|
US5190864A
(en)
|
1986-04-15 |
1993-03-02 |
Northeastern University |
Enzyme amplification by using free enzyme to release enzyme from an immobilized enzyme material
|
|
US4937188A
(en)
|
1986-04-15 |
1990-06-26 |
Northeastern University |
Enzyme activity amplification method for increasing assay sensitivity
|
|
US4801726A
(en)
|
1986-04-15 |
1989-01-31 |
Northeastern University |
Repetitive hit-and-run immunoassay and stable support-analyte conjugates; applied to T-2 toxin
|
|
US5412083A
(en)
|
1992-04-16 |
1995-05-02 |
Northeastern University |
Carbohydrate heterobifunctional cross-linking reagent
|
|
US5429746A
(en)
|
1994-02-22 |
1995-07-04 |
Smith Kline Beecham Corporation |
Antibody purification
|
|
WO1996025425A1
(en)
|
1995-02-16 |
1996-08-22 |
Massachusetts Health Research Institute, Inc. |
Purified tetanus toxoid and toxin
|
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
|
US5695760A
(en)
*
|
1995-04-24 |
1997-12-09 |
Boehringer Inglehiem Pharmaceuticals, Inc. |
Modified anti-ICAM-1 antibodies and their use in the treatment of inflammation
|
|
EP0964057B1
(en)
|
1998-05-11 |
2004-12-22 |
Tosoh Corporation |
Method for separating nucleic acids by means of liquid chromatography
|
|
US7070959B1
(en)
|
1999-06-08 |
2006-07-04 |
Regeneron Pharmaceuticals, Inc. |
Modified chimeric polypeptides with improved pharmacokinetic properties
|
|
US7303746B2
(en)
|
1999-06-08 |
2007-12-04 |
Regeneron Pharmaceuticals, Inc. |
Methods of treating eye disorders with modified chimeric polypeptides
|
|
US7087411B2
(en)
|
1999-06-08 |
2006-08-08 |
Regeneron Pharmaceuticals, Inc. |
Fusion protein capable of binding VEGF
|
|
US7306799B2
(en)
|
1999-06-08 |
2007-12-11 |
Regeneron Pharmaceuticals, Inc. |
Use of VEGF inhibitors for treatment of eye disorders
|
|
IL155002A0
(en)
|
2000-10-12 |
2003-10-31 |
Genentech Inc |
Reduced-viscosity concentrated protein formulations
|
|
US20020064860A1
(en)
|
2000-11-29 |
2002-05-30 |
Schering Corporation |
Method for purifying adenoviruses
|
|
US7101982B2
(en)
|
2001-03-30 |
2006-09-05 |
Immunex Corporation |
Control of ph transitions during chromatography
|
|
WO2004020971A2
(en)
|
2002-08-28 |
2004-03-11 |
Introgen Therapeutics Inc. |
Chromatographic methods for adenovirus purification
|
|
DK1545574T3
(da)
|
2002-09-13 |
2014-09-08 |
Biogen Idec Inc |
Fremgangsmåde til rensning af polypeptider ved simuleret moving-bed-chromatografi
|
|
SE0300612D0
(sv)
*
|
2003-03-05 |
2003-03-05 |
Amersham Biosciences Ab |
A method of preparing ligands for hydrophobic interaction chromatography
|
|
JPWO2004087761A1
(ja)
|
2003-03-31 |
2006-07-27 |
麒麟麦酒株式会社 |
ヒトモノクローナル抗体およびヒトポリクローナル抗体の精製
|
|
WO2005000898A2
(en)
|
2003-06-27 |
2005-01-06 |
Biogen Idec Ma Inc. |
Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous antibody-solutions
|
|
ATE462716T1
(de)
|
2003-10-24 |
2010-04-15 |
Amgen Inc |
Verfahren zur aufreinigung von proteinen in einer durchflussfraktion aus der chromatographie mit hydrophoben wechselwirkungen
|
|
US8084032B2
(en)
|
2004-01-21 |
2011-12-27 |
Ajinomoto Co., Inc. |
Purification method which prevents denaturation of an antibody
