JP7170663B2 - インドリノベンゾジアゼピン誘導体の調製方法 - Google Patents

インドリノベンゾジアゼピン誘導体の調製方法 Download PDF

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JP7170663B2
JP7170663B2 JP2019556698A JP2019556698A JP7170663B2 JP 7170663 B2 JP7170663 B2 JP 7170663B2 JP 2019556698 A JP2019556698 A JP 2019556698A JP 2019556698 A JP2019556698 A JP 2019556698A JP 7170663 B2 JP7170663 B2 JP 7170663B2
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compound
formula
optionally substituted
carbon atoms
reaction
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JP2020517625A (ja
JP2020517625A5 (enExample
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ジェラルド，ボードワン
シルバ，リチャード・エイ
ミラー，マイケル・ルイス
シズカ，マナミ
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イミュノジェン・インコーポレーテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2019556698A 2017-04-20 2018-04-19 インドリノベンゾジアゼピン誘導体の調製方法 Active JP7170663B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022174347A JP2023015178A (ja) 2017-04-20 2022-10-31 インドリノベンゾジアゼピン誘導体の調製方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762487695P 2017-04-20 2017-04-20
US62/487,695 2017-04-20
PCT/US2018/028253 WO2018195245A1 (en) 2017-04-20 2018-04-19 Methods of preparing indolinobenzodiazepine derivatives

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JP2022174347A Division JP2023015178A (ja) 2017-04-20 2022-10-31 インドリノベンゾジアゼピン誘導体の調製方法

Publications (3)

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JP2020517625A JP2020517625A (ja) 2020-06-18
JP2020517625A5 JP2020517625A5 (enExample) 2021-05-27
JP7170663B2 true JP7170663B2 (ja) 2022-11-14

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JP2019556698A Active JP7170663B2 (ja) 2017-04-20 2018-04-19 インドリノベンゾジアゼピン誘導体の調製方法
JP2022174347A Ceased JP2023015178A (ja) 2017-04-20 2022-10-31 インドリノベンゾジアゼピン誘導体の調製方法

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US (4) US10442809B2 (enExample)
EP (1) EP3612533A1 (enExample)
JP (2) JP7170663B2 (enExample)
KR (2) KR20230154089A (enExample)
CN (2) CN110573510B (enExample)
AU (2) AU2018254463B2 (enExample)
CA (1) CA3060086A1 (enExample)
IL (4) IL293192B2 (enExample)
MA (1) MA51510A (enExample)
SG (1) SG11201909564XA (enExample)
TW (2) TWI790228B (enExample)
WO (1) WO2018195245A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230154089A (ko) 2017-04-20 2023-11-07 이뮤노젠 아이엔씨 인돌리노벤조다이아제핀 유도체를 제조하는 방법
AU2022325888A1 (en) * 2021-08-13 2024-02-22 Immunogen, Inc. Improved methods for preparing cytotoxic benzodiazepine derivatives
WO2024005123A1 (ja) 2022-06-30 2024-01-04 東レ株式会社 癌の治療及び／又は予防用医薬組成物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012516896A (ja) 2009-02-05 2012-07-26 イミュノジェン・インコーポレーテッド 新規ベンゾジアゼピン誘導体
JP2014521591A (ja) 2011-02-15 2014-08-28 イミュノジェン・インコーポレーテッド 細胞傷害性ベンゾジアゼピン誘導体

