|
US5563250A
(en)
|
1987-12-02 |
1996-10-08 |
Neorx Corporation |
Cleavable conjugates for the delivery and release of agents in native form
|
|
US5082767A
(en)
|
1989-02-27 |
1992-01-21 |
Hatfield G Wesley |
Codon pair utilization
|
|
US5505931A
(en)
|
1993-03-04 |
1996-04-09 |
The Dow Chemical Company |
Acid cleavable compounds, their preparation and use as bifunctional acid-labile crosslinking agents
|
|
US5681702A
(en)
|
1994-08-30 |
1997-10-28 |
Chiron Corporation |
Reduction of nonspecific hybridization by using novel base-pairing schemes
|
|
US5585108A
(en)
|
1994-12-30 |
1996-12-17 |
Nanosystems L.L.C. |
Formulations of oral gastrointestinal therapeutic agents in combination with pharmaceutically acceptable clays
|
|
US5795587A
(en)
|
1995-01-23 |
1998-08-18 |
University Of Pittsburgh |
Stable lipid-comprising drug delivery complexes and methods for their production
|
|
US5891680A
(en)
|
1995-02-08 |
1999-04-06 |
Whitehead Institute For Biomedical Research |
Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12
|
|
US6265389B1
(en)
|
1995-08-31 |
2001-07-24 |
Alkermes Controlled Therapeutics, Inc. |
Microencapsulation and sustained release of oligonucleotides
|
|
US6630351B1
(en)
|
1999-06-07 |
2003-10-07 |
Mirus Corporation |
Compositions and methods for drug delivery using pH sensitive molecules
|
|
US5922685A
(en)
|
1996-06-05 |
1999-07-13 |
Powderject Vaccines, Inc. |
IL-12 gene therapy of tumors
|
|
US6214966B1
(en)
|
1996-09-26 |
2001-04-10 |
Shearwater Corporation |
Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
|
|
JP2001503258A
(ja)
|
1996-10-18 |
2001-03-13 |
バレンティス・インコーポレーテッド |
遺伝子発現および搬送系および用途
|
|
US5994104A
(en)
|
1996-11-08 |
1999-11-30 |
Royal Free Hospital School Of Medicine |
Interleukin-12 fusion protein
|
|
US20030073640A1
(en)
|
1997-07-23 |
2003-04-17 |
Ribozyme Pharmaceuticals, Inc. |
Novel compositions for the delivery of negatively charged molecules
|
|
US6004573A
(en)
|
1997-10-03 |
1999-12-21 |
Macromed, Inc. |
Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
|
|
ATE550042T1
(de)
|
1997-11-20 |
2012-04-15 |
Vical Inc |
Behandlung von krebs mithilfe cytokin- exprimierender polynukleotide und zusammensetzungen dafür
|
|
US6517869B1
(en)
|
1997-12-12 |
2003-02-11 |
Expression Genetics, Inc. |
Positively charged poly(alpha-(omega-aminoalkyl)lycolic acid) for the delivery of a bioactive agent via tissue and cellular uptake
|
|
AU1819499A
(en)
|
1997-12-12 |
1999-06-28 |
Samyang Corporation |
Positively-charged poly{alpha-(omega-aminoalkyl)glycolic acid} for the delivery of a bioactive agent via tissue and cellular uptake
|
|
DE69941447D1
(de)
|
1998-01-05 |
2009-11-05 |
Univ Washington |
Erhöhter transport unter benutzung membranzerstörender stoffe
|
|
US6426086B1
(en)
|
1998-02-03 |
2002-07-30 |
The Regents Of The University Of California |
pH-sensitive, serum-stable liposomes
|
|
DE69939740D1
(de)
|
1998-05-20 |
2008-11-27 |
Expression Genetics Inc |
Laktose oder galaktose-polyethylen glykol-gepfropfte poly-l-lysin als genträger
|
|
US7091192B1
(en)
|
1998-07-01 |
2006-08-15 |
California Institute Of Technology |
Linear cyclodextrin copolymers
|
|
EP1117720A4
(en)
|
1998-07-13 |
2001-11-14 |
Expression Genetics Inc |
POLYESTER POLY-L-LYSINE ANALOG USED AS A BIODEGRADABLE SOLUBLE GENE CONVEYOR
|
|
AU761520B2
(en)
|
1998-09-15 |
2003-06-05 |
Genetics Institute, Llc |
Treatment of Kaposi's Sarcoma with IL-12
|
|
AU6270499A
(en)
|
1998-09-29 |
2000-04-17 |
Phylos, Inc. |
Synthesis of codon randomized nucleic acids
|
|
EP1156781B1
(en)
|
1999-02-26 |
2005-06-08 |
Chiron Corporation |
Microemulsions with adsorbed macromolecules and microparticles
|
|
US7098032B2
(en)
|
2001-01-02 |
2006-08-29 |
Mirus Bio Corporation |
Compositions and methods for drug delivery using pH sensitive molecules
|
|
EP1212422B1
(en)
|
1999-08-24 |
2007-02-21 |
Medarex, Inc. |
Human ctla-4 antibodies and their uses
|
|
US7737108B1
(en)
|
2000-01-07 |
2010-06-15 |
University Of Washington |
Enhanced transport using membrane disruptive agents
|
|
ATE305801T1
(de)
|
2000-01-20 |
2005-10-15 |
Univ Zuerich Inst Fuer Medizin |
Intratumorale verabreichung nackter il-12 codierender nukleinsäuremoleküle
|
|
ES2164011B1
(es)
|
2000-02-25 |
2003-05-16 |
Inst Cientifico Tecnol Navarra |
Uso combinado de la quimiocina ip-10 y la interleucina-12 en la preparacion de composiciones para el tratamiento de tumores malignos.
