AU2003262794A1 - Total synthesis of heparin - Google Patents

Total synthesis of heparin

Info

Publication number
AU2003262794A1
AU2003262794A1 AU2003262794A AU2003262794A AU2003262794A1 AU 2003262794 A1 AU2003262794 A1 AU 2003262794A1 AU 2003262794 A AU2003262794 A AU 2003262794A AU 2003262794 A AU2003262794 A AU 2003262794A AU 2003262794 A1 AU2003262794 A1 AU 2003262794A1
Authority
AU
Australia
Prior art keywords
heparin
total synthesis
synthesis
total
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003262794A
Other versions
AU2003262794A8 (en
Inventor
Roger Barthelson
Xi Chen
Jill Kelly
Aliakbar Mobasseri
Elisabeth Otvos-Papp
Pavlo Pristatsky
Sami Saribas
Thomas T. Stevenson
Jin Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neose Technologies Inc
Original Assignee
Neose Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neose Technologies Inc filed Critical Neose Technologies Inc
Publication of AU2003262794A1 publication Critical patent/AU2003262794A1/en
Publication of AU2003262794A8 publication Critical patent/AU2003262794A8/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
AU2003262794A 2002-08-23 2003-08-22 Total synthesis of heparin Abandoned AU2003262794A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40563402P 2002-08-23 2002-08-23
US60/405,634 2002-08-23
PCT/US2003/026349 WO2004017910A2 (en) 2002-08-23 2003-08-22 Total synthesis of heparin

Publications (2)

Publication Number Publication Date
AU2003262794A1 true AU2003262794A1 (en) 2004-03-11
AU2003262794A8 AU2003262794A8 (en) 2004-03-11

Family

ID=31946908

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003262794A Abandoned AU2003262794A1 (en) 2002-08-23 2003-08-22 Total synthesis of heparin

Country Status (2)

Country Link
AU (1) AU2003262794A1 (en)
WO (1) WO2004017910A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040171819A1 (en) 2002-10-10 2004-09-02 Aventis Pharma S.A. Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
EP1885865A4 (en) * 2005-05-12 2010-12-22 Univ North Carolina Enzymatic synthesis of sulfated polysaccharides
EP1951394A4 (en) * 2005-11-21 2011-01-19 Ge Healthcare Bio Sciences Ab A method of chromatography using semi-synthetic heparin ligands
US7745584B2 (en) * 2006-05-22 2010-06-29 California Institute Of Technology Antibodies to sulfated carbohydrates
US8912149B1 (en) 2007-11-28 2014-12-16 California Institute Of Technology Glycosaminoglycan mimetics
EP2655421B1 (en) 2010-12-23 2022-02-09 The University of North Carolina At Chapel Hill Chemoenzymatic synthesis of structurally homogeneous ultra-low molecular weight heparins
EP3011043B1 (en) * 2013-06-17 2022-05-11 The University of North Carolina At Chapel Hill Reversible heparin molecules
US9770461B2 (en) 2013-08-02 2017-09-26 California Institute Of Technology Tailored glycopolymers as anticoagulant heparin mimetics
US10227370B2 (en) 2013-08-02 2019-03-12 California Institute Of Technology Heparan sulfate/heparin mimetics with anti-chemokine and anti-inflammatory activity
CN110191958A (en) * 2017-01-19 2019-08-30 味之素株式会社 Produce the method with the heparosan compound of the hexuronic acid residue through isomerization
WO2018165656A1 (en) 2017-03-10 2018-09-13 The University Of North Carolina At Chapel Hill Short-acting heparin-based anticoagulant compounds and methods
EP3691653A4 (en) 2017-11-03 2021-08-11 The University Of North Carolina At Chapel Hill Sulfated oligosaccharides having anti-inflammatory activity
EP3810152A4 (en) 2018-06-20 2022-04-27 The University of North Carolina at Chapel Hill Cell protective methods and compositions
WO2020013346A1 (en) * 2018-07-11 2020-01-16 Ajinomoto Co., Inc. Method for enzymatic sulfurylation of alcohols and amines using bacterium of the family enterobacteriaceae
AU2020310172A1 (en) * 2019-07-09 2022-03-03 Optimvia Llc Methods for synthesizing anticoagulant polysaccharides
CN114763518B (en) * 2021-09-10 2023-04-28 江南大学 Construction and application of yeast engineering bacteria for producing heparin by fermentation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6030807A (en) * 1996-09-10 2000-02-29 The Rockefeller University Highly regulable promoter for heterologous gene expression

Also Published As

Publication number Publication date
WO2004017910A2 (en) 2004-03-04
WO2004017910A3 (en) 2004-09-30
AU2003262794A8 (en) 2004-03-11

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase