CN116622006B - 短效的基于肝素的抗凝血剂化合物和方法 - Google Patents

短效的基于肝素的抗凝血剂化合物和方法 Download PDF

Info

Publication number
CN116622006B
CN116622006B CN202310342719.2A CN202310342719A CN116622006B CN 116622006 B CN116622006 B CN 116622006B CN 202310342719 A CN202310342719 A CN 202310342719A CN 116622006 B CN116622006 B CN 116622006B
Authority
CN
China
Prior art keywords
synthetic heparin
ost
synthetic
analog
heparin analog
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202310342719.2A
Other languages
English (en)
Chinese (zh)
Other versions
CN116622006A (zh
Inventor
刘健
王章杰
谢柏宏
徐咏梅
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
Original Assignee
University of North Carolina at Chapel Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of North Carolina at Chapel Hill filed Critical University of North Carolina at Chapel Hill
Publication of CN116622006A publication Critical patent/CN116622006A/zh
Application granted granted Critical
Publication of CN116622006B publication Critical patent/CN116622006B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN202310342719.2A 2017-03-10 2018-03-12 短效的基于肝素的抗凝血剂化合物和方法 Active CN116622006B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762469643P 2017-03-10 2017-03-10
US62/469,643 2017-03-10
PCT/US2018/021986 WO2018165656A1 (en) 2017-03-10 2018-03-12 Short-acting heparin-based anticoagulant compounds and methods
CN201880020095.XA CN110446511B (zh) 2017-03-10 2018-03-12 短效的基于肝素的抗凝血剂化合物和方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201880020095.XA Division CN110446511B (zh) 2017-03-10 2018-03-12 短效的基于肝素的抗凝血剂化合物和方法

Publications (2)

Publication Number Publication Date
CN116622006A CN116622006A (zh) 2023-08-22
CN116622006B true CN116622006B (zh) 2025-05-30

Family

ID=63449042

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202310342719.2A Active CN116622006B (zh) 2017-03-10 2018-03-12 短效的基于肝素的抗凝血剂化合物和方法
CN201880020095.XA Active CN110446511B (zh) 2017-03-10 2018-03-12 短效的基于肝素的抗凝血剂化合物和方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201880020095.XA Active CN110446511B (zh) 2017-03-10 2018-03-12 短效的基于肝素的抗凝血剂化合物和方法

Country Status (5)

Country Link
US (2) US11903963B2 (https=)
EP (1) EP3579897A4 (https=)
JP (2) JP7330893B2 (https=)
CN (2) CN116622006B (https=)
WO (1) WO2018165656A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116622006B (zh) 2017-03-10 2025-05-30 北卡罗来纳大学查珀尔希尔分校 短效的基于肝素的抗凝血剂化合物和方法
US11993627B2 (en) 2017-07-03 2024-05-28 The University Of North Carolina At Chapel Hill Enzymatic synthesis of homogeneous chondroitin sulfate oligosaccharides
JP7495061B2 (ja) 2017-11-03 2024-06-04 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 抗炎症作用を有する硫酸化オリゴ糖
CN112437667B (zh) 2018-06-20 2024-05-28 北卡罗来纳大学查珀尔希尔分校 细胞保护方法和组合物
JP2022523638A (ja) 2019-01-15 2022-04-26 オプティムヴィア、エルエルシー 改変型硫酸アリール依存性酵素
JP2022540849A (ja) 2019-07-09 2022-09-20 オプティムヴィア、エルエルシー 抗凝固性多糖類の合成方法
JP7801217B2 (ja) 2019-11-13 2026-01-16 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 肝虚血再灌流障害におけるヘパラン硫酸（ｈｓ）オリゴ糖の効果
US20250154290A1 (en) * 2022-02-17 2025-05-15 Kyushu University, National University Corporation Recombinant heparin-like substance and method for producing the same
CN115417937B (zh) * 2022-08-12 2023-06-06 山东大学 一种含双抗凝血酶结合序列的肝素十二糖及其制备方法与应用
CN116120484B (zh) * 2022-09-01 2024-11-08 山东大学 一种抗凝血肝素寡糖苯联二聚体及其制备方法与应用

