JP2006501277A5 - - Google Patents
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- JP2006501277A5 JP2006501277A5 JP2004537412A JP2004537412A JP2006501277A5 JP 2006501277 A5 JP2006501277 A5 JP 2006501277A5 JP 2004537412 A JP2004537412 A JP 2004537412A JP 2004537412 A JP2004537412 A JP 2004537412A JP 2006501277 A5 JP2006501277 A5 JP 2006501277A5
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- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- formula
- compound
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims description 14
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 31
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000004429 atom Chemical group 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- 208000030507 AIDS Diseases 0.000 claims 2
- 206010012438 Dermatitis atopic Diseases 0.000 claims 2
- 206010020751 Hypersensitivity Diseases 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000001132 Osteoporosis Diseases 0.000 claims 2
- 230000007815 allergy Effects 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 201000008937 atopic dermatitis Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- BIQDLXRMNLJNOR-UHFFFAOYSA-N 2-[2-(8-chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-5-yl)oxyethylamino]acetamide Chemical compound C1=2C(OCCNCC(=O)N)=CC=C(Cl)C=2NC(=O)NC21CCCCC2 BIQDLXRMNLJNOR-UHFFFAOYSA-N 0.000 claims 1
- KOCFXLAHAIRSES-UHFFFAOYSA-N 8-chloro-5-(methylsulfinylmethoxy)spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one Chemical compound C1=2C(OCS(=O)C)=CC=C(Cl)C=2NC(=O)NC21CCCCC2 KOCFXLAHAIRSES-UHFFFAOYSA-N 0.000 claims 1
- BNHDUQCRMVNFFB-UHFFFAOYSA-N 8-fluoro-5-(3-methylsulfinylpropoxy)spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one Chemical compound C1=2C(OCCCS(=O)C)=CC=C(F)C=2NC(=O)NC21CCCCC2 BNHDUQCRMVNFFB-UHFFFAOYSA-N 0.000 claims 1
- NFQMWKNAADJCSF-UHFFFAOYSA-N 8-fluoro-5-(methylsulfinylmethoxy)spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one Chemical compound C1=2C(OCS(=O)C)=CC=C(F)C=2NC(=O)NC21CCCCC2 NFQMWKNAADJCSF-UHFFFAOYSA-N 0.000 claims 1
- -1 8′-Fluoro-5 ′-{[1- (1H-pyrazol-3-ylmethyl) azetidin-3-yl] oxy} 1′H-spiro [cyclohexane-1,4′-quinazoline] Chemical compound 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 206010010741 Conjunctivitis Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 206010028289 Muscle atrophy Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 229940123304 Phosphodiesterase 7 inhibitor Drugs 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 230000020763 muscle atrophy Effects 0.000 claims 1
- 201000000585 muscular atrophy Diseases 0.000 claims 1
- IMZMUNGROJZNFZ-UHFFFAOYSA-N n-[2-[2-(8-chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-5-yl)oxyethylamino]ethyl]acetamide Chemical compound C1=2C(OCCNCCNC(=O)C)=CC=C(Cl)C=2NC(=O)NC21CCCCC2 IMZMUNGROJZNFZ-UHFFFAOYSA-N 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000002606 phosphodiesterase VII inhibitor Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
- 208000024794 sputum Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 9
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 239000011541 reaction mixture Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000003054 catalyst Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- 239000012044 organic layer Substances 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 description 2
