TWI790228B - 製備吲哚啉苯并二氮平衍生物之方法 - Google Patents

製備吲哚啉苯并二氮平衍生物之方法 Download PDF

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Publication number
TWI790228B
TWI790228B TW107113286A TW107113286A TWI790228B TW I790228 B TWI790228 B TW I790228B TW 107113286 A TW107113286 A TW 107113286A TW 107113286 A TW107113286 A TW 107113286A TW I790228 B TWI790228 B TW I790228B
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TW
Taiwan
Prior art keywords
compound
formula
optionally substituted
independently selected
carbon atoms
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Application number
TW107113286A
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English (en)
Chinese (zh)
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TW201838998A (zh
Inventor
巴杜茵 吉拉
理查 A 希維
麥克 路伊斯 米勒
真名美 靜
Original Assignee
美商伊繆諾金公司
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Publication of TW201838998A publication Critical patent/TW201838998A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
TW107113286A 2017-04-20 2018-04-19 製備吲哚啉苯并二氮平衍生物之方法 TWI790228B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762487695P 2017-04-20 2017-04-20
US62/487,695 2017-04-20

Publications (2)

Publication Number Publication Date
TW201838998A TW201838998A (zh) 2018-11-01
TWI790228B true TWI790228B (zh) 2023-01-21

Family

ID=62117004

Family Applications (2)

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TW107113286A TWI790228B (zh) 2017-04-20 2018-04-19 製備吲哚啉苯并二氮平衍生物之方法
TW111149203A TWI840039B (zh) 2017-04-20 2018-04-19 製備吲哚啉苯并二氮平衍生物之方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW111149203A TWI840039B (zh) 2017-04-20 2018-04-19 製備吲哚啉苯并二氮平衍生物之方法

Country Status (12)

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US (4) US10442809B2 (enExample)
EP (1) EP3612533A1 (enExample)
JP (2) JP7170663B2 (enExample)
KR (2) KR20230154089A (enExample)
CN (2) CN110573510B (enExample)
AU (2) AU2018254463B2 (enExample)
CA (1) CA3060086A1 (enExample)
IL (4) IL293192B2 (enExample)
MA (1) MA51510A (enExample)
SG (1) SG11201909564XA (enExample)
TW (2) TWI790228B (enExample)
WO (1) WO2018195245A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230154089A (ko) 2017-04-20 2023-11-07 이뮤노젠 아이엔씨 인돌리노벤조다이아제핀 유도체를 제조하는 방법
AU2022325888A1 (en) * 2021-08-13 2024-02-22 Immunogen, Inc. Improved methods for preparing cytotoxic benzodiazepine derivatives
WO2024005123A1 (ja) 2022-06-30 2024-01-04 東レ株式会社 癌の治療及び／又は予防用医薬組成物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010091150A1 (en) * 2009-02-05 2010-08-12 Immunogen, Inc. Novel benzodiazepine derivatives
WO2012128868A1 (en) * 2011-02-15 2012-09-27 Immunogen, Inc. Cytotoxic benzodiazepine derivatives

