KR20230154089A - 인돌리노벤조다이아제핀 유도체를 제조하는 방법 - Google Patents

인돌리노벤조다이아제핀 유도체를 제조하는 방법 Download PDF

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Publication number
KR20230154089A
KR20230154089A KR1020237036717A KR20237036717A KR20230154089A KR 20230154089 A KR20230154089 A KR 20230154089A KR 1020237036717 A KR1020237036717 A KR 1020237036717A KR 20237036717 A KR20237036717 A KR 20237036717A KR 20230154089 A KR20230154089 A KR 20230154089A
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KR
South Korea
Prior art keywords
compound
formula
carbon atoms
reaction
optionally substituted
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KR1020237036717A
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English (en)
Korean (ko)
Inventor
보두앙 제라드
리차드 에이. 실바
마이클 루이스 밀러
마나미 시즈카
Original Assignee
이뮤노젠 아이엔씨
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Application filed by 이뮤노젠 아이엔씨 filed Critical 이뮤노젠 아이엔씨
Publication of KR20230154089A publication Critical patent/KR20230154089A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1020237036717A 2017-04-20 2018-04-19 인돌리노벤조다이아제핀 유도체를 제조하는 방법 Pending KR20230154089A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762487695P 2017-04-20 2017-04-20
US62/487,695 2017-04-20
PCT/US2018/028253 WO2018195245A1 (en) 2017-04-20 2018-04-19 Methods of preparing indolinobenzodiazepine derivatives
KR1020197033777A KR102595714B1 (ko) 2017-04-20 2018-04-19 인돌리노벤조다이아제핀 유도체를 제조하는 방법

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020197033777A Division KR102595714B1 (ko) 2017-04-20 2018-04-19 인돌리노벤조다이아제핀 유도체를 제조하는 방법

Publications (1)

Publication Number Publication Date
KR20230154089A true KR20230154089A (ko) 2023-11-07

Family

ID=62117004

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020237036717A Pending KR20230154089A (ko) 2017-04-20 2018-04-19 인돌리노벤조다이아제핀 유도체를 제조하는 방법
KR1020197033777A Active KR102595714B1 (ko) 2017-04-20 2018-04-19 인돌리노벤조다이아제핀 유도체를 제조하는 방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020197033777A Active KR102595714B1 (ko) 2017-04-20 2018-04-19 인돌리노벤조다이아제핀 유도체를 제조하는 방법

Country Status (12)

Country Link
US (4) US10442809B2 (enExample)
EP (1) EP3612533A1 (enExample)
JP (2) JP7170663B2 (enExample)
KR (2) KR20230154089A (enExample)
CN (2) CN110573510B (enExample)
AU (2) AU2018254463B2 (enExample)
CA (1) CA3060086A1 (enExample)
IL (4) IL293192B2 (enExample)
MA (1) MA51510A (enExample)
SG (1) SG11201909564XA (enExample)
TW (2) TWI790228B (enExample)
WO (1) WO2018195245A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230154089A (ko) 2017-04-20 2023-11-07 이뮤노젠 아이엔씨 인돌리노벤조다이아제핀 유도체를 제조하는 방법
AU2022325888A1 (en) * 2021-08-13 2024-02-22 Immunogen, Inc. Improved methods for preparing cytotoxic benzodiazepine derivatives
WO2024005123A1 (ja) 2022-06-30 2024-01-04 東レ株式会社 癌の治療及び／又は予防用医薬組成物

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3453266A (en) 1966-03-14 1969-07-01 American Home Prod 1,2,5-benzothiadiazepine 1,1-dioxides
US3506646A (en) 1966-06-27 1970-04-14 American Home Prod Process for the preparation of 7h-pyrido (1,2-b)(1,2,5)benzothiadiazepine 5,5 - dioxides and pyrrolo(1,2-b)(1,2,5)benzothiadiazepine 5,5-dioxides
US3875162A (en) 1973-07-26 1975-04-01 Squibb & Sons Inc Certain 6H-pyrimido{8 1,2-c{9 {8 1,3,5{9 benzothiadiaza compounds
US4003905A (en) 1974-12-11 1977-01-18 E. R. Squibb & Sons, Inc. Diels-alder adducts of benzdiazepines
US4444688A (en) 1981-05-11 1984-04-24 Ciba-Geigy Corporation Imidazobenzothiadiazepines
JP2920385B2 (ja) 1988-08-18 1999-07-19 武田薬品工業株式会社 １，２，５‐ベンゾチアジアゼピン誘導体，その製造法および用途
JP3006615B2 (ja) * 1989-02-08 2000-02-07 電気化学工業株式会社 Ｄ―β―ヒドロキシアミノ酸の製造法
US6660856B2 (en) * 2002-03-08 2003-12-09 Kaohsiung Medical University Synthesis of pyrrolo[2,1-c][1,4]benzodiazepine analogues
GB0209467D0 (en) 2002-04-25 2002-06-05 Astrazeneca Ab Chemical compounds
RU2314309C2 (ru) 2003-03-31 2008-01-10 Каунсил Оф Сайентифик Энд Индастриал Рисерч Пирроло [2.1-c][1.4] бензодиазепины, способ их получения и фармацевтическая композиция на их основе
RU2338747C2 (ru) 2003-03-31 2008-11-20 Каунсил Оф Сайентифик Энд Индастриал Рисерч ДИМЕРЫ ПИРРОЛО [2, 1-c][1, 4] БЕНЗОДИАЗЕПИНА В КАЧЕСТВЕ ПРОТИВООПУХОЛЕВЫХ СРЕДСТВ И СПОСОБ ИХ ПОЛУЧЕНИЯ
JP5977522B2 (ja) * 2009-02-05 2016-08-24 イミュノジェン・インコーポレーテッド 新規ベンゾジアゼピン誘導体
TWI617555B (zh) * 2011-02-15 2018-03-11 免疫原公司 細胞毒性苯并二氮呯衍生物
GB201201100D0 (en) * 2012-01-20 2012-03-07 Medical Res Council Polypeptides and methods
JP2017527562A (ja) 2014-09-03 2017-09-21 イミュノジェン・インコーポレーテッド 細胞毒性ベンゾジアゼピン誘導体
DK3189056T3 (da) 2014-09-03 2020-09-14 Immunogen Inc Cytotoksiske benzodiazepinderivater
PE20171185A1 (es) 2015-01-14 2017-08-22 Bristol Myers Squibb Co Dimeros de benzodiazepina unidos con puentes de heteroarileno, conjugados de estos, y sus metodos de preparacion y uso
KR20230154089A (ko) 2017-04-20 2023-11-07 이뮤노젠 아이엔씨 인돌리노벤조다이아제핀 유도체를 제조하는 방법
EP4361128A3 (en) * 2018-11-12 2024-07-17 ImmunoGen, Inc. Methods of preparing cytotoxic benzodiazepine derivatives

Also Published As

Publication number Publication date
IL305224A (en) 2023-10-01
JP2023015178A (ja) 2023-01-31
US20210292329A1 (en) 2021-09-23
JP2020517625A (ja) 2020-06-18
MA51510A (fr) 2020-11-11
AU2022215237B2 (en) 2024-05-02
US20240067652A1 (en) 2024-02-29
EP3612533A1 (en) 2020-02-26
CN110573510B (zh) 2022-10-11
IL270008B (en) 2022-06-01
IL311609A (en) 2024-05-01
RU2019136798A3 (enExample) 2021-09-23
US11760759B2 (en) 2023-09-19
CA3060086A1 (en) 2018-10-25
JP7170663B2 (ja) 2022-11-14
AU2022215237A1 (en) 2022-09-01
US20200109145A1 (en) 2020-04-09
KR102595714B1 (ko) 2023-10-31
AU2018254463B2 (en) 2022-05-12
TW202337888A (zh) 2023-10-01
IL293192A (en) 2022-07-01
IL293192B2 (en) 2024-01-01
CN110573510A (zh) 2019-12-13
CN115448926A (zh) 2022-12-09
TWI840039B (zh) 2024-04-21
SG11201909564XA (en) 2019-11-28
WO2018195245A1 (en) 2018-10-25
US10442809B2 (en) 2019-10-15
US20180339989A1 (en) 2018-11-29
TWI790228B (zh) 2023-01-21
IL305224B1 (en) 2024-05-01
RU2019136798A (ru) 2021-05-20
IL293192B1 (en) 2023-09-01
US10968228B2 (en) 2021-04-06
IL305224B2 (en) 2024-09-01
AU2018254463A1 (en) 2019-11-07
KR20190140977A (ko) 2019-12-20
TW201838998A (zh) 2018-11-01

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