|
EP0711804A3
(de)
|
1994-11-14 |
1999-09-22 |
Ciba SC Holding AG |
Kryptolichtschutzmittel
|
|
JP3512911B2
(ja)
|
1995-07-11 |
2004-03-31 |
富士写真フイルム株式会社 |
紫外線吸収剤前駆体化合物、それを含有する感光性樹脂組成物及び画像形成方法
|
|
ES2213286T3
(es)
|
1997-07-24 |
2004-08-16 |
Zenyaku Kogyo Kabushiki Kaisha |
Compuestos heterociclicos y agente antitumoral que los contiene como ingredientes activos.
|
|
JPH11174638A
(ja)
|
1997-12-08 |
1999-07-02 |
Konica Corp |
ハロゲン化銀カラー写真感光材料
|
|
AU2001265137B2
(en)
|
2000-05-30 |
2007-06-14 |
Indiana University Research And Technology Corporation |
Compositions and methods for identifying agents which modulate PTEN function and PI-3 kinase pathways
|
|
KR100833371B1
(ko)
|
2001-04-27 |
2008-05-28 |
젠야쿠코교가부시키가이샤 |
헤테로시클릭 화합물 및 이를 유효 성분으로 하는 항종양제
|
|
DE10207037A1
(de)
|
2002-02-20 |
2003-08-28 |
Bayer Cropscience Gmbh |
2-Amino-4-bicyclyamino-6H-1,3.5-triazine, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren
|
|
AU2003225800A1
(en)
|
2002-03-15 |
2003-09-29 |
Hayley Binch |
Azolylaminoazine as inhibitors of protein kinases
|
|
US6846928B2
(en)
|
2002-03-15 |
2005-01-25 |
Vertex Pharmaceuticals Incorporated |
Compositions useful as inhibitors of protein kinases
|
|
US20040009981A1
(en)
|
2002-03-15 |
2004-01-15 |
David Bebbington |
Compositions useful as inhibitors of protein kinases
|
|
WO2003077921A1
(en)
|
2002-03-15 |
2003-09-25 |
Vertex Pharmaceuticals, Inc. |
Azinylaminoazoles as inhibitors of protein kinases
|
|
JPWO2003097862A1
(ja)
|
2002-05-17 |
2005-09-15 |
協和醗酵工業株式会社 |
抗糖尿病作用を有する物質の探索方法
|
|
KR101046015B1
(ko)
|
2002-10-25 |
2011-07-01 |
젠야쿠코교가부시키가이샤 |
헤테로고리 화합물 및 이것을 유효성분으로 하는 항종양제
|
|
DK2316831T3
(da)
|
2002-11-21 |
2013-06-10 |
Novartis Ag |
2-(Morpholin-4-yl)pyrimidiner som phosphotidylinositol (PI)-3-kinaseinhibitorer samt deres anvendelse ved behandling af cancer
|
|
US7223759B2
(en)
|
2003-09-15 |
2007-05-29 |
Anadys Pharmaceuticals, Inc. |
Antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds
|
|
ES2389203T3
(es)
|
2004-01-12 |
2012-10-24 |
Ym Biosciences Australia Pty Ltd |
Inhibidores de quinasa selectivos
|
|
KR101130913B1
(ko)
|
2004-03-31 |
2012-03-28 |
젠야쿠코교가부시키가이샤 |
헤테로시클릭 화합물 및 이를 활성 성분으로서 포함하는항악성종양제
|
|
CA2577937C
(en)
|
2004-08-26 |
2010-12-21 |
Pfizer Inc. |
Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors
|
|
WO2006053109A1
(en)
|
2004-11-10 |
2006-05-18 |
Synta Pharmaceuticals Corp. |
Heteroaryl compounds
|
|
JP2008519850A
(ja)
|
2004-11-10 |
2008-06-12 |
シンタ ファーマシューティカルズ コーポレーション |
Ｉｌ−１２調節化合物
|
|
SI1864665T1
(sl)
|
2005-03-11 |
2012-09-28 |
Zenyaku Kogyo Kk |
Imunosupresivno sredstvo, ki obsega heterociklično spojino kot učinkovino
|
|
GB0525080D0
(en)
|
2005-12-09 |
2006-01-18 |
Astrazeneca Ab |
Pyrimidine derivatives
|
|
GB0525081D0
(en)
|
2005-12-09 |
2006-01-18 |
Astrazeneca Ab |
Pyrimidine derivatives
|
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
|
US20070244110A1
(en)
|
2006-04-14 |
2007-10-18 |
Zenyaku Kogyo Kabushiki Kaisha |
Treatment of prostate cancer, melanoma or hepatic cancer
|
|
PL2041139T3
(pl)
|
2006-04-26 |
2012-05-31 |
Hoffmann La Roche |
Związki farmaceutyczne
|
|
AU2007243466B2
(en)
|
2006-04-26 |
2012-01-19 |
F. Hoffmann-La Roche Ag |
Phosphoinositide 3-kinase inhibitor compounds and pharmaceutical compositions containing them
|
|
AU2007282535B9
(en)
|
2006-08-08 |
2013-06-20 |
