|
US4937188A
(en)
|
1986-04-15 |
1990-06-26 |
Northeastern University |
Enzyme activity amplification method for increasing assay sensitivity
|
|
US4801726A
(en)
|
1986-04-15 |
1989-01-31 |
Northeastern University |
Repetitive hit-and-run immunoassay and stable support-analyte conjugates; applied to T-2 toxin
|
|
US5190864A
(en)
|
1986-04-15 |
1993-03-02 |
Northeastern University |
Enzyme amplification by using free enzyme to release enzyme from an immobilized enzyme material
|
|
US5412083A
(en)
|
1992-04-16 |
1995-05-02 |
Northeastern University |
Carbohydrate heterobifunctional cross-linking reagent
|
|
US5429746A
(en)
|
1994-02-22 |
1995-07-04 |
Smith Kline Beecham Corporation |
Antibody purification
|
|
AU4986596A
(en)
|
1995-02-16 |
1996-09-04 |
Massachusetts Health Research Institute, Inc. |
Purified tetanus toxoid and toxin
|
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
|
US5695760A
(en)
|
1995-04-24 |
1997-12-09 |
Boehringer Inglehiem Pharmaceuticals, Inc. |
Modified anti-ICAM-1 antibodies and their use in the treatment of inflammation
|
|
EP0964057B1
(en)
|
1998-05-11 |
2004-12-22 |
Tosoh Corporation |
Method for separating nucleic acids by means of liquid chromatography
|
|
US7306799B2
(en)
|
1999-06-08 |
2007-12-11 |
Regeneron Pharmaceuticals, Inc. |
Use of VEGF inhibitors for treatment of eye disorders
|
|
US7087411B2
(en)
|
1999-06-08 |
2006-08-08 |
Regeneron Pharmaceuticals, Inc. |
Fusion protein capable of binding VEGF
|
|
US7070959B1
(en)
|
1999-06-08 |
2006-07-04 |
Regeneron Pharmaceuticals, Inc. |
Modified chimeric polypeptides with improved pharmacokinetic properties
|
|
US7303746B2
(en)
|
1999-06-08 |
2007-12-04 |
Regeneron Pharmaceuticals, Inc. |
Methods of treating eye disorders with modified chimeric polypeptides
|
|
JP4340062B2
(ja)
|
2000-10-12 |
2009-10-07 |
ジェネンテック・インコーポレーテッド |
粘度の減少した濃縮タンパク質製剤
|
|
US20020064860A1
(en)
|
2000-11-29 |
2002-05-30 |
Schering Corporation |
Method for purifying adenoviruses
|
|
US7101982B2
(en)
|
2001-03-30 |
2006-09-05 |
Immunex Corporation |
Control of ph transitions during chromatography
|
|
US20100333219A1
(en)
*
|
2001-11-30 |
2010-12-30 |
Synageva Biopharma Corp. |
Methods of protein production using ovomucoid regulatory regions
|
|
EP1585964A4
(en)
|
2002-08-28 |
2008-07-16 |
Introgen Therapeutics Inc |
CHROMATOGRAPHIC METHODS FOR PURIFYING ADENOVIRUSES
|
|
EP1545574B8
(en)
|
2002-09-13 |
2014-09-24 |
Biogen Idec Inc. |
Method of purifying polypeptides by simulated moving bed chromatography
|
|
SE0300612D0
(sv)
*
|
2003-03-05 |
2003-03-05 |
Amersham Biosciences Ab |
A method of preparing ligands for hydrophobic interaction chromatography
|
|
JPWO2004087761A1
(ja)
|
2003-03-31 |
2006-07-27 |
麒麟麦酒株式会社 |
ヒトモノクローナル抗体およびヒトポリクローナル抗体の精製
|
|
US7700097B2
(en)
|
2003-06-27 |
2010-04-20 |
Biogen Idec Ma Inc. |
Purification and preferential synthesis of binding molecules
|
|
DE602004026343D1
(de)
|
2003-10-24 |
2010-05-12 |
Amgen Inc |
Verfahren zur aufreinigung von proteinen in einer durchflussfraktion aus der chromatographie mit hydrophoben wechselwirkungen
|
|