- 235000011152 sodium sulphate Nutrition 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- RUTKJXMYXZFXPQ-UHFFFAOYSA-N 2-fluoro-5-methoxyaniline Chemical compound COC1=CC=C(F)C(N)=C1 RUTKJXMYXZFXPQ-UHFFFAOYSA-N 0.000 description 1
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 1
- 229920001410 Microfiber Polymers 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- FHKPLLOSJHHKNU-INIZCTEOSA-N [(3S)-3-[8-(1-ethyl-5-methylpyrazol-4-yl)-9-methylpurin-6-yl]oxypyrrolidin-1-yl]-(oxan-4-yl)methanone Chemical compound C(C)N1N=CC(=C1C)C=1N(C2=NC=NC(=C2N=1)O[C@@H]1CN(CC1)C(=O)C1CCOCC1)C FHKPLLOSJHHKNU-INIZCTEOSA-N 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 239000003658 microfiber Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20020292275 EP1400244A1 (en) | 2002-09-17 | 2002-09-17 | New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors |
| PCT/IB2003/003965 WO2004026818A1 (en) | 2002-09-17 | 2003-09-08 | New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006501277A JP2006501277A (ja) | 2006-01-12 |
| JP2006501277A5 true JP2006501277A5 (enExample) | 2006-10-19 |
Family
ID=31896987
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004537412A Withdrawn JP2006501277A (ja) | 2002-09-17 | 2003-09-08 | 新規なスピロ縮合キナゾリノンおよびそれらのホスホジエステラーゼ阻害剤としての使用 |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US7429598B2 (enExample) |
| EP (2) | EP1400244A1 (enExample) |
| JP (1) | JP2006501277A (enExample) |
| KR (1) | KR20050057371A (enExample) |
| CN (1) | CN1681507A (enExample) |
| AP (1) | AP2005003251A0 (enExample) |
| AR (1) | AR041271A1 (enExample) |
| AU (1) | AU2003259496A1 (enExample) |
| BR (1) | BR0314379A (enExample) |
| CA (1) | CA2499330C (enExample) |
| CO (1) | CO5540391A2 (enExample) |
| CR (1) | CR7728A (enExample) |
| EA (1) | EA200500312A1 (enExample) |
| EC (1) | ECSP055671A (enExample) |
| GT (1) | GT200300201A (enExample) |
| HN (1) | HN2003000285A (enExample) |
| HR (1) | HRP20050223A2 (enExample) |
| IS (1) | IS7700A (enExample) |
| MA (1) | MA27439A1 (enExample) |
| MX (1) | MXPA05002913A (enExample) |
| NO (1) | NO20051695L (enExample) |
| OA (1) | OA12924A (enExample) |
| PA (1) | PA8582801A1 (enExample) |
| PE (1) | PE20050073A1 (enExample) |
| PL (1) | PL375977A1 (enExample) |
| TN (1) | TNSN05073A1 (enExample) |
| TW (1) | TWI251590B (enExample) |
| UY (1) | UY27986A1 (enExample) |
| WO (1) | WO2004026818A1 (enExample) |
| ZA (1) | ZA200501381B (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2425013T3 (es) | 2002-06-12 | 2013-10-10 | Symphony Evolution, Inc. | Inhibidores de ADAM-10 humana |
| GB0504209D0 (en) * | 2005-03-01 | 2005-04-06 | Pfizer Ltd | New use of PDE7 inhibitors |
| WO2006092692A1 (en) * | 2005-03-01 | 2006-09-08 | Pfizer Limited | Use of combinations of pde7 inhibitors and alpha-2-delty ligands for the treatment of neuropathic pain |
| CA2599662A1 (en) * | 2005-03-01 | 2006-09-08 | Pfizer Limited | Use of pde7 inhibitors for the treatment of neuropathic pain |
| EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス，インコーポレイティド | ムスカリン性受容体調節による神経発生 |
| CA2625153A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| JP2009517453A (ja) | 2005-12-02 | 2009-04-30 | ファイザー・リミテッド | Ｐｄｅ７阻害剤としてのスピロ環式キナゾリン誘導体 |