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US3453266A (en) 1966-03-14 1969-07-01 American Home Prod 1,2,5-benzothiadiazepine 1,1-dioxides
US3506646A (en) 1966-06-27 1970-04-14 American Home Prod Process for the preparation of 7h-pyrido (1,2-b)(1,2,5)benzothiadiazepine 5,5 - dioxides and pyrrolo(1,2-b)(1,2,5)benzothiadiazepine 5,5-dioxides
US3875162A (en) 1973-07-26 1975-04-01 Squibb & Sons Inc Certain 6H-pyrimido{8 1,2-c{9 {8 1,3,5{9 benzothiadiaza compounds
US4003905A (en) 1974-12-11 1977-01-18 E. R. Squibb & Sons, Inc. Diels-alder adducts of benzdiazepines
US4444688A (en) 1981-05-11 1984-04-24 Ciba-Geigy Corporation Imidazobenzothiadiazepines
JP2920385B2 (ja) 1988-08-18 1999-07-19 武田薬品工業株式会社 １，２，５‐ベンゾチアジアゼピン誘導体，その製造法および用途
JP3006615B2 (ja) * 1989-02-08 2000-02-07 電気化学工業株式会社 Ｄ―β―ヒドロキシアミノ酸の製造法
US6660856B2 (en) * 2002-03-08 2003-12-09 Kaohsiung Medical University Synthesis of pyrrolo[2,1-c][1,4]benzodiazepine analogues
GB0209467D0 (en) 2002-04-25 2002-06-05 Astrazeneca Ab Chemical compounds
RU2314309C2 (ru) 2003-03-31 2008-01-10 Каунсил Оф Сайентифик Энд Индастриал Рисерч Пирроло [2.1-c][1.4] бензодиазепины, способ их получения и фармацевтическая композиция на их основе
RU2338747C2 (ru) 2003-03-31 2008-11-20 Каунсил Оф Сайентифик Энд Индастриал Рисерч ДИМЕРЫ ПИРРОЛО [2, 1-c][1, 4] БЕНЗОДИАЗЕПИНА В КАЧЕСТВЕ ПРОТИВООПУХОЛЕВЫХ СРЕДСТВ И СПОСОБ ИХ ПОЛУЧЕНИЯ
GB201201100D0 (en) * 2012-01-20 2012-03-07 Medical Res Council Polypeptides and methods
JP2017527562A (ja) 2014-09-03 2017-09-21 イミュノジェン・インコーポレーテッド 細胞毒性ベンゾジアゼピン誘導体
DK3189056T3 (da) 2014-09-03 2020-09-14 Immunogen Inc Cytotoksiske benzodiazepinderivater
PE20171185A1 (es) 2015-01-14 2017-08-22 Bristol Myers Squibb Co Dimeros de benzodiazepina unidos con puentes de heteroarileno, conjugados de estos, y sus metodos de preparacion y uso
KR20230154089A (ko) 2017-04-20 2023-11-07 이뮤노젠 아이엔씨 인돌리노벤조다이아제핀 유도체를 제조하는 방법
EP4361128A3 (en) * 2018-11-12 2024-07-17 ImmunoGen, Inc. Methods of preparing cytotoxic benzodiazepine derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012516896A (ja) 2009-02-05 2012-07-26 イミュノジェン・インコーポレーテッド 新規ベンゾジアゼピン誘導体
JP2014521591A (ja) 2011-02-15 2014-08-28 イミュノジェン・インコーポレーテッド 細胞傷害性ベンゾジアゼピン誘導体

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IL305224A (en) 2023-10-01
JP2023015178A (ja) 2023-01-31
US20210292329A1 (en) 2021-09-23
JP2020517625A (ja) 2020-06-18
MA51510A (fr) 2020-11-11
AU2022215237B2 (en) 2024-05-02
KR20230154089A (ko) 2023-11-07
US20240067652A1 (en) 2024-02-29
EP3612533A1 (en) 2020-02-26
CN110573510B (zh) 2022-10-11
IL270008B (en) 2022-06-01
IL311609A (en) 2024-05-01
RU2019136798A3 (enExample) 2021-09-23
US11760759B2 (en) 2023-09-19
CA3060086A1 (en) 2018-10-25
AU2022215237A1 (en) 2022-09-01
US20200109145A1 (en) 2020-04-09
KR102595714B1 (ko) 2023-10-31
AU2018254463B2 (en) 2022-05-12
TW202337888A (zh) 2023-10-01
IL293192A (en) 2022-07-01
IL293192B2 (en) 2024-01-01
CN110573510A (zh) 2019-12-13
CN115448926A (zh) 2022-12-09
TWI840039B (zh) 2024-04-21
SG11201909564XA (en) 2019-11-28
WO2018195245A1 (en) 2018-10-25
US10442809B2 (en) 2019-10-15
US20180339989A1 (en) 2018-11-29
TWI790228B (zh) 2023-01-21
IL305224B1 (en) 2024-05-01
RU2019136798A (ru) 2021-05-20
IL293192B1 (en) 2023-09-01
US10968228B2 (en) 2021-04-06
IL305224B2 (en) 2024-09-01
AU2018254463A1 (en) 2019-11-07
KR20190140977A (ko) 2019-12-20
TW201838998A (zh) 2018-11-01

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