JP2020510119A5 - - Google Patents
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- JP2020510119A5 JP2020510119A5 JP2019549419A JP2019549419A JP2020510119A5 JP 2020510119 A5 JP2020510119 A5 JP 2020510119A5 JP 2019549419 A JP2019549419 A JP 2019549419A JP 2019549419 A JP2019549419 A JP 2019549419A JP 2020510119 A5 JP2020510119 A5 JP 2020510119A5
- Authority
- JP
- Japan
- Prior art keywords
- synthetic
- heparinoid
- synthetic heparinoid
- group
- ost
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920001499 Heparinoid Polymers 0.000 claims 22
- 239000002554 heparinoid Substances 0.000 claims 22
- 238000000034 method Methods 0.000 claims 11
- 150000002016 disaccharides Chemical group 0.000 claims 7
- 238000005670 sulfation reaction Methods 0.000 claims 6
- 239000000758 substrate Substances 0.000 claims 5
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical class OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- LQNUZADURLCDLV-UHFFFAOYSA-N nitrobenzene Chemical group [O-][N+](=O)C1=CC=CC=C1 LQNUZADURLCDLV-UHFFFAOYSA-N 0.000 claims 3
- 125000000547 substituted alkyl group Chemical group 0.000 claims 3
- 125000003107 substituted aryl group Chemical group 0.000 claims 3
- 230000002194 synthesizing effect Effects 0.000 claims 3
- 108090000790 Enzymes Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims 2
- 108700023372 Glycosyltransferases Proteins 0.000 claims 2
- 102000051366 Glycosyltransferases Human genes 0.000 claims 2
- 206010062506 Heparin-induced thrombocytopenia Diseases 0.000 claims 2
- 108010018682 PRT064445 Proteins 0.000 claims 2
- IAJILQKETJEXLJ-QTBDOELSSA-N aldehydo-D-glucuronic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-QTBDOELSSA-N 0.000 claims 2
- 230000001858 anti-Xa Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 229940097043 glucuronic acid Drugs 0.000 claims 2
- 230000014508 negative regulation of coagulation Effects 0.000 claims 2
- ZXNYUXIMAXVSFN-IVMDWMLBSA-N 2,2,2-trifluoro-n-[(3r,4r,5s,6r)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide Chemical compound OC[C@H]1OC(O)[C@H](NC(=O)C(F)(F)F)[C@@H](O)[C@@H]1O ZXNYUXIMAXVSFN-IVMDWMLBSA-N 0.000 claims 1
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 102100023937 Heparan sulfate glucosamine 3-O-sulfotransferase 1 Human genes 0.000 claims 1
- 101001048058 Homo sapiens Heparan sulfate glucosamine 3-O-sulfotransferase 1 Proteins 0.000 claims 1
- 102100023315 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase Human genes 0.000 claims 1
- 108010056664 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase Proteins 0.000 claims 1
- 241000606856 Pasteurella multocida Species 0.000 claims 1
- 102000001708 Protein Isoforms Human genes 0.000 claims 1
- 108010029485 Protein Isoforms Proteins 0.000 claims 1
- 229950002054 andexanet alfa Drugs 0.000 claims 1
- 239000003146 anticoagulant agent Substances 0.000 claims 1
- 229940127219 anticoagulant drug Drugs 0.000 claims 1
- 239000004019 antithrombin Substances 0.000 claims 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 229960002442 glucosamine Drugs 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 229940025770 heparinoids Drugs 0.000 claims 1
- 150000002772 monosaccharides Chemical class 0.000 claims 1
- 229920001542 oligosaccharide Polymers 0.000 claims 1
- 150000002482 oligosaccharides Chemical class 0.000 claims 1
- 229940051027 pasteurella multocida Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002441 reversible effect Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023129964A JP7702454B2 (ja) | 2017-03-10 | 2023-08-09 | 短時間作用型ヘパリンベースの抗凝集剤化合物及び方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762469643P | 2017-03-10 | 2017-03-10 | |
| US62/469,643 | 2017-03-10 | ||
