Corporation | Substituted 4-aminoisoindoline-1,3-dione compounds and their use for treating lymphoma |
| CN113713095B (zh) * | 2018-05-23 | 2025-07-15 | 细胞基因公司 | 用于组合使用的抗增殖化合物和针对bcma和cd3的双特异性抗体 |
| US10969381B2 (en) | 2018-05-23 | 2021-04-06 | Celgene Corporation | Methods for treating multiple myeloma and the use of companion biomarkers for 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile |
| MX2021005366A (es) | 2018-11-08 | 2021-09-10 | Juno Therapeutics Inc | Metodos y combinaciones para el tratamiento y modulacion de celulas t. |
| FI3908281T3 (fi) * | 2019-01-09 | 2024-10-01 | Celgene Corp | Antiproliferatiivisia yhdisteitä ja toisia aktiivisia aineita käytettäväksi multippelin myelooman hoidossa |
| CN118324742A (zh) * | 2019-01-09 | 2024-07-12 | 细胞基因公司 | 包含氧代异吲哚化合物及其盐的固体形式,以及包含它们的组合物和它们的使用方法 |
| US11779580B2 (en) * | 2019-01-09 | 2023-10-10 | Celgene Corporation | Pharmaceutical compositions comprising (s)-4-(4-(4- (((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrtle and methods of using the |
| KR20210152515A (ko) | 2019-04-12 | 2021-12-15 | 씨4 테라퓨틱스, 인코포레이티드 | 이카로스 및 아이올로스의 트리시클릭 분해제 |
| AR119715A1 (es) | 2019-04-12 | 2022-01-05 | Celgene Corp | Métodos para tratar linfoma no hodgkin con el uso de 2-(2,6-dioxopiperidin-3-il)-4-((2-fluoro-4-((3-morfolinoazetidin-1-il)metil)bencil)amino)isoindolin-1,3-diona |
| WO2021080935A1 (en) | 2019-10-21 | 2021-04-29 | Celgene Corporation | Methods of treating hematological malignancies using 2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benz yl)amino)isoindoline-1,3-dione |
| US20230065745A1 (en) | 2019-11-27 | 2023-03-02 | Captor Therapeutics S.A. | Piperidine-2,6-dione derivatives which bind to cereblon, and methods of use thereof |
| AU2020392427B2 (en) | 2019-11-27 | 2024-03-07 | Captor Therapeutics S.A. | Piperidine-2, 6-dione derivatives which bind to cereblon, and methods of use thereof |
| JP7408819B2 (ja) | 2020-01-20 | 2024-01-05 | カング バイオファーマシューティカルズ リミテッド | イソインドリン誘導体、並びにその医薬組成物及び使用 |
| IL297139A (en) * | 2020-04-17 | 2022-12-01 | Escient Pharmaceuticals Inc | Modulators of mas-related g-protein receptor x4 and related products and methods |
| EP4142723A2 (en) * | 2020-04-28 | 2023-03-08 | Juno Therapeutics, Inc. | Combination of bcma-directed t cell therapy and an immunomodulatory compound |
| JP2023524068A (ja) * | 2020-04-30 | 2023-06-08 | ブリストル－マイヤーズ スクイブ カンパニー | サイトカイン関連有害事象を治療する方法 |
| JP2023531512A (ja) | 2020-06-25 | 2023-07-24 | セルジーン コーポレーション | 併用療法を用いて癌を治療するための方法 |
| CN113896711A (zh) * | 2020-07-06 | 2022-01-07 | 北京诺诚健华医药科技有限公司 | 杂环类免疫调节剂 |
| DK4178548T3 (da) * | 2020-07-07 | 2024-08-19 | Celgene Corp | Farmaceutiske sammensætninger omfattende (S)-4-(4-(4-(((2-(2,6-DIOXOPIPERIDIN-3-YL)-1-OXOISOINDOLIN-4-YL)OXY)METHYL)BENZYL)PIPERAZIN-1-YL)-3-FLUORBENZONITRIL |
| AU2021314401A1 (en) * | 2020-07-20 | 2023-03-09 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Sulfur-containing isoindoline derivative, and preparation method therefor and medical use thereof |
| BR112023001956A2 (pt) | 2020-08-03 | 2023-02-28 | Captor Therapeutics S A | Composto de fórmula (ia), (ib), (ic) ou (ii), composição farmacêutica, composto para uso ou composição farmacêutica para uso em um método de tratamento de câncer |
| WO2022146151A1 (en) | 2020-12-30 | 2022-07-07 | Captor Therapeutics S.A. | Novel compounds which bind to cereblon, and methods of use thereof |
