JPWO2019014100A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2019014100A5 JPWO2019014100A5 JP2020500862A JP2020500862A JPWO2019014100A5 JP WO2019014100 A5 JPWO2019014100 A5 JP WO2019014100A5 JP 2020500862 A JP2020500862 A JP 2020500862A JP 2020500862 A JP2020500862 A JP 2020500862A JP WO2019014100 A5 JPWO2019014100 A5 JP WO2019014100A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutical composition
- multiple myeloma
- administered
- active agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 31
- 208000034578 Multiple myelomas Diseases 0.000 claims description 11
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 9
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims description 6
- 229910052805 deuterium Inorganic materials 0.000 claims description 6
- 229940125782 compound 2 Drugs 0.000 claims description 5
- 229940125904 compound 1 Drugs 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 27
- 239000013543 active substance Substances 0.000 claims 10
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 6
- 229960003957 dexamethasone Drugs 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 4
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 claims 3
- 101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 claims 3
- 229960002204 daratumumab Drugs 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 208000034951 Genetic Translocation Diseases 0.000 claims 2
- 229960001467 bortezomib Drugs 0.000 claims 2
- GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 claims 2
- 229960002438 carfilzomib Drugs 0.000 claims 2
- BLMPQMFVWMYDKT-NZTKNTHTSA-N carfilzomib Chemical group C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)[C@]1(C)OC1)NC(=O)CN1CCOCC1)CC1=CC=CC=C1 BLMPQMFVWMYDKT-NZTKNTHTSA-N 0.000 claims 2
- 108010021331 carfilzomib Proteins 0.000 claims 2
- 231100000590 oncogenic Toxicity 0.000 claims 2
- 230000002246 oncogenic effect Effects 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- PKYIMGFMRFVOMB-LDLOPFEMSA-N (2R)-2-[5-[3-chloro-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy]phenyl]propanoic acid Chemical compound COc1ccccc1-c1nccc(COc2ccccc2C[C@@H](Oc2ncnc3sc(c(-c4ccc(OCCN5CCN(C)CC5)c(Cl)c4C)c23)-c2ccc(F)cc2)C(O)=O)n1 PKYIMGFMRFVOMB-LDLOPFEMSA-N 0.000 claims 1
- QRDAPCMJAOQZSU-KQQUZDAGSA-N (e)-3-[4-[(e)-3-(3-fluorophenyl)-3-oxoprop-1-enyl]-1-methylpyrrol-2-yl]-n-hydroxyprop-2-enamide Chemical compound C1=C(\C=C\C(=O)NO)N(C)C=C1\C=C\C(=O)C1=CC=CC(F)=C1 QRDAPCMJAOQZSU-KQQUZDAGSA-N 0.000 claims 1
- VLIUIBXPEDFJRF-UHFFFAOYSA-N 2-(n-(2-chlorophenyl)anilino)-n-[7-(hydroxyamino)-7-oxoheptyl]pyrimidine-5-carboxamide Chemical group N1=CC(C(=O)NCCCCCCC(=O)NO)=CN=C1N(C=1C(=CC=CC=1)Cl)C1=CC=CC=C1 VLIUIBXPEDFJRF-UHFFFAOYSA-N 0.000 claims 1
- AAAQFGUYHFJNHI-SFHVURJKSA-N 2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide Chemical compound N([C@H](C1=NN=C(C)N1C1=CC=C(OC)C=C11)CC(=O)NCC)=C1C1=CC=C(Cl)C=C1 AAAQFGUYHFJNHI-SFHVURJKSA-N 0.000 claims 1
- VMOBEAUQUPPPON-UHFFFAOYSA-N 3-fluoro-4-piperazin-1-ylbenzonitrile Chemical compound FC1=CC(C#N)=CC=C1N1CCNCC1 VMOBEAUQUPPPON-UHFFFAOYSA-N 0.000 claims 1
- UWZAJPITKGWMFJ-UHFFFAOYSA-N 4-[2-(cyclopropylmethoxy)-5-methylsulfonylphenyl]-2-methylisoquinolin-1-one Chemical compound Cn1cc(-c2cc(ccc2OCC2CC2)S(C)(=O)=O)c2ccccc2c1=O UWZAJPITKGWMFJ-UHFFFAOYSA-N 0.000 claims 1
- 239000012664 BCL-2-inhibitor Substances 0.000 claims 1
- 229940123711 Bcl2 inhibitor Drugs 0.000 claims 1