Chugai Seiyaku Kabushiki Kaisha |
Pyrimidine derivative as PI3K inhibitor and use thereof
|
|
WO2008032036A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
6-benzimidaz0lyl-2-m0rph0lin0-4- (azetidine, pyrrolidine, piperidine or azepine) pyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
|
|
EP2061784A1
(en)
|
2006-09-14 |
2009-05-27 |
AstraZeneca AB |
2-benzimidazolyl-6-morpholino-4-phenylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
|
|
WO2008032060A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
4-benzimidaz0lyl-6-m0rph0lin0-2-piperazinylpyrimidine derivatives as p13k and mtor inhibitors for the treatment of proliferative disorders
|
|
WO2008032089A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
4-benzimidaz0lyl-2-m0rph0lin0-6-piperidin-4-ylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
|
|
WO2008032077A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
Pyrimidine derivatives
|
|
EP2057147A1
(en)
|
2006-09-14 |
2009-05-13 |
Astra Zeneca AB |
Pyrimidine derivatives
|
|
WO2008032091A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
4-benzimidaz0lyl-6-m0rph0lin0-2-piperidin-4-ylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
|
|
WO2008032027A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
Pyrimidine derivatives
|
|
WO2008032041A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
Pyrimidine derivatives having inhibitory activity against pi3k enzymes
|
|
WO2008032033A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
4-benzimidazolyl-2-morpholino-6-piperazinylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
|
|
CN101563340A
(zh)
|
2006-09-14 |
2009-10-21 |
阿斯利康(瑞典)有限公司 |
用作pi3k和mtor抑制剂用于治疗增殖性疾病的2-苯并咪唑基-6-吗啉代-4-哌啶-4-基嘧啶衍生物
|
|
CN101563339A
(zh)
|
2006-09-14 |
2009-10-21 |
阿斯利康(瑞典)有限公司 |
作为 p i 3 k和 m t o r抑制剂用于治疗增殖性疾病的 2 -苯并咪唑基 - 6 -吗啉代 - 4 - (氮杂环丁烷、吡咯烷、哌啶或氮杂)嘧啶衍生物
|
|
CA2675558A1
(en)
|
2007-02-06 |
2008-08-14 |
Novartis Ag |
Pi 3-kinase inhibitors and methods of their use
|
|
US20080221103A1
(en)
|
2007-03-09 |
2008-09-11 |
Orchid Research Laboratories Ltd. |
New heterocyclic compounds
|
|
US20080234262A1
(en)
|
2007-03-21 |
2008-09-25 |
Wyeth |
Pyrazolopyrimidine analogs and their use as mtor kinase and pi3 kinase inhibitors
|
|
US20080233127A1
(en)
|
2007-03-21 |
2008-09-25 |
Wyeth |
Imidazolopyrimidine analogs and their use as pi3 kinase and mtor inhibitors
|
|
JP2010529193A
(ja)
|
2007-06-11 |
2010-08-26 |
ミイカナ セラピューティクス インコーポレイテッド |
置換ピラゾール化合物
|
|
JP2010533161A
(ja)
|
2007-07-09 |
2010-10-21 |
アストラゼネカ アクチボラグ |
化合物−９４６
|
|
ES2406129T3
(es)
|
2007-10-05 |
2013-06-05 |
Verastem, Inc. |
Derivados de purina sustituidos con pirimidina
|
|
EP2209785A1
(en)
|
2007-10-05 |
2010-07-28 |
S*BIO Pte Ltd |
2-morpholinylpurines as inhibitors of pi3k
|
|
EP2218718A1
(en)
|
2007-11-22 |
2010-08-18 |
Zenyaku Kogyo Kabushikikaisha |
Amorphous form of heterocyclic compound, solid dispersion and medicinal preparation each comprising the same, and process for production of the same
|
|
US8193182B2
(en)
|
2008-01-04 |
2012-06-05 |
Intellikine, Inc. |
Substituted isoquinolin-1(2H)-ones, and methods of use thereof
|
|
MX2010007746A
(es)
|
2008-01-15 |
2010-08-18 |
Wyeth Llc |
Compuestos de 3h-[1,2,3]triazolo[4,5-d]pirimidina, su uso como inhibidores de diana de rapamicina de mamifero quinasa y fosfatidilinositol quinasa y su sintesis.