| CN114685429A (zh) * | 2020-12-31 | 2022-07-01 | 江苏恒瑞医药股份有限公司 | 碳链环己二酰亚胺类化合物、其制备方法及其在医药上的应用 |
| WO2022152821A1 (en) | 2021-01-13 | 2022-07-21 | Monte Rosa Therapeutics Ag | Isoindolinone compounds |
| EP4347037A1 (en) * | 2021-05-27 | 2024-04-10 | Celgene Corporation | Methods of treating multiple myeloma using combination therapy |
| WO2022255890A1 (en) | 2021-06-01 | 2022-12-08 | Captor Therapeutics S.A. | Compounds which bind to cereblon, and use thereof |
| WO2022255889A1 (en) | 2021-06-01 | 2022-12-08 | Captor Therapeutics S.A. | Compounds which bind to cereblon, and use thereof |
| CA3223636A1 (en) | 2021-08-06 | 2023-02-09 | Christopher Walton CARROLL | Compositions and methods for selective degradation of engineered proteins |
| CN116023319A (zh) * | 2021-10-25 | 2023-04-28 | 英格尔医药科技(上海)有限公司 | 制备布瓦西坦的方法 |
| CA3248757A1 (en) * | 2022-01-19 | 2025-07-09 | Jiangsu Hengrui Pharmaceuticals Co Ltd | CRYSTALLINE FORM OF A SULFUR-CONTAINING ISOINDOLINE DERIVATIVE |
| WO2024167423A1 (en) | 2023-02-07 | 2024-08-15 | Captor Therapeutics S.A. | Gspt1 degrader compounds |
Family Cites Families (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0011313A1 (en) | 1977-07-09 | 1980-05-28 | LUCAS INDUSTRIES public limited company | Road vehicle electrical systems |
| DE2848746A1 (de) | 1978-11-10 | 1980-05-22 | Wolfgang Arheiliger | Dichtung fuer eine schwellenlose tuere mit drehfluegel |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| US6051227A (en) | 1995-07-25 | 2000-04-18 | The Regents Of The University Of California, Office Of Technology Transfer | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| US5811097A (en) | 1995-07-25 | 1998-09-22 | The Regents Of The University Of California | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| US5855887A (en) | 1995-07-25 | 1999-01-05 | The Regents Of The University Of California | Blockade of lymphocyte down-regulation associated with CTLA-4 signaling |
| US5948893A (en) | 1996-01-17 | 1999-09-07 | The United States Of America As Represented By The Secretary Of The Navy | Murine hybridoma and antibody binding to CD28 receptor secreted by the hybridoma and method of using the antibody |
| US6207157B1 (en) | 1996-04-23 | 2001-03-27 | The United States Of America As Represented By The Department Of Health And Human Services | Conjugate vaccine for nontypeable Haemophilus influenzae |
| WO2000034437A2 (en) | 1998-12-08 | 2000-06-15 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| EE05627B1 (et) | 1998-12-23 | 2013-02-15 | Pfizer Inc. | CTLA-4 vastased inimese monoklonaalsed antikehad |
| EP1212422B1 (en) | 1999-08-24 | 2007-02-21 | Medarex, Inc. | Human ctla-4 antibodies and their uses |
| US7605238B2 (en) | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
| CA2466279A1 (en) | 2001-11-13 | 2003-05-22 | Dana-Farber Cancer Institute, Inc. | Agents that modulate immune cell activation and methods of use thereof |
| CN101899114A (zh) | 2002-12-23 | 2010-12-01 | 惠氏公司 | 抗pd-1抗体及其用途 |
| GB0325956D0 (en) | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
| US20060074103A1 (en) | 2004-10-06 | 2006-04-06 | Corte James R | Cyclic beta-amino acid derivatives as factor Xa inhibitors |
| CN109485727A (zh) | 2005-05-09 | 2019-03-19 | 小野药品工业株式会社 | 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法 |
