PH12017501029B1 - Biaryl derivative as gpr120 agonist - Google Patents

Biaryl derivative as gpr120 agonist

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Publication number
PH12017501029B1
PH12017501029B1 PH1/2017/501029A PH12017501029A PH12017501029B1 PH 12017501029 B1 PH12017501029 B1 PH 12017501029B1 PH 12017501029 A PH12017501029 A PH 12017501029A PH 12017501029 B1 PH12017501029 B1 PH 12017501029B1
Authority
PH
Philippines
Prior art keywords
biaryl derivative
diabetes
chemical formula
gpr120 agonist
same
Prior art date
Application number
PH1/2017/501029A
Other languages
English (en)
Other versions
PH12017501029A1 (en
Inventor
Eun Sil Choi
Hyun Woo Joo
Seung Wan Kang
Byung Gyu Kim
Sung Wook Kim
Young Kwan Kim
Chang Seok Lee
Sang Dae Lee
Seung Yup Paek
Sang Yun Park
Original Assignee
Lg Chemical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Chemical Ltd filed Critical Lg Chemical Ltd
Publication of PH12017501029A1 publication Critical patent/PH12017501029A1/en
Publication of PH12017501029B1 publication Critical patent/PH12017501029B1/en

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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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