| WO2007087684A1 (en) | 2006-02-03 | 2007-08-09 | Bionomics Limited | Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| MX2008014320A (es) | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
| EP2382975A3 (en) | 2006-05-09 | 2012-02-29 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| JP2010502722A (ja) | 2006-09-08 | 2010-01-28 | ブレインセルス，インコーポレイティド | ４−アシルアミノピリジン誘導体を含む組み合わせ |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| AU2008230710B2 (en) * | 2007-03-27 | 2014-04-10 | Omeros Corporation | The use of PDE7 inhibitors for the treatment of movement disorders |
| US8637528B2 (en) | 2007-03-27 | 2014-01-28 | Omeros Corporation | Use of PDE7 inhibitors for the treatment of movement disorders |
| US20100216823A1 (en) * | 2007-05-24 | 2010-08-26 | Pfizer Inc. | Spirocyclic Derivatives |
| CL2008001933A1 (es) | 2007-06-29 | 2009-09-25 | Millennium Pharm Inc | Compuestos derivados de pirimidina, inhibidores de la raf quinasa; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar trastornos proliferativos, cardiacos, neurodegenerativos, inflamatorios, oseos, inmunologicos enfermedad viral, entre otros. |
| CA2694284A1 (en) * | 2007-06-29 | 2009-01-08 | Jennifer Cossrow | Heterocyclic compounds useful as raf kinase inhibitors |
| SG193842A1 (en) | 2008-08-06 | 2013-10-30 | Biomarin Pharm Inc | Dihydropyridophthalazinone inhibitors of poly(adp-ribose)polymerase (parp) |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| CN106943406A (zh) | 2010-02-03 | 2017-07-14 | 麦迪韦逊科技有限公司 | 用于pten基因缺失相关疾病的治疗的聚(adp‑核糖)聚合酶(parp)的二氢吡啶并酞嗪酮抑制剂 |
| US20110190266A1 (en) * | 2010-02-04 | 2011-08-04 | Daniel Chu | 5,6,6a,7,8,9-HEXAHYDRO-2H-PYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) |
| SI2533640T1 (sl) * | 2010-02-08 | 2017-02-28 | Medivation Technologies, Inc. | Postopki sinteze derivatov dihidropiridoftalazinona |
| PL2630146T3 (pl) | 2010-10-21 | 2020-11-02 | Medivation Technologies Llc | Krystaliczna sól tosylanowa (8S,9R)-5-fluoro-8-(4-fluorofenylo)-9-(1-metylo-1H-1,2,4-triazol-5-ilo)-8,9-dihydro-2H-pirydo[4,3,2-de]ftalazyno-3(7H)-onu |
| US9220715B2 (en) | 2010-11-08 | 2015-12-29 | Omeros Corporation | Treatment of addiction and impulse-control disorders using PDE7 inhibitors |
| CN107375296A (zh) | 2010-11-08 | 2017-11-24 | 奥默罗斯公司 | 使用pde7抑制剂治疗成瘾和冲动控制障碍 |
| EP2804603A1 (en) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| EP3652180B1 (en) | 2017-07-12 | 2023-11-29 | Dart NeuroScience, LLC | Substituted benzoxazole and benzofuran compounds as pde7 inhibitors |
| CN112574202B (zh) * | 2020-12-11 | 2021-11-09 | 台州学院 | 一种螺喹唑啉-2-酮类衍生物及其制备方法和应用 |
| CN119894518A (zh) | 2022-08-18 | 2025-04-25 | 米托迪治愈有限责任公司 | 取代的苯并噁唑和苯并呋喃化合物用于治疗和预防与慢性疲劳、筋疲力尽和/或劳累不耐受相关的疾病的用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5959685A (ja) * | 1982-09-28 | 1984-04-05 | Kyowa Hakko Kogyo Co Ltd | 新規なピペリジン誘導体 |
| JPS5959865A (ja) * | 1982-09-30 | 1984-04-05 | Ube Ind Ltd | 耐熱鋳鋼 |
| US4906630A (en) * | 1985-11-22 | 1990-03-06 | Rorer Pharmaceutical Corporation | Method of increasing cardiac contractility using pharmaceutical compositions comprising benzodiazinone- pyridazinone or hydroxy-pyrazolyl compounds |
| US4666913A (en) * | 1985-11-22 | 1987-05-19 | William H. Rorer, Inc. | Hydroxy and aminothiazolyl-benzodiazinone compounds, cardiotonic compositions including the same, and their uses |