|
|
WO2009093981A1
(en)
|
2008-01-23 |
2009-07-30 |
S Bio Pte Ltd |
Triazine compounds as kinase inhibitors
|
|
US20090192176A1
(en)
|
2008-01-30 |
2009-07-30 |
Wyeth |
1H-PYRAZOLO[3,4-D]PYRIMIDINE, PURINE, 7H-PURIN-8(9H)-ONE, 3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE, AND THIENO[3,2-D]PYRIMIDINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES
|
|
CL2009000241A1
(es)
|
2008-02-07 |
2010-09-03 |
Chugai Pharmaceutical Co Ltd |
Compuestos derivados de 5-(2-morfolin-4-il-7h-pirrolo[2,3-d]pirimidin-4-il)pirimidin-2-ilamina; proceso de preparacion; composicion farmaceutica; y uso de los compuestos para tratar o prevenir una enfermedad proliferativa tal como el cancer.
|
|
WO2009120094A2
(en)
|
2008-03-27 |
2009-10-01 |
Auckland Uniservices Limited |
Substituted pyrimidines and triazines and their use in cancer therapy
|
|
MY155653A
(en)
|
2008-05-23 |
2015-11-13 |
Wyeth Llc |
Triazine compounds as p13 kinase and mtor inhibitors
|
|
WO2009157880A1
(en)
|
2008-06-27 |
2009-12-30 |
S*Bio Pte Ltd |
Pyrazine substituted purines
|
|
AU2009269087A1
(en)
|
2008-07-07 |
2010-01-14 |
Xcovery Holding Company Llc |
PI3K isoform selective inhibitors
|
|
WO2010048149A2
(en)
|
2008-10-20 |
2010-04-29 |
Kalypsys, Inc. |
Heterocyclic modulators of gpr119 for treatment of disease
|
|
GB2465405A
(en)
|
2008-11-10 |
2010-05-19 |
Univ Basel |
Triazine, pyrimidine and pyridine analogues and their use in therapy
|
|
KR20170060179A
(ko)
|
2008-11-13 |
2017-05-31 |
길리아드 칼리스토가 엘엘씨 |
혈액 종양에 대한 요법
|
|
EP2397479A4
(en)
|
2009-02-12 |
2012-08-01 |
Astellas Pharma Inc |
HETERO RING DERIVATIVE
|
|
WO2010110686A1
(en)
|
2009-03-27 |
2010-09-30 |
Pathway Therapeutics Limited |
Pyrimidinyl and 1,3,5 triazinyl benzimidazoles and their use in cancer therapy
|
|
CA2756067A1
(en)
*
|
2009-03-27 |
2010-09-30 |
Pathway Therapeutics, Inc. |
Pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy
|
|
SG182247A1
(en)
|
2009-05-27 |
2012-08-30 |
Hoffmann La Roche |
Bicyclic indole-pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use
|
|
MX2011012520A
(es)
|
2009-05-27 |
2011-12-12 |
Hoffmann La Roche |
Compuestos inhibidores de pi3k de pirimidina biciclicos selectivos para p110 delta y metodos de uso de los mismos.