US8084032B2
(en)
|
2004-01-21 |
2011-12-27 |
Ajinomoto Co., Inc. |
Purification method which prevents denaturation of an antibody
|
|
SE0400501D0
(sv)
|
2004-02-27 |
2004-02-27 |
Amersham Biosciences Ab |
Antibody purification
|
|
CA2552639C
(en)
|
2004-02-27 |
2012-05-01 |
Ge Healthcare Bio-Sciences Ab |
A process for the purification of antibodies
|
|
CA2558399C
(en)
*
|
2004-03-02 |
2015-05-19 |
Seattle Genetics, Inc. |
Partially loaded antibodies and methods of their conjugation
|
|
SE0400886D0
(sv)
|
2004-04-02 |
2004-04-02 |
Amersham Biosciences Ab |
Process of purification
|
|
US20060027454A1
(en)
|
2004-08-09 |
2006-02-09 |
Dinovo Augustine |
Procedure for the fractionation of proteins by using sequential ion exchange and hydrophobic interaction chromatography as prefractionation steps before analysis by two dimensional electrophoresis
|
|
US7795405B2
(en)
|
2004-08-09 |
2010-09-14 |
Guild Associates, Inc. |
Procedure for the fractionation of proteins by using sequential ion exchange and hydrophobic interaction chromatography as prefractionation steps before analysis by two dimensional electrophoresis
|
|
BRPI0518216C8
(pt)
|
2004-10-21 |
2017-03-21 |
Ge Healthcare Bio Sciences Ab |
ligante de cromatografia, métodos de preparação de uma matriz de separação, e de separação de um ou mais anticorpos de um ou mais outros compostos em uma amostra líquida, matriz de separação, e, coluna de cromatografia descartável.
|
|
WO2007024249A2
(en)
*
|
2004-11-10 |
2007-03-01 |
Macrogenics, Inc. |
Engineering fc antibody regions to confer effector function
|
|
EP1877438A2
(en)
|
2005-02-02 |
2008-01-16 |
Regeneron Pharmaceuticals, Inc. |
Method of treating eye injury with local administration of a vegf inhibitor
|
|
CA2597996A1
(en)
*
|
2005-03-08 |
2006-09-14 |
Tanox, Inc. |
Methods for determining the bivalency of protein and antibody therapeutics
|
|
WO2007064281A1
(en)
|
2005-12-02 |
2007-06-07 |
Ge Healthcare Bio-Sciences Ab |
Hydrophobic interaction chromatography
|
|
KR20080104160A
(ko)
|
2006-03-28 |
2008-12-01 |
에프. 호프만-라 로슈 아게 |
항-ｉｇｆ-１ｒ 인간 단일클론 항체 제형
|
|
EP2738179A1
(en)
|
2006-04-05 |
2014-06-04 |
AbbVie Biotechnology Ltd |
Antibody purification
|
|
SI2944306T1
(sl)
|
2006-06-16 |
2021-04-30 |
Regeneron Pharmaceuticals, Inc. |
Formulacije antagonista VEGF, primerne za intravitrealno dajanje
|
|
US9766217B2
(en)
|
2006-09-08 |
2017-09-19 |
Novo Nordisk A/S |
Methods of optimizing chromatographic separation of polypeptides
|
|
US8969532B2
(en)
|
2006-10-03 |
2015-03-03 |
Novo Nordisk A/S |
Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
|
|
WO2008079914A1
(en)
*
|
2006-12-21 |
2008-07-03 |
Novartis Ag |
Antibody quantitation
|
|
WO2008109721A1
(en)
|
2007-03-06 |
2008-09-12 |
Introgen Therapeutics, Inc. |
Chromatographic methods for assessing adenovirus purity
|
|
TW200902554A
(en)
*
|
2007-05-08 |
2009-01-16 |
Genentech Inc |
Cysteine engineered anti-MUC16 antibodies and antibody drug conjugates
|
|
US8003364B2
(en)
|
2007-05-14 |
2011-08-23 |
Bavarian Nordic A/S |
Purification of vaccinia viruses using hydrophobic interaction chromatography
