CN110573510B - 制备吲哚啉并苯并二氮杂䓬衍生物的方法 - Google Patents

制备吲哚啉并苯并二氮杂䓬衍生物的方法 Download PDF

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Publication number
CN110573510B
CN110573510B CN201880025787.3A CN201880025787A CN110573510B CN 110573510 B CN110573510 B CN 110573510B CN 201880025787 A CN201880025787 A CN 201880025787A CN 110573510 B CN110573510 B CN 110573510B
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compound
formula
reaction
carried out
mixture
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CN110573510A (zh
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B·格莱德
R·A·西尔瓦
M·L·米勒
M·施祖卡
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Immunogen Inc
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Immunogen Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN201880025787.3A 2017-04-20 2018-04-19 制备吲哚啉并苯并二氮杂䓬衍生物的方法 Active CN110573510B (zh)

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Application Number Priority Date Filing Date Title
CN202211145894.4A CN115448926A (zh) 2017-04-20 2018-04-19 制备吲哚啉并苯并二氮杂䓬衍生物的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762487695P 2017-04-20 2017-04-20
US62/487,695 2017-04-20
PCT/US2018/028253 WO2018195245A1 (en) 2017-04-20 2018-04-19 Methods of preparing indolinobenzodiazepine derivatives

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CN202211145894.4A Division CN115448926A (zh) 2017-04-20 2018-04-19 制备吲哚啉并苯并二氮杂䓬衍生物的方法

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CN110573510A CN110573510A (zh) 2019-12-13
CN110573510B true CN110573510B (zh) 2022-10-11

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CN202211145894.4A Pending CN115448926A (zh) 2017-04-20 2018-04-19 制备吲哚啉并苯并二氮杂䓬衍生物的方法

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US (4) US10442809B2 (enExample)
EP (1) EP3612533A1 (enExample)
JP (2) JP7170663B2 (enExample)
KR (2) KR20230154089A (enExample)
CN (2) CN110573510B (enExample)
AU (2) AU2018254463B2 (enExample)
CA (1) CA3060086A1 (enExample)
IL (4) IL293192B2 (enExample)
MA (1) MA51510A (enExample)
SG (1) SG11201909564XA (enExample)
TW (2) TWI790228B (enExample)
WO (1) WO2018195245A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230154089A (ko) 2017-04-20 2023-11-07 이뮤노젠 아이엔씨 인돌리노벤조다이아제핀 유도체를 제조하는 방법
AU2022325888A1 (en) * 2021-08-13 2024-02-22 Immunogen, Inc. Improved methods for preparing cytotoxic benzodiazepine derivatives
WO2024005123A1 (ja) 2022-06-30 2024-01-04 東レ株式会社 癌の治療及び／又は予防用医薬組成物

Citations (3)

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US6660856B2 (en) * 2002-03-08 2003-12-09 Kaohsiung Medical University Synthesis of pyrrolo[2,1-c][1,4]benzodiazepine analogues
CN102365021A (zh) * 2009-02-05 2012-02-29 免疫基因公司 新型苯并二氮杂*衍生物
CN103687623A (zh) * 2011-02-15 2014-03-26 伊缪诺金公司 细胞毒性苯并二氮杂*衍生物

