AU2018301335B2 - Antiproliferative compounds and methods of use thereof - Google Patents

Antiproliferative compounds and methods of use thereof Download PDF

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Publication number
AU2018301335B2
AU2018301335B2 AU2018301335A AU2018301335A AU2018301335B2 AU 2018301335 B2 AU2018301335 B2 AU 2018301335B2 AU 2018301335 A AU2018301335 A AU 2018301335A AU 2018301335 A AU2018301335 A AU 2018301335A AU 2018301335 B2 AU2018301335 B2 AU 2018301335B2
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Prior art keywords
compound
multiple myeloma
days
administered
dexamethasone
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AU2018301335A1 (en
Inventor
Matthew D. Alexander
Gerald D. Artman Iii
Gordon L. BRAY
James Carmichael
Soraya Carrancio
Brian E. Cathers
Matthew D. Correa
Joshua Hansen
Courtney G. Havens
Timothy S. Kercher
Antonia Lopez-Girona
Xiaoling Lu
Hon-Wah Man
Mark A. Nagy
Rama K. Narla
Joseph R. Piccotti
Daniel W. Pierce
Paula A. Tavares-Greco
Brandon W. Whitefield
Lilly L. Wong
Nanfei Zou
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Celgene Corp
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Celgene Corp
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Priority to AU2022287569A priority Critical patent/AU2022287569B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AU2018301335A 2017-07-10 2018-07-09 Antiproliferative compounds and methods of use thereof Active AU2018301335B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2022287569A AU2022287569B2 (en) 2017-07-10 2022-12-13 Antiproliferative compounds and methods of use thereof

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762530778P 2017-07-10 2017-07-10
US62/530,778 2017-07-10
US201762593185P 2017-11-30 2017-11-30
US62/593,185 2017-11-30
US201862675581P 2018-05-23 2018-05-23
US62/675,581 2018-05-23
PCT/US2018/041230 WO2019014100A1 (en) 2017-07-10 2018-07-09 ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF

Related Child Applications (1)

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AU2022287569A Division AU2022287569B2 (en) 2017-07-10 2022-12-13 Antiproliferative compounds and methods of use thereof

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AU2018301335A1 AU2018301335A1 (en) 2020-01-30
AU2018301335B2 true AU2018301335B2 (en) 2022-09-15

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EP (2) EP4467143A3 (enExample)
JP (1) JP7258009B2 (enExample)
KR (1) KR102656934B1 (enExample)
CN (1) CN110869021B (enExample)
AU (2) AU2018301335B2 (enExample)
CA (1) CA3069138A1 (enExample)
CL (1) CL2020000060A1 (enExample)
CO (1) CO2020000193A2 (enExample)
DK (1) DK3651766T3 (enExample)
EC (1) ECSP20001149A (enExample)
ES (1) ES2992913T3 (enExample)
FI (1) FI3651766T3 (enExample)
HR (1) HRP20241553T1 (enExample)
HU (1) HUE069137T2 (enExample)
IL (1) IL271889B2 (enExample)
LT (1) LT3651766T (enExample)
MX (1) MX2023000085A (enExample)
PL (1) PL3651766T3 (enExample)
PT (1) PT3651766T (enExample)
RS (1) RS66162B1 (enExample)
SA (1) SA520411007B1 (enExample)
SG (1) SG11202000143PA (enExample)
SI (1) SI3651766T1 (enExample)
SM (1) SMT202400470T1 (enExample)
TW (2) TWI830576B (enExample)
WO (1) WO2019014100A1 (enExample)
ZA (1) ZA202000157B (enExample)

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FI3908281T3 (fi) * 2019-01-09 2024-10-01 Celgene Corp Antiproliferatiivisia yhdisteitä ja toisia aktiivisia aineita käytettäväksi multippelin myelooman hoidossa
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