|
|
CN102625799A
(zh)
|
2009-06-25 |
2012-08-01 |
安姆根有限公司 |
杂环化合物及其用途
|
|
CA2781865A1
(en)
|
2009-06-25 |
2010-12-29 |
Amgen Inc. |
Polycyclic derivatives of pyridine and their use in the treatment of (inter alia) rheumatoid arthritis and similar diseases
|
|
EP2445902A2
(en)
|
2009-06-25 |
2012-05-02 |
Amgen, Inc |
Heterocyclic compounds and their uses as inhibitors of pi3k activity
|
|
JP2012531435A
(ja)
|
2009-06-25 |
2012-12-10 |
アムジエン・インコーポレーテツド |
ＰＩ３Ｋ阻害剤としての４Ｈ−ピリド［１，２−ａ］ピリミジン−４−オン誘導体
|
|
CA2767008C
(en)
|
2009-07-07 |
2018-01-30 |
Pathway Therapeutics, Inc. |
Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy
|
|
ES2570177T3
(es)
|
2010-08-10 |
2016-05-17 |
Astellas Pharma Inc |
Compuesto heterocíclico
|
|
JP2014500275A
(ja)
|
2010-12-06 |
2014-01-09 |
フォリカ，インコーポレイテッド |
禿頭症を治療するため、および毛髪の成長を促進するための方法
|
|
KR101527710B1
(ko)
*
|
2011-01-11 |
2015-06-09 |
인하대학교 산학협력단 |
모바일 장치에서의 오디오 신호 품질 측정
|
|
WO2012129562A2
(en)
|
2011-03-24 |
2012-09-27 |
The Scripps Research Institute |
Compounds and methods for inducing chondrogenesis
|
|
EP2691388A1
(en)
|
2011-03-28 |
2014-02-05 |
MEI Pharma, Inc. |
(fused ring arylamino and heterocyclylamino) pyrimidynyl and 1,3,5-triazinyl benzimidazoles, pharmaceutical compositions thereof, and their use in treating proliferative diseases
|
|
CN107501241B
(zh)
|
2011-03-28 |
2020-10-13 |
梅制药公司 |
化合物、含有其的药物组合物以及它们在治疗增生性疾病中的用途
|
|
CA2831590A1
(en)
|
2011-03-28 |
2012-10-04 |
Mei Pharma, Inc. |
(alpha-substituted cycloalkylamino and heterocyclylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, pharmaceutical compositions thereof, and their use in treating proliferative diseases
|
|
WO2012178123A1
(en)
|
2011-06-22 |
2012-12-27 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
JP2014522818A
(ja)
|
2011-06-22 |
2014-09-08 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Ａｔｒキナーゼ阻害剤として有用な化合物
|
|
WO2012178125A1
(en)
|
2011-06-22 |
2012-12-27 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
WO2013006408A1
(en)
|
2011-07-01 |
2013-01-10 |
Tempero Pharmaceuticals, Inc. |
Compounds and methods
|
|
EP2776386B1
(de)
|
2011-11-11 |
2019-11-20 |
Merck Patent GmbH |
Verfahren zur herstellung von arylaminen
|
|
UA116544C2
(uk)
|
2012-08-09 |
2018-04-10 |
Селджин Корпорейшн |
Спосіб лікування раку з використанням 3-(4-((4-(морфолінометил)бензил)оксі)-1-оксоізоіндолін-2-іл)піперидин-2,6-діону
|
|
WO2014055647A1
(en)
|
2012-10-03 |
2014-04-10 |
Mei Pharma, Inc. |
(sulfinyl and sulfonyl benzimidazolyl) pyrimidines and triazines, pharmaceutical compositions thereof, and their use for treating proliferative diseases
|
|
US9963452B2
(en)
|
2013-03-14 |
2018-05-08 |
Augusta Pharmaceuticals Inc. |
Methods, compounds, and compositions for inhibition of ROS
