JP2020512363A - 成人及び青年における低ホスファターゼ症（ｈｐｐ）を治療する方法 - Google Patents

成人及び青年における低ホスファターゼ症（ｈｐｐ）を治療する方法 Download PDF

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JP2020512363A
JP2020512363A JP2019553247A JP2019553247A JP2020512363A JP 2020512363 A JP2020512363 A JP 2020512363A JP 2019553247 A JP2019553247 A JP 2019553247A JP 2019553247 A JP2019553247 A JP 2019553247A JP 2020512363 A JP2020512363 A JP 2020512363A
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salp
years
hpp
patient
week
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JP2020512363A5 (https=
Inventor
モーズリー，スコット，エドワード
デンカー，アンドリュー，イー．
パン，ウェイ−ジアン
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アレクシオン ファーマシューティカルズ， インコーポレイテッド
アレクシオン ファーマシューティカルズ， インコーポレイテッド
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Publication of JP2020512363A publication Critical patent/JP2020512363A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03001—Alkaline phosphatase (3.1.3.1)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2019553247A 2017-03-31 2018-03-29 成人及び青年における低ホスファターゼ症（ｈｐｐ）を治療する方法 Pending JP2020512363A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023035689A JP2023085277A (ja) 2017-03-31 2023-03-08 成人及び青年における低ホスファターゼ症（ｈｐｐ）を治療する方法

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762480213P 2017-03-31 2017-03-31
US62/480,213 2017-03-31
US201762502255P 2017-05-05 2017-05-05
US62/502,255 2017-05-05
US201862643953P 2018-03-16 2018-03-16
US62/643,953 2018-03-16
PCT/US2018/025206 WO2018183720A1 (en) 2017-03-31 2018-03-29 Methods for treating hypophosphatasia (hpp) in adults and adolescents

Related Child Applications (1)

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JP2023035689A Division JP2023085277A (ja) 2017-03-31 2023-03-08 成人及び青年における低ホスファターゼ症（ｈｐｐ）を治療する方法

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JP2020512363A true JP2020512363A (ja) 2020-04-23
JP2020512363A5 JP2020512363A5 (https=) 2021-05-06

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JP2019553247A Pending JP2020512363A (ja) 2017-03-31 2018-03-29 成人及び青年における低ホスファターゼ症（ｈｐｐ）を治療する方法
JP2023035689A Pending JP2023085277A (ja) 2017-03-31 2023-03-08 成人及び青年における低ホスファターゼ症（ｈｐｐ）を治療する方法

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US (1) US11224637B2 (https=)
EP (1) EP3600383A4 (https=)
JP (2) JP2020512363A (https=)
KR (2) KR20190129058A (https=)
CN (1) CN110719786A (https=)
AU (1) AU2018243320B2 (https=)
BR (1) BR112019020506A2 (https=)
CA (1) CA3057502A1 (https=)
MX (1) MX2019011508A (https=)
WO (1) WO2018183720A1 (https=)

Cited By (1)

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JP2023540741A (ja) * 2020-09-04 2023-09-26 アレクシオン ファーマシューティカルズ， インコーポレイテッド 骨石灰化障害を処置する方法

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WO2019183208A1 (en) 2018-03-20 2019-09-26 Synthetic Biologics, Inc. Intestinal alkaline phosphatase formulations
ES2972119T3 (es) 2018-08-10 2024-06-11 Alexion Pharma Inc Cicatrización ósea en implantes utilizando fosfatasa alcalina
KR20220005560A (ko) 2019-05-06 2022-01-13 신세틱 바이오로직스, 인코퍼레이티드 알칼리성 포스페이트-기반 종양학 치료제
KR20220111693A (ko) 2019-12-09 2022-08-09 알렉시온 파마슈티칼스, 인코포레이티드 알칼리성 포스파타제 폴리펩티드 및 이의 이용 방법
EP4084819A1 (en) * 2020-01-03 2022-11-09 The United States of America, as represented by the Secretary, Department of Health and Human Services Tnap locally administered for promoting periodontal health
EP4236928A4 (en) 2020-10-30 2024-08-28 1Cbio, Inc. ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE 1 (ENPP1) INHIBITORS AND THEIR USES
WO2024206782A1 (en) * 2023-03-31 2024-10-03 1Cbio, Inc. Ectonucleotide pyrophosphatase/phosphodiesterase 1 (enpp1) inhibitors for the treatment of hypophosphatasia

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JP2007533669A (ja) * 2004-04-21 2007-11-22 エノビア ファーマ インコーポレイティド 骨送達複合体ならびにタンパク質に骨を標的化させるためのその使用方法
JP2017505128A (ja) * 2014-01-24 2017-02-16 アーエム−ファルマ ベー．フェー．ＡＭ−Ｐｈａｒｍａ Ｂ．Ｖ． キメラアルカリホスファターゼ様タンパク質

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