- JQNINBDKGLWYMU-GEAQBIRJSA-N CO[C@H]1\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)C2=CC3=C(OC[C@]4(CCCC5=C4C=CC(Cl)=C5)CN3C[C@@H]3CC[C@@H]13)C=C2 Chemical compound CO[C@H]1\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)C2=CC3=C(OC[C@]4(CCCC5=C4C=CC(Cl)=C5)CN3C[C@@H]3CC[C@@H]13)C=C2 JQNINBDKGLWYMU-GEAQBIRJSA-N 0.000 claims 1
- 102000003910 Cyclin D Human genes 0.000 claims 1
- 108090000259 Cyclin D Proteins 0.000 claims 1
- 102000006311 Cyclin D1 Human genes 0.000 claims 1
- 108010058546 Cyclin D1 Proteins 0.000 claims 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 1
- 102100027842 Fibroblast growth factor receptor 3 Human genes 0.000 claims 1
- 101710182396 Fibroblast growth factor receptor 3 Proteins 0.000 claims 1
- 101001056180 Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1 Proteins 0.000 claims 1
- 101000979190 Homo sapiens Transcription factor MafB Proteins 0.000 claims 1
- 102100026539 Induced myeloid leukemia cell differentiation protein Mcl-1 Human genes 0.000 claims 1
- 229940123628 Lysine (K)-specific demethylase 1A inhibitor Drugs 0.000 claims 1
- -1 MMset Proteins 0.000 claims 1
- NBAIXBAUHIQQGF-UHFFFAOYSA-N NC1CCN(CC1)C=1N(C(C(=C(N1)C1=CC(=C(C#N)C=C1)F)C1=CC(=C(C=C1)OC)F)=O)C Chemical compound NC1CCN(CC1)C=1N(C(C(=C(N1)C1=CC(=C(C#N)C=C1)F)C1=CC(=C(C=C1)OC)F)=O)C NBAIXBAUHIQQGF-UHFFFAOYSA-N 0.000 claims 1
- 229940079156 Proteasome inhibitor Drugs 0.000 claims 1
- 102100023234 Transcription factor MafB Human genes 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 229940124660 anti-multiple myeloma Drugs 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 229940125763 bromodomain inhibitor Drugs 0.000 claims 1
- 238000009108 consolidation therapy Methods 0.000 claims 1
- 229960004397 cyclophosphamide Drugs 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 229960004679 doxorubicin Drugs 0.000 claims 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 1
- 229960005420 etoposide Drugs 0.000 claims 1
- 238000009093 first-line therapy Methods 0.000 claims 1
- 229940121372 histone deacetylase inhibitor Drugs 0.000 claims 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 229960004942 lenalidomide Drugs 0.000 claims 1
- GOTYRUGSSMKFNF-UHFFFAOYSA-N lenalidomide Chemical compound C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O GOTYRUGSSMKFNF-UHFFFAOYSA-N 0.000 claims 1
- 238000009115 maintenance therapy Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- AICOOMRHRUFYCM-ZRRPKQBOSA-N oxazine, 1 Chemical compound C([C@@H]1[C@H](C(C[C@]2(C)[C@@H]([C@H](C)N(C)C)[C@H](O)C[C@]21C)=O)CC1=CC2)C[C@H]1[C@@]1(C)[C@H]2N=C(C(C)C)OC1 AICOOMRHRUFYCM-ZRRPKQBOSA-N 0.000 claims 1
- 229960005184 panobinostat Drugs 0.000 claims 1
- FWZRWHZDXBDTFK-ZHACJKMWSA-N panobinostat Chemical compound CC1=NC2=CC=C[CH]C2=C1CCNCC1=CC=C(\C=C\C(=O)NO)C=C1 FWZRWHZDXBDTFK-ZHACJKMWSA-N 0.000 claims 1
- 229960000688 pomalidomide Drugs 0.000 claims 1
- UVSMNLNDYGZFPF-UHFFFAOYSA-N pomalidomide Chemical compound O=C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O UVSMNLNDYGZFPF-UHFFFAOYSA-N 0.000 claims 1
- 239000003207 proteasome inhibitor Substances 0.000 claims 1
- 229940125092 pulrodemstat Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 229940125327 trotabresib Drugs 0.000 claims 1
- LQBVNQSMGBZMKD-UHFFFAOYSA-N venetoclax Chemical compound C=1C=C(Cl)C=CC=1C=1CC(C)(C)CCC=1CN(CC1)CCN1C(C=C1OC=2C=C3C=CNC3=NC=2)=CC=C1C(=O)NS(=O)(=O)C(C=C1[N+]([O-])=O)=CC=C1NCC1CCOCC1 LQBVNQSMGBZMKD-UHFFFAOYSA-N 0.000 claims 1