|
|
WO2005082483A1
(en)
|
2004-02-27 |
2005-09-09 |
Ge Healthcare Bio-Sciences Ab |
A process for the purification of antibodies
|
|
SE0400501D0
(sv)
|
2004-02-27 |
2004-02-27 |
Amersham Biosciences Ab |
Antibody purification
|
|
SE0400886D0
(sv)
|
2004-04-02 |
2004-04-02 |
Amersham Biosciences Ab |
Process of purification
|
|
US7795405B2
(en)
|
2004-08-09 |
2010-09-14 |
Guild Associates, Inc. |
Procedure for the fractionation of proteins by using sequential ion exchange and hydrophobic interaction chromatography as prefractionation steps before analysis by two dimensional electrophoresis
|
|
US20060027454A1
(en)
|
2004-08-09 |
2006-02-09 |
Dinovo Augustine |
Procedure for the fractionation of proteins by using sequential ion exchange and hydrophobic interaction chromatography as prefractionation steps before analysis by two dimensional electrophoresis
|
|
WO2006043895A1
(en)
|
2004-10-21 |
2006-04-27 |
Ge Healthcare Bio-Sciences Ab |
A method of antibody purification
|
|
CA2621047A1
(en)
|
2005-02-02 |
2006-08-24 |
Regeneron Pharmaceuticals, Inc. |
Method of treating eye injury with local administration of a vegf inhibitor
|
|
US20080299671A1
(en)
|
2005-12-02 |
2008-12-04 |
Ge Healthcare Bio-Sciences Ab |
Hydrophobic Interaction Chromatography
|
|
RU2008142359A
(ru)
|
2006-03-28 |
2010-05-10 |
Ф.Хоффманн-Ля Рош Аг (Ch) |
Композиция человеческого моноклонального антитела к igf-1r
|
|
EP2738178A1
(en)
|
2006-04-05 |
2014-06-04 |
AbbVie Biotechnology Ltd |
Antibody purification
|
|
SI2944306T1
(sl)
|
2006-06-16 |
2021-04-30 |
Regeneron Pharmaceuticals, Inc. |
Formulacije antagonista VEGF, primerne za intravitrealno dajanje
|
|
WO2008028974A1
(en)
|
2006-09-08 |
2008-03-13 |
Novo Nordisk A/S |
Methods of optimizing chromatographic separation of polypeptides
|
|
JP2010505874A
(ja)
|
2006-10-03 |
2010-02-25 |
ノヴォ ノルディスク アー/エス |
ポリペプチドコンジュゲートの精製方法
|
|
WO2008079914A1
(en)
*
|
2006-12-21 |
2008-07-03 |
Novartis Ag |
Antibody quantitation
|
|
WO2008109721A1
(en)
|
2007-03-06 |
2008-09-12 |
Introgen Therapeutics, Inc. |
Chromatographic methods for assessing adenovirus purity
|
|
CL2008001334A1
(es)
*
|
2007-05-08 |
2008-09-22 |
Genentech Inc |
Anticuerpo anti-muc16 disenado con cisteina; conjugado que lo comprende; metodo de produccion; formulacion farmaceutica que lo comprende; y su uso para tratar el cancer.
|
|
US8003364B2
(en)
|
2007-05-14 |
2011-08-23 |
Bavarian Nordic A/S |
Purification of vaccinia viruses using hydrophobic interaction chromatography
|
|
WO2009058769A1
(en)
|
2007-10-30 |
2009-05-07 |
Schering Corporation |
Purification of antibodies containing hydrophobic variants
|
|
US8568586B2
(en)
|
2008-01-25 |
2013-10-29 |
Biogen Idec Ma Inc. |
Automated system and method for monitoring chromatography column performance, and applications thereof
|
|
DK2338049T3
(da)
|
2008-08-15 |
2021-03-01 |
Biogen Ma Inc |
Fremgangsmåder til evaluering af en kromatografisøjles ydeevne
|
|
US20100069617A1
(en)
|
2008-09-12 |
2010-03-18 |
Ge Healthcare Bio-Sciences Ab |
Enhanced protein aggregate removal by mixed mode chromatography on hydrophobic interaction media in the presence of protein-excluded zwitterions
