JP2020517625A5 - - Google Patents
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- Publication number
- JP2020517625A5 JP2020517625A5 JP2019556698A JP2019556698A JP2020517625A5 JP 2020517625 A5 JP2020517625 A5 JP 2020517625A5 JP 2019556698 A JP2019556698 A JP 2019556698A JP 2019556698 A JP2019556698 A JP 2019556698A JP 2020517625 A5 JP2020517625 A5 JP 2020517625A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- carbon atoms
- optionally substituted
- branched
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C1C(N([C@@](C2)C=Nc3cc(O)c(*)cc33)C3=O)=C2C(*)=C(*)C1* Chemical compound *C1C(N([C@@](C2)C=Nc3cc(O)c(*)cc33)C3=O)=C2C(*)=C(*)C1* 0.000 description 3
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022174347A JP2023015178A (ja) | 2017-04-20 | 2022-10-31 | インドリノベンゾジアゼピン誘導体の調製方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762487695P | 2017-04-20 | 2017-04-20 | |
| US62/487,695 | 2017-04-20 | ||
| PCT/US2018/028253 WO2018195245A1 (en) | 2017-04-20 | 2018-04-19 | Methods of preparing indolinobenzodiazepine derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022174347A Division JP2023015178A (ja) | 2017-04-20 | 2022-10-31 | インドリノベンゾジアゼピン誘導体の調製方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020517625A JP2020517625A (ja) | 2020-06-18 |
| JP2020517625A5 true JP2020517625A5 (enExample) | 2021-05-27 |
| JP7170663B2 JP7170663B2 (ja) | 2022-11-14 |
Family
ID=62117004
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019556698A Active JP7170663B2 (ja) | 2017-04-20 | 2018-04-19 | インドリノベンゾジアゼピン誘導体の調製方法 |
| JP2022174347A Ceased JP2023015178A (ja) | 2017-04-20 | 2022-10-31 | インドリノベンゾジアゼピン誘導体の調製方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022174347A Ceased JP2023015178A (ja) | 2017-04-20 | 2022-10-31 | インドリノベンゾジアゼピン誘導体の調製方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US10442809B2 (enExample) |
| EP (1) | EP3612533A1 (enExample) |
| JP (2) | JP7170663B2 (enExample) |
| KR (2) | KR20230154089A (enExample) |
| CN (2) | CN110573510B (enExample) |
| AU (2) | AU2018254463B2 (enExample) |
| CA (1) | CA3060086A1 (enExample) |
| IL (4) | IL293192B2 (enExample) |
| MA (1) | MA51510A (enExample) |
| SG (1) | SG11201909564XA (enExample) |
| TW (2) | TWI790228B (enExample) |
| WO (1) | WO2018195245A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20230154089A (ko) | 2017-04-20 | 2023-11-07 | 이뮤노젠 아이엔씨 | 인돌리노벤조다이아제핀 유도체를 제조하는 방법 |
| AU2022325888A1 (en) * | 2021-08-13 | 2024-02-22 | Immunogen, Inc. | Improved methods for preparing cytotoxic benzodiazepine derivatives |
| WO2024005123A1 (ja) | 2022-06-30 | 2024-01-04 | 東レ株式会社 | 癌の治療及び／又は予防用医薬組成物 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3453266A (en) | 1966-03-14 | 1969-07-01 | American Home Prod | 1,2,5-benzothiadiazepine 1,1-dioxides |
| US3506646A (en) | 1966-06-27 | 1970-04-14 | American Home Prod | Process for the preparation of 7h-pyrido (1,2-b)(1,2,5)benzothiadiazepine 5,5 - dioxides and pyrrolo(1,2-b)(1,2,5)benzothiadiazepine 5,5-dioxides |
| US3875162A (en) | 1973-07-26 | 1975-04-01 | Squibb & Sons Inc | Certain 6H-pyrimido{8 1,2-c{9 {8 1,3,5{9 benzothiadiaza compounds |
| US4003905A (en) | 1974-12-11 | 1977-01-18 | E. R. Squibb & Sons, Inc. | Diels-alder adducts of benzdiazepines |
| US4444688A (en) | 1981-05-11 | 1984-04-24 | Ciba-Geigy Corporation | Imidazobenzothiadiazepines |