- 229960001183 venetoclax Drugs 0.000 claims 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 1
- 229960004528 vincristine Drugs 0.000 claims 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 1
- 230000000155 isotopic effect Effects 0.000 description 6
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- QGZKDVFQNNGYKY-OUBTZVSYSA-N Ammonia-15N Chemical compound [15NH3] QGZKDVFQNNGYKY-OUBTZVSYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-OUBTZVSYSA-N Carbon-13 Chemical compound [13C] OKTJSMMVPCPJKN-OUBTZVSYSA-N 0.000 description 1
- 229940126214 compound 3 Drugs 0.000 description 1
- 239000000032 diagnostic agent Substances 0.000 description 1
- 229940039227 diagnostic agent Drugs 0.000 description 1
- 239000012216 imaging agent Substances 0.000 description 1
- 238000011503 in vivo imaging Methods 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762530778P | 2017-07-10 | 2017-07-10 | |
| US62/530,778 | 2017-07-10 | ||
| US201762593185P | 2017-11-30 | 2017-11-30 | |
| US62/593,185 | 2017-11-30 | ||
| US201862675581P | 2018-05-23 | 2018-05-23 | |
| US62/675,581 | 2018-05-23 | ||
| PCT/US2018/041230 WO2019014100A1 (en) | 2017-07-10 | 2018-07-09 | ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2020526534A JP2020526534A (ja) | 2020-08-31 |
| JP2020526534A5 JP2020526534A5 (enExample) | 2021-09-02 |
| JPWO2019014100A5 true JPWO2019014100A5 (enExample) | 2022-11-02 |
| JP7258009B2 JP7258009B2 (ja) | 2023-04-14 |
Family
ID=63036419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020500862A Active JP7258009B2 (ja) | 2017-07-10 | 2018-07-09 | 抗増殖化合物及びその使用方法 |
Country Status (28)
| Country | Link |
|---|---|
| US (5) | US10357489B2 (enExample) |
| EP (2) | EP4467143A3 (enExample) |
| JP (1) | JP7258009B2 (enExample) |
| KR (1) | KR102656934B1 (enExample) |
| CN (1) | CN110869021B (enExample) |
| AU (2) | AU2018301335B2 (enExample) |
| CA (1) | CA3069138A1 (enExample) |
| CL (1) | CL2020000060A1 (enExample) |
| CO (1) | CO2020000193A2 (enExample) |
| DK (1) | DK3651766T3 (enExample) |
| EC (1) | ECSP20001149A (enExample) |
| ES (1) | ES2992913T3 (enExample) |
| FI (1) | FI3651766T3 (enExample) |
| HR (1) | HRP20241553T1 (enExample) |
| HU (1) | HUE069137T2 (enExample) |
| IL (1) | IL271889B2 (enExample) |
| LT (1) | LT3651766T (enExample) |
| MX (1) | MX2023000085A (enExample) |
| PL (1) | PL3651766T3 (enExample) |
| PT (1) | PT3651766T (enExample) |
| RS (1) | RS66162B1 (enExample) |
| SA (1) | SA520411007B1 (enExample) |
| SG (1) | SG11202000143PA (enExample) |
| SI (1) | SI3651766T1 (enExample) |
| SM (1) | SMT202400470T1 (enExample) |
| TW (2) | TWI791552B (enExample) |
| WO (1) | WO2019014100A1 (enExample) |
| ZA (1) | ZA202000157B (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3651766T3 (pl) * | 2017-07-10 | 2025-03-03 | Celgene Corporation | 4-(4-(4-(((2-(2,6-dioksopiperydyn-3-ylo)-1-oksoizoindolin-4-ylo)oksy)metylo)benzylo)piperazyn-1-ylo)-3-fluorobenzonitryl jako związek przeciwproliferacyjny |
| WO2019191112A1 (en) | 2018-03-26 | 2019-10-03 | C4 Therapeutics, Inc. | Cereblon binders for the degradation of ikaros |
| MX2020011183A (es) * | 2018-04-23 | 2020-11-12 | Celgene Corp | Compuestos de 4-aminoisoindolina-1,3-diona sustituidos y su uso para el tratamiento de linfoma. |
| US10969381B2 (en) * | 2018-05-23 | 2021-04-06 | Celgene Corporation | Methods for treating multiple myeloma and the use of companion biomarkers for 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile |
| HRP20230449T1 (hr) * | 2018-05-23 | 2023-07-21 | Celgene Corporation | Antiproliferativni spojevi i bispecifična protutijela protiv bcma i cd3 za kombiniranu upotrebu |
| AU2019377854A1 (en) | 2018-11-08 | 2021-05-27 | Juno Therapeutics, Inc. | Methods and combinations for treatment and T cell modulation |
| AU2020206694B2 (en) * | 2019-01-09 | 2025-05-22 | Celgene Corporation | Solid forms comprising (S)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl) benzyl)piperazin-1-yl)-3-fluorobenzonitrile and salts thereof, and compositions comprising and methods of using the same |
| KR20210113290A (ko) * | 2019-01-09 | 2021-09-15 | 셀진 코포레이션 | (s)-4-(4-(4-(((2-(2,6-다이옥소피페리딘-3-일)-1-옥소아이소인돌린-4-일)옥시)메틸)벤질)피페라진-1-일)-3-플루오로벤조나이트릴을 포함하는 약제학적 조성물 및 이의 사용 방법 |
| PL3908281T3 (pl) * | 2019-01-09 | 2024-11-25 | Celgene Corporation | Związki przeciwproliferacyjne i drugie środki aktywne do zastosowania w leczeniu szpiczaka mnogiego |
| EA202192738A1 (ru) | 2019-04-12 | 2022-03-17 | С4 Терапьютикс, Инк. | Трициклические соединения, обеспечивающие разрушение белка ikaros и белка aiolos |
| AR119715A1 (es) | 2019-04-12 | 2022-01-05 | Celgene Corp | Métodos para tratar linfoma no hodgkin con el uso de 2-(2,6-dioxopiperidin-3-il)-4-((2-fluoro-4-((3-morfolinoazetidin-1-il)metil)bencil)amino)isoindolin-1,3-diona |
| EP4048278B1 (en) | 2019-10-21 | 2023-11-01 | Celgene Corporation | Methods of treating hematological malignancies using 2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benz yl)amino)isoindoline-1,3-dione |
| KR20220106801A (ko) | 2019-11-27 | 2022-07-29 | 캡터 테라퓨틱스 에스.에이. | 세레블론에 결합하는 피페리딘-2,6-디온 유도체 및 이의 사용 방법 |
| WO2021105335A1 (en) | 2019-11-27 | 2021-06-03 | Captor Therapeutics S.A. | Piperidine-2, 6-dione derivatives which bind to cereblon, and methods of use thereof |
| CA3168456A1 (en) | 2020-01-20 | 2021-07-29 | Kangpu Biopharmaceuticals, Ltd. | Isoindoline derivative, and pharmaceutical composition and use thereof |
| CN115397412B (zh) * | 2020-04-17 | 2025-03-25 | 伊赛恩特制药公司 | Mas相关g蛋白受体x4的调节剂及相关产物和方法 |
| WO2021222330A2 (en) * | 2020-04-28 | 2021-11-04 | Juno Therapeutics, Inc. | Combination of bcma-directed t cell therapy and an immunomodulatory compound |
| US20230172923A1 (en) * | 2020-04-30 | 2023-06-08 | Bristol-Myers Squibb Company | Methods of treating cytokine-related adverse events |
| EP4171550A1 (en) | 2020-06-25 | 2023-05-03 | Celgene Corporation | Methods for treating cancer with combination therapies |
| CN113896711A (zh) * | 2020-07-06 | 2022-01-07 | 北京诺诚健华医药科技有限公司 | 杂环类免疫调节剂 |
| KR20230035598A (ko) * | 2020-07-07 | 2023-03-14 | 셀진 코포레이션 | (s)-4-(4-(4-(((2-(2,6-디옥소피페리딘-3-일)-1-옥소이소인돌린-4-일)옥시)메틸)벤질)피페라진-1-일)-3-플루오로벤조니트릴을 포함하는 약제학적 조성물 및 이를 사용하는 방법 |
| MX2023000868A (es) | 2020-07-20 | 2023-02-22 | Jiangsu Hengrui Pharmaceuticals Co Ltd | Derivado de isoindolina que contiene azufre, metodo de preparacion y uso medico del mismo. |
| IL300308A (en) | 2020-08-03 | 2023-04-01 | Captor Therapeutics S A | Low molecular weight protein complexes and their applications |
| WO2022146151A1 (en) | 2020-12-30 | 2022-07-07 | Captor Therapeutics S.A. | Novel compounds which bind to cereblon, and methods of use thereof |
| CN114685429A (zh) * | 2020-12-31 | 2022-07-01 | 江苏恒瑞医药股份有限公司 | 碳链环己二酰亚胺类化合物、其制备方法及其在医药上的应用 |
| MX2023008296A (es) | 2021-01-13 | 2023-09-29 | Monte Rosa Therapeutics Inc | Compuestos de isoindolinona. |