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
IT1232939B (it) 1987-11-06 1992-03-10 Opocrin Spa Eparan solfato caratterizzato da elevata attivita' antitrombotica, elevata biodisponibilita', assenza di attivita' anticoagulante; suo processo di estrazione da organi e da tessuti e relative composizioni farmaceutiche
US4865870A (en) 1988-07-07 1989-09-12 Becton, Dickinson And Company Method for rendering a substrate surface antithrombogenic
PT93847A (pt) 1989-04-24 1990-11-20 Harvard College Processo para a preparacao de oligossacaridos de baixo peso molecular derivados de heparina ou de sulfato de heparano despolimerizados e de composicoes farmaceuticas que os contem
US5378829A (en) 1990-04-23 1995-01-03 Akzo N.V. Sulfated glycosaminoglycanoid derivatives of the heparin and heparan sulfate type
WO1993005167A1 (en) 1991-09-06 1993-03-18 Children's Medical Center Corporation Cell-type specific heparan sulfate proteoglycans and their uses
IT1260137B (it) 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato
US5527785A (en) 1993-05-14 1996-06-18 The Regents Of The University Of California Selectin receptor modulating compositions
JP3818676B2 (ja) 1994-07-22 2006-09-06 生化学工業株式会社 ヘパラン硫酸６−ｏ−硫酸基転移酵素
IT1271057B (it) 1994-11-04 1997-05-26 Inalco Spa Polisaccaridi aventi un elevato contenuto di acido iduronico
JP3672359B2 (ja) 1995-07-24 2005-07-20 生化学工業株式会社 ヘパラン硫酸 ２−ｏ−硫酸基転移酵素
DK0852491T3 (da) 1995-09-29 2004-12-20 Biomarin Pharm Inc Anvendelse af heparinaser til at mindske inflammatoriske responser
US5935824A (en) 1996-01-31 1999-08-10 Technologene, Inc. Protein expression system
US6861254B1 (en) 1997-10-24 2005-03-01 Massachusetts Institute Of Technology Heparan sulfate D-glucosaminyl 3-O-sulfotransferases, and uses therefor
US7307159B2 (en) 2001-05-08 2007-12-11 The Board Of Regents Of The University Of Oklahoma Heparin/heparosan synthase from P. multocida and methods of making and using same
US8088604B2 (en) 1998-04-02 2012-01-03 The Board Of Regents Of The University Of Oklahoma Production of defined monodisperse heparosan polymers and unnatural polymers with polysaccharide synthases
IL127851A0 (en) 1998-12-30 1999-10-28 Applied Research Systems Inhibition of TNF activity
US6624141B1 (en) 1999-03-17 2003-09-23 The Regents Of The University Of Michigan Protamine fragment compositions and methods of use
US6255088B1 (en) 1999-05-11 2001-07-03 The Scripps Research Institute Enzymatic sulfation of biomolecules
US6977248B1 (en) * 1999-08-25 2005-12-20 Massachusetts Institute Of Technology Pharmaceutical preparations for the inhibition of herpes simplex virus 1 entry
EP1471870B1 (en) 2000-01-10 2014-08-20 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Use of lipid conjugates in the treatment of disease
US7101859B2 (en) 2000-01-10 2006-09-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases
DE60140941D1 (de) 2000-07-07 2010-02-11 Seikagaku Kogyo Co Ltd Hyaluronsäure oligosaccharid fraktionen und medikamente, die diese enthalten
US8067196B2 (en) 2001-03-28 2011-11-29 Massachusetts Institute Of Technology 6-O sulfated polysaccharides and methods of preparation thereof
DK2070939T3 (da) 2001-05-25 2014-06-23 Univ Duke Modulatorer af farmakologiske midler
WO2003018598A2 (en) 2001-08-30 2003-03-06 University College Dublin Monosaccharide derivatives
AU2003247808A1 (en) 2002-07-05 2004-01-23 Anders Malmstrom Purified and isolated heparan sulfate 3-o-sulfotransferase isoform 5 nucleic acids and polypeptides and therapeutic and screening methods using same
GB0216861D0 (en) 2002-07-19 2002-08-28 Univ Birmingham Saccharide libraries
AU2003262794A1 (en) 2002-08-23 2004-03-11 Neose Technologies, Inc. Total synthesis of heparin
WO2005014619A2 (en) 2003-03-28 2005-02-17 Thomas Jefferson University Heparin-binding peptides and uses thereof
US20040259142A1 (en) 2003-06-04 2004-12-23 Imperial College Innovations Limited Products and methods