| US4764512A (en) | 1986-08-27 | 1988-08-16 | Rorer Pharmaceutical Corporation | Benzodiazinone-pyridone compounds, cardiotonic compositions including the same, and their uses |
| US5102886A (en) | 1990-10-12 | 1992-04-07 | American Home Products Corporation | 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors |
| IL102764A0 (en) * | 1991-08-16 | 1993-01-31 | Merck & Co Inc | Quinazoline derivatives,and pharmaceutical compositions containing them |
| WO2000066560A1 (en) | 1999-05-04 | 2000-11-09 | American Home Products Corporation | Quinazolinone and benzoxazine derivatives as progesterone receptor modulators |
| WO2002076953A1 (en) * | 2001-03-21 | 2002-10-03 | Warner-Lambert Company Llc | New spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors |
| US6596167B2 (en) | 2001-03-26 | 2003-07-22 | Koch Membrane Systems, Inc. | Hydrophilic hollow fiber ultrafiltration membranes that include a hydrophobic polymer and a method of making these membranes |
-
2002
- 2002-09-17 EP EP20020292275 patent/EP1400244A1/en not_active Withdrawn
-
2003
- 2003-09-08 AU AU2003259496A patent/AU2003259496A1/en not_active Abandoned
- 2003-09-08 CA CA 2499330 patent/CA2499330C/en not_active Expired - Fee Related
- 2003-09-08 MX MXPA05002913A patent/MXPA05002913A/es active IP Right Grant
- 2003-09-08 HR HR20050223A patent/HRP20050223A2/hr not_active Application Discontinuation
- 2003-09-08 OA OA1200500073A patent/OA12924A/en unknown
- 2003-09-08 EP EP20030797455 patent/EP1542694A1/en not_active Withdrawn
- 2003-09-08 JP JP2004537412A patent/JP2006501277A/ja not_active Withdrawn
- 2003-09-08 WO PCT/IB2003/003965 patent/WO2004026818A1/en not_active Ceased
- 2003-09-08 PL PL37597703A patent/PL375977A1/xx not_active Application Discontinuation
- 2003-09-08 KR KR1020057004511A patent/KR20050057371A/ko not_active Ceased
- 2003-09-08 AP AP2005003251A patent/AP2005003251A0/xx unknown
- 2003-09-08 EA EA200500312A patent/EA200500312A1/ru unknown
- 2003-09-08 CN CNA038221284A patent/CN1681507A/zh active Pending
- 2003-09-08 BR BR0314379A patent/BR0314379A/pt not_active IP Right Cessation
- 2003-09-16 AR ARP030103355 patent/AR041271A1/es unknown
- 2003-09-16 TW TW92125477A patent/TWI251590B/zh not_active IP Right Cessation
- 2003-09-16 PA PA8582801A patent/PA8582801A1/es unknown
- 2003-09-16 PE PE2003000943A patent/PE20050073A1/es not_active Application Discontinuation
- 2003-09-17 UY UY27986A patent/UY27986A1/es not_active Application Discontinuation
- 2003-09-17 GT GT200300201A patent/GT200300201A/es unknown
- 2003-09-17 HN HN2003000285A patent/HN2003000285A/es unknown
- 2003-09-17 US US10/667,111 patent/US7429598B2/en not_active Expired - Fee Related
-
2005
- 2005-02-16 ZA ZA200501381A patent/ZA200501381B/xx unknown
- 2005-02-17 IS IS7700A patent/IS7700A/is unknown
- 2005-03-10 CR CR7728A patent/CR7728A/es not_active Application Discontinuation
- 2005-03-11 EC ECSP055671 patent/ECSP055671A/es unknown
- 2005-03-16 CO CO05024530A patent/CO5540391A2/es not_active Application Discontinuation
- 2005-03-17 MA MA28153A patent/MA27439A1/fr unknown
- 2005-03-17 TN TNP2005000073A patent/TNSN05073A1/fr unknown
- 2005-04-05 NO NO20051695A patent/NO20051695L/no not_active Application Discontinuation
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