| BR112023022679A2 (pt) | 2021-05-27 | 2024-01-23 | Bristol Myers Squibb Co | Métodos de tratamento de mieloma múltiplo usando terapia combinada |
| WO2022255889A1 (en) | 2021-06-01 | 2022-12-08 | Captor Therapeutics S.A. | Compounds which bind to cereblon, and use thereof |
| WO2022255890A1 (en) | 2021-06-01 | 2022-12-08 | Captor Therapeutics S.A. | Compounds which bind to cereblon, and use thereof |
| IL309653A (en) | 2021-08-06 | 2024-02-01 | Celgene Corp | Composition and methods for selective degradation of transgenic proteins |
| CN116023319A (zh) * | 2021-10-25 | 2023-04-28 | 英格尔医药科技(上海)有限公司 | 制备布瓦西坦的方法 |
| AU2023210002A1 (en) * | 2022-01-19 | 2024-08-22 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Crystalline form of sulfur-containing isoindoline derivative |
| WO2024167423A1 (en) | 2023-02-07 | 2024-08-15 | Captor Therapeutics S.A. | Gspt1 degrader compounds |
Family Cites Families (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0011312A1 (en) | 1977-07-09 | 1980-05-28 | LUCAS INDUSTRIES public limited company | Road vehicle electrical systems |
| DE2848746A1 (de) | 1978-11-10 | 1980-05-22 | Wolfgang Arheiliger | Dichtung fuer eine schwellenlose tuere mit drehfluegel |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| US5855887A (en) | 1995-07-25 | 1999-01-05 | The Regents Of The University Of California | Blockade of lymphocyte down-regulation associated with CTLA-4 signaling |
| US5811097A (en) | 1995-07-25 | 1998-09-22 | The Regents Of The University Of California | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| US6051227A (en) | 1995-07-25 | 2000-04-18 | The Regents Of The University Of California, Office Of Technology Transfer | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| US5948893A (en) | 1996-01-17 | 1999-09-07 | The United States Of America As Represented By The Secretary Of The Navy | Murine hybridoma and antibody binding to CD28 receptor secreted by the hybridoma and method of using the antibody |
| US6207157B1 (en) | 1996-04-23 | 2001-03-27 | The United States Of America As Represented By The Department Of Health And Human Services | Conjugate vaccine for nontypeable Haemophilus influenzae |
| AU2477400A (en) | 1998-12-08 | 2000-06-26 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| EE05627B1 (et) | 1998-12-23 | 2013-02-15 | Pfizer Inc. | CTLA-4 vastased inimese monoklonaalsed antikehad |
| US7605238B2 (en) | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
| EP1212422B1 (en) | 1999-08-24 | 2007-02-21 | Medarex, Inc. | Human ctla-4 antibodies and their uses |
| CA2466279A1 (en) | 2001-11-13 | 2003-05-22 | Dana-Farber Cancer Institute, Inc. | Agents that modulate immune cell activation and methods of use thereof |
| BR0316880A (pt) | 2002-12-23 | 2005-10-25 | Wyeth Corp | Anticorpos contra pd-1 e usos dos mesmos |
| GB0325956D0 (en) | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
| US20060074103A1 (en) | 2004-10-06 | 2006-04-06 | Corte James R | Cyclic beta-amino acid derivatives as factor Xa inhibitors |
| EP2439273B1 (en) | 2005-05-09 | 2019-02-27 | Ono Pharmaceutical Co., Ltd. | Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics |
| KR101888321B1 (ko) | 2005-07-01 | 2018-08-13 | 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. | 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체 |
| GB0514018D0 (en) | 2005-07-07 | 2005-08-17 | Ionix Pharmaceuticals Ltd | Chemical compounds |