| JP2920385B2 (ja) | 1988-08-18 | 1999-07-19 | 武田薬品工業株式会社 | １，２，５‐ベンゾチアジアゼピン誘導体，その製造法および用途 |
| JP3006615B2 (ja) * | 1989-02-08 | 2000-02-07 | 電気化学工業株式会社 | Ｄ―β―ヒドロキシアミノ酸の製造法 |
| US6660856B2 (en) * | 2002-03-08 | 2003-12-09 | Kaohsiung Medical University | Synthesis of pyrrolo[2,1-c][1,4]benzodiazepine analogues |
| GB0209467D0 (en) | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| RU2314309C2 (ru) | 2003-03-31 | 2008-01-10 | Каунсил Оф Сайентифик Энд Индастриал Рисерч | Пирроло [2.1-c][1.4] бензодиазепины, способ их получения и фармацевтическая композиция на их основе |
| RU2338747C2 (ru) | 2003-03-31 | 2008-11-20 | Каунсил Оф Сайентифик Энд Индастриал Рисерч | ДИМЕРЫ ПИРРОЛО [2, 1-c][1, 4] БЕНЗОДИАЗЕПИНА В КАЧЕСТВЕ ПРОТИВООПУХОЛЕВЫХ СРЕДСТВ И СПОСОБ ИХ ПОЛУЧЕНИЯ |
| JP5977522B2 (ja) * | 2009-02-05 | 2016-08-24 | イミュノジェン・インコーポレーテッド | 新規ベンゾジアゼピン誘導体 |
| TWI617555B (zh) * | 2011-02-15 | 2018-03-11 | 免疫原公司 | 細胞毒性苯并二氮呯衍生物 |
| GB201201100D0 (en) * | 2012-01-20 | 2012-03-07 | Medical Res Council | Polypeptides and methods |
| JP2017527562A (ja) | 2014-09-03 | 2017-09-21 | イミュノジェン・インコーポレーテッド | 細胞毒性ベンゾジアゼピン誘導体 |
| DK3189056T3 (da) | 2014-09-03 | 2020-09-14 | Immunogen Inc | Cytotoksiske benzodiazepinderivater |
| PE20171185A1 (es) | 2015-01-14 | 2017-08-22 | Bristol Myers Squibb Co | Dimeros de benzodiazepina unidos con puentes de heteroarileno, conjugados de estos, y sus metodos de preparacion y uso |
| KR20230154089A (ko) | 2017-04-20 | 2023-11-07 | 이뮤노젠 아이엔씨 | 인돌리노벤조다이아제핀 유도체를 제조하는 방법 |
| EP4361128A3 (en) * | 2018-11-12 | 2024-07-17 | ImmunoGen, Inc. | Methods of preparing cytotoxic benzodiazepine derivatives |
-
2018
- 2018-04-19 KR KR1020237036717A patent/KR20230154089A/ko active Pending
- 2018-04-19 AU AU2018254463A patent/AU2018254463B2/en not_active Ceased
- 2018-04-19 JP JP2019556698A patent/JP7170663B2/ja active Active
- 2018-04-19 IL IL293192A patent/IL293192B2/en unknown
- 2018-04-19 TW TW107113286A patent/TWI790228B/zh not_active IP Right Cessation
- 2018-04-19 CA CA3060086A patent/CA3060086A1/en active Pending
- 2018-04-19 CN CN201880025787.3A patent/CN110573510B/zh active Active
- 2018-04-19 EP EP18723156.8A patent/EP3612533A1/en not_active Withdrawn
- 2018-04-19 US US15/956,835 patent/US10442809B2/en active Active
- 2018-04-19 MA MA051510A patent/MA51510A/fr unknown
- 2018-04-19 WO PCT/US2018/028253 patent/WO2018195245A1/en not_active Ceased
- 2018-04-19 IL IL270008A patent/IL270008B/en unknown
- 2018-04-19 TW TW111149203A patent/TWI840039B/zh active
- 2018-04-19 SG SG11201909564X patent/SG11201909564XA/en unknown
- 2018-04-19 KR KR1020197033777A patent/KR102595714B1/ko active Active
- 2018-04-19 IL IL305224A patent/IL305224B2/en unknown
- 2018-04-19 IL IL311609A patent/IL311609A/en unknown
- 2018-04-19 CN CN202211145894.4A patent/CN115448926A/zh active Pending
-
2019
- 2019-09-04 US US16/560,379 patent/US10968228B2/en active Active
-
2021
- 2021-02-26 US US17/186,234 patent/US11760759B2/en active Active
-
2022
- 2022-08-11 AU AU2022215237A patent/AU2022215237B2/en not_active Expired - Fee Related
- 2022-10-31 JP JP2022174347A patent/JP2023015178A/ja not_active Ceased
-
2023
- 2023-08-02 US US18/229,579 patent/US20240067652A1/en not_active Abandoned
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