| PCT/US2018/021986 WO2018165656A1 (en) | 2017-03-10 | 2018-03-12 | Short-acting heparin-based anticoagulant compounds and methods |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023129964A Division JP7702454B2 (ja) | 2017-03-10 | 2023-08-09 | 短時間作用型ヘパリンベースの抗凝集剤化合物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020510119A JP2020510119A (ja) | 2020-04-02 |
| JP2020510119A5 true JP2020510119A5 (https=) | 2021-04-08 |
| JP7330893B2 JP7330893B2 (ja) | 2023-08-22 |
Family
ID=63449042
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019549419A Active JP7330893B2 (ja) | 2017-03-10 | 2018-03-12 | 短時間作用型ヘパリンベースの抗凝集剤化合物及び方法 |
| JP2023129964A Active JP7702454B2 (ja) | 2017-03-10 | 2023-08-09 | 短時間作用型ヘパリンベースの抗凝集剤化合物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023129964A Active JP7702454B2 (ja) | 2017-03-10 | 2023-08-09 | 短時間作用型ヘパリンベースの抗凝集剤化合物及び方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US11903963B2 (https=) |
| EP (1) | EP3579897A4 (https=) |
| JP (2) | JP7330893B2 (https=) |
| CN (2) | CN116622006B (https=) |
| WO (1) | WO2018165656A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116622006B (zh) | 2017-03-10 | 2025-05-30 | 北卡罗来纳大学查珀尔希尔分校 | 短效的基于肝素的抗凝血剂化合物和方法 |
| US11993627B2 (en) | 2017-07-03 | 2024-05-28 | The University Of North Carolina At Chapel Hill | Enzymatic synthesis of homogeneous chondroitin sulfate oligosaccharides |
| JP7495061B2 (ja) | 2017-11-03 | 2024-06-04 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 抗炎症作用を有する硫酸化オリゴ糖 |
| CN112437667B (zh) | 2018-06-20 | 2024-05-28 | 北卡罗来纳大学查珀尔希尔分校 | 细胞保护方法和组合物 |
| JP2022523638A (ja) | 2019-01-15 | 2022-04-26 | オプティムヴィア、エルエルシー | 改変型硫酸アリール依存性酵素 |
| JP2022540849A (ja) | 2019-07-09 | 2022-09-20 | オプティムヴィア、エルエルシー | 抗凝固性多糖類の合成方法 |
| JP7801217B2 (ja) | 2019-11-13 | 2026-01-16 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 肝虚血再灌流障害におけるヘパラン硫酸（ｈｓ）オリゴ糖の効果 |
| US20250154290A1 (en) * | 2022-02-17 | 2025-05-15 | Kyushu University, National University Corporation | Recombinant heparin-like substance and method for producing the same |
| CN115417937B (zh) * | 2022-08-12 | 2023-06-06 | 山东大学 | 一种含双抗凝血酶结合序列的肝素十二糖及其制备方法与应用 |
| CN116120484B (zh) * | 2022-09-01 | 2024-11-08 | 山东大学 | 一种抗凝血肝素寡糖苯联二聚体及其制备方法与应用 |
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| JP6670235B2 (ja) | 2013-06-17 | 2020-03-18 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒルＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｎｏｒｔｈ Ｃａｒｏｌｉｎａ Ａｔ Ｃｈａｐｅｌ Ｈｉｌｌ | 可逆的ヘパリン分子、その製法及びその使用方法 |
| CN116622006B (zh) | 2017-03-10 | 2025-05-30 | 北卡罗来纳大学查珀尔希尔分校 | 短效的基于肝素的抗凝血剂化合物和方法 |
| US11993627B2 (en) | 2017-07-03 | 2024-05-28 | The University Of North Carolina At Chapel Hill | Enzymatic synthesis of homogeneous chondroitin sulfate oligosaccharides |
| JP7495061B2 (ja) | 2017-11-03 | 2024-06-04 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 抗炎症作用を有する硫酸化オリゴ糖 |
| CN112437667B (zh) | 2018-06-20 | 2024-05-28 | 北卡罗来纳大学查珀尔希尔分校 | 细胞保护方法和组合物 |
| JP7801217B2 (ja) | 2019-11-13 | 2026-01-16 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 肝虚血再灌流障害におけるヘパラン硫酸（ｈｓ）オリゴ糖の効果 |
| JP7670561B2 (ja) | 2021-06-28 | 2025-04-30 | 日本航空電子工業株式会社 | コネクタ |
-
2018
- 2018-03-12 CN CN202310342719.2A patent/CN116622006B/zh active Active
- 2018-03-12 EP EP18764628.6A patent/EP3579897A4/en active Pending
- 2018-03-12 JP JP2019549419A patent/JP7330893B2/ja active Active
- 2018-03-12 WO PCT/US2018/021986 patent/WO2018165656A1/en not_active Ceased
- 2018-03-12 US US16/492,858 patent/US11903963B2/en active Active
- 2018-03-12 CN CN201880020095.XA patent/CN110446511B/zh active Active
-
2023
- 2023-07-17 US US18/222,910 patent/US12539311B2/en active Active
- 2023-08-09 JP JP2023129964A patent/JP7702454B2/ja active Active
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