|
|
AU3958101A
(en)
|
2000-03-15 |
2001-09-24 |
Univ Pohang |
Genes of il-12p40 subunit mutated for improving the activity of il-12 and use thereof for dna vaccine adjuvant
|
|
KR20020010206A
(ko)
|
2000-07-27 |
2002-02-04 |
이시우 |
인터루킨 12와 보조활성인자 b7.1 유전자를 함유하는dna 벡터 및 이벡터가 도입된 항암 세포백신
|
|
US6696038B1
(en)
|
2000-09-14 |
2004-02-24 |
Expression Genetics, Inc. |
Cationic lipopolymer as biocompatible gene delivery agent
|
|
US20040142474A1
(en)
|
2000-09-14 |
2004-07-22 |
Expression Genetics, Inc. |
Novel cationic lipopolymer as a biocompatible gene delivery agent
|
|
US6649138B2
(en)
|
2000-10-13 |
2003-11-18 |
Quantum Dot Corporation |
Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media
|
|
US6897196B1
(en)
|
2001-02-07 |
2005-05-24 |
The Regents Of The University Of California |
pH sensitive lipids based on ortho ester linkers, composition and method
|
|
US6652886B2
(en)
|
2001-02-16 |
2003-11-25 |
Expression Genetics |
Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents
|
|
ES2340499T3
(es)
|
2001-06-05 |
2010-06-04 |
Curevac Gmbh |
Arnm de antigeno tumoral estabilizado con un contenido de g/c aumentado.
|
|
AU2002354799A1
(en)
|
2001-07-03 |
2003-01-21 |
University Of Utah Research Foundation |
Soluble steroidal peptides for nucleic acid delivery
|
|
US6586524B2
(en)
|
2001-07-19 |
2003-07-01 |
Expression Genetics, Inc. |
Cellular targeting poly(ethylene glycol)-grafted polymeric gene carrier
|
|
EP1412065A2
(en)
|
2001-07-27 |
2004-04-28 |
President And Fellows Of Harvard College |
Laminar mixing apparatus and methods
|
|
EP2447370B1
(en)
|
2001-09-28 |
2018-07-18 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
MicroRNA molecules
|
|
EP1474109B1
(en)
|
2001-12-21 |
2010-08-25 |
Alcon, Inc. |
Use of synthetic inorganic nanoparticles as carriers for ophthalmic drugs
|
|
US20050222064A1
(en)
|
2002-02-20 |
2005-10-06 |
Sirna Therapeutics, Inc. |
Polycationic compositions for cellular delivery of polynucleotides
|
|
US20050152980A1
(en)
|
2002-03-13 |
2005-07-14 |
Michael Ausborn |
Pharmeutical microparticles
|
|
EP1490494A1
(en)
|
2002-04-01 |
2004-12-29 |
Walter Reed Army Institute of Research |
Method of designing synthetic nucleic acid sequences for optimal protein expression in a host cell
|
|
WO2003092665A2
(en)
|
2002-05-02 |
2003-11-13 |
Massachusetts Eye And Ear Infirmary |
Ocular drug delivery systems and use thereof
|
|
US7595303B1
(en)
|
2002-09-05 |
2009-09-29 |
University Of South Florida |
Genetic adjuvants for immunotherapy
|
|
DE10260805A1
(de)
|
2002-12-23 |
2004-07-22 |
Geneart Gmbh |
Verfahren und Vorrichtung zum Optimieren einer Nucleotidsequenz zur Expression eines Proteins
|
|
CN1798502A
(zh)
|
2003-05-30 |
2006-07-05 |
南佛罗里达大学 |
治疗恶性肿瘤的方法
|
|
US7883720B2
(en)
|
2003-07-09 |
2011-02-08 |
Wisconsin Alumni Research Foundation |
Charge-dynamic polymers and delivery of anionic compounds
|
|
US8506967B2
(en)
|
2003-07-11 |
2013-08-13 |
Novavax, Inc. |
Functional influenza virus like particles (VLPs)
|
|
US8592197B2
(en)
|
2003-07-11 |
2013-11-26 |
Novavax, Inc. |
Functional influenza virus-like particles (VLPs)
|
|
US7683036B2
(en)
|
2003-07-31 |
2010-03-23 |
Regulus Therapeutics Inc. |
Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
|
|
WO2005040767A2
(en)
|
2003-10-17 |
2005-05-06 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention |
Air-sampling device and method of use
|
|
GB0329146D0
(en)
|
2003-12-16 |
2004-01-21 |
Glaxosmithkline Biolog Sa |
Vaccine
|
|
US8372966B2
(en)
|
2003-12-19 |
2013-02-12 |
University Of Cincinnati |
Oligonucleotide decoys and methods of use
|
|
CA2563533C
(en)
|
2004-04-15 |
2013-10-01 |
Shmuel A. Ben-Sasson |
Compositions capable of facilitating penetration across a biological barrier
|
|
CA2608862C
(en)
|
2004-06-11 |
2020-05-05 |
Trustees Of Tufts College |
Silk-based drug delivery system
|
|
DE102004042546A1
(de)
|
2004-09-02 |
2006-03-09 |
Curevac Gmbh |
Kombinationstherapie zur Immunstimulation
|
|
EP1640018A1
(en)
|
2004-09-24 |
2006-03-29 |
Universität Zürich |
Combinational therapy for treating cancer
|
|
US8057821B2
(en)
|
2004-11-03 |
2011-11-15 |
Egen, Inc. |
Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof
|
|
WO2006063249A2
(en)
|
2004-12-10 |
2006-06-15 |
Justin Hanes |
Functionalized poly (ether-anhydride) block copolymers
|
|
US7404969B2
(en)
|
2005-02-14 |
2008-07-29 |
Sirna Therapeutics, Inc. |
Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules
|
|
WO2007086881A2
(en)
|
2005-02-14 |
2007-08-02 |
Sirna Therapeutics, Inc. |
Cationic lipids and formulated molecular compositions containing them
|
|
WO2006110776A2
(en)
|
2005-04-12 |
2006-10-19 |
Nektar Therapeutics Al, Corporation |
Polyethylene glycol cojugates of antimicrobial agents
|
|
DK2439273T3
(da)
|
2005-05-09 |
2019-06-03 |
Ono Pharmaceutical Co |
Humane monoklonale antistoffer til programmeret død-1(pd-1) og fremgangsmåder til behandling af cancer ved anvendelse af anti-pd-1- antistoffer alene eller i kombination med andre immunterapeutika
|
|
CN102016814B
(zh)
|
2005-06-17 |
2013-10-23 |
北卡罗来纳大学查珀尔希尔分校 |
纳米粒子制备方法、系统及材料
|
|
CA2613442C
(en)
|
2005-06-30 |
2016-08-23 |
Archemix Corp. |
Materials and methods for the generation of fully 2'-modified nucleic acid transcripts
|
|
US8101385B2
(en)
|
2005-06-30 |
2012-01-24 |
Archemix Corp. |
Materials and methods for the generation of transcripts comprising modified nucleotides
|
|
PT1907424E
(pt)
|
2005-07-01 |
2015-10-09 |
Squibb & Sons Llc |
Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1)
|
|
JP5135220B2
(ja)
|
2005-09-01 |
2013-02-06 |
ノバルティス ヴァクシンズ アンド ダイアグノスティクス ゲーエムベーハー アンド カンパニー カーゲー |
血清群c髄膜炎菌を含む複数ワクチン接種
|
|
DE102005046490A1
(de)
|
2005-09-28 |
2007-03-29 |
Johannes-Gutenberg-Universität Mainz |
Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen
|
|
AU2006325030B2
(en)
|
2005-12-16 |
2012-07-26 |
Cellectis |
Cell penetrating peptide conjugates for delivering nucleic acids into cells
|
|
PL1966238T3
(pl)
|
2005-12-30 |
2012-09-28 |
Merck Patent Gmbh |
Warianty interleukiny-12p40 o polepszonej stabilności
|
|
US7833754B2
(en)
|
2006-01-13 |
2010-11-16 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
IL-12 for expression in mammalian cell
|
|
KR101241477B1
(ko)
|
2006-01-27 |
2013-03-08 |
엘지이노텍 주식회사 |
질화물 반도체 발광소자 및 그 제조 방법
|
|
KR100859972B1
(ko)
|
2006-02-20 |
2008-09-25 |
이화여자대학교 산학협력단 |
막투과 단백질 도메인 펩타이드
|
|
US8309680B2
(en)
|
2006-02-21 |
2012-11-13 |
Nektar Therapeutics |
Segmented degradable polymers and conjugates made therefrom
|
|
WO2007113648A2
(en)
|
2006-04-05 |
2007-10-11 |
Pfizer Products Inc. |
Ctla4 antibody combination therapy
|
|
US20080046192A1
(en)
|
2006-08-16 |
2008-02-21 |
Richard Lathrop |
Polypepetide-encoding nucleotide sequences with refined translational kinetics and methods of making same
|
|
JP5630998B2
(ja)
|
2006-05-15 |
2014-11-26 |
マサチューセッツ インスティテュート オブ テクノロジー |
機能的粒子のためのポリマー
|
|
US8313777B2
(en)
|
2006-10-05 |
2012-11-20 |
The Johns Hopkins University |
Water-dispersible oral, parenteral, and topical formulations for poorly water soluble drugs using smart polymeric nanoparticles
|
|
DE102006051516A1
(de)
|
2006-10-31 |
2008-05-08 |
Curevac Gmbh |
(Basen-)modifizierte RNA zur Expressionssteigerung eines Proteins
|
|
EP2500015A1
(en)
|
2006-12-05 |
2012-09-19 |
Landec Corporation |
Delivery of drugs
|
|
AU2007339280B2
(en)
|
2006-12-21 |
2013-12-05 |
Stryker Corporation |
Sustained-release formulations comprising crystals, macromolecular gels, and particulate suspensions of biologic agents
|
|
WO2008078180A2
(en)
|
2006-12-22 |
2008-07-03 |
Archemix Corp. |
Materials and methods for the generation of transcripts comprising modified nucleotides
|
|
JP5606738B2
(ja)
|
2006-12-27 |
2014-10-15 |
ウェルズ ファーゴ バンク ナショナル アソシエイション |
解離可能な連結を有する第ix因子部分−ポリマー共役体
|
|
CA2689042A1
(en)
|
2007-02-16 |
2008-08-28 |
Merck & Co., Inc. |
Compositions and methods for potentiated activity of biologicaly active molecules
|
|
WO2008109712A2
(en)
|
2007-03-05 |
2008-09-12 |
Washington University |
Nanoparticle delivery systems for membrane-integrating peptides
|
|
HUE040417T2
(hu)
|
2007-05-04 |
2019-03-28 |
Marina Biotech Inc |
Aminosavlipidek és alkalmazásuk
|
|
WO2008134879A1
(en)
|
2007-05-04 |
2008-11-13 |
University Health Network |
Il-12 immunotherapy for cancer
|
|
BR122017025062B8
(pt)
|
2007-06-18 |
2021-07-27 |
Merck Sharp & Dohme |
anticorpo monoclonal ou fragmento de anticorpo para o receptor de morte programada humano pd-1, polinucleotídeo e composição compreendendo o referido anticorpo ou fragmento
|
|
TWI359030B
(en)
|
2007-08-24 |
2012-03-01 |
Univ Nat Taiwan |
Treatment of cellular proliferative disorders
|
|
US8476419B2
(en)
|
2007-09-14 |
2013-07-02 |
Vrije Universiteit Brussel |
Enhancing the T-cells stimulatory capacity of human antigen presenting cells and their use in vaccination
|
|