| ES2399447T3 (es) | 2006-02-17 | 2013-04-01 | F. Hoffmann-La Roche Ag | Derivados benzoil-piperidina como moduladores de 5HT2/D3 |
| WO2008091670A2 (en) | 2007-01-24 | 2008-07-31 | Polyera Corporation | Organic semiconductor materials and precursors thereof |
| BRPI0809011A8 (pt) | 2007-03-20 | 2019-01-15 | Celgene Corp | composto, composição farmacêutica, método de tratamento, controle ou prevenção de uma doença ou distúrbio, e, forma de dosagem unitária única |
| NZ600758A (en) | 2007-06-18 | 2013-09-27 | Merck Sharp & Dohme | Antibodies to human programmed death receptor pd-1 |
| US8168757B2 (en) | 2008-03-12 | 2012-05-01 | Merck Sharp & Dohme Corp. | PD-1 binding proteins |
| MX2011003195A (es) | 2008-09-26 | 2011-08-12 | Dana Farber Cancer Inst Inc | Anticuerpos anti-pd-1, pd-l1 y pd-l2 humanos y usos de los mismos. |
| US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| WO2010057087A1 (en) | 2008-11-17 | 2010-05-20 | Plextronics, Inc. | Organic photovoltaic devices comprising substituted endohedral metallofullerenes |
| US8217149B2 (en) | 2008-12-09 | 2012-07-10 | Genentech, Inc. | Anti-PD-L1 antibodies, compositions and articles of manufacture |
| WO2010068292A1 (en) | 2008-12-12 | 2010-06-17 | Ariad Pharmaceuticals, Inc. | Azaindole derivatives as kinase inhibitors |
| JP5844159B2 (ja) | 2009-02-09 | 2016-01-13 | ユニヴェルシテ デクス−マルセイユＵｎｉｖｅｒｓｉｔｅ Ｄ’Ａｉｘ−Ｍａｒｓｅｉｌｌｅ | Ｐｄ−１抗体およびｐｄ−ｌ１抗体ならびにその使用 |
| JP2013512251A (ja) | 2009-11-24 | 2013-04-11 | アンプリミューン、インコーポレーテッド | Ｐｄ−ｌ１／ｐｄ−ｌ２の同時阻害 |
| US20130022629A1 (en) | 2010-01-04 | 2013-01-24 | Sharpe Arlene H | Modulators of Immunoinhibitory Receptor PD-1, and Methods of Use Thereof |
| LT3202460T (lt) * | 2010-02-11 | 2019-10-10 | Celgene Corporation | Arilmetoksi izoindolino dariniai ir kompozicijos, apimantys ir jų panaudojimo būdus |
| US20110312996A1 (en) | 2010-05-17 | 2011-12-22 | Intermune, Inc. | Novel inhibitors of hepatitis c virus replication |
| JP2013532153A (ja) | 2010-06-18 | 2013-08-15 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | 慢性免疫病に対する免疫治療のためのｔｉｍ−３およびｐｄ−１に対する二重特異性抗体 |
| US8907053B2 (en) | 2010-06-25 | 2014-12-09 | Aurigene Discovery Technologies Limited | Immunosuppression modulating compounds |
| WO2012037226A1 (en) | 2010-09-14 | 2012-03-22 | Exelixis, Inc. | Inhibitors of pi3k-delta and methods of their use and manufacture |
| JP5728921B2 (ja) | 2010-12-10 | 2015-06-03 | コニカミノルタ株式会社 | 光学フィルム、及びそれを用いた偏光板、液晶表示装置 |
| ES2650744T3 (es) | 2010-12-14 | 2018-01-22 | Electrophoretics Limited | Inhibidores de la caseína quinasa 1 delta (CK1delta) |
| WO2012135299A1 (en) | 2011-03-28 | 2012-10-04 | Deuteria Pharmaceuticals Inc | 2',6'-dioxo-3'-deutero-piperdin-3-yl-isoindoline compounds |
| US9221839B2 (en) | 2011-04-07 | 2015-12-29 | Merck Sharp & Dohme Corp. | C5-C6 oxacyclic-fused thiadiazine dioxide compounds as BACE inhibitors, compositions, and their use |
| TW201408652A (zh) | 2012-07-11 | 2014-03-01 | Hoffmann La Roche | 作爲ＲＯＲｃ調節劑之芳基磺內醯胺衍生物 |
| IN2015DN00886A (enExample) | 2012-08-09 | 2015-06-12 | Celgene Corp | |
| EP2892887B1 (en) | 2012-09-04 | 2020-07-15 | Celgene Corporation | Isotopologues of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl) piperidine-2-6-dione and methods of preparation thereof |
| WO2014116573A1 (en) | 2013-01-22 | 2014-07-31 | Celgene Corporation | Processes for the preparation of isotopologues of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and pharmaceutically acceptable salts thereof |
