JP2020023577A5 - - Google Patents

Download PDF

Info

Publication number
JP2020023577A5
JP2020023577A5 JP2019203369A JP2019203369A JP2020023577A5 JP 2020023577 A5 JP2020023577 A5 JP 2020023577A5 JP 2019203369 A JP2019203369 A JP 2019203369A JP 2019203369 A JP2019203369 A JP 2019203369A JP 2020023577 A5 JP2020023577 A5 JP 2020023577A5
Authority
JP
Japan
Prior art keywords
difluoro
phenyl
acid
acetic acid
pyridyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019203369A
Other languages
English (en)
Japanese (ja)
Other versions
JP6862033B2 (ja
JP2020023577A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2020023577A publication Critical patent/JP2020023577A/ja
Publication of JP2020023577A5 publication Critical patent/JP2020023577A5/ja
Application granted granted Critical
Publication of JP6862033B2 publication Critical patent/JP6862033B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019203369A 2014-12-24 2019-11-08 Gpr120アゴニストとしてのビアリール誘導体 Expired - Fee Related JP6862033B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2014-0188399 2014-12-24
KR20140188399 2014-12-24

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2017534217A Division JP6935064B2 (ja) 2014-12-24 2015-12-23 Gpr120アゴニストとしてのビアリール誘導体

Publications (3)

Publication Number Publication Date
JP2020023577A JP2020023577A (ja) 2020-02-13
JP2020023577A5 true JP2020023577A5 (enExample) 2020-11-12
JP6862033B2 JP6862033B2 (ja) 2021-04-21

Family

ID=56151591

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2017534217A Active JP6935064B2 (ja) 2014-12-24 2015-12-23 Gpr120アゴニストとしてのビアリール誘導体
JP2019203369A Expired - Fee Related JP6862033B2 (ja) 2014-12-24 2019-11-08 Gpr120アゴニストとしてのビアリール誘導体

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2017534217A Active JP6935064B2 (ja) 2014-12-24 2015-12-23 Gpr120アゴニストとしてのビアリール誘導体

Country Status (15)

Country Link
US (2) US11261186B2 (enExample)
EP (1) EP3239143B1 (enExample)
JP (2) JP6935064B2 (enExample)
KR (1) KR101829290B1 (enExample)
CN (2) CN107567443B (enExample)
AU (2) AU2015367977B9 (enExample)
BR (1) BR112017013465A2 (enExample)
CA (2) CA3121986C (enExample)
DK (1) DK3239143T3 (enExample)
GT (1) GT201700143A (enExample)
MX (1) MX385777B (enExample)
MY (1) MY189770A (enExample)
PH (1) PH12017501029B1 (enExample)
RU (1) RU2683648C2 (enExample)
WO (1) WO2016105118A2 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG193982A1 (en) 2011-03-28 2013-11-29 Mei Pharma Inc (alpha- substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5 -triazinyl benzimidazoles, pharmaceutical compositions containing them, and these compounds for use in treating proliferative diseases
WO2016040222A1 (en) * 2014-09-09 2016-03-17 Bristol-Myers Squibb Company Cyclopropanecarboxylic acid gpr120 modulators
CN108299425B (zh) * 2015-03-24 2020-09-18 上海璎黎药业有限公司 稠环衍生物、其制备方法、中间体、药物组合物及应用
WO2018138369A1 (en) 2017-01-30 2018-08-02 Chemcom S.A. Compounds reducing malodour perception and the use thereof
GB201704714D0 (en) * 2017-03-24 2017-05-10 Caldan Therapeutics Ltd Pharmaceutical compounds
KR20240097982A (ko) 2017-05-23 2024-06-27 메이 파마, 아이엔씨. 병용 요법
AU2018318129A1 (en) 2017-08-14 2020-03-26 Mei Pharma, Inc. Combination therapy
CN109912566A (zh) * 2017-12-12 2019-06-21 南京大学 一类含喹啉环的新型荧光母核的合成
AU2019255363A1 (en) * 2018-04-20 2020-11-05 Krish Biotech Research Private Limited Method of treatment of non-alcoholic steatohepatitis, nash
KR102661053B1 (ko) 2018-04-26 2024-04-26 화이자 인코포레이티드 사이클린 의존성 키나제 억제제로서 2-아미노-피리딘 또는 2-아미노-피리미딘 유도체
US10934279B2 (en) 2018-06-13 2021-03-02 Pfizer Inc. GLP-1 receptor agonists and uses thereof
AU2019387370A1 (en) 2018-11-30 2021-06-10 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
US20240018140A1 (en) * 2020-09-17 2024-01-18 Merck Sharp & Dohme Llc Modified imidazopyridines as glucosylceramide synthase inhibitors
CN111995586B (zh) * 2020-09-27 2023-03-21 蚌埠学院 一种农用除草剂的合成方法
CN115703766B (zh) * 2021-08-10 2025-08-08 天地恒一制药股份有限公司 Glp-1受体激动剂及其用途
CN114380730B (zh) * 2021-12-16 2023-12-05 广西大学 硝基芳烃脱硝偶联合成n-芳基吡咯和n-芳基吲哚的方法
WO2023141469A2 (en) * 2022-01-18 2023-07-27 Tessellate Therapeutics, Inc. Therapeutic compounds and methods of use thereof
CN115160120B (zh) * 2022-08-02 2024-08-27 乐威医药(江苏)股份有限公司 一种多烷氧基芳香酮的合成方法

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1082231A (en) * 1913-03-26 1913-12-23 E J Hudnall Method of setting tiles, bricks, and mosaics.
IT1211135B (it) * 1981-11-24 1989-09-29 Ausonia Farma Srl Composti ad attivita'analgesica e antiinfiammatoria, processo per la loro preparazione e relative composizioni farmaceutiche.
FR2665159B1 (fr) * 1990-07-24 1992-11-13 Rhone Poulenc Sante Nouveaux derives de la pyridine et de la quinoleine, leur preparation et les compositions pharmaceutiques qui les contiennent.
CA2400368A1 (en) 1992-12-02 1994-06-09 Allen J. Duplantier Catechol diethers as selective pde iv inhibitors
US5665777A (en) * 1995-11-14 1997-09-09 Abbott Laboratories Biphenyl hydroxamate inhibitors of matrix metalloproteinases
DE19633746A1 (de) * 1996-08-22 1998-02-26 Basf Ag Substituierte 2-Phenylpyridine
US6576664B1 (en) 1997-08-18 2003-06-10 Bristol-Myers Squibb Pharma Company Inhibitors of aggrecanase and matrix metalloproteinases for the treatment of arthritis
WO1999026921A1 (en) 1997-11-24 1999-06-03 Merck & Co., Inc. SUBSTITUTED β-ALANINE DERIVATIVES AS CELL ADHESION INHIBITORS
JP2000159751A (ja) * 1998-11-20 2000-06-13 Torii Yakuhin Kk ベンゼン誘導体
FR2791982B1 (fr) * 1999-04-06 2002-12-27 Inst Nat Sante Rech Med Inhibiteurs de lta4 hydrolase et leurs applications therapeutiques.
ES2247070T3 (es) 2000-02-16 2006-03-01 Neurogen Corporation Arilpirazinas sustituidas.
FR2812876B1 (fr) 2000-08-08 2002-09-27 Galderma Res & Dev Nouveaux composes bi-aromatiques activateurs des recepteurs de type ppar-gamma et leur utilisation dans des compositions cosmetiques ou pharmaceutiques
US6858600B2 (en) 2001-05-08 2005-02-22 Yale University Proteomimetic compounds and methods
WO2002098409A1 (en) * 2001-06-07 2002-12-12 Wyeth Combination therapy for type ii diabetes or syndrome x
US6908939B2 (en) 2001-12-21 2005-06-21 Galderma Research & Development S.N.C. Biaromatic ligand activators of PPARγ receptors
ES2437391T3 (es) 2002-02-06 2014-01-10 Vertex Pharmaceuticals, Inc. Compuestos de heteroarilo útiles como inhibidores de GSK-3
WO2003070686A1 (en) 2002-02-21 2003-08-28 Asahi Kasei Pharma Corporation Substituted phenylalkanoic acid derivative and use thereof
PL373763A1 (en) 2002-04-30 2005-09-19 Ucb, S.A. 2,6-quinolinyl and 2,6-naphthyl derivatives, processes for preparing them and their uses as vla-4 inhibitors
AU2002368112A1 (en) * 2002-07-29 2004-02-16 Shizuoka Coffein Co., Ltd. Pyrimidine derivatives
DE10250743A1 (de) 2002-10-31 2004-05-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Amid-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
AU2004210711B2 (en) 2003-02-12 2010-07-08 Transtech Pharma, Inc. Substituted azole derivatives as therapeutic agents
SE0301010D0 (sv) 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
GB0312654D0 (en) 2003-06-03 2003-07-09 Glaxo Group Ltd Therapeutically useful compounds
EP1658273B1 (en) 2003-08-20 2007-01-03 Eli Lilly And Company Compounds, methods and formulations for the oral delivery of a glucagon like peptide (glp)-1 compound or an melanocortin 4 receptor (mc4) agonist peptide
FR2869611B1 (fr) * 2004-05-03 2006-07-28 Merck Sante Soc Par Actions Si Derives de l'acide hexenoique, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique
EP1798224A1 (en) * 2004-10-05 2007-06-20 Shionogi Co., Ltd. Biaryl derivative
GB0422057D0 (en) * 2004-10-05 2004-11-03 Astrazeneca Ab Novel compounds
EA013539B1 (ru) * 2005-02-22 2010-06-30 Рэнбакси Лабораториз Лимитед Производные 5-фенилпентановой кислоты в качестве ингибиторов матричной металлопротеиназы для лечения астмы и других заболеваний
EP1883652A2 (en) * 2005-05-26 2008-02-06 Bristol-Myers Squibb Company N-terminally modified glp-1 receptor modulators
WO2007017289A2 (en) 2005-08-10 2007-02-15 Bayer Schering Pharma Aktiengesellschaft Acyltryptophanols for fertility control
GB0525323D0 (en) 2005-12-13 2006-01-18 Sterix Ltd Compound
AU2007265373B2 (en) 2006-06-29 2013-02-21 Atnx Spv, Llc Biaryl compositions and methods for modulating a kinase cascade
ES2614931T3 (es) 2006-08-04 2017-06-02 Beth Israel Deaconess Medical Center Inhibidores de la piruvato cinasa y métodos de tratamiento de enfermedad
KR101467590B1 (ko) * 2006-08-22 2014-12-01 랜박시 래보러터리스 리미티드 매트릭스 메탈로프로테나제 저해제
RU2009114747A (ru) * 2006-09-21 2010-10-27 Новартис АГ (CH) Производные пиррола, применимые в лечении цитокин-опосредованных заболеваний
JP2010505789A (ja) * 2006-10-04 2010-02-25 エフ.ホフマン−ラ ロシュ アーゲー Hdl−コレステロール上昇剤としての3−ピリジンカルボキサミド及び2−ピラジンカルボキサミド誘導体
US8153660B2 (en) * 2006-10-27 2012-04-10 Boehringer Ingelheim International Gmbh Piperidyl-propane-thiol CCR3 modulators
WO2008066131A1 (en) * 2006-12-01 2008-06-05 Banyu Pharmaceutical Co., Ltd. Novel phenyl-isoxazol-3-ol derivative
US20110009384A1 (en) 2007-02-09 2011-01-13 Takeda Pharmaceutical Company Limited Fused ring compounds as partial agonists of ppar-gamma
KR20090113901A (ko) * 2007-02-22 2009-11-02 아이알엠 엘엘씨 G 단백질-커플링된 수용체를 조절하기 위한 화합물 및 방법
CA2677705A1 (en) * 2007-02-22 2008-08-28 Irm Llc Thiazole derivatives as modulators of g protein-coupled receptors
WO2008139987A1 (ja) * 2007-04-26 2008-11-20 Japan Science And Technology Agency Gタンパク質共役型レセプタ-作動剤
DK2152670T3 (en) * 2007-04-27 2014-02-24 Actelion Pharmaceuticals Ltd BROKEN SEX-LEADED RING CONNECTIONS
WO2009011285A1 (ja) * 2007-07-13 2009-01-22 Taisho Pharmaceutical Co., Ltd. ヘテロアリールベンゼン化合物
JP4834699B2 (ja) * 2007-07-30 2011-12-14 田辺三菱製薬株式会社 医薬組成物
WO2009074829A1 (en) 2007-12-12 2009-06-18 Astrazeneca Ab Peptidyl nitriles and use thereof as dipeptidyl peptidase i inhibitors
US20110039860A1 (en) * 2008-05-07 2011-02-17 Cangming Yang Soluble epoxide hydrolase inhibitors, compositions containing such compounds and methods of treatment
MX2010014569A (es) 2008-06-24 2011-03-29 Irm Llc Compuestos y metodos para modular los receptores acoplados con proteina-g.
JP2012506386A (ja) * 2008-10-21 2012-03-15 メタボレックス, インコーポレイテッド アリールgpr120受容体アゴニストおよびその使用
EP2352374B1 (en) 2008-10-29 2014-09-24 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
TW201031649A (en) 2008-12-02 2010-09-01 Organon Nv 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivatives
WO2010070076A1 (en) * 2008-12-19 2010-06-24 Crystax Pharmaceuticals, S.L. Alkanoic acid derivatives and their therapeutic use as hdac inhibitors
EP2423176A4 (en) 2009-04-22 2012-11-07 Astellas Pharma Inc CARBOXYLIC ACID COMPOUND
CA2763565A1 (en) 2009-05-28 2010-12-02 Novartis Ag Substituted aminobutyric derivatives as neprilysin inhibitors
US8586776B2 (en) * 2009-11-05 2013-11-19 Fibrostatin, S.L. GPBP inhibition using Q2 peptidomimetics
AR081930A1 (es) * 2010-06-16 2012-10-31 Ardea Biosciences Inc Compuestos de tioacetato
JP5746334B2 (ja) * 2010-06-16 2015-07-08 シマベイ セラピューティクス, インコーポレーテッド Gpr120受容体作動薬及びその使用
JP2013540145A (ja) 2010-10-21 2013-10-31 ウニベルシテート デス ザールランデス コルチゾール依存性疾患の治療用の選択的cyp11b1阻害剤
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
NZ610983A (en) 2010-12-15 2014-10-31 Theravance Biopharma R & D Ip Llc Neprilysin inhibitors
EP2651930B1 (en) * 2010-12-16 2015-10-28 Boehringer Ingelheim International GmbH Biarylamide inhibitors of leukotriene production
WO2012081736A1 (en) * 2010-12-17 2012-06-21 Mitsubishi Tanabe Pharma Corporation Continuous arycyclic compound
JP5842630B2 (ja) * 2011-03-16 2016-01-13 株式会社リコー カルバゾール誘導体、及び半導体ナノ結晶
US20140303163A1 (en) 2011-03-24 2014-10-09 Ying Luo Use of kinase inhibitors in preventing and treating inflammatory disorder
US9145391B2 (en) * 2011-05-10 2015-09-29 Merck Sharp & Dohme Corp. Bipyridylaminopyridines as Syk inhibitors
WO2013056679A1 (en) * 2011-10-21 2013-04-25 Beijing Hanmi Pharmaceutical Co., Ltd Novel heteroaryl-amino derivatives
WO2013139341A1 (en) * 2012-03-20 2013-09-26 Syddansk Universitet Gpr120 receptor modulators
HK1206735A1 (en) * 2012-04-06 2016-01-15 辉瑞公司 Diacylglycerol acyltransferase 2 inhibitors
PT2859009T (pt) * 2012-06-08 2018-01-18 Gilead Sciences Inc Inibidores macrocíclicos dos vírus flaviviridae
WO2013185766A1 (en) 2012-06-15 2013-12-19 Syddansk Universitet Gpr120 receptor modulators
AU2013329064A1 (en) 2012-10-11 2015-04-16 Merck Sharp & Dohme Corp. Substituted spiropiperidinyl compounds useful as GPR120 agonists
ES2749467T3 (es) * 2012-11-20 2020-03-20 Biogen Ma Inc Agentes moduladores de S1p y/o ATX
JP6401773B2 (ja) 2013-03-11 2018-10-10 ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン Betブロモドメイン阻害剤およびこれを用いる治療方法
SG11201506796XA (en) * 2013-03-14 2015-09-29 Bristol Myers Squibb Co Bicyclo [2.2.1] acid gpr120 modulators
JP6322704B2 (ja) * 2013-06-27 2018-05-09 エルジー・ケム・リミテッド Gpr120アゴニストとしてのビアリール誘導体
WO2016040222A1 (en) * 2014-09-09 2016-03-17 Bristol-Myers Squibb Company Cyclopropanecarboxylic acid gpr120 modulators
WO2016038540A1 (en) * 2014-09-11 2016-03-17 Piramal Enterprises Limited Fused heterocyclic compounds as gpr120 agonists
AU2015324914B2 (en) 2014-10-02 2018-10-04 Neurobiogen Co., Ltd. Alpha-aminoamide derivative compound and pharmaceutical composition containing the same