|
|
KR20110091678A
(ko)
|
2008-10-20 |
2011-08-12 |
아보트 러보러터리즈 |
단백질 a 친화성 크로마토그래피를 이용한 항체의 분리 및 정제
|
|
NZ592097A
(en)
|
2008-10-20 |
2013-01-25 |
Abbott Lab |
Viral inactivation during purification of il-12 and il-18 antibodies
|
|
NZ613809A
(en)
|
2009-05-04 |
2015-02-27 |
Abbvie Biotechnology Ltd |
Stable high protein concentration formulations of human anti-tnf-alpha-antibodies
|
|
CN102803478B
(zh)
|
2009-06-16 |
2016-04-27 |
建新公司 |
用于纯化重组aav载体的改进方法
|
|
SI2459291T1
(en)
*
|
2009-07-30 |
2018-06-29 |
F. Hoffmann-La Roche Ag |
Portable separator for chromatographic columns
|
|
US8821879B2
(en)
*
|
2009-09-04 |
2014-09-02 |
Xoma Technology Ltd. |
Anti-botulism antibody coformulations
|
|
PL3037104T3
(pl)
|
2009-10-20 |
2020-11-16 |
Abbvie Inc. |
Izolacja i oczyszczanie przeciwciał anty-il-13 z zastosowaniem chromatografii powinowactwa z białkiem a
|
|
US8246833B2
(en)
|
2009-12-17 |
2012-08-21 |
Ge Healthcare Bio-Sciences Ab |
Chromatography column and maintenance method
|
|
EA201201132A1
(ru)
|
2010-02-12 |
2013-03-29 |
ДСМ АйПи АССЕТС Б.В. |
Очистка антител с помощью единого функционального блока
|
|
WO2012030512A1
(en)
|
2010-09-03 |
2012-03-08 |
Percivia Llc. |
Flow-through protein purification process
|
|
MX344727B
(es)
|
2010-11-11 |
2017-01-05 |
Abbvie Biotechnology Ltd |
Formulaciones liquidas de anticuerpos anti-tnf-alfa de alta concentracion mejoradas.
|
|
SG191186A1
(en)
|
2010-12-15 |
2013-07-31 |
Baxter Int |
Eluate collection using conductivity gradient
|
|
EP2500073A1
(en)
*
|
2011-03-17 |
2012-09-19 |
ChromaCon AG |
Method for identification and purification of multi-specific polypeptides
|
|
TWI589299B
(zh)
|
2011-10-11 |
2017-07-01 |
再生元醫藥公司 |
用於治療類風濕性關節炎之組成物及其使用方法
|
|
US9943594B2
(en)
|
2011-10-11 |
2018-04-17 |
Sanofi Biotechnology |
Methods for the treatment of rheumatoid arthritis
|
|
AU2012351751B2
(en)
*
|
2011-10-19 |
2017-09-07 |
Novimmune S.A. |
Methods of purifying antibodies
|
|
EP2773439A4
(en)
|
2011-10-31 |
2015-07-01 |
Merck Sharp & Dohme |
CHROMATOGRAPHY METHOD FOR RESOLVING HETEROGENIC ANTIBODY AGGREGATES
|
|
US8871209B2
(en)
|
2011-11-14 |
2014-10-28 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for increasing muscle mass and muscle strength by specifically antagonizing GDF8 and or Activin A
|
|
AU2012340826A1
(en)
|
2011-11-21 |
2014-05-29 |
Genentech, Inc. |
Purification of anti-c-met antibodies
|
|
JP6092892B2
(ja)
|
2011-12-15 |
2017-03-08 |
プレステージ バイオファーマ プライベート リミテッド |
抗体の精製方法
|
|
WO2013158273A1
(en)
|
2012-04-20 |
2013-10-24 |
Abbvie Inc. |
Methods to modulate c-terminal lysine variant distribution
|
|
WO2013158279A1
(en)
|
2012-04-20 |
2013-10-24 |
Abbvie Inc. |
Protein purification methods to reduce acidic species
|
|
US9067990B2
(en)
|
2013-03-14 |
2015-06-30 |
Abbvie, Inc. |
Protein purification using displacement chromatography
|
|
US20140154270A1
(en)
|
2012-05-21 |
2014-06-05 |
Chen Wang |
Purification of non-human antibodies using kosmotropic salt enhanced protein a affinity chromatography
|
|
US20130336957A1
(en)
|
2012-05-21 |
2013-12-19 |
Abbvie, Inc. |
Novel purification of human, humanized, or chimeric antibodies using protein a affinity chromatography
|
|
WO2013176754A1
(en)
|
2012-05-24 |
2013-11-28 |
Abbvie Inc. |
Novel purification of antibodies using hydrophobic interaction chromatography
|
|
EP2879691B1
(en)
|
2012-08-06 |
2019-03-27 |
Biogen MA Inc. |
Methods for inactivating enveloped viruses
|
|
US9650411B2
(en)
|
2012-08-07 |
2017-05-16 |
Kyowa Hakko Kirin Co., Ltd. |
Method of purifying protein
|
|
JOP20200236A1
(ar)
*
|
2012-09-21 |
2017-06-16 |
Regeneron Pharma |
الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها
|
|
JP6326066B2
(ja)
|
2012-12-20 |
2018-05-16 |
メディミューン,エルエルシー |
凝集プロファイルが改善されている液状抗体製剤
|
|
JO3405B1
(ar)
|
2013-01-09 |
2019-10-20 |
Regeneron Pharma |
الأجسام المضادة لمضاد مستقبل عامل النمو المشتق من الصفائح الدموية - بيتا واستخداماتها
|
|
HK1219964A1
(zh)
|
2013-03-08 |
2017-04-21 |
Genzyme Corporation |
治疗性蛋白药物物质的整合连续制造
|
|
CA2905010A1
(en)
|
2013-03-12 |
2014-09-18 |
Abbvie Inc. |
Human antibodies that bind human tnf-alpha and methods of preparing the same
|
|
US10023608B1
(en)
|
2013-03-13 |
2018-07-17 |
Amgen Inc. |
Protein purification methods to remove impurities
|
|
KR101813708B1
(ko)
*
|
2013-03-13 |
2017-12-29 |
(주) 아이벤트러스 |
소수성 상호작용 부위내에 전기적 상호작용이 도입된 단백질 및 이의 제조방법
|
|
CA2926384A1
(en)
|
2013-03-14 |
2014-10-02 |
Abbvie Inc. |
Low acidic species compositions and methods for producing and using the same
|
|
US9017687B1
(en)
|
2013-10-18 |
2015-04-28 |
Abbvie, Inc. |
Low acidic species compositions and methods for producing and using the same using displacement chromatography
|
|
WO2014152199A1
(en)
*
|
2013-03-15 |
2014-09-25 |
Abbvie Inc. |
Antibody drug conjugate (adc) purification
|
|
PL2970378T3
(pl)
|
2013-03-15 |
2021-12-06 |
Biogen Ma Inc. |
Chromatografia oddziaływań hydrofobowych białek w warunkach bez soli
|
|
ES2834113T3
(es)
|
2013-03-15 |
2021-06-16 |
H Lundbeck As |
Purificación de anticuerpos y monitorización de la pureza
|
|
CA2911514A1
(en)
|
2013-05-06 |
2014-11-13 |
Scholar Rock, Inc. |
Compositions and methods for growth factor modulation
|
|
US10111953B2
(en)
|
2013-05-30 |
2018-10-30 |
Regeneron Pharmaceuticals, Inc. |
Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (PCSK9)
|
|
TWI682780B
(zh)
|
2013-05-30 |
2020-01-21 |
美商再生元醫藥公司 |
醫藥組成物用於製造治療與pcsk9功能獲得性突變有關之體染色體顯性高膽固醇血症的藥物之用途
|
|
TWI633891B
(zh)
|
2013-06-04 |
2018-09-01 |
再生元醫藥公司 |
藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法
|
|
KR101569783B1
(ko)
|
2013-06-05 |
2015-11-19 |
한화케미칼 주식회사 |
항체의 정제 방법
|
|
US9150938B2
(en)
|
2013-06-12 |
2015-10-06 |
Orochem Technologies, Inc. |
Tagatose production from deproteinized whey and purification by continuous chromatography
|
|
AR096713A1
(es)
|
2013-06-25 |
2016-01-27 |
Cadila Healthcare Ltd |
Proceso de purificación para anticuerpos monoclonales
|
|
EP3041593B1
(en)
|
2013-09-05 |
2025-01-29 |
F. Hoffmann-La Roche AG |
Method of cleaning a chromatography material for its reuse
|
|
BR112016004437A2
(pt)
|
2013-09-13 |
2017-10-17 |
Genentech Inc |
métodos de imunoteste e de seleção de linhagem de células, anticorpos e kit