| KR101411165B1 (ko) | 2005-07-01 | 2014-06-25 | 메다렉스, 엘.엘.시. | 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날항체 |
| GB0514018D0 (en) | 2005-07-07 | 2005-08-17 | Ionix Pharmaceuticals Ltd | Chemical compounds |
| RU2396265C2 (ru) | 2006-02-17 | 2010-08-10 | Ф. Хоффманн-Ля Рош Аг | Производные бензоилпиперидина в качестве модуляторов рецепторов 5ht2 и d3 |
| WO2008091670A2 (en) | 2007-01-24 | 2008-07-31 | Polyera Corporation | Organic semiconductor materials and precursors thereof |
| EP2142534B1 (en) | 2007-03-20 | 2016-08-10 | Celgene Corporation | 4'-o-substituted isoindoline derivatives and compositions comprising and methods of using the same |
| NZ600758A (en) | 2007-06-18 | 2013-09-27 | Merck Sharp & Dohme | Antibodies to human programmed death receptor pd-1 |
| EP2262837A4 (en) | 2008-03-12 | 2011-04-06 | Merck Sharp & Dohme | PD-1 BINDING PROTEINS |
| ES2592216T3 (es) | 2008-09-26 | 2016-11-28 | Dana-Farber Cancer Institute, Inc. | Anticuerpos anti-PD-1, PD-L1 y PD-L2 humanos y sus usos |
| US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| WO2010057087A1 (en) | 2008-11-17 | 2010-05-20 | Plextronics, Inc. | Organic photovoltaic devices comprising substituted endohedral metallofullerenes |
| WO2010077634A1 (en) | 2008-12-09 | 2010-07-08 | Genentech, Inc. | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| CA2744563A1 (en) | 2008-12-12 | 2010-06-17 | Ariad Pharmaceuticals, Inc. | Azaindole derivatives as kinase inhibitors |
| US8741295B2 (en) | 2009-02-09 | 2014-06-03 | Universite De La Mediterranee | PD-1 antibodies and PD-L1 antibodies and uses thereof |
| US20130017199A1 (en) | 2009-11-24 | 2013-01-17 | AMPLIMMUNE ,Inc. a corporation | Simultaneous inhibition of pd-l1/pd-l2 |
| US20130022629A1 (en) | 2010-01-04 | 2013-01-24 | Sharpe Arlene H | Modulators of Immunoinhibitory Receptor PD-1, and Methods of Use Thereof |
| SG10201501062SA (en) * | 2010-02-11 | 2015-04-29 | Celgene Corp | Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same |
| WO2011146401A1 (en) | 2010-05-17 | 2011-11-24 | Intermune, Inc. | Novel inhibitors of hepatitis c virus replication |
| US9163087B2 (en) | 2010-06-18 | 2015-10-20 | The Brigham And Women's Hospital, Inc. | Bi-specific antibodies against TIM-3 and PD-1 for immunotherapy in chronic immune conditions |
| US8907053B2 (en) | 2010-06-25 | 2014-12-09 | Aurigene Discovery Technologies Limited | Immunosuppression modulating compounds |
| ES2612503T3 (es) | 2010-09-14 | 2017-05-17 | Exelixis, Inc. | Compuestos 9H-purina como inhibidores de PI3K-delta y métodos para su preparación |
| JP5728921B2 (ja) | 2010-12-10 | 2015-06-03 | コニカミノルタ株式会社 | 光学フィルム、及びそれを用いた偏光板、液晶表示装置 |
| WO2012080729A2 (en) | 2010-12-14 | 2012-06-21 | Electrophoretics Limited | CASEIN KINASE 1δ (CK1δ) INHIBITORS |
| AU2012236655B2 (en) | 2011-03-28 | 2016-09-22 | Deuterx, Llc, | 2',6'-dioxo-3'-deutero-piperdin-3-yl-isoindoline compounds |
| WO2012138734A1 (en) | 2011-04-07 | 2012-10-11 | Merck Sharp & Dohme Corp. | C5-c6 oxacyclic-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
| TW201408652A (zh) | 2012-07-11 | 2014-03-01 | Hoffmann La Roche | 作爲ＲＯＲｃ調節劑之芳基磺內醯胺衍生物 |
| EP2882442B1 (en) | 2012-08-09 | 2021-06-09 | Celgene Corporation | Methods of treating cancer using 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione |
| US9682952B2 (en) | 2012-09-04 | 2017-06-20 | Celgene Corporation | Isotopologues of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl) piperidine-2-6-dione and methods of preparation thereof |
| WO2014116573A1 (en) | 2013-01-22 | 2014-07-31 | Celgene Corporation | Processes for the preparation of isotopologues of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and pharmaceutically acceptable salts thereof |
| US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| CN113244205A (zh) | 2013-08-22 | 2021-08-13 | 万达制药公司 | 多发性骨髓瘤的治疗 |
| WO2016012965A2 (en) | 2014-07-25 | 2016-01-28 | Piramal Enterprises Limited | Substituted phenyl alkanoic acid compounds as gpr120 agonists and uses thereof |
| WO2016019386A1 (en) | 2014-08-01 | 2016-02-04 | Green Revolution Cooling, Inc. | Controller for oil-cooled rack with multiple modes of operation |
| EP3310169B1 (en) | 2015-05-30 | 2023-05-17 | PTC Therapeutics, Inc. | Methods for modulating rna splicing |
| HK1250235A1 (zh) | 2015-07-08 | 2018-12-07 | F. Hoffmann-La Roche Ag | 作为rorc调节剂的芳基磺内酰胺衍生物 |
| EP3429591B1 (en) | 2016-03-16 | 2023-03-15 | Kura Oncology, Inc. | Substituted thieno[2,3-d]pyrimidine derivatives as inhibitors of menin-mll and methods of use |
| KR102387316B1 (ko) | 2016-04-06 | 2022-04-15 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | Mdm2 단백질 분해제 |
| US20190054097A1 (en) | 2016-04-21 | 2019-02-21 | Bioventures, Llc | Compositions targeting senescent cells and the uses thereof |
| KR102447884B1 (ko) | 2016-04-21 | 2022-09-27 | 바이오벤처스, 엘엘씨 | 항-세포자멸적 bcl-2 계열 단백질의 열화를 유도하는 화합물 및 이의 용도 |
| CN109642048A (zh) | 2016-08-30 | 2019-04-16 | 陶氏环球技术有限责任公司 | 减小丙烯醛浓度的方法 |
| AU2017343565A1 (en) | 2016-10-10 | 2019-05-30 | Cellerant Therapeutics, Inc. | Isoquinolidinobenzodiazepine (IQB)-1(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimers |
| HUE070289T2 (hu) | 2016-10-11 | 2025-05-28 | Arvinas Operations Inc | Vegyületek és módszerek az androgénreceptor célzott lebontására |
| ES2916335T3 (es) | 2016-10-20 | 2022-06-30 | Celgene Corp | Receptores de antígeno quimérico heterodimerizable basados en cereblon |
| CA3045037A1 (en) | 2016-12-08 | 2018-06-14 | Icahn School Of Medicine At Mount Sinai | Compositions and methods for treating cdk4/6-mediated cancer |
| EP3577109A4 (en) | 2017-01-31 | 2020-11-18 | Arvinas Operations, Inc. | CEREMONY LIGANDS AND BIFUNCTIONAL COMPOUNDS CONTAINING THEM |
| US10357489B2 (en) * | 2017-07-10 | 2019-07-23 | Celgene Corporation | Antiproliferative compounds and methods of use thereof |
| US10513515B2 (en) | 2017-08-25 | 2019-12-24 | Biotheryx, Inc. | Ether compounds and uses thereof |
| JP7565078B2 (ja) | 2017-12-13 | 2024-10-10 | 上海科技大学 | Ａｌｋタンパク質分解剤及びそれらの癌療法における使用 |
| CN113713095B (zh) * | 2018-05-23 | 2025-07-15 | 细胞基因公司 | 用于组合使用的抗增殖化合物和针对bcma和cd3的双特异性抗体 |
| CN108690020A (zh) | 2018-07-04 | 2018-10-23 | 清华大学 | 一种靶向降解bet蛋白的化合物及其应用 |
| CN108794453A (zh) | 2018-07-05 | 2018-11-13 | 清华大学 | 一种靶向降解fak蛋白的化合物及其应用 |
-
2018
- 2018-07-09 US US16/030,695 patent/US10357489B2/en active Active
- 2018-07-09 CN CN201880045745.6A patent/CN110869021B/zh active Active
- 2018-07-09 SI SI201831174T patent/SI3651766T1/sl unknown
- 2018-07-09 TW TW112101268A patent/TWI830576B/zh active
- 2018-07-09 ES ES18746444T patent/ES2992913T3/es active Active
