JP2020525411A - 肝細胞癌のための免疫療法 - Google Patents

肝細胞癌のための免疫療法 Download PDF

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Publication number
JP2020525411A
JP2020525411A JP2019566957A JP2019566957A JP2020525411A JP 2020525411 A JP2020525411 A JP 2020525411A JP 2019566957 A JP2019566957 A JP 2019566957A JP 2019566957 A JP2019566957 A JP 2019566957A JP 2020525411 A JP2020525411 A JP 2020525411A
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seq
nos
cdr
antibody
hcc
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Pending
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JP2019566957A
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Japanese (ja)
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JP2020525411A5 (https=
Inventor
ワン、ライ
リ、カン
キ、キンチョウ
ホウ、ジーニー
ウー、チョン
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BeOne Medicines Ltd
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BeOne Medicines Ltd
Beigene Ltd
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Publication of JP2020525411A publication Critical patent/JP2020525411A/ja
Publication of JP2020525411A5 publication Critical patent/JP2020525411A5/ja
Priority to JP2023064789A priority Critical patent/JP2023080215A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2019566957A 2017-06-26 2018-06-26 肝細胞癌のための免疫療法 Pending JP2020525411A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023064789A JP2023080215A (ja) 2017-06-26 2023-04-12 肝細胞癌のための免疫療法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762524967P 2017-06-26 2017-06-26
US62/524,967 2017-06-26
CN2017090397 2017-06-27
CNPCT/CN2017/090397 2017-06-27
PCT/CN2018/092827 WO2019001417A1 (en) 2017-06-26 2018-06-26 IMMUNOTHERAPY FOR HEPATOCELLULAR CARCINOMA

Related Child Applications (1)

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JP2023064789A Division JP2023080215A (ja) 2017-06-26 2023-04-12 肝細胞癌のための免疫療法

Publications (2)

Publication Number Publication Date
JP2020525411A true JP2020525411A (ja) 2020-08-27
JP2020525411A5 JP2020525411A5 (https=) 2021-07-26

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JP2019566957A Pending JP2020525411A (ja) 2017-06-26 2018-06-26 肝細胞癌のための免疫療法
JP2023064789A Pending JP2023080215A (ja) 2017-06-26 2023-04-12 肝細胞癌のための免疫療法

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US (1) US11597768B2 (https=)
EP (1) EP3645569A4 (https=)
JP (2) JP2020525411A (https=)
KR (1) KR102757960B1 (https=)
CN (1) CN110799543A (https=)
AU (1) AU2018290532A1 (https=)
TW (2) TWI877099B (https=)
WO (1) WO2019001417A1 (https=)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
JP2023547947A (ja) * 2020-11-11 2023-11-14 ビオンテック・ソシエタス・エウロパエア プログラム細胞死－１タンパク質に対するモノクローナル抗体および医薬におけるその使用

Families Citing this family (13)

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CN112552401B (zh) 2013-09-13 2023-08-25 广州百济神州生物制药有限公司 抗pd1抗体及其作为治疗剂与诊断剂的用途
CN106604742B (zh) 2014-07-03 2019-01-11 百济神州有限公司 抗pd-l1抗体及其作为治疗剂及诊断剂的用途
US10864203B2 (en) 2016-07-05 2020-12-15 Beigene, Ltd. Combination of a PD-1 antagonist and a RAF inhibitor for treating cancer
WO2018033853A2 (en) 2016-08-16 2018-02-22 Beigene, Ltd. Crystalline form of (s)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof
WO2018033135A1 (en) 2016-08-19 2018-02-22 Beigene, Ltd. Use of a combination comprising a btk inhibitor for treating cancers
US11555038B2 (en) 2017-01-25 2023-01-17 Beigene, Ltd. Crystalline forms of (S)-7-(1-(but-2-ynoyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof
EP3645569A4 (en) 2017-06-26 2021-03-24 BeiGene, Ltd. IMMUNOTHERAPY FOR LIVER CELL CARCINOMA
WO2019108795A1 (en) 2017-11-29 2019-06-06 Beigene Switzerland Gmbh Treatment of indolent or aggressive b-cell lymphomas using a combination comprising btk inhibitors
RS66218B1 (sr) * 2019-07-01 2024-12-31 Tonix Pharma Ltd Anti-cd154 antitela i njihove upotrebe
CN111808194B (zh) * 2020-07-13 2021-04-20 北京凯因科技股份有限公司 一种结合密蛋白的用于治疗癌症的人源化抗体
KR20220023024A (ko) 2020-08-20 2022-03-02 경상국립대학교병원 간세포암 환자의 생존율 예측을 위한 정보제공방법
KR20230055751A (ko) 2021-10-19 2023-04-26 가톨릭대학교 산학협력단 간세포암 특이적 표적 엑소좀 조성물 및 이의 용도
TW202508632A (zh) * 2023-08-15 2025-03-01 瑞士商百濟神州瑞士有限責任公司 使用抗ｐｄ－１及化學療法治療肺癌

Citations (1)

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JP2016533763A (ja) * 2013-09-13 2016-11-04 ベイジーン リミテッド 抗ｐｄ−１抗体並びにその治療及び診断のための使用

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WO2019001417A1 (en) 2019-01-03
KR20200020902A (ko) 2020-02-26
TWI877099B (zh) 2025-03-21

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