AU2018254463B2 - Methods of preparing indolinobenzodiazepine derivatives - Google Patents

Methods of preparing indolinobenzodiazepine derivatives Download PDF

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Publication number
AU2018254463B2
AU2018254463B2 AU2018254463A AU2018254463A AU2018254463B2 AU 2018254463 B2 AU2018254463 B2 AU 2018254463B2 AU 2018254463 A AU2018254463 A AU 2018254463A AU 2018254463 A AU2018254463 A AU 2018254463A AU 2018254463 B2 AU2018254463 B2 AU 2018254463B2
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AU
Australia
Prior art keywords
compound
formula
equivalent
reaction
mixture
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Ceased
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AU2018254463A
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English (en)
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AU2018254463A1 (en
Inventor
Baudouin GÉRARD
Michael Louis Miller
Manami Shizuka
Richard A. Silva
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Immunogen Inc
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Immunogen Inc
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Publication date
Application filed by Immunogen Inc filed Critical Immunogen Inc
Publication of AU2018254463A1 publication Critical patent/AU2018254463A1/en
Application granted granted Critical
Publication of AU2018254463B2 publication Critical patent/AU2018254463B2/en
Priority to AU2022215237A priority Critical patent/AU2022215237B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AU2018254463A 2017-04-20 2018-04-19 Methods of preparing indolinobenzodiazepine derivatives Ceased AU2018254463B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2022215237A AU2022215237B2 (en) 2017-04-20 2022-08-11 Methods of preparing indolinobenzodiazepine derivatives

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762487695P 2017-04-20 2017-04-20
US62/487,695 2017-04-20
PCT/US2018/028253 WO2018195245A1 (en) 2017-04-20 2018-04-19 Methods of preparing indolinobenzodiazepine derivatives

Related Child Applications (1)

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AU2022215237A Division AU2022215237B2 (en) 2017-04-20 2022-08-11 Methods of preparing indolinobenzodiazepine derivatives

Publications (2)

Publication Number Publication Date
AU2018254463A1 AU2018254463A1 (en) 2019-11-07
AU2018254463B2 true AU2018254463B2 (en) 2022-05-12

Family

ID=62117004

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2018254463A Ceased AU2018254463B2 (en) 2017-04-20 2018-04-19 Methods of preparing indolinobenzodiazepine derivatives
AU2022215237A Expired - Fee Related AU2022215237B2 (en) 2017-04-20 2022-08-11 Methods of preparing indolinobenzodiazepine derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2022215237A Expired - Fee Related AU2022215237B2 (en) 2017-04-20 2022-08-11 Methods of preparing indolinobenzodiazepine derivatives

Country Status (12)

Country Link
US (4) US10442809B2 (enExample)
EP (1) EP3612533A1 (enExample)
JP (2) JP7170663B2 (enExample)
KR (2) KR20230154089A (enExample)
CN (2) CN110573510B (enExample)
AU (2) AU2018254463B2 (enExample)
CA (1) CA3060086A1 (enExample)
IL (4) IL293192B2 (enExample)
MA (1) MA51510A (enExample)
SG (1) SG11201909564XA (enExample)
TW (2) TWI790228B (enExample)
WO (1) WO2018195245A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230154089A (ko) 2017-04-20 2023-11-07 이뮤노젠 아이엔씨 인돌리노벤조다이아제핀 유도체를 제조하는 방법
AU2022325888A1 (en) * 2021-08-13 2024-02-22 Immunogen, Inc. Improved methods for preparing cytotoxic benzodiazepine derivatives
WO2024005123A1 (ja) 2022-06-30 2024-01-04 東レ株式会社 癌の治療及び／又は予防用医薬組成物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010091150A1 (en) * 2009-02-05 2010-08-12 Immunogen, Inc. Novel benzodiazepine derivatives
WO2012128868A1 (en) * 2011-02-15 2012-09-27 Immunogen, Inc. Cytotoxic benzodiazepine derivatives