DE60336400D1 (de) 2003-10-24 2011-04-28 3M Innovative Properties Co Wässrige Dispersionen von Polytetrafluorethylenteilchen
US7655445B2 (en) 2003-11-12 2010-02-02 Massachusetts Institute Of Technology Methods for synthesis of sulfated saccharides
US7619637B2 (en) 2004-04-09 2009-11-17 Samsung Electronics Co., Ltd. Systems and methods for improved gamut mapping from one image data set to another
US7638503B2 (en) 2004-05-26 2009-12-29 California Institute Of Technology Small molecule stimulators of neuronal growth
US20050282775A1 (en) 2004-06-16 2005-12-22 Paringenix, Inc. Method and medicament for sulfated polysaccharide treatment of inflammation without inducing platelet activation and heparin-induced thrombocytopenia syndrome
WO2006015171A2 (en) 2004-07-28 2006-02-09 The Texas A & M University System Use of glycosoaminoglycans for the prevention and treatment of sepsis
EP1885865A4 (en) 2005-05-12 2010-12-22 Univ North Carolina ENZYMATIC SYNTHESIS OF SULFATED POLYSACCHARIDES
US8129148B2 (en) 2005-08-24 2012-03-06 Seikagaku Corporation Process for preparation of chondroitin fraction
EP2447285A3 (en) 2006-05-25 2013-01-16 Momenta Pharmaceuticals, Inc. Low molecular weight heparin composition and uses thereof
WO2009014715A2 (en) 2007-07-23 2009-01-29 The University Of North Carolina At Chapel Hill Enzymatic synthesis of sulfated polysaccharides without iduronic acid residues
ES2567079T3 (es) 2007-11-02 2016-04-19 Momenta Pharmaceuticals, Inc. Composiciones de polisacáridos que no son anticoagulantes
WO2009079693A1 (en) 2007-12-21 2009-07-02 Glycan Biosciences Design and selection of medicaments that modulate the function and activity of interleukin 13
MX2011004907A (es) 2008-11-14 2011-07-29 Portola Pharm Inc Antidotos para inhibidores del factor xa y metodos para el uso de los mismos en combinacion con agentes de coagulacion de sangre.
BRPI1007325A2 (pt) 2009-02-02 2019-09-24 Otsuka Pharma Co Ltd "baixo peso molecular de polissulfatados derivados de ácido hialurônico e medicamentos que contenham o mesmo."
AU2010233151A1 (en) 2009-04-09 2011-11-17 The University Of North Carolina At Chapel Hill Methods of treating edema related to ischemia-reperfusion
US20110054236A1 (en) 2009-08-25 2011-03-03 The Regents Of The University Of Michigan Compositions and methods for targeting tumors
US20120322760A1 (en) 2009-09-23 2012-12-20 Momenta Pharmaceuticals, Inc. Methods of treatment with a low molecular weight heparin composition
JP2014501730A (ja) 2010-12-01 2014-01-23 ジ オーストラリアン ナショナル ユニバーシティ ヒストン阻害
WO2012088416A2 (en) 2010-12-23 2012-06-28 The University Of North Carolina At Chapel Hill Chemoenzymatic synthesis of structurally homogeneous ultra-low molecular weight heparins
WO2012116048A1 (en) 2011-02-22 2012-08-30 Rensselaer Polytechnic Institute Single step heparosan n-deacetylation and depolymerization for making bioengineered heparin
WO2012162789A1 (en) 2011-06-01 2012-12-06 University Of British Columbia Polymers for reversing heparin-based anticoagulation
CN105188750A (zh) 2013-03-08 2015-12-23 德国杰特贝林生物制品有限公司 治疗和预防远端缺血-再灌注损伤
JP6670235B2 (ja) 2013-06-17 2020-03-18 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒルＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｎｏｒｔｈ Ｃａｒｏｌｉｎａ Ａｔ Ｃｈａｐｅｌ Ｈｉｌｌ 可逆的ヘパリン分子、その製法及びその使用方法
CN116622006B (zh) 2017-03-10 2025-05-30 北卡罗来纳大学查珀尔希尔分校 短效的基于肝素的抗凝血剂化合物和方法
US11993627B2 (en) 2017-07-03 2024-05-28 The University Of North Carolina At Chapel Hill Enzymatic synthesis of homogeneous chondroitin sulfate oligosaccharides
JP7495061B2 (ja) 2017-11-03 2024-06-04 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 抗炎症作用を有する硫酸化オリゴ糖
CN112437667B (zh) 2018-06-20 2024-05-28 北卡罗来纳大学查珀尔希尔分校 细胞保护方法和组合物
JP7801217B2 (ja) 2019-11-13 2026-01-16 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 肝虚血再灌流障害におけるヘパラン硫酸（ｈｓ）オリゴ糖の効果
JP7670561B2 (ja) 2021-06-28 2025-04-30 日本航空電子工業株式会社 コネクタ