CA2715078C
(en)
|
2007-09-26 |
2019-07-23 |
Intrexon Corporation |
Synthetic 5'utrs, expression vectors, and methods for increasing transgene expression
|
|
EP2436376B1
(en)
|
2007-09-28 |
2014-07-09 |
BIND Therapeutics, Inc. |
Cancer cell targeting using nanoparticles
|
|
SG10201408162PA
(en)
|
2007-12-11 |
2015-01-29 |
Scripps Research Inst |
Compositions and methods related to mrna translational enhancer elements
|
|
WO2009114854A1
(en)
|
2008-03-14 |
2009-09-17 |
Egen, Inc. |
Biodegradable cross-linked branched poly (alkylene imines)
|
|
US8715964B2
(en)
|
2008-05-11 |
2014-05-06 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Expression of IL-12 family heterodimers
|
|
PL215513B1
(pl)
|
2008-06-06 |
2013-12-31 |
Univ Warszawski |
Nowe boranofosforanowe analogi dinukleotydów, ich zastosowanie, czasteczka RNA, sposób otrzymywania RNA oraz sposób otrzymywania peptydów lub bialka
|
|
US8126653B2
(en)
|
2008-07-31 |
2012-02-28 |
Dna Twopointo, Inc. |
Synthetic nucleic acids for expression of encoded proteins
|
|
US8401798B2
(en)
|
2008-06-06 |
2013-03-19 |
Dna Twopointo, Inc. |
Systems and methods for constructing frequency lookup tables for expression systems
|
|
US7561973B1
(en)
|
2008-07-31 |
2009-07-14 |
Dna Twopointo, Inc. |
Methods for determining properties that affect an expression property value of polynucleotides in an expression system
|
|
WO2009149539A1
(en)
|
2008-06-10 |
2009-12-17 |
Université de Montréal |
Enhancing antigen-specific cd8+ t cell response using irf-7 mrna
|
|
JP2011525180A
(ja)
|
2008-06-16 |
2011-09-15 |
バインド バイオサイエンシズ インコーポレイテッド |
治療的標的化ナノ粒子の製作に用いるためのジブロックコポリマーで官能化された標的薬の製造方法
|
|
WO2010005726A2
(en)
|
2008-06-16 |
2010-01-14 |
Bind Biosciences Inc. |
Therapeutic polymeric nanoparticles with mtor inhibitors and methods of making and using same
|
|
US8318211B2
(en)
|
2008-06-16 |
2012-11-27 |
Bind Biosciences, Inc. |
Therapeutic polymeric nanoparticles comprising vinca alkaloids and methods of making and using same
|
|
EA020954B1
(ru)
|
2008-06-16 |
2015-03-31 |
Бинд Терапьютикс, Инк. |
Загруженные лекарственным средством полимерные наночастицы, фармацевтическая композиция и способ лечения рака
|
|
US20100009424A1
(en)
|
2008-07-14 |
2010-01-14 |
Natasha Forde |
Sonoporation systems and methods
|
|
WO2010021865A1
(en)
|
2008-08-18 |
2010-02-25 |
Merck Sharp & Dohme Corp. |
Novel lipid nanoparticles and novel components for delivery of nucleic acids
|
|
AU2009288730B2
(en)
|
2008-08-25 |
2013-06-20 |
Amplimmune, Inc. |
Compositions of PD-1 antagonists and methods of use
|
|
US20100087337A1
(en)
|
2008-09-10 |
2010-04-08 |
Bind Biosciences, Inc. |
High Throughput Fabrication of Nanoparticles
|
|
CN101684456A
(zh)
*
|
2008-09-28 |
2010-03-31 |
江门罗森生物制药有限公司 |
一种体外培养条件下扩增人nk细胞的方法
|
|
US20120015899A1
(en)
|
2008-10-25 |
2012-01-19 |
Plant Bioscience, Limited |
Modified plant virus particles and uses therefor
|
|
EP3269395A1
(en)
|
2008-11-07 |
2018-01-17 |
Massachusetts Institute Of Technology |
Aminoalcohol lipidoids and uses thereof
|
|
EP3255060A1
(en)
|
2008-12-09 |
2017-12-13 |
F. Hoffmann-La Roche AG |
Anti-pd-l1 antibodies and their use to enhance t-cell function
|
|
JP2012512175A
(ja)
|
2008-12-15 |
2012-05-31 |
バインド バイオサイエンシズ インコーポレイテッド |
治療薬を徐放するための長時間循環性ナノ粒子
|
|
WO2010080724A1
(en)
|
2009-01-12 |
2010-07-15 |
Merck Sharp & Dohme Corp. |
Novel lipid nanoparticles and novel components for delivery of nucleic acids
|
|
WO2010087791A1
(en)
|
2009-01-27 |
2010-08-05 |
Utc Power Corporation |
Distributively cooled, integrated water-gas shift reactor and vaporizer
|
|
US8669085B2
(en)
|
2009-02-05 |
2014-03-11 |
Ut-Battelle, Llc |
Transformation of gram positive bacteria by sonoporation
|
|
US8460696B2
(en)
|
2009-03-20 |
2013-06-11 |
Egen, Inc. |
Polyamine derivatives
|
|
CN107252489A
(zh)
|
2009-04-13 |
2017-10-17 |
法国健康和医学研究院 |
Hpv颗粒及其用途
|
|
WO2010126766A1
(en)
|
2009-04-30 |
2010-11-04 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Inducible interleukin-12
|
|
KR101766408B1
(ko)
|
2009-06-10 |
2017-08-10 |
알닐람 파마슈티칼스 인코포레이티드 |
향상된 지질 조성물
|
|
JP5894913B2
(ja)
|
2009-06-15 |
2016-03-30 |
アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. |
Pcsk9遺伝子を標的とする、脂質で製剤化されたdsrna
|
|
WO2011000107A1
(en)
|
2009-07-01 |
2011-01-06 |
Protiva Biotherapeutics, Inc. |
Novel lipid formulations for delivery of therapeutic agents to solid tumors
|
|
US8569256B2
(en)
|
2009-07-01 |
2013-10-29 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods for the delivery of therapeutic agents
|
|
ES2579936T3
(es)
|
2009-08-20 |
2016-08-17 |
Sirna Therapeutics, Inc. |
Nuevos lípidos catiónicos con diversos grupos de cabeza para el suministro oligonucleotídico
|
|
EP2485770A4
(en)
|
2009-10-08 |
2013-04-10 |
Merck Sharp & Dohme |
Novel cationic lipids with short lipid chains for oligonucleotide delivery
|
|
CN107028886A
(zh)
|
2009-11-04 |
2017-08-11 |
不列颠哥伦比亚大学 |
含有核酸的脂质粒子及相关的方法
|
|
US9415113B2
(en)
|
2009-11-18 |
2016-08-16 |
University Of Washington |
Targeting monomers and polymers having targeting blocks
|
|
WO2011066342A2
(en)
|
2009-11-24 |
2011-06-03 |
Amplimmune, Inc. |
Simultaneous inhibition of pd-l1/pd-l2
|
|
WO2011069529A1
(en)
|
2009-12-09 |
2011-06-16 |
Curevac Gmbh |
Mannose-containing solution for lyophilization, transfection and/or injection of nucleic acids
|
|
EP2515942B1
(en)
|
2009-12-15 |
2020-02-12 |
Pfizer Inc. |
Therapeutic polymeric nanoparticle compositions with high glass transition temperature or high molecular weight copolymers
|
|
EA201290497A1
(ru)
|
2009-12-15 |
2013-01-30 |
Байнд Байосайенсиз, Инк. |
Терапевтические полимерные наночастицы, включающие кортикостероиды, и способы получения таковых
|
|
WO2011084521A2
(en)
|
2009-12-15 |
2011-07-14 |
Bind Biosciences, Inc. |
Therapeutic polymeric nanoparticles comprising epothilone and methods of making and using same
|
|
WO2011085231A2
(en)
|
2010-01-08 |
2011-07-14 |
Selecta Biosciences, Inc. |
Synthetic virus-like particles conjugated to human papillomavirus capsid peptides for use as vaccines
|
|
EP2525781A1
(en)
|
2010-01-22 |
2012-11-28 |
Schering Corporation |
Novel cationic lipids for oligonucleotide delivery
|
|
US20130231287A1
(en)
|
2010-02-25 |
2013-09-05 |
Parimala Nacharaju |
Pegylated albumin polymers and uses thereof
|
|
US20130037977A1
(en)
|
2010-04-08 |
2013-02-14 |
Paul A. Burke |
Preparation of Lipid Nanoparticles
|
|
US20110250264A1
(en)
|
2010-04-09 |
2011-10-13 |
Pacira Pharmaceuticals, Inc. |
Method for formulating large diameter synthetic membrane vesicles
|
|
US20110262491A1
(en)
|
2010-04-12 |
2011-10-27 |
Selecta Biosciences, Inc. |
Emulsions and methods of making nanocarriers
|
|
WO2011143230A1
(en)
|
2010-05-10 |
2011-11-17 |
Alnylam Pharmaceuticals |
Methods and compositions for delivery of active agents
|
|
US20130123338A1
(en)
|
2010-05-12 |
2013-05-16 |
Protiva Biotherapeutics, Inc. |
Novel cationic lipids and methods of use thereof
|
|
US8802863B2
(en)
|
2010-05-24 |
2014-08-12 |
Sirna Therapeutics, Inc. |
Amino alcohol cationic lipids for oligonucleotide delivery
|
|
US9376679B2
(en)
|
2010-05-26 |
2016-06-28 |
Micromedmark Biotech Co. Ltd. |
Microvesicles carrying small interfering RNAs, preparation methods and uses thereof
|
|
DK2575767T3
(en)
|
2010-06-04 |
2017-03-13 |
Sirna Therapeutics Inc |
HOWEVER UNKNOWN LOW MOLECULAR CATIONIC LIPIDS TO PROCESS OIGONUCLEOTIDES
|
|
RU2556800C2
(ru)
|
2010-06-14 |
2015-07-20 |
Ф.Хоффманн-Ля Рош Аг |
Пептиды, проникающие в клетки, и их применения
|
|
WO2011163483A2
(en)
|
2010-06-25 |
2011-12-29 |
Massachusetts Institute Of Technology |
Polymers for biomaterials and therapeutics
|
|
MX342608B
(es)
|
2010-07-06 |
2016-10-06 |
Novartis Ag * |
Particulas de suministro similares a viriones para moleculas de arn de autorreplicacion.
|
|
NZ606591A
(en)
|
2010-07-06 |
2015-02-27 |
Novartis Ag |
Cationic oil-in-water emulsions
|
|
ES2557382T3
(es)
|
2010-07-06 |
2016-01-25 |
Glaxosmithkline Biologicals Sa |
Liposomas con lípidos que tienen un valor de pKa ventajoso para el suministro de ARN
|
|
WO2012012772A2
(en)
|
2010-07-22 |
2012-01-26 |
The Johns Hopkins University |
Drug eluting hydrogels for catheter delivery
|
|
KR101761388B1
(ko)
|
2010-07-30 |
2017-07-25 |
큐어백 아게 |
트랜스펙션 및 면역 자극을 위한 이황화-크로스링크된 양이온 성분 및 핵산의 복합체
|
|
WO2012021516A2
(en)
|
2010-08-09 |
2012-02-16 |
The Trustees Of The University Of Pennsylvania |
Nanoparticle-oligonucletide hybrid structures and methods of use thereof
|
|
EP2606072A4
(en)
|
2010-08-19 |
2016-04-20 |
Peg Biosciences Inc |
SYNERGISTIC BIOMOLECULAR POLYMER CONJUGATES
|
|
LT4226941T
(lt)
|
2010-08-31 |
2025-01-10 |
Glaxosmithkline Biologicals Sa |
Pegilintos liposomos, skirtos imunogeną koduojančios rnr pristatymui
|
|
MX2013002332A
(es)
|
2010-08-31 |
2013-03-18 |
Novartis Ag |
Lipidos apropiados para suministro liposomal del arn que codifica la proteina.
|
|
SI4043040T1
(sl)
|
2010-08-31 |
2023-04-28 |
Glaxosmithkline Biologicals Sa |
Mali liposomi za dostavo imunogen-kodirajoče RNA
|
|
US10307372B2
(en)
|
2010-09-10 |
2019-06-04 |
The Johns Hopkins University |
Rapid diffusion of large polymeric nanoparticles in the mammalian brain
|
|
US8466122B2
(en)
|
2010-09-17 |
2013-06-18 |
Protiva Biotherapeutics, Inc. |
Trialkyl cationic lipids and methods of use thereof
|
|
CA2809858C
(en)
|
2010-09-20 |
2019-11-12 |
Sirna Therapeutics, Inc. |
Novel low molecular weight cationic lipids for oligonucleotide delivery
|
|
EP2618846A1
(en)
|
2010-09-24 |
2013-07-31 |
Mallinckrodt LLC |
Aptamer conjugates for targeting of therapeutic and/or diagnostic nanocarriers
|
|
CA2811430A1
(en)
|
2010-09-30 |
2012-04-05 |
Merck Sharp & Dohme Corp. |
Low molecular weight cationic lipids for oligonucleotide delivery
|
|
US9782342B2
(en)
|
2010-10-11 |
2017-10-10 |
Wichita State University |
Composite magnetic nanoparticle drug delivery system
|
|
FI122520B
(fi)
|
2010-10-15 |
2012-03-15 |
Vesna Blazevic |
Noroviruksen kapsidi ja rotaviruksen VP6-proteiini käytettäväksi yhdistelmärokotteena
|
|
EP3485913A1
(en)
|
2010-10-21 |
2019-05-22 |
Sirna Therapeutics, Inc. |
Low molecular weight cationic lipids for oligonucleotide delivery
|
|
US20150056300A1
(en)
|
2010-10-22 |
2015-02-26 |
Bind Therapeutics, Inc. |
Therapeutic nanoparticles with high molecular weight copolymers
|
|
WO2012061259A2
(en)
|
2010-11-05 |
2012-05-10 |
Merck Sharp & Dohme Corp. |
Novel low molecular weight cyclic amine containing cationic lipids for oligonucleotide delivery
|
|
EP2651445A2
(en)
|
2010-12-16 |
2013-10-23 |
SPRNA GmbH |
Pharmaceutical composition consisting of rna having alkali metal as counter ion and formulated with dications
|
|
WO2012109121A1
(en)
|
2011-02-07 |
2012-08-16 |
Purdue Research Foundation |
Carbohydrate nanoparticles for prolonged efficacy of antimicrobial peptide
|
|
US20120207840A1
(en)
|
2011-02-10 |
2012-08-16 |
Aura Biosciences, Inc. |
Virion Derived Protein Nanoparticles For Delivering Diagnostic Or Therapeutic Agents For The Treatment Of Non-Melanoma Skin Cancer
|
|
EP2489371A1
(en)
|
2011-02-18 |
2012-08-22 |
Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria |
Carrier peptides for drug delivery
|
|
US8846850B2
(en)
|
2011-02-22 |
2014-09-30 |
Rutgers, The State University Of New Jersey |
Amphiphilic macromolecules for nucleic acid delivery
|
|
WO2012116714A1
(en)
|
2011-03-02 |
2012-09-07 |
Curevac Gmbh |
Vaccination in elderly patients
|
|
CA2828940C
(en)
|
2011-03-10 |
2024-04-16 |
Provectus Pharmaceuticals, Inc. |
Combination of local and systemic immunomodulative therapies for enhanced treatment of cancer
|
|
AU2012236099A1
(en)
|
2011-03-31 |
2013-10-03 |
Moderna Therapeutics, Inc. |
Delivery and formulation of engineered nucleic acids
|
|
US20120283503A1
(en)
|
2011-04-29 |
2012-11-08 |
The Johns Hopkins University |
Nanoparticle loaded stem cells and their use in mri guided hyperthermia
|
|
US8691750B2
(en)
|
2011-05-17 |
2014-04-08 |
Axolabs Gmbh |
Lipids and compositions for intracellular delivery of biologically active compounds
|
|
RU2013154295A
(ru)
|
2011-06-08 |
2015-07-20 |
Шир Хьюман Дженетик Терапис, Инк. |
КОМПОЗИЦИИ ЛИПИДНЫХ НАНОЧАСТИЦ И СПОСОБЫ ДЛЯ ДОСТАВКИ мРНК
|
|
JP5970065B2
(ja)
|
2011-07-08 |
2016-08-17 |
バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH |
ピラゾール酸をアントラニル酸エステルと反応させる工程によってテトラゾール置換アントラニル酸ジアミド誘導体を製造する方法
|
|
WO2013009717A1
(en)
|
2011-07-10 |
2013-01-17 |
Elisabet De Los Pinos |
Virion derived protein nanoparticles for delivering diagnostic or therapeutic agents for the treatment of skin-related diseases
|
|
US20130012566A1
(en)
|
2011-07-10 |
2013-01-10 |
Aura Biosciences, Inc. |
Virion Derived Protein Nanoparticles For Delivering Diagnostic Or Therapeutic Agents For The Treatment of Alopecia
|
|
JP2014527071A
(ja)
|
2011-08-31 |
2014-10-09 |
マリンクロッド エルエルシー |
H−ホスホネートによるナノ粒子pegの改変
|
|
US9126966B2
(en)
|
2011-08-31 |
2015-09-08 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods of use thereof
|
|
EP2755986A4
(en)
|
2011-09-12 |
2015-05-20 |
Moderna Therapeutics Inc |
MANIPULATED NUCLEIC ACIDS AND METHOD OF APPLICATION THEREFOR
|
|
DE19216461T1
(de)
|
2011-10-03 |
2021-10-07 |
Modernatx, Inc. |
Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon
|
|
WO2013051672A1
(ja)
|
2011-10-04 |
2013-04-11 |
株式会社ヤクルト本社 |
チアゾリジン誘導体又はその塩を有効成分とする医薬品
|
|
EP2766035B1
(en)
|
2011-10-11 |
2018-03-28 |
Universität Zürich Prorektorat MNW |