|
|
CN105722532A
(zh)
|
2013-09-13 |
2016-06-29 |
豪夫迈·罗氏有限公司 |
包含纯化的重组多肽的方法和组合物
|
|
US10081681B2
(en)
*
|
2013-09-20 |
2018-09-25 |
Bristol-Myers Squibb Company |
Combination of anti-LAG-3 antibodies and anti-PD-1 antibodies to treat tumors
|
|
US8946395B1
(en)
|
2013-10-18 |
2015-02-03 |
Abbvie Inc. |
Purification of proteins using hydrophobic interaction chromatography
|
|
WO2015061526A1
(en)
|
2013-10-25 |
2015-04-30 |
Medimmune, Llc |
Antibody purification
|
|
US10115576B2
(en)
|
2013-12-12 |
2018-10-30 |
Waters Technologies Corporation |
Method and an apparatus for analyzing a complex sample
|
|
JO3701B1
(ar)
*
|
2014-05-23 |
2021-01-31 |
Regeneron Pharma |
مضادات حيوية بشرية لمتلازمة الشرق الأوسط التنفسية - بروتين كورونا فيروس الشوكي
|
|
FR3025515B1
(fr)
|
2014-09-05 |
2016-09-09 |
Lab Francais Du Fractionnement |
Procede de purification d'un anticorps monoclonal
|
|
TW201628649A
(zh)
|
2014-10-09 |
2016-08-16 |
再生元醫藥公司 |
減少醫藥調配物中微可見顆粒之方法
|
|
JP2016088937A
(ja)
*
|
2014-10-31 |
2016-05-23 |
オーストリッチファーマ株式会社 |
エボラウイルスに対する抗体および抗体の製造方法
|
|
WO2016089886A2
(en)
|
2014-12-02 |
2016-06-09 |
Regeneron Pharmaceuticals, Inc. |
Methods for treating dry eye disease by administering an il-6r antagonist
|
|
WO2016118707A1
(en)
|
2015-01-21 |
2016-07-28 |
Oncobiologics, Inc. |
Modulation of charge variants in a monoclonal antibody composition
|
|
TWI710573B
(zh)
|
2015-01-26 |
2020-11-21 |
美商再生元醫藥公司 |
抗伊波拉病毒醣蛋白之人類抗體
|
|
TWI756187B
(zh)
|
2015-10-09 |
2022-03-01 |
美商再生元醫藥公司 |
抗lag3抗體及其用途
|
|
SI3394103T1
(sl)
|
2015-12-22 |
2023-10-30 |
Regeneron Pharmaceuticals, Inc. |
Kombinacija protiteles proti-PD-1 in bispecifičnih protiteles proti-CD20/proti-CD3 za zdravljenje raka
|
|
CA3009322A1
(en)
|
2015-12-22 |
2017-06-29 |
Regeneron Pharmaceuticals, Inc. |
Bispecific anti-cd20/anti-cd3 antibodies to treat acute lymphoblastic leukemia
|
|
EP3184119A1
(en)
|
2015-12-23 |
2017-06-28 |
Themis Bioscience GmbH |
Chromatography based purification strategies for measles scaffold based viruses
|
|
GB201602938D0
(en)
|
2016-02-19 |
2016-04-06 |
Ucb Biopharma Sprl |
Protein purification
|
|
CN109641928B
(zh)
|
2016-06-14 |
2022-08-30 |
比奥根Ma公司 |
用于寡核苷酸纯化的疏水性相互作用色谱法
|
|
WO2018027195A1
(en)
|
2016-08-05 |
2018-02-08 |
Abbvie Biotherapeutics Inc. |
Compositions containing reduced amounts of daclizumab acidic isoforms and methods for preparing the same
|
|
US10626376B2
(en)
|
2016-11-14 |
2020-04-21 |
St. Jude Children's Research Hospital |
Method for isolating and purifying adeno-associated virus particles using salt
|
|
US11697670B2
(en)
|
2017-08-22 |
2023-07-11 |
Biogen Ma Inc. |
Methods for purifying antibodies having reduced high molecular weight aggregates
|
|
JP7462566B2
(ja)
|
2018-03-16 |
2024-04-05 |
ブリストル-マイヤーズ スクイブ カンパニー |
タンパク質生産の間の代謝酵素活性およびジスルフィド結合還元
|
|
WO2019178495A1
(en)
|
2018-03-16 |
2019-09-19 |
Biogen Ma Inc. |
Methods for purifying recombinant adeno-associated viruses
|
|
KR20200136464A
(ko)
|
2018-03-29 |
2020-12-07 |
브리스톨-마이어스 스큅 컴퍼니 |
단량체성 모노클로날 항체를 정제하는 방법
|
|
EP3810650A1
(en)
|
2018-06-19 |
2021-04-28 |
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