Similar Documents

Publication Publication Date Title
JP2020023577A5 (enExample)
RU2017126199A (ru) Биарильное производное в качестве агониста gpr120
JP2004532227A5 (enExample)
RU2016102313A (ru) Биарильные производные в качестве агонистов gpr120
RU2451673C2 (ru) ПРОИЗВОДНЫЕ ПИРИДИНА И ПИРИМИДИНА В КАЧЕСТВЕ АНТАГОНИСТОВ mGluR2
FI3555076T3 (fi) Uusia fenyylipropionihappojohdannaisia ja niiden käyttötapoja
JP2010508338A5 (enExample)
JP2010525025A5 (enExample)
JP2012528178A5 (enExample)
JP2008513514A5 (enExample)
JP2015526441A5 (enExample)
CA2490888A1 (en) Diaminopyrimidinecarboxamide derivative
CA2663366A1 (en) Compounds and compositions as protein kinase inhibitors
RU2010110640A (ru) Соединения и композиции 5-(4-(галогеналкокси)фенил)пиримидин-2-амина в качестве ингибиторов киназ
JP2004529931A5 (enExample)
ME00427B (me) N-supstituisani hidroksipiramidinon karboksamidni inhibitori hiv integraze
JP2017535525A5 (enExample)
JP2007039461A5 (enExample)
JP2017511329A5 (enExample)
IL161493A (en) Pyrimidine derivatives and pharmaceutical compositions containing the same
HRP20110809T1 (hr) Protuupalni pirimidini i njihove uporabe
NZ604004A (en) Pyridone and aza-pyridone compounds and methods of use
JP2006516572A5 (enExample)
JP2004504301A5 (enExample)
JP2004536814A5 (enExample)