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US3453266A (en) 1966-03-14 1969-07-01 American Home Prod 1,2,5-benzothiadiazepine 1,1-dioxides
US3506646A (en) 1966-06-27 1970-04-14 American Home Prod Process for the preparation of 7h-pyrido (1,2-b)(1,2,5)benzothiadiazepine 5,5 - dioxides and pyrrolo(1,2-b)(1,2,5)benzothiadiazepine 5,5-dioxides
US3875162A (en) 1973-07-26 1975-04-01 Squibb & Sons Inc Certain 6H-pyrimido{8 1,2-c{9 {8 1,3,5{9 benzothiadiaza compounds
US4003905A (en) 1974-12-11 1977-01-18 E. R. Squibb & Sons, Inc. Diels-alder adducts of benzdiazepines
US4444688A (en) 1981-05-11 1984-04-24 Ciba-Geigy Corporation Imidazobenzothiadiazepines
JP2920385B2 (ja) 1988-08-18 1999-07-19 武田薬品工業株式会社 １，２，５‐ベンゾチアジアゼピン誘導体，その製造法および用途
JP3006615B2 (ja) * 1989-02-08 2000-02-07 電気化学工業株式会社 Ｄ―β―ヒドロキシアミノ酸の製造法
US6660856B2 (en) * 2002-03-08 2003-12-09 Kaohsiung Medical University Synthesis of pyrrolo[2,1-c][1,4]benzodiazepine analogues
GB0209467D0 (en) 2002-04-25 2002-06-05 Astrazeneca Ab Chemical compounds
RU2314309C2 (ru) 2003-03-31 2008-01-10 Каунсил Оф Сайентифик Энд Индастриал Рисерч Пирроло [2.1-c][1.4] бензодиазепины, способ их получения и фармацевтическая композиция на их основе
RU2338747C2 (ru) 2003-03-31 2008-11-20 Каунсил Оф Сайентифик Энд Индастриал Рисерч ДИМЕРЫ ПИРРОЛО [2, 1-c][1, 4] БЕНЗОДИАЗЕПИНА В КАЧЕСТВЕ ПРОТИВООПУХОЛЕВЫХ СРЕДСТВ И СПОСОБ ИХ ПОЛУЧЕНИЯ
GB201201100D0 (en) * 2012-01-20 2012-03-07 Medical Res Council Polypeptides and methods
JP2017527562A (ja) 2014-09-03 2017-09-21 イミュノジェン・インコーポレーテッド 細胞毒性ベンゾジアゼピン誘導体
DK3189056T3 (da) 2014-09-03 2020-09-14 Immunogen Inc Cytotoksiske benzodiazepinderivater
PE20171185A1 (es) 2015-01-14 2017-08-22 Bristol Myers Squibb Co Dimeros de benzodiazepina unidos con puentes de heteroarileno, conjugados de estos, y sus metodos de preparacion y uso
KR20230154089A (ko) 2017-04-20 2023-11-07 이뮤노젠 아이엔씨 인돌리노벤조다이아제핀 유도체를 제조하는 방법
EP4361128A3 (en) * 2018-11-12 2024-07-17 ImmunoGen, Inc. Methods of preparing cytotoxic benzodiazepine derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010091150A1 (en) * 2009-02-05 2010-08-12 Immunogen, Inc. Novel benzodiazepine derivatives
WO2012128868A1 (en) * 2011-02-15 2012-09-27 Immunogen, Inc. Cytotoxic benzodiazepine derivatives

Also Published As

Publication number Publication date
IL305224A (en) 2023-10-01
JP2023015178A (ja) 2023-01-31
US20210292329A1 (en) 2021-09-23
JP2020517625A (ja) 2020-06-18
MA51510A (fr) 2020-11-11
AU2022215237B2 (en) 2024-05-02
KR20230154089A (ko) 2023-11-07
US20240067652A1 (en) 2024-02-29
EP3612533A1 (en) 2020-02-26
CN110573510B (zh) 2022-10-11
IL270008B (en) 2022-06-01
IL311609A (en) 2024-05-01
RU2019136798A3 (enExample) 2021-09-23
US11760759B2 (en) 2023-09-19
CA3060086A1 (en) 2018-10-25
JP7170663B2 (ja) 2022-11-14
AU2022215237A1 (en) 2022-09-01
US20200109145A1 (en) 2020-04-09
KR102595714B1 (ko) 2023-10-31
TW202337888A (zh) 2023-10-01
IL293192A (en) 2022-07-01
IL293192B2 (en) 2024-01-01
CN110573510A (zh) 2019-12-13
CN115448926A (zh) 2022-12-09
TWI840039B (zh) 2024-04-21
SG11201909564XA (en) 2019-11-28
WO2018195245A1 (en) 2018-10-25
US10442809B2 (en) 2019-10-15
US20180339989A1 (en) 2018-11-29
TWI790228B (zh) 2023-01-21
IL305224B1 (en) 2024-05-01
RU2019136798A (ru) 2021-05-20
IL293192B1 (en) 2023-09-01
US10968228B2 (en) 2021-04-06
IL305224B2 (en) 2024-09-01
AU2018254463A1 (en) 2019-11-07
KR20190140977A (ko) 2019-12-20
TW201838998A (zh) 2018-11-01

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