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3453266A (en) 1966-03-14 1969-07-01 American Home Prod 1,2,5-benzothiadiazepine 1,1-dioxides
US3506646A (en) 1966-06-27 1970-04-14 American Home Prod Process for the preparation of 7h-pyrido (1,2-b)(1,2,5)benzothiadiazepine 5,5 - dioxides and pyrrolo(1,2-b)(1,2,5)benzothiadiazepine 5,5-dioxides
US3875162A (en) 1973-07-26 1975-04-01 Squibb & Sons Inc Certain 6H-pyrimido{8 1,2-c{9 {8 1,3,5{9 benzothiadiaza compounds
US4003905A (en) 1974-12-11 1977-01-18 E. R. Squibb & Sons, Inc. Diels-alder adducts of benzdiazepines
US4444688A (en) 1981-05-11 1984-04-24 Ciba-Geigy Corporation Imidazobenzothiadiazepines
JP2920385B2 (ja) 1988-08-18 1999-07-19 武田薬品工業株式会社 １，２，５‐ベンゾチアジアゼピン誘導体，その製造法および用途
JP3006615B2 (ja) * 1989-02-08 2000-02-07 電気化学工業株式会社 Ｄ―β―ヒドロキシアミノ酸の製造法
US6660856B2 (en) * 2002-03-08 2003-12-09 Kaohsiung Medical University Synthesis of pyrrolo[2,1-c][1,4]benzodiazepine analogues
GB0209467D0 (en) 2002-04-25 2002-06-05 Astrazeneca Ab Chemical compounds
RU2314309C2 (ru) 2003-03-31 2008-01-10 Каунсил Оф Сайентифик Энд Индастриал Рисерч Пирроло [2.1-c][1.4] бензодиазепины, способ их получения и фармацевтическая композиция на их основе
RU2338747C2 (ru) 2003-03-31 2008-11-20 Каунсил Оф Сайентифик Энд Индастриал Рисерч ДИМЕРЫ ПИРРОЛО [2, 1-c][1, 4] БЕНЗОДИАЗЕПИНА В КАЧЕСТВЕ ПРОТИВООПУХОЛЕВЫХ СРЕДСТВ И СПОСОБ ИХ ПОЛУЧЕНИЯ
GB201201100D0 (en) * 2012-01-20 2012-03-07 Medical Res Council Polypeptides and methods
JP2017527562A (ja) 2014-09-03 2017-09-21 イミュノジェン・インコーポレーテッド 細胞毒性ベンゾジアゼピン誘導体
DK3189056T3 (da) 2014-09-03 2020-09-14 Immunogen Inc Cytotoksiske benzodiazepinderivater
PE20171185A1 (es) 2015-01-14 2017-08-22 Bristol Myers Squibb Co Dimeros de benzodiazepina unidos con puentes de heteroarileno, conjugados de estos, y sus metodos de preparacion y uso
KR20230154089A (ko) 2017-04-20 2023-11-07 이뮤노젠 아이엔씨 인돌리노벤조다이아제핀 유도체를 제조하는 방법
EP4361128A3 (en) * 2018-11-12 2024-07-17 ImmunoGen, Inc. Methods of preparing cytotoxic benzodiazepine derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010091150A1 (en) * 2009-02-05 2010-08-12 Immunogen, Inc. Novel benzodiazepine derivatives
WO2012128868A1 (en) * 2011-02-15 2012-09-27 Immunogen, Inc. Cytotoxic benzodiazepine derivatives

Also Published As

Publication number Publication date
IL305224A (en) 2023-10-01
JP2023015178A (ja) 2023-01-31
US20210292329A1 (en) 2021-09-23
JP2020517625A (ja) 2020-06-18
MA51510A (fr) 2020-11-11
AU2022215237B2 (en) 2024-05-02
KR20230154089A (ko) 2023-11-07
US20240067652A1 (en) 2024-02-29
EP3612533A1 (en) 2020-02-26
CN110573510B (zh) 2022-10-11
IL270008B (en) 2022-06-01
IL311609A (en) 2024-05-01
RU2019136798A3 (enExample) 2021-09-23
US11760759B2 (en) 2023-09-19
CA3060086A1 (en) 2018-10-25
JP7170663B2 (ja) 2022-11-14
AU2022215237A1 (en) 2022-09-01
US20200109145A1 (en) 2020-04-09
KR102595714B1 (ko) 2023-10-31
AU2018254463B2 (en) 2022-05-12
TW202337888A (zh) 2023-10-01
IL293192A (en) 2022-07-01
IL293192B2 (en) 2024-01-01
CN110573510A (zh) 2019-12-13
CN115448926A (zh) 2022-12-09
TWI840039B (zh) 2024-04-21
SG11201909564XA (en) 2019-11-28
WO2018195245A1 (en) 2018-10-25
US10442809B2 (en) 2019-10-15
US20180339989A1 (en) 2018-11-29
IL305224B1 (en) 2024-05-01
RU2019136798A (ru) 2021-05-20
IL293192B1 (en) 2023-09-01
US10968228B2 (en) 2021-04-06
IL305224B2 (en) 2024-09-01
AU2018254463A1 (en) 2019-11-07
KR20190140977A (ko) 2019-12-20
TW201838998A (zh) 2018-11-01

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