| US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| KR20220153684A (ko) | 2013-08-22 | 2022-11-18 | 반다 파마슈티칼즈, 인코퍼레이티드. | 다발성 골수종 치료 |
| CA2955919A1 (en) | 2014-07-25 | 2016-01-28 | Piramal Enterprises Limited | Substituted phenyl alkanoic acid compounds as gpr120 agonists and uses thereof |
| WO2016019386A1 (en) | 2014-08-01 | 2016-02-04 | Green Revolution Cooling, Inc. | Controller for oil-cooled rack with multiple modes of operation |
| EP3310169B1 (en) | 2015-05-30 | 2023-05-17 | PTC Therapeutics, Inc. | Methods for modulating rna splicing |
| WO2017005900A1 (en) | 2015-07-08 | 2017-01-12 | F. Hoffmann-La Roche Ag | ARYL SULTAM DERIVATIVES AS RORc MODULATORS |
| RS64261B1 (sr) | 2016-03-16 | 2023-07-31 | Kura Oncology Inc | Supstituisani derivati tieno[2,3-d]pirimidina kao inhibitori menin-mll i načini upotrebe |
| CN113788818A (zh) | 2016-04-06 | 2021-12-14 | 密执安大学评议会 | Mdm2蛋白质降解剂 |
| US20190054097A1 (en) | 2016-04-21 | 2019-02-21 | Bioventures, Llc | Compositions targeting senescent cells and the uses thereof |
| KR102447884B1 (ko) | 2016-04-21 | 2022-09-27 | 바이오벤처스, 엘엘씨 | 항-세포자멸적 bcl-2 계열 단백질의 열화를 유도하는 화합물 및 이의 용도 |
| MX2019002163A (es) | 2016-08-30 | 2019-06-17 | Dow Global Technologies Llc | Metodo de atenuacion de concentracion de acroleina. |
| WO2018071455A1 (en) | 2016-10-10 | 2018-04-19 | Cellerant Therapeutics, Inc. | Isoquinolidinobenzodiazepine (iqb)-1(chloromethyl)-2,3-dihydro-1h-benzo[e]indole (cbi) dimers |
| KR20250044800A (ko) | 2016-10-11 | 2025-04-01 | 아비나스 오퍼레이션스, 인코포레이티드 | 안드로겐 수용체의 표적 분해용 화합물 및 방법 |
| EP4092049A1 (en) | 2016-10-20 | 2022-11-23 | Celgene Corporation | Cereblon-based heterodimerizable chimeric antigen receptors |
| AU2017370694A1 (en) | 2016-12-08 | 2019-07-25 | Icahn School Of Medicine At Mount Sinai | Compositions and methods for treating CDK4/6-mediated cancer |
| CN110612294B (zh) | 2017-01-31 | 2024-01-16 | 阿尔维纳斯运营股份有限公司 | 人小脑蛋白配体和包含其的双官能化合物 |
| PL3651766T3 (pl) * | 2017-07-10 | 2025-03-03 | Celgene Corporation | 4-(4-(4-(((2-(2,6-dioksopiperydyn-3-ylo)-1-oksoizoindolin-4-ylo)oksy)metylo)benzylo)piperazyn-1-ylo)-3-fluorobenzonitryl jako związek przeciwproliferacyjny |
| US10513515B2 (en) | 2017-08-25 | 2019-12-24 | Biotheryx, Inc. | Ether compounds and uses thereof |
| CN109912655B (zh) | 2017-12-13 | 2021-12-10 | 上海科技大学 | Alk蛋白降解剂及其抗肿瘤应用 |
| HRP20230449T1 (hr) * | 2018-05-23 | 2023-07-21 | Celgene Corporation | Antiproliferativni spojevi i bispecifična protutijela protiv bcma i cd3 za kombiniranu upotrebu |
| CN108690020A (zh) | 2018-07-04 | 2018-10-23 | 清华大学 | 一种靶向降解bet蛋白的化合物及其应用 |
| CN108794453A (zh) | 2018-07-05 | 2018-11-13 | 清华大学 | 一种靶向降解fak蛋白的化合物及其应用 |
-
2018
- 2018-07-09 PL PL18746444.1T patent/PL3651766T3/pl unknown
- 2018-07-09 ES ES18746444T patent/ES2992913T3/es active Active
- 2018-07-09 PT PT187464441T patent/PT3651766T/pt unknown
- 2018-07-09 EP EP24192984.3A patent/EP4467143A3/en active Pending
- 2018-07-09 CA CA3069138A patent/CA3069138A1/en active Pending
- 2018-07-09 RS RS20241263A patent/RS66162B1/sr unknown
- 2018-07-09 HR HRP20241553TT patent/HRP20241553T1/hr unknown
- 2018-07-09 SI SI201831174T patent/SI3651766T1/sl unknown
- 2018-07-09 LT LTEPPCT/US2018/041230T patent/LT3651766T/lt unknown
- 2018-07-09 SG SG11202000143PA patent/SG11202000143PA/en unknown
- 2018-07-09 JP JP2020500862A patent/JP7258009B2/ja active Active
- 2018-07-09 KR KR1020207003734A patent/KR102656934B1/ko active Active