|
|
WO2009058769A1
(en)
|
2007-10-30 |
2009-05-07 |
Schering Corporation |
Purification of antibodies containing hydrophobic variants
|
|
CA2712732C
(en)
|
2008-01-25 |
2018-11-27 |
Biogen Idec Ma Inc. |
Automated system and method for monitoring chromatography column performance, and applications thereof
|
|
DK2338049T3
(da)
|
2008-08-15 |
2021-03-01 |
Biogen Ma Inc |
Fremgangsmåder til evaluering af en kromatografisøjles ydeevne
|
|
US20100069617A1
(en)
|
2008-09-12 |
2010-03-18 |
Ge Healthcare Bio-Sciences Ab |
Enhanced protein aggregate removal by mixed mode chromatography on hydrophobic interaction media in the presence of protein-excluded zwitterions
|
|
TW201024318A
(en)
|
2008-10-20 |
2010-07-01 |
Abbott Lab |
Isolation and purification of antibodies using protein A affinity chromatography
|
|
SG195577A1
(en)
|
2008-10-20 |
2013-12-30 |
Abbott Lab |
Viral inactivation during purification of antibodies
|
|
NZ595694A
(en)
|
2009-05-04 |
2013-09-27 |
Abbvie Biotechnology Ltd |
Stable high protein concentration formulations of human anti-tnf-alpha-antibodies
|
|
KR101812813B1
(ko)
|
2009-06-16 |
2017-12-27 |
젠자임 코포레이션 |
재조합 ａａｖ 벡터에 대한 개선된 정제 방법
|
|
CN102471377B
(zh)
*
|
2009-07-24 |
2015-04-22 |
霍夫曼-拉罗奇有限公司 |
优化抗体的生产
|
|
CA2768326C
(en)
*
|
2009-07-30 |
2019-01-08 |
F. Hoffmann-La Roche Ag |
Moveable chromatography column separator
|
|
US8821879B2
(en)
*
|
2009-09-04 |
2014-09-02 |
Xoma Technology Ltd. |
Anti-botulism antibody coformulations
|
|
ES2813398T3
(es)
|
2009-10-20 |
2021-03-23 |
Abbvie Inc |
Aislamiento y purificación de anticuerpos anti-IL-13 usando cromatografía de afinidad a Proteína A
|
|
US8246833B2
(en)
|
2009-12-17 |
2012-08-21 |
Ge Healthcare Bio-Sciences Ab |
Chromatography column and maintenance method
|
|
AU2011214361C1
(en)
|
2010-02-12 |
2016-01-14 |
Dpx Holdings B.V. |
Single unit antibody purification
|
|
WO2012030512A1
(en)
|
2010-09-03 |
2012-03-08 |
Percivia Llc. |
Flow-through protein purification process
|
|
CN103458926B
(zh)
|
2010-11-11 |
2016-10-26 |
艾伯维生物技术有限公司 |
改进的高浓度抗TNF α 抗体液体制剂
|
|
AU2011343813B2
(en)
|
2010-12-15 |
2015-05-21 |
Takeda Pharmaceutical Company Limited |
Eluate collection using conductivity gradient
|
|
EP2500073A1
(en)
*
|
2011-03-17 |
2012-09-19 |
ChromaCon AG |
Method for identification and purification of multi-specific polypeptides
|
|
US9943594B2
(en)
|
2011-10-11 |
2018-04-17 |
Sanofi Biotechnology |
Methods for the treatment of rheumatoid arthritis
|
|
TWI589299B
(zh)
|
2011-10-11 |
2017-07-01 |
再生元醫藥公司 |
用於治療類風濕性關節炎之組成物及其使用方法
|
|
ES2767135T3
(es)
*
|
2011-10-19 |
2020-06-16 |
Novimmune Sa |
Métodos para purificar anticuerpos
|
|
WO2013066707A1
(en)
|
2011-10-31 |
2013-05-10 |
Merck Sharp & Dohme Corp. |
Chromatography process for resolving heterogeneous antibody aggregates
|
|
JP6177249B2
(ja)
|
2011-11-14 |
2017-08-09 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． |
Ｇｄｆ８及び／又はアクチビンａに特異的に拮抗することによって筋肉量及び筋力を増加させる組成物及び方法
|
|
MX2014005885A
(es)
|
2011-11-21 |
2014-09-04 |
Genentech Inc |
Purificacion de anticuerpos anti-c-met.