- 2018-07-09 KR KR1020207003734A patent/KR102656934B1/ko active Active
- 2018-07-09 HU HUE18746444A patent/HUE069137T2/hu unknown
- 2018-07-09 SM SM20240470T patent/SMT202400470T1/it unknown
- 2018-07-09 PL PL18746444.1T patent/PL3651766T3/pl unknown
- 2018-07-09 RS RS20241263A patent/RS66162B1/sr unknown
- 2018-07-09 JP JP2020500862A patent/JP7258009B2/ja active Active
- 2018-07-09 DK DK18746444.1T patent/DK3651766T3/da active
- 2018-07-09 CA CA3069138A patent/CA3069138A1/en active Pending
- 2018-07-09 LT LTEPPCT/US2018/041230T patent/LT3651766T/lt unknown
- 2018-07-09 FI FIEP18746444.1T patent/FI3651766T3/fi active
- 2018-07-09 PT PT187464441T patent/PT3651766T/pt unknown
- 2018-07-09 WO PCT/US2018/041230 patent/WO2019014100A1/en not_active Ceased
- 2018-07-09 IL IL271889A patent/IL271889B2/en unknown
- 2018-07-09 HR HRP20241553TT patent/HRP20241553T1/hr unknown
- 2018-07-09 AU AU2018301335A patent/AU2018301335B2/en active Active
- 2018-07-09 EP EP24192984.3A patent/EP4467143A3/en active Pending
- 2018-07-09 SG SG11202000143PA patent/SG11202000143PA/en unknown
- 2018-07-09 EP EP18746444.1A patent/EP3651766B1/en active Active
- 2018-07-09 TW TW107123698A patent/TWI791552B/zh active
-
2019
- 2019-06-03 US US16/430,189 patent/US10675281B2/en active Active
-
2020
- 2020-01-08 SA SA520411007A patent/SA520411007B1/ar unknown
- 2020-01-08 EC ECSENADI20201149A patent/ECSP20001149A/es unknown
- 2020-01-09 CL CL2020000060A patent/CL2020000060A1/es unknown
- 2020-01-09 ZA ZA2020/00157A patent/ZA202000157B/en unknown
- 2020-01-09 CO CONC2020/0000193A patent/CO2020000193A2/es unknown
- 2020-01-10 MX MX2023000085A patent/MX2023000085A/es unknown
- 2020-04-27 US US16/859,357 patent/US11185543B2/en active Active
-
2021
- 2021-11-08 US US17/521,432 patent/US12029738B2/en active Active
-
2022
- 2022-12-13 AU AU2022287569A patent/AU2022287569B2/en active Active
-
2024
- 2024-01-23 US US18/419,894 patent/US20240207255A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020526534A5 (enExample) | ||
| JPWO2019014100A5 (enExample) | ||
| HRP20241553T1 (hr) | 4-(4-(4-(((2-(2,6-dioksopiperidin-3-il)-l-oksoizoindolin-4-il)oksi)metil)benzil)piperazin-l-il)-3-fluorobenzonitril kao antiproliferativni spoj | |
| JP2020503374A5 (enExample) | ||
| JP5661037B2 (ja) | 結核についての併用療法 | |
| CN101142198B (zh) | 用于治疗疾病的异*唑坎布雷它斯丁衍生物 | |
| JP2015509535A5 (enExample) | ||
| JP2016512531A5 (enExample) | ||
| JP5167241B2 (ja) | 癌の処置用のヒストンデアセチラーゼ阻害剤としての、ｎ−ヒドロキシ−３−（４−｛３−フェニル−ｓ−オキソ−プロペニル｝−フェニル）−アクリルアミド誘導体及びその関連化合物 | |
| JP6595078B2 (ja) | アミノカルボニルカルバメート化合物 | |
| JP2016517851A5 (enExample) | ||
| RU2011136537A (ru) | Кристаллическая форма (r)-3-(4-(2-метилтетразол-5-ил)пиридин-5-ил)-3-фторфенил)-5-гидроксиметил оксазолидин-2-он диводород фосфата | |
| JP2019518050A5 (enExample) | ||
| IL205501A (en) | Preparation of preparations for the treatment of arthritis | |
| JP2007507494A5 (enExample) | ||
| JP2013542267A5 (enExample) | ||
| JP2020111571A5 (enExample) | ||
| EA034992B1 (ru) | Комбинации лекарственных средств для лечения множественной миеломы | |
| JP2019520344A5 (enExample) | ||
| CA2526989A1 (en) | Hydroxyamidine and hydroxyguanidine compounds as urokinase inhibitors | |
| RU2016150537A (ru) | Новые соединения | |
| JP2015522592A5 (enExample) | ||
| JP2016523830A5 (enExample) | ||
| JP2009040767A5 (enExample) | ||
| JP2018530617A5 (enExample) |