- 2018-07-09 EP EP18746444.1A patent/EP3651766B1/en active Active
- 2018-07-09 IL IL271889A patent/IL271889B2/en unknown
- 2018-07-09 WO PCT/US2018/041230 patent/WO2019014100A1/en not_active Ceased
- 2018-07-09 AU AU2018301335A patent/AU2018301335B2/en active Active
- 2018-07-09 DK DK18746444.1T patent/DK3651766T3/da active
- 2018-07-09 SM SM20240470T patent/SMT202400470T1/it unknown
- 2018-07-09 FI FIEP18746444.1T patent/FI3651766T3/fi active
- 2018-07-09 CN CN201880045745.6A patent/CN110869021B/zh active Active
- 2018-07-09 HU HUE18746444A patent/HUE069137T2/hu unknown
- 2018-07-09 TW TW107123698A patent/TWI791552B/zh active
- 2018-07-09 US US16/030,695 patent/US10357489B2/en active Active
- 2018-07-09 TW TW112101268A patent/TWI830576B/zh active
-
2019
- 2019-06-03 US US16/430,189 patent/US10675281B2/en active Active
-
2020
- 2020-01-08 SA SA520411007A patent/SA520411007B1/ar unknown
- 2020-01-08 EC ECSENADI20201149A patent/ECSP20001149A/es unknown
- 2020-01-09 CO CONC2020/0000193A patent/CO2020000193A2/es unknown
- 2020-01-09 CL CL2020000060A patent/CL2020000060A1/es unknown
- 2020-01-09 ZA ZA2020/00157A patent/ZA202000157B/en unknown
- 2020-01-10 MX MX2023000085A patent/MX2023000085A/es unknown
- 2020-04-27 US US16/859,357 patent/US11185543B2/en active Active
-
2021
- 2021-11-08 US US17/521,432 patent/US12029738B2/en active Active
-
2022
- 2022-12-13 AU AU2022287569A patent/AU2022287569B2/en active Active
-
2024
- 2024-01-23 US US18/419,894 patent/US20240207255A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPWO2019014100A5 (enExample) | ||
| JP2020526534A5 (enExample) | ||
| FI3651766T3 (fi) | 4-(4-(4-(((2-(2,6-dioksopiperidin-3-yyli)-l-oksoisoindolin-4-yyli)oksi)metyyli)bentsyyli)piperatsin-1-yyli)-3-fluoribentsonitriili antiproliferatiivisena yhdisteenä | |
| AU2018201012B2 (en) | Nuclear transport modulators and uses thereof | |
| EP1423115B1 (en) | Antiangiogenic activity of nitrogen substituted thalidomide analogs | |
| CA2915365C (en) | Nuclear transport modulators and uses thereof | |
| EP2968278A1 (en) | Methods of promoting wound healing using crm1 inhibitors | |
| PT1613598E (pt) | Métodos para preparar formas cristalinas de aripiprazol | |
| JP2010529088A5 (enExample) | ||
| EA020071B1 (ru) | Замещенные производные триазолопиридазина | |
| JP2019070057A (ja) | 抗ウイルス化合物の固体形態 | |
| TW202200594A (zh) | 一種glp-1受體激動劑的晶型a及其製備方法 | |
| CN102153547A (zh) | 含有并环的噁唑烷酮抗菌素 | |
| BR112018074381B1 (pt) | [8-(fenil sulfonil)-3,8-diazabiciclo[3.2.1]oct-3-il] (1h-1,2,3-triazol-4-il) metanonas, seu uso e seus métodos de preparação, composição e combinação farmacêutica, intermediários e seu uso | |
| JP2024506559A (ja) | 標的放射線療法における使用のための多量体キレート剤化合物 | |
| BR112020020596A2 (pt) | Método para a preparação de uma 1,2,4-triazolona trissubstituída em 2,4,5 | |
| JPWO2021007245A5 (enExample) | ||
| HUE028850T2 (en) | N-((S) -2,3-Dihydroxypropyl) -3- (2-fluoro-4-iodo-phenylamino) -isonicotinamide solid forms | |
| CA2164296C (en) | Heterocyclic chemistry | |
| JPS58192825A (ja) | グリセロール誘導体 | |
| CN116547007A (zh) | 放射性药物和方法 | |
| CN102190656B (zh) | 含有五元杂环的噁唑烷酮抗菌素 | |
| EP4605084A2 (en) | 2-substituted 3,4 a, 5, 7, 8, 8 a-hexahydro-4h-thiop yrano [4,3- d]pyrimidin-4-ones for wound treatment | |
| JPWO2002083633A1 (ja) | トシル酸スプラタスト結晶 | |
| WO2011065905A1 (en) | Solid forms of 4-{(r)-(3-aminophenyl)[4-(4-fluorobenzyl)-piperazin-1-yl]methyl}-n,n-diethylbenzamide, compositions thereof, and uses therewith |