MX2021002281A - Metodos para caracterizar complejos proteicos. - Google Patents
Metodos para caracterizar complejos proteicos.Info
- Publication number
- MX2021002281A MX2021002281A MX2021002281A MX2021002281A MX2021002281A MX 2021002281 A MX2021002281 A MX 2021002281A MX 2021002281 A MX2021002281 A MX 2021002281A MX 2021002281 A MX2021002281 A MX 2021002281A MX 2021002281 A MX2021002281 A MX 2021002281A
- Authority
- MX
- Mexico
- Prior art keywords
- protein complexes
- methods
- wall
- characterizing
- characterizing protein
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/0005—Field flow fractionation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Abstract
En la presente descripción se proporcionan métodos para caracterizar complejos proteicos formados entre productos farmacéuticos proteicos y ligandos solubles. Los métodos descritos pueden determinar el tamaño, la heterogeneidad, y la conformación de los complejos proteicos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862724700P | 2018-08-30 | 2018-08-30 | |
PCT/US2019/048526 WO2020047067A1 (en) | 2018-08-30 | 2019-08-28 | Methods for characterizing protein complexes |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021002281A true MX2021002281A (es) | 2021-05-27 |
Family
ID=68063024
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021002281A MX2021002281A (es) | 2018-08-30 | 2019-08-28 | Metodos para caracterizar complejos proteicos. |
Country Status (14)
Country | Link |
---|---|
US (2) | US11754569B2 (es) |
EP (1) | EP3775926A1 (es) |
JP (1) | JP2021535361A (es) |
KR (1) | KR20210053816A (es) |
CN (1) | CN112601963A (es) |
AU (1) | AU2019333047A1 (es) |
BR (1) | BR112020026348A2 (es) |
CA (1) | CA3100038A1 (es) |
EA (1) | EA202190032A1 (es) |
IL (1) | IL280884A (es) |
MX (1) | MX2021002281A (es) |
SG (1) | SG11202011969WA (es) |
TW (1) | TW202024639A (es) |
WO (1) | WO2020047067A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2022543669A (ja) | 2019-08-08 | 2022-10-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 新規抗原結合分子フォーマット |
AU2022314734A1 (en) | 2021-07-19 | 2024-02-08 | Regeneron Pharmaceuticals, Inc. | Il12 receptor agonists and methods of use thereof |
US20230279153A1 (en) | 2021-11-11 | 2023-09-07 | Regeneron Pharmaceuticals, Inc. | Cd20-pd1 binding molecules and methods of use thereof |
CN114874349B (zh) * | 2022-06-15 | 2023-03-10 | 河北大学 | 一种基于场流分离技术分离纯化灵芝多糖的方法 |
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US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
TW574597B (en) | 2002-03-08 | 2004-02-01 | Asml Netherlands Bv | Mask for use in lithography, method of making a mask, lithographic apparatus, and device manufacturing method |
PT2374818E (pt) | 2006-06-02 | 2013-02-13 | Regeneron Pharma | Anticorpos com elevada afinidade para o receptor il-6 humano |
US7608693B2 (en) | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
AU2008282152B2 (en) | 2007-07-31 | 2013-12-19 | Regeneron Pharmaceuticals, Inc. | Human antibodies to human CD20 and method of using thereof |
US8309088B2 (en) | 2007-08-10 | 2012-11-13 | Regeneron Pharmaceuticals, Inc. | Method of treating osteoarthritis with an antibody to NGF |
JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
PT2975051T (pt) | 2009-06-26 | 2021-05-04 | Regeneron Pharma | Anticorpos biespecíficos rapidamente isolados com formato de imunoglobulina nativa |
JO3417B1 (ar) | 2010-01-08 | 2019-10-20 | Regeneron Pharma | الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r |
JP2013528570A (ja) | 2010-03-31 | 2013-07-11 | ユニベルシテ ドゥ ジュネーブ | 安定化された抗体調製物およびその使用 |
JO3340B1 (ar) | 2010-05-26 | 2019-03-13 | Regeneron Pharma | مضادات حيوية لـعامل تمايز النمو 8 البشري |
JOP20190250A1 (ar) | 2010-07-14 | 2017-06-16 | Regeneron Pharma | صيغ مستقرة تحتوي على الأجسام المضادة لمضاد عامل نمو الأعصاب |
AR083044A1 (es) | 2010-09-27 | 2013-01-30 | Regeneron Pharma | Anticuerpos anti-cd48 y usos de los mismos |