|
|
EP2832358A1
(en)
|
2013-08-02 |
2015-02-04 |
Bionsil S.r.l. |
Pharmaceutical kit for use in the treatment of colon and colorectal cancer
|
|
EP3076974A1
(en)
|
2013-12-05 |
2016-10-12 |
Acerta Pharma B.V. |
Therapeutic combination of a pi3k inhibitor and a btk inhibitor
|
|
CA2935897C
(en)
|
2014-02-19 |
2018-07-03 |
Piramal Enterprises Limited |
Compounds for use as gpr120 agonists
|
|
WO2015193740A2
(en)
|
2014-06-17 |
2015-12-23 |
Acerta Pharma B.V. |
Therapeutic combinations of a btk inhibitor, a pi3k inhibitor and/or a jak-2 inhibitor
|
|
JP6626085B2
(ja)
*
|
2014-07-15 |
2019-12-25 |
ザ・ジョンズ・ホプキンス・ユニバーシティー |
骨髄由来抑制細胞の抑制及び免疫チェックポイント阻害の方法
|
|
RS63364B1
(sr)
*
|
2014-08-11 |
2022-07-29 |
Acerta Pharma Bv |
Terapeutske kombinacije btk inhibitora, pd-1 inhibitora i/ili pd-l1 inhibitora
|
|
US20170231995A1
(en)
|
2014-08-11 |
2017-08-17 |
Acerta Pharma B.V. |
BTK Inhibitors to Treat Solid Tumors Through Modulation of the Tumor Microenvironment
|
|
CA2979671C
(en)
|
2014-09-23 |
2020-03-10 |
Genentech, Inc. |
Methods of using anti-cd79b immunoconjugates
|
|
MX385777B
(es)
|
2014-12-24 |
2025-03-04 |
Lg Chemical Ltd |
Derivado de biarilo como agonista de gpr120.
|
|
CR20180109A
(es)
|
2015-07-20 |
2018-05-03 |
Genzyme Corp |
Inhibidores de receptor del factor estimulador de colonias 1 (csf-1r)
|
|
CN105130960B
(zh)
*
|
2015-07-31 |
2018-07-06 |
沈阳药科大学 |
1,3,5-三嗪类衍生物及其应用
|
|
WO2017035234A1
(en)
|
2015-08-24 |
2017-03-02 |
Epizyme, Inc. |
Method for treating cancer
|
|
ES2900482T3
(es)
|
2015-10-01 |
2022-03-17 |
Gilead Sciences Inc |
Combinación de un inhibidor de Btk y un inhibidor de punto de control para el tratamiento del cáncer
|
|
WO2017066705A1
(en)
|
2015-10-14 |
2017-04-20 |
Aquinnah Pharmaceuticals, Inc. |
Compounds, compositions and methods of use against stress granules
|
|
US11365252B2
(en)
|
2016-07-20 |
2022-06-21 |
University Of Utah Research Foundation |
CD229 CAR T cells and methods of use thereof
|
|
CN109982687A
(zh)
|
2016-09-19 |
2019-07-05 |
梅制药公司 |
联合疗法
|
|
WO2018060833A1
(en)
|
2016-09-27 |
2018-04-05 |
Novartis Ag |
Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
|
|
EP3630118A4
(en)
*
|
2017-05-23 |
2021-03-31 |
MEI Pharma, Inc. |
COMBINATION THERAPY
|
|
MX2020001727A
(es)
|
2017-08-14 |
2020-03-20 |
Mei Pharma Inc |
Terapia de combinacion.
|
|
CN112165939A
(zh)
|
2018-03-21 |
2021-01-01 |
梅制药公司 |
联合疗法
|
|
JP2021534116A
(ja)
|
2018-08-14 |
2021-12-09 |
エムイーアイ ファーマ，インク． |
再発性の濾胞性リンパ腫の処置
|
|
WO2020036995A1
(en)
|
2018-08-14 |
2020-02-20 |
Mei Pharma, Inc. |
Combination therapy
|
|
WO2020036999A1
(en)
|
2018-08-14 |
2020-02-20 |
Mei Pharma, Inc. |
Treatment of b cell malignancies
|
|
TW202038945A
(zh)
|
2018-12-21 |
2020-11-01 |
美商梅製藥公司 |
組合療法
|