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US3506646A (en) 1966-06-27 1970-04-14 American Home Prod Process for the preparation of 7h-pyrido (1,2-b)(1,2,5)benzothiadiazepine 5,5 - dioxides and pyrrolo(1,2-b)(1,2,5)benzothiadiazepine 5,5-dioxides
US3875162A (en) 1973-07-26 1975-04-01 Squibb & Sons Inc Certain 6H-pyrimido{8 1,2-c{9 {8 1,3,5{9 benzothiadiaza compounds
US4003905A (en) 1974-12-11 1977-01-18 E. R. Squibb & Sons, Inc. Diels-alder adducts of benzdiazepines
US4444688A (en) 1981-05-11 1984-04-24 Ciba-Geigy Corporation Imidazobenzothiadiazepines
JP2920385B2 (ja) 1988-08-18 1999-07-19 武田薬品工業株式会社 １，２，５‐ベンゾチアジアゼピン誘導体，その製造法および用途
JP3006615B2 (ja) * 1989-02-08 2000-02-07 電気化学工業株式会社 Ｄ―β―ヒドロキシアミノ酸の製造法
GB0209467D0 (en) 2002-04-25 2002-06-05 Astrazeneca Ab Chemical compounds
RU2314309C2 (ru) 2003-03-31 2008-01-10 Каунсил Оф Сайентифик Энд Индастриал Рисерч Пирроло [2.1-c][1.4] бензодиазепины, способ их получения и фармацевтическая композиция на их основе
RU2338747C2 (ru) 2003-03-31 2008-11-20 Каунсил Оф Сайентифик Энд Индастриал Рисерч ДИМЕРЫ ПИРРОЛО [2, 1-c][1, 4] БЕНЗОДИАЗЕПИНА В КАЧЕСТВЕ ПРОТИВООПУХОЛЕВЫХ СРЕДСТВ И СПОСОБ ИХ ПОЛУЧЕНИЯ
GB201201100D0 (en) * 2012-01-20 2012-03-07 Medical Res Council Polypeptides and methods
JP2017527562A (ja) 2014-09-03 2017-09-21 イミュノジェン・インコーポレーテッド 細胞毒性ベンゾジアゼピン誘導体
DK3189056T3 (da) 2014-09-03 2020-09-14 Immunogen Inc Cytotoksiske benzodiazepinderivater
PE20171185A1 (es) 2015-01-14 2017-08-22 Bristol Myers Squibb Co Dimeros de benzodiazepina unidos con puentes de heteroarileno, conjugados de estos, y sus metodos de preparacion y uso
KR20230154089A (ko) 2017-04-20 2023-11-07 이뮤노젠 아이엔씨 인돌리노벤조다이아제핀 유도체를 제조하는 방법
EP4361128A3 (en) * 2018-11-12 2024-07-17 ImmunoGen, Inc. Methods of preparing cytotoxic benzodiazepine derivatives

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
US6660856B2 (en) * 2002-03-08 2003-12-09 Kaohsiung Medical University Synthesis of pyrrolo[2,1-c][1,4]benzodiazepine analogues
CN102365021A (zh) * 2009-02-05 2012-02-29 免疫基因公司 新型苯并二氮杂*衍生物
CN103687623A (zh) * 2011-02-15 2014-03-26 伊缪诺金公司 细胞毒性苯并二氮杂*衍生物

Non-Patent Citations (3)

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Title
A New Facile Procedure for the Preparation of Pyrrolo[2,1-c] [l,4]benzodiazepines :Synthesis of the Antibiotic DC-81 and its Thio Analogue;Ahmed Kamal, 等;《Tetrahedron Letters》;19961231;第37卷(第13期);第2281-2284页 *
Mayuko Ori，等.Stereospecific synthesis of 2,2,3-trisubstituted tetrahydroquinolines: application to the total syntheses of benzastatin E and natural virantmycin.《Tetrahedron》.2005,第61卷(第8期),2075-2104. *
Stereospecific synthesis of 2,2,3-trisubstituted tetrahydroquinolines: application to the total syntheses of benzastatin E and natural virantmycin;Mayuko Ori，等;《Tetrahedron》;20050122;第61卷(第8期);第2075-2104页，尤其流程7步骤(a) *

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IL305224A (en) 2023-10-01
JP2023015178A (ja) 2023-01-31
US20210292329A1 (en) 2021-09-23
JP2020517625A (ja) 2020-06-18
MA51510A (fr) 2020-11-11
AU2022215237B2 (en) 2024-05-02
KR20230154089A (ko) 2023-11-07
US20240067652A1 (en) 2024-02-29
EP3612533A1 (en) 2020-02-26
IL270008B (en) 2022-06-01
IL311609A (en) 2024-05-01
RU2019136798A3 (enExample) 2021-09-23
US11760759B2 (en) 2023-09-19
CA3060086A1 (en) 2018-10-25
JP7170663B2 (ja) 2022-11-14
AU2022215237A1 (en) 2022-09-01
US20200109145A1 (en) 2020-04-09
KR102595714B1 (ko) 2023-10-31
AU2018254463B2 (en) 2022-05-12
TW202337888A (zh) 2023-10-01
IL293192A (en) 2022-07-01
IL293192B2 (en) 2024-01-01
CN110573510A (zh) 2019-12-13
CN115448926A (zh) 2022-12-09
TWI840039B (zh) 2024-04-21
SG11201909564XA (en) 2019-11-28
WO2018195245A1 (en) 2018-10-25
US10442809B2 (en) 2019-10-15
US20180339989A1 (en) 2018-11-29
TWI790228B (zh) 2023-01-21
IL305224B1 (en) 2024-05-01
RU2019136798A (ru) 2021-05-20
IL293192B1 (en) 2023-09-01
US10968228B2 (en) 2021-04-06
IL305224B2 (en) 2024-09-01
AU2018254463A1 (en) 2019-11-07
KR20190140977A (ko) 2019-12-20
TW201838998A (zh) 2018-11-01

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