PL2624865T3 (pl) | 2010-10-06 | 2018-11-30 | Regeneron Pharmaceuticals, Inc. | Stabilizowane preparaty zawierające przeciwciała przeciwko receptorowi interleukiny-4 (IL-4R) |
JO3756B1 (ar) | 2010-11-23 | 2021-01-31 | Regeneron Pharma | اجسام مضادة بشرية لمستقبلات الجلوكاجون |
JO3412B1 (ar) | 2011-06-17 | 2019-10-20 | Regeneron Pharma | أجسام مضادة ل angptl3 واستخداماتها |
HUE038570T2 (hu) | 2011-11-14 | 2018-10-29 | Regeneron Pharma | Készítmények és eljárások izomtömeg és izomerõ növelésére GDF8 és/vagy aktivin A specifikus antagonizálásával |
US9402898B2 (en) | 2012-01-23 | 2016-08-02 | Regeneron Pharmaceuticals, Inc. | Stabilized formulations containing anti-Ang2 antibodies |
US10481164B2 (en) * | 2012-03-26 | 2019-11-19 | Amgen Inc. | Method for using light scattering in real time to directly monitor and control impurity removal in purification processes |
DK2839290T3 (da) | 2012-04-17 | 2019-06-11 | Aeneas Gmbh & Co Kg | Fremgangsmåde til præsymptomatisk diagnose af cøliaki og glutensensitivitet |
JO3820B1 (ar) | 2012-05-03 | 2021-01-31 | Regeneron Pharma | أجسام مضادة بشرية لـ fel d1وطرق لاستخدامها |
TW201843172A (zh) | 2012-06-25 | 2018-12-16 | 美商再生元醫藥公司 | 抗-egfr抗體及其用途 |
AR092098A1 (es) | 2012-08-13 | 2015-03-25 | Regeneron Pharma | ANTICUERPOS ANTI-PCSK9 CON CARACTERISTICAS DE UNION DEPENDIENTES DEL pH |
JOP20200236A1 (ar) | 2012-09-21 | 2017-06-16 | Regeneron Pharma | الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها |
JO3405B1 (ar) | 2013-01-09 | 2019-10-20 | Regeneron Pharma | الأجسام المضادة لمضاد مستقبل عامل النمو المشتق من الصفائح الدموية - بيتا واستخداماتها |
JO3532B1 (ar) | 2013-03-13 | 2020-07-05 | Regeneron Pharma | الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها |
TWI659968B (zh) | 2013-03-14 | 2019-05-21 | 再生元醫藥公司 | 針對呼吸道融合病毒f蛋白質的人類抗體及其使用方法 |
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TWI641620B (zh) | 2013-08-21 | 2018-11-21 | 再生元醫藥公司 | 抗-prlr抗體及其用途 |
TWI680138B (zh) | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗pd-l1之人類抗體 |
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TWI710573B (zh) | 2015-01-26 | 2020-11-21 | 美商再生元醫藥公司 | 抗伊波拉病毒醣蛋白之人類抗體 |
WO2017129737A1 (en) | 2016-01-27 | 2017-08-03 | Csl Behring Recombinant Facility Ag | Recombinant igg fc multimers |
CA3083113A1 (en) * | 2017-12-13 | 2019-06-20 | Regeneron Pharmaceuticals, Inc. | Anti-c5 antibody combinations and uses thereof |
-
2019
- 2019-08-28 TW TW108130758A patent/TW202024639A/zh unknown
- 2019-08-28 WO PCT/US2019/048526 patent/WO2020047067A1/en unknown
- 2019-08-28 MX MX2021002281A patent/MX2021002281A/es unknown
- 2019-08-28 US US16/553,312 patent/US11754569B2/en active Active
- 2019-08-28 EA EA202190032A patent/EA202190032A1/ru unknown
- 2019-08-28 KR KR1020207037969A patent/KR20210053816A/ko active Search and Examination
- 2019-08-28 BR BR112020026348-6A patent/BR112020026348A2/pt unknown
- 2019-08-28 CN CN201980055175.3A patent/CN112601963A/zh active Pending
- 2019-08-28 EP EP19773980.8A patent/EP3775926A1/en active Pending
- 2019-08-28 AU AU2019333047A patent/AU2019333047A1/en active Pending
- 2019-08-28 SG SG11202011969WA patent/SG11202011969WA/en unknown
- 2019-08-28 JP JP2021504752A patent/JP2021535361A/ja active Pending
- 2019-08-28 CA CA3100038A patent/CA3100038A1/en active Pending
-
2021
- 2021-02-15 IL IL280884A patent/IL280884A/en unknown
-
2023
- 2023-07-06 US US18/218,957 patent/US20240019443A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20240019443A1 (en) | 2024-01-18 |
US11754569B2 (en) | 2023-09-12 |
CA3100038A1 (en) | 2020-03-05 |
TW202024639A (zh) | 2020-07-01 |
JP2021535361A (ja) | 2021-12-16 |
BR112020026348A2 (pt) | 2021-03-30 |
US20200072844A1 (en) | 2020-03-05 |
IL280884A (en) | 2021-04-29 |
KR20210053816A (ko) | 2021-05-12 |
WO2020047067A1 (en) | 2020-03-05 |
CN112601963A (zh) | 2021-04-02 |
EA202190032A1 (ru) | 2021-03-12 |
SG11202011969WA (en) | 2020-12-30 |
AU2019333047A1 (en) | 2020-12-03 |
EP3775926A1 (en) | 2021-02-17 |
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