|
|
BR112014011900A2
(pt)
|
2011-12-15 |
2017-05-16 |
Hanwha Chemical Corp |
um método de purificação de anticorpo
|
|
WO2013158279A1
(en)
|
2012-04-20 |
2013-10-24 |
Abbvie Inc. |
Protein purification methods to reduce acidic species
|
|
US9067990B2
(en)
|
2013-03-14 |
2015-06-30 |
Abbvie, Inc. |
Protein purification using displacement chromatography
|
|
WO2013158273A1
(en)
|
2012-04-20 |
2013-10-24 |
Abbvie Inc. |
Methods to modulate c-terminal lysine variant distribution
|
|
TW201348246A
(zh)
|
2012-05-21 |
2013-12-01 |
Abbvie Inc |
利用蛋白質ａ親和性層析之人類、人類化或嵌合抗體之新穎純化
|
|
US20140154270A1
(en)
|
2012-05-21 |
2014-06-05 |
Chen Wang |
Purification of non-human antibodies using kosmotropic salt enhanced protein a affinity chromatography
|
|
US9249182B2
(en)
|
2012-05-24 |
2016-02-02 |
Abbvie, Inc. |
Purification of antibodies using hydrophobic interaction chromatography
|
|
DK2879691T3
(da)
|
2012-08-06 |
2019-06-11 |
Biogen Ma Inc |
Fremgangsmåder og sammensætninger til inaktivering af kappebærende vira
|
|
US9650411B2
(en)
|
2012-08-07 |
2017-05-16 |
Kyowa Hakko Kirin Co., Ltd. |
Method of purifying protein
|
|
JOP20200236A1
(ar)
*
|
2012-09-21 |
2017-06-16 |
Regeneron Pharma |
الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها
|
|
GB201218341D0
(en)
*
|
2012-10-12 |
2012-11-28 |
Orign Sciences Ltd |
Diagnostic method
|
|
EP3266466A1
(en)
|
2012-12-20 |
2018-01-10 |
Medimmune, LLC |
Liquid antibody formulation with improved aggregation properties
|
|
JO3405B1
(ar)
|
2013-01-09 |
2019-10-20 |
Regeneron Pharma |
الأجسام المضادة لمضاد مستقبل عامل النمو المشتق من الصفائح الدموية - بيتا واستخداماتها
|
|
CN118388581A
(zh)
|
2013-03-08 |
2024-07-26 |
建新公司 |
治疗性蛋白药物物质的整合连续制造
|
|
SG11201507230PA
(en)
|
2013-03-12 |
2015-10-29 |
Abbvie Inc |
Human antibodies that bind human tnf-alpha and methods of preparing the same
|
|
US10023608B1
(en)
|
2013-03-13 |
2018-07-17 |
Amgen Inc. |
Protein purification methods to remove impurities
|
|
EP2975061A4
(en)
*
|
2013-03-13 |
2017-03-01 |
Ibentrus Inc. |
Protein in which electrical interaction is introduced within hydrophobic interaction site and preparation method therefor
|
|
KR20150129033A
(ko)
|
2013-03-14 |
2015-11-18 |
애브비 인코포레이티드 |
저 산성 종 조성물 및 이의 제조 및 사용 방법
|
|
US9017687B1
(en)
|
2013-10-18 |
2015-04-28 |
Abbvie, Inc. |
Low acidic species compositions and methods for producing and using the same using displacement chromatography
|
|
ES2834113T3
(es)
|
2013-03-15 |
2021-06-16 |
H Lundbeck As |
Purificación de anticuerpos y monitorización de la pureza
|
|
MX2015012562A
(es)
*
|
2013-03-15 |
2016-06-21 |
Abbvie Inc |
Purificacion de conjugados anticuerpo-farmaco (cafs).
|
|
DK2970378T3
(da)
|
2013-03-15 |
2021-08-23 |
Biogen Ma Inc |
Hydrofob interaktionsproteinkromatografi under saltfrie betingelser
|
|
HUE052232T2
(hu)
|
2013-05-06 |
2021-04-28 |
Scholar Rock Inc |
Készítmények és eljárások növekedési faktor modulálására
|
|
TWI682780B
(zh)
|
2013-05-30 |
2020-01-21 |
美商再生元醫藥公司 |
醫藥組成物用於製造治療與ｐｃｓｋ９功能獲得性突變有關之體染色體顯性高膽固醇血症的藥物之用途
|
|
US10111953B2
(en)
|
2013-05-30 |
2018-10-30 |
Regeneron Pharmaceuticals, Inc. |
Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (PCSK9)
|
|
TWI755763B
(zh)
|
2013-06-04 |
2022-02-21 |
美商再生元醫藥公司 |
藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法
|
|
KR101569783B1
(ko)
|
2013-06-05 |
2015-11-19 |
한화케미칼 주식회사 |
항체의 정제 방법
|
|
US9150938B2
(en)
|
2013-06-12 |
2015-10-06 |
Orochem Technologies, Inc. |
Tagatose production from deproteinized whey and purification by continuous chromatography
|
|
TWI596107B
(zh)
|
2013-06-25 |
2017-08-21 |
卡地拉保健有限公司 |
單株抗體之新穎純化方法
|
|
JP6602765B2
(ja)
|
2013-09-05 |
2019-11-06 |
ジェネンテック， インコーポレイテッド |
クロマトグラフィー再使用のための方法
|
|
RU2016107435A
(ru)
|
2013-09-13 |
2017-10-18 |
Дженентек, Инк. |
Композиции и способы обнаружения и количественного определения белка клеток-хозяев в клеточных линиях и рекомбинантные полипептидные продукты
|
|
EP3683232A1
(en)
|
2013-09-13 |
2020-07-22 |
F. Hoffmann-La Roche AG |
Methods and compositions comprising purified recombinant polypeptides
|
|
AU2014323523B2
(en)
*
|
2013-09-20 |
2020-02-20 |
Bristol-Myers Squibb Company |
Combination of anti-LAG-3 antibodies and anti-PD-1 antibodies to treat tumors
|
|
US8946395B1
(en)
|
2013-10-18 |
2015-02-03 |
Abbvie Inc. |
Purification of proteins using hydrophobic interaction chromatography
|
|
EP3060578A4
(en)
|
2013-10-25 |
2017-07-05 |
Medlmmune, LLC |
Antibody purification
|
|
US10115576B2
(en)
|
2013-12-12 |
2018-10-30 |
Waters Technologies Corporation |
Method and an apparatus for analyzing a complex sample
|
|
WO2015099838A2
(en)
*
|
2013-12-24 |
2015-07-02 |
Novelmed Therapeutics, Inc. |
Compositions and methods of treating ocular diseases
|
|
JO3701B1
(ar)
|
2014-05-23 |
2021-01-31 |
Regeneron Pharma |
مضادات حيوية بشرية لمتلازمة الشرق الأوسط التنفسية - بروتين كورونا فيروس الشوكي
|
|
FR3025515B1
(fr)
|
2014-09-05 |
2016-09-09 |
Lab Francais Du Fractionnement |
Procede de purification d'un anticorps monoclonal
|
|
TW201628649A
(zh)
|
2014-10-09 |
2016-08-16 |
再生元醫藥公司 |
減少醫藥調配物中微可見顆粒之方法
|
|
JP2016088937A
(ja)
*
|
2014-10-31 |
2016-05-23 |
オーストリッチファーマ株式会社 |
エボラウイルスに対する抗体および抗体の製造方法
|
|
EP3226899A4
(en)
|
2014-12-02 |
2018-09-05 |
Regeneron Pharmaceuticals, Inc. |
Methods for treating dry eye disease by administering an il-6r antagonist
|
|
US10696735B2
(en)
|
2015-01-21 |
2020-06-30 |
Outlook Therapeutics, Inc. |
