HK1250235A1 - 作為rorc調節劑的芳基磺內酰胺衍生物 - Google Patents

作為rorc調節劑的芳基磺內酰胺衍生物

Info

Publication number
HK1250235A1
HK1250235A1 HK18109703.9A HK18109703A HK1250235A1 HK 1250235 A1 HK1250235 A1 HK 1250235A1 HK 18109703 A HK18109703 A HK 18109703A HK 1250235 A1 HK1250235 A1 HK 1250235A1
Authority
HK
Hong Kong
Prior art keywords
sultam derivatives
aryl
rorc modulators
rorc
modulators
Prior art date
Application number
HK18109703.9A
Other languages
English (en)
Inventor
Benjamin Fauber
Emanuela Gancia
Tammy Ladduwahetty
David Vesey
Paul Winship
Olivier Rene
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1250235A1 publication Critical patent/HK1250235A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK18109703.9A 2015-07-08 2018-07-26 作為rorc調節劑的芳基磺內酰胺衍生物 HK1250235A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562190071P 2015-07-08 2015-07-08
US201662345195P 2016-06-03 2016-06-03
PCT/EP2016/066271 WO2017005900A1 (en) 2015-07-08 2016-07-08 ARYL SULTAM DERIVATIVES AS RORc MODULATORS

Publications (1)

Publication Number Publication Date
HK1250235A1 true HK1250235A1 (zh) 2018-12-07

Family

ID=56368995

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18109703.9A HK1250235A1 (zh) 2015-07-08 2018-07-26 作為rorc調節劑的芳基磺內酰胺衍生物

Country Status (6)

Country Link
US (1) US10259808B2 (zh)
EP (1) EP3319962B1 (zh)
JP (1) JP2018519353A (zh)
CN (1) CN107690431A (zh)
HK (1) HK1250235A1 (zh)
WO (1) WO2017005900A1 (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202000143PA (en) 2017-07-10 2020-02-27 Celgene Corp Antiproliferative compounds and methods of use thereof
AU2019290722B2 (en) * 2018-06-21 2023-12-21 Betta Pharmaceuticals Co., Ltd Crystal form of compound for inhibiting the activity of CDK4/6 and use thereof
EP3894402B1 (en) * 2018-12-14 2023-07-05 F. Hoffmann-La Roche AG N-containing chromen-4-one derivatives for the treatment and prophylaxis of hepatitis b virus infection
US20230089247A1 (en) * 2019-12-24 2023-03-23 Zydus Lifesciences Limited Novel compounds suitable for the treatment of dyslipidemia

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR092348A1 (es) * 2012-07-11 2015-04-15 Hoffmann La Roche DERIVADOS DE ARIL-SULTAMO COMO MODULADORES DE RORc
RU2016131345A (ru) * 2014-01-10 2018-02-16 Ф. Хоффманн-Ля Рош Аг ПРОИЗВОДНЫЕ АРИЛСУЛЬТАМОВ В КАЧЕСТВЕ МОДУЛЯТОРОВ ОРФАННОГО РЕЦЕПТОРА ГАММА, РОДСТВЕННОГО РЕЦЕПТОРУ РЕТИНОЕВОЙ КИСЛОТЫ (RORc)
MX2016008721A (es) * 2014-01-10 2017-01-26 Hoffmann La Roche Derivados de aril sultama como moduladores del receptor huerfano relacionado con acido retinoico (rorc).
US9552885B2 (en) * 2014-12-10 2017-01-24 Sandisk Technologies Llc Partial block erase for open block reading in non-volatile memory
JP2017537966A (ja) * 2014-12-17 2017-12-21 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ＲＯＲｃモジュレーターとしてのヘテロアリールアルキレンアリールスルタム誘導体

Also Published As

Publication number Publication date
CN107690431A (zh) 2018-02-13
US10259808B2 (en) 2019-04-16
EP3319962B1 (en) 2020-05-13
US20180105516A1 (en) 2018-04-19
JP2018519353A (ja) 2018-07-19
WO2017005900A1 (en) 2017-01-12
EP3319962A1 (en) 2018-05-16

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