MX350355B - Composiciones y metodos para aumentar la masa muscular y la fuerza muscular antagonizando especificamente gdf8 y/o activina a. - Google Patents

Composiciones y metodos para aumentar la masa muscular y la fuerza muscular antagonizando especificamente gdf8 y/o activina a.

Info

Publication number
MX350355B
MX350355B MX2014005865A MX2014005865A MX350355B MX 350355 B MX350355 B MX 350355B MX 2014005865 A MX2014005865 A MX 2014005865A MX 2014005865 A MX2014005865 A MX 2014005865A MX 350355 B MX350355 B MX 350355B
Authority
MX
Mexico
Prior art keywords
activin
compositions
gdf8
methods
specific binding
Prior art date
Application number
MX2014005865A
Other languages
English (en)
Other versions
MX2014005865A (es
Inventor
Stitt Trevor
Latres Esther
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2014005865A publication Critical patent/MX2014005865A/es
Publication of MX350355B publication Critical patent/MX350355B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06—Anabolic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se refiere a una composición que comprende una proteína de unión específica para GDF8 y una proteína de unión específica para Activina A, en donde la proteína de unión específica para GDF8 es un anticuerpo anti-GDF-8 o un fragmento de unión al antígeno de éste que inhibe GDF-8, y en donde la proteína de unión específica para Activina A es un anticuerpo anti-Activina A o fragmento d eunión al antígeno de éste que inhibe Activina A.
MX2014005865A 2011-11-14 2012-11-14 Composiciones y metodos para aumentar la masa muscular y la fuerza muscular antagonizando especificamente gdf8 y/o activina a. MX350355B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161559175P 2011-11-14 2011-11-14
US201261607024P 2012-03-06 2012-03-06
US201261661451P 2012-06-19 2012-06-19
PCT/US2012/064911 WO2013074557A1 (en) 2011-11-14 2012-11-14 Compositions and methods for increasing muscle mass and muscle strength by specifically antagonizing gdf8 and/or activin a

Publications (2)

Publication Number Publication Date
MX2014005865A MX2014005865A (es) 2014-10-17
MX350355B true MX350355B (es) 2017-09-04

Family

ID=47228083

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014005865A MX350355B (es) 2011-11-14 2012-11-14 Composiciones y metodos para aumentar la masa muscular y la fuerza muscular antagonizando especificamente gdf8 y/o activina a.

Country Status (19)

Country Link
US (7) US8871209B2 (es)
EP (1) EP2780368B1 (es)
JP (1) JP6177249B2 (es)
KR (1) KR102048189B1 (es)
AU (1) AU2012339722B2 (es)
CA (1) CA2855822C (es)
CY (1) CY1119994T1 (es)
DK (1) DK2780368T3 (es)
ES (1) ES2663946T3 (es)
HK (1) HK1202559A1 (es)
HR (1) HRP20180201T1 (es)
HU (1) HUE038570T2 (es)
LT (1) LT2780368T (es)
MX (1) MX350355B (es)
PL (1) PL2780368T3 (es)
PT (1) PT2780368T (es)
RS (1) RS56796B1 (es)
SI (1) SI2780368T1 (es)
WO (1) WO2013074557A1 (es)

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US20150010568A1 (en) 2015-01-08
PT2780368T (pt) 2018-03-22
ES2663946T3 (es) 2018-04-17
JP2014534239A (ja) 2014-12-18
CY1119994T1 (el) 2018-12-12
HUE038570T2 (hu) 2018-10-29
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CA2855822C (en) 2022-11-15
AU2012339722A1 (en) 2014-06-05
US20240117027A1 (en) 2024-04-11
US20170226197A1 (en) 2017-08-10
WO2013074557A1 (en) 2013-05-23
LT2780368T (lt) 2018-03-12
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US20130122007A1 (en) 2013-05-16
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US20200010540A1 (en) 2020-01-09
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US20170008956A1 (en) 2017-01-12
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