Modulation of charge variants in a monoclonal antibody composition
|
|
TWI710573B
(zh)
|
2015-01-26 |
2020-11-21 |
美商再生元醫藥公司 |
抗伊波拉病毒醣蛋白之人類抗體
|
|
TWI756187B
(zh)
|
2015-10-09 |
2022-03-01 |
美商再生元醫藥公司 |
抗ｌａｇ３抗體及其用途
|
|
HUE063377T2
(hu)
|
2015-12-22 |
2024-01-28 |
Regeneron Pharma |
Anti-PD-1 antitestek és bispecifikus anti-CD20/anti-CD3 antitestek kombinációja a rák kezelésére
|
|
US20170174781A1
(en)
|
2015-12-22 |
2017-06-22 |
Regeneron Pharmaceuticals, Inc. |
Bispecific Anti-CD20/Anti-CD3 Antibodies to Treat Acute Lymphoblastic Leukemia
|
|
EP3184119A1
(en)
|
2015-12-23 |
2017-06-28 |
Themis Bioscience GmbH |
Chromatography based purification strategies for measles scaffold based viruses
|
|
GB201602938D0
(en)
|
2016-02-19 |
2016-04-06 |
Ucb Biopharma Sprl |
Protein purification
|
|
JP7075359B2
(ja)
|
2016-06-14 |
2022-05-25 |
バイオジェン・エムエイ・インコーポレイテッド |
オリゴヌクレオチドの精製のための疎水性相互作用クロマトグラフィー
|
|
WO2018027195A1
(en)
|
2016-08-05 |
2018-02-08 |
Abbvie Biotherapeutics Inc. |
Compositions containing reduced amounts of daclizumab acidic isoforms and methods for preparing the same
|
|
US10626376B2
(en)
|
2016-11-14 |
2020-04-21 |
St. Jude Children's Research Hospital |
Method for isolating and purifying adeno-associated virus particles using salt
|
|
MA49962A
(fr)
|
2017-08-22 |
2020-07-01 |
Biogen Ma Inc |
Procédés de purification d'anticorps présentant des agrégats réduits à poids moléculaire élevé
|
|
CN111902160B
(zh)
|
2018-03-16 |
2025-05-09 |
百时美施贵宝公司 |
蛋白质生产期间的代谢酶活性和二硫键还原
|
|
WO2019178495A1
(en)
|
2018-03-16 |
2019-09-19 |
Biogen Ma Inc. |
Methods for purifying recombinant adeno-associated viruses
|
|
WO2019191416A1
(en)
|
2018-03-29 |
2019-10-03 |
Bristol-Myers Squibb Company |
Methods of purifying monomeric monoclonal antibodies
|
|
KR102882390B1
(ko)
|
2018-06-19 |
2025-11-05 |
브리스톨-마이어스 스큅 컴퍼니 |
크로마토그래피를 사용하여 단백질을 정제하는 방법
|
|
TWI853823B
(zh)
|
2018-07-02 |
2024-09-01 |
美商里珍納龍藥品有限公司 |
自混合物製備多肽之系統及方法
|
|
EP3826743A4
(en)
|
2018-07-25 |
2022-09-14 |
Merck Sharp & Dohme Corp. |
METHODS FOR SEPARATION OF HOST CELL LIPASES FROM A PRODUCTION PROTEIN IN CHROMATOGRAPHIC METHODS
|
|
JP2021534151A
(ja)
|
2018-08-15 |
2021-12-09 |
ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company |
下流クロマトグラフィーにおける再酸化によるタンパク質断片化制御戦略
|
|
EP3876996A1
(en)
|
2018-11-05 |
2021-09-15 |
Bristol-Myers Squibb Company |
Method for purifying pegylated protein
|
|
US20220135619A1
(en)
|
2019-02-24 |
2022-05-05 |
Bristol-Myers Squibb Company |
Methods of isolating a protein
|
|
JP7570344B2
(ja)
|
2019-03-29 |
2024-10-21 |
ブリストル－マイヤーズ スクイブ カンパニー |
クロマトグラフィー樹脂の疎水性を測定する方法
|
|
US20220267796A1
(en)
|
2019-06-28 |
2022-08-25 |
Takeda Pharmaceutical Company Limited |
Adeno-associated virus purification methods
|