Combination medicament comprising il-12 and an agent for blockade of t-cell inhibitory molecules for tumour therapy
|
|
US20130116408A1
(en)
|
2011-11-05 |
2013-05-09 |
Aura Biosciences, Inc. |
Virion Derived Protein Nanoparticles For Delivering Radioisotopes For The Diagnosis And Treatment Of Malignant And Systemic Disease And The Monitoring Of Therapy
|
|
US20130115247A1
(en)
|
2011-11-05 |
2013-05-09 |
Aura Biosciences, Inc. |
Virion Derived Protein Nanoparticles For Delivering Radioisotopes For The Diagnosis And Treatment Of Malignant And Systemic Disease And The Monitoring Of Therapy
|
|
ES2985784T3
(es)
|
2011-11-18 |
2024-11-07 |
Regeneron Pharma |
Micropartículas de proteínas recubiertas con polímeros para formulaciones de liberación prolongada para su uso en el humor vítreo del ojo para tratar trastornos oculares vasculares
|
|
KR101764096B1
(ko)
|
2011-11-28 |
2017-08-02 |
메르크 파텐트 게엠베하 |
항-pd-l1 항체 및 그의 용도
|
|
WO2013082111A2
(en)
|
2011-11-29 |
2013-06-06 |
The University Of North Carolina At Chapel Hill |
Geometrically engineered particles and methods for modulating macrophage or immune responses
|
|
WO2013086354A1
(en)
|
2011-12-07 |
2013-06-13 |
Alnylam Pharmaceuticals, Inc. |
Biodegradable lipids for the delivery of active agents
|
|
WO2013086373A1
(en)
|
2011-12-07 |
2013-06-13 |
Alnylam Pharmaceuticals, Inc. |
Lipids for the delivery of active agents
|
|
AU2012347605B2
(en)
|
2011-12-07 |
2017-09-21 |
Alnylam Pharmaceuticals, Inc. |
Branched alkyl and cycloalkyl terminated biodegradable lipids for the delivery of active agents
|
|
GB201121070D0
(en)
|
2011-12-07 |
2012-01-18 |
Isis Innovation |
composition for delivery of biotherapeutics
|
|
EP2787977A4
(en)
|
2011-12-09 |
2015-05-06 |
Univ California |
LIPOSOMAL ACTIVE INVERTING
|
|
JP6333730B2
(ja)
|
2011-12-12 |
2018-05-30 |
ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア |
改善されたil−12遺伝子構築物を含む組成物、及びそれを用いたワクチン、免疫治療剤及び方法
|
|
RU2664698C2
(ru)
|
2011-12-13 |
2018-08-21 |
Энджинеик Молекьюлар Деливери Пти Лтд |
Полученные из бактерий интактные мини-клетки для доставки лекарственных средств к опухолям мозга
|
|
CA3018046A1
(en)
|
2011-12-16 |
2013-06-20 |
Moderna Therapeutics, Inc. |
Modified nucleoside, nucleotide, and nucleic acid compositions
|
|
WO2013106072A1
(en)
|
2012-01-10 |
2013-07-18 |
Sorbent Therapeutics, Inc. |
Compositions comprising crosslinked cation-binding polymers and uses thereof
|
|
WO2013106073A1
(en)
|
2012-01-10 |
2013-07-18 |
Sorbent Therapeutics, Inc. |
Compositions comprising crosslinked cation-binding polymers and uses thereof
|
|
WO2013106086A1
(en)
|
2012-01-10 |
2013-07-18 |
Sorbent Therapeutics, Inc. |
Compositions comprising crosslinked cation-binding polymers and uses thereof
|
|
CN104159606A
(zh)
|
2012-01-12 |
2014-11-19 |
Stc.Unm公司 |
含有hpv l2的免疫原性vlp及相关组合物和方法
|
|
WO2013105101A1
(en)
|
2012-01-13 |
2013-07-18 |
Department Of Biotechnology |
Solid lipid nanoparticles entrapping hydrophilic/ amphiphilic drug and a process for preparing the same
|
|
EP2804632B1
(en)
|
2012-01-19 |
2019-09-18 |
The Johns Hopkins University |
Nanoparticle formulations with enhanced mucosal penetration
|
|
EP2623121A1
(en)
|
2012-01-31 |
2013-08-07 |
Bayer Innovation GmbH |
Pharmaceutical composition comprising a polymeric carrier cargo complex and an antigen
|
|
WO2013116656A1
(en)
|
2012-02-03 |
2013-08-08 |
Emory University |
Immunostimulatory compositions, particles, and uses related thereto
|
|
WO2013119602A1
(en)
|
2012-02-06 |
2013-08-15 |
President And Fellows Of Harvard College |
Arrdc1-mediated microvesicles (armms) and uses thereof
|
|
WO2013119877A1
(en)
|
2012-02-07 |
2013-08-15 |
Aura Biosciences, Inc. |
Virion-derived nanospheres for selective delivery of therapeutic and diagnostic agents to cancer cells
|
|
KR102181258B1
(ko)
|
2012-02-16 |
2020-11-20 |
브이엘피 테라퓨틱스 엘엘씨 |
바이러스 유사 입자 조성물
|
|
JP6356614B2
(ja)
|
2012-02-17 |
2018-07-11 |
ユニバーシティ・オブ・ジョージア・リサーチ・ファウンデイション・インコーポレイテッド |
薬剤のミトコンドリア輸送のためのナノ粒子
|
|
WO2013123523A1
(en)
|
2012-02-19 |
2013-08-22 |
Nvigen, Inc. |
Uses of porous nanostructure in delivery
|
|
WO2013124867A1
(en)
|
2012-02-21 |
2013-08-29 |
Amrita Vishwa Vidyapeetham University |
Polymer - polymer or polymer - protein core - shell nano medicine loaded with multiple drug molecules
|
|
EP2817287B1
(en)
|
2012-02-24 |
2018-10-03 |
Arbutus Biopharma Corporation |
Trialkyl cationic lipids and methods of use thereof
|
|
WO2013151665A2
(en)
|
2012-04-02 |
2013-10-10 |
modeRNA Therapeutics |
Modified polynucleotides for the production of proteins associated with human disease
|
|
CN104411338A
(zh)
|
2012-04-02 |
2015-03-11 |
现代治疗公司 |
用于产生与人类疾病相关的生物制剂和蛋白质的修饰多核苷酸
|
|
HK1203971A1
(en)
|
2012-05-15 |
2015-11-06 |
Bristol-Myers Squibb Company |
Cancer immunotherapy by disrupting pd-1/pd-l1 signaling
|
|
WO2014028429A2
(en)
|
2012-08-14 |
2014-02-20 |
Moderna Therapeutics, Inc. |
Enzymes and polymerases for the synthesis of rna
|
|
WO2014093924A1
(en)
|
2012-12-13 |
2014-06-19 |
Moderna Therapeutics, Inc. |
Modified nucleic acid molecules and uses thereof
|
|
EP4331620A3
(en)
|
2012-12-07 |
2024-12-04 |
Translate Bio, Inc. |
Lipidic nanoparticles for mrna delivery
|
|
AU2013374345A1
(en)
|
2013-01-17 |
2015-08-06 |
Moderna Therapeutics, Inc. |
Signal-sensor polynucleotides for the alteration of cellular phenotypes
|
|
US9974845B2
(en)
|
2013-02-22 |
2018-05-22 |
Curevac Ag |
Combination of vaccination and inhibition of the PD-1 pathway
|
|
US20160022840A1
(en)
|
2013-03-09 |
2016-01-28 |
Moderna Therapeutics, Inc. |
Heterologous untranslated regions for mrna
|
|
WO2014152211A1
(en)
|
2013-03-14 |
2014-09-25 |
Moderna Therapeutics, Inc. |
Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
|
|
US20140363493A1
(en)
|
2013-06-10 |
2014-12-11 |
Albert Einstein College Of Medicine Of Yeshiva University |
LIPID NANOPARTICLES FOR TARGETED siRNA DELIVERY
|
|
JP6620093B2
(ja)
|
2013-07-23 |
2019-12-11 |
アービュートゥス バイオファーマ コーポレイションArbutus Biopharma Corporation |
メッセンジャーrnaを送達するための組成物及び方法
|
|
CN112552401B
(zh)
|
2013-09-13 |
2023-08-25 |
广州百济神州生物制药有限公司 |
抗pd1抗体及其作为治疗剂与诊断剂的用途
|
|
US20160367651A1
(en)
|
2013-10-01 |
2016-12-22 |
Mie University |
T cell inducing vaccine containing an interepitope sequence that promotes antigen presentation
|
|
EP3052521A1
(en)
|
2013-10-03 |
2016-08-10 |
Moderna Therapeutics, Inc. |
Polynucleotides encoding low density lipoprotein receptor
|
|
AU2014337156A1
(en)
|
2013-10-18 |
2016-05-12 |
Modernatx, Inc. |
Compositions and methods for tolerizing cellular systems
|
|
JP6506749B2
(ja)
|
2013-10-22 |
2019-04-24 |
シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド |
フェニルケトン尿症のためのmRNA療法
|
|
JP2017501712A
(ja)
|
2013-12-18 |
2017-01-19 |
イントレキソン コーポレーション |
単鎖il−12核酸、ポリペプチド、およびそれらの使用
|
|
CN113057959B
(zh)
|
2014-02-11 |
2024-07-16 |
阿尔尼拉姆医药品有限公司 |
己酮糖激酶(KHK)iRNA组合物及其使用方法
|
|
US10821175B2
(en)
|
2014-02-25 |
2020-11-03 |
Merck Sharp & Dohme Corp. |
Lipid nanoparticle vaccine adjuvants and antigen delivery systems
|
|
US20170143848A1
(en)
|
2014-03-24 |
2017-05-25 |
Shire Human Genetic Therapies, Inc. |
Mrna therapy for the treatment of ocular diseases
|
|
HUE060907T2
(hu)
|
2014-06-25 |
2023-04-28 |
Acuitas Therapeutics Inc |
Új lipidek és lipid nanorészecske formulációk nukleinsavak bevitelére
|
|
EP3197911A4
(en)
*
|
2014-09-22 |
2018-06-20 |
Intrexon Corporation |
Improved therapeutic control of heterodimeric and single chain forms of interleukin-12
|
|
US11786457B2
(en)
|
2015-01-30 |
2023-10-17 |
President And Fellows Of Harvard College |
Peritumoral and intratumoral materials for cancer therapy
|
|
CN108064176A
(zh)
|
2015-04-22 |
2018-05-22 |
库瑞瓦格股份公司 |
用于治疗肿瘤疾病的含有rna的组合物
|
|
US10682401B2
(en)
|
2015-05-19 |
2020-06-16 |
Morphogenesis, Inc. |
Multi-indication mRNA cancer immunotherapy
|
|
WO2016187407A1
(en)
|
2015-05-19 |
2016-11-24 |
Morphogenesis, Inc. |
Cancer vaccine comprising mrna encoding a m-like-protein
|
|
CN105119800B
(zh)
|
2015-07-07 |
2018-07-31 |
卫小会 |
一种共享导航信息的通讯方法及系统
|
|
JP6948313B6
(ja)
|
2015-09-17 |
2022-01-14 |
モデルナティエックス インコーポレイテッド |
治療剤の細胞内送達のための化合物および組成物
|
|
EP3359670B2
(en)
|
2015-10-05 |
2024-02-14 |
ModernaTX, Inc. |
Methods for therapeutic administration of messenger ribonucleic acid drugs
|
|
EP3205356A1
(en)
|
2016-02-10 |
2017-08-16 |
Onkoloski Institut Ljubljana |
Plasmid expression vector encoding human interleukin 12 under transcriptional control of p21 promoter and without antibiotic resistance for cancer gene therapy and other uses thereof
|
|
EP3211000B1
(en)
|
2016-02-25 |
2019-01-30 |
Provecs Medical GmbH |
Novel immunostimulating vector system
|
|
SI3458083T1
(sl)
|
2016-05-18 |
2023-03-31 |
Modernatx, Inc. |
Polinukleotidi, ki kodirajo interlevkin-12 (IL12) in njihova uporaba
|
|
CN109715205A
(zh)
|
2016-08-19 |
2019-05-03 |
库瑞瓦格股份公司 |
用于癌症治疗的rna
|
|
EP3523323A4
(en)
|
2016-10-07 |
2020-06-17 |
Board of Regents, The University of Texas System |
T-CELLS WITH EXPRESSION OF MEMBRANE-ANCHORED IL-12 FOR THE TREATMENT OF CANCER
|
|
JP7285220B2
(ja)
|
2017-05-18 |
2023-06-01 |
モデルナティエックス インコーポレイテッド |
連結したインターロイキン-12(il12)ポリペプチドをコードするポリヌクレオチドを含む脂質ナノ粒子
|