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Chemoenzymatic synthesis of Homogeneous Ultralow Molecular Weight Heparins;Y. Xu等;SCIENCE;20111027;第334卷;第498-501页 *
Using a 3-O-Sulfated Heparin Octasaccharide To Inhibit the Entry of Herpes Simplex Virus Type 1;Ronald Copeland等;Biochemistry;20080506;第47卷;第5774–5783页 *

Also Published As

Publication number Publication date
US20240066048A1 (en) 2024-02-29
EP3579897A1 (en) 2019-12-18
JP2020510119A (ja) 2020-04-02
US12539311B2 (en) 2026-02-03
JP7330893B2 (ja) 2023-08-22
CN116622006A (zh) 2023-08-22
JP2023166387A (ja) 2023-11-21
CN110446511B (zh) 2024-04-02
CN110446511A (zh) 2019-11-12
EP3579897A4 (en) 2020-12-30
US20210137967A1 (en) 2021-05-13
US11903963B2 (en) 2024-02-20
WO2018165656A1 (en) 2018-09-13
JP7702454B2 (ja) 2025-07-03

Similar Documents

Publication Publication Date Title
CN116622006B (zh) 短效的基于肝素的抗凝血剂化合物和方法
Noti et al. Chemical approaches to define the structure-activity relationship of heparin-like glycosaminoglycans
Linhardt 2003 Claude S. Hudson Award address in carbohydrate chemistry. Heparin: structure and activity
JP4861596B2 (ja) ヒアルロン酸オリゴ糖画分およびそれを含む医薬
JP6670235B2 (ja) 可逆的ヘパリン分子、その製法及びその使用方法
Peterson et al. Design of biologically active heparan sulfate and heparin using an enzyme-based approach
US11203772B2 (en) Chemoenzymatic synthesis of structurally homogeneous ultra-low molecular weight heparins
Tripathi et al. Microbial heparin/heparan sulphate lyases: potential and applications
Fareed Heparin, its fractions, fragments and derivatives some newer perspectives
CN105504097B (zh) 一种硫酸化肝素寡糖及其制备方法和应用
Wang et al. Investigation of the biological functions of heparan sulfate using a chemoenzymatic synthetic approach
Miguez et al. Control of tissue homeostasis by the extracellular matrix: Synthetic heparan sulfate as a promising therapeutic for periodontal health and bone regeneration
BR112013027389B1 (pt) Processo para o preparo de sal sódico de sulfato de condroitina
AU2010283614B2 (en) FGF receptor-activating N-acyl octasaccharides, preparation thereof, and therapeutic use thereof
US20190002596A1 (en) Sulfated heparin oligosaccharide and preparation method and application thereof
JP2010518251A (ja) ビオチンまたはビオチン誘導体との少なくとも１つの共有結合を含むヘパリン、これらの調製方法およびこれらの使用
HK40098551A (zh) 短效的基於肝素的抗凝血剂化合物和方法
HK40098551B (zh) 短效的基於肝素的抗凝血剂化合物和方法
US20140349962A1 (en) Rapid two-step synthesis of anti-coagulants
JP4528898B2 (ja) ケモカイン受容体ｃｃｒ１０の発現誘導剤
O'Leary Chemical and Enzymatic Methods for the Analysis and Synthesis of Heparin and Heparan Sulfate
Joshi Chemical synthesis of 3-o-sulfated heparan sulfate oligosaccharides as diagnostic biomarkers and standards for exploring protein-carbohydrate interactions
Zong Explore the interaction of protein and synthetic heparan sulfate via a modular approach
Class et al. Patent application title: REVERSIBLE HEPARIN MOLECULES AND METHODS OF MAKING AND USING THE SAME Inventors: Jian Liu (Chapel Hill, NC, US) Yongmei Xu (Durham, NC, US) Robert J. Linhardt (Albany, NY, US) Robert J. Linhardt (Albany, NY, US) Edward Harris (Lincoln, NE, US)
Islam Synthesis of glycosaminoglycan analogues as potential therapeutic agents

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40098551

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant