HRP20191342T1 - Anti-phf-tau antitijela i njihove upotrebe - Google Patents
Anti-phf-tau antitijela i njihove upotrebe Download PDFInfo
- Publication number
- HRP20191342T1 HRP20191342T1 HRP20191342T HRP20191342T1 HR P20191342 T1 HRP20191342 T1 HR P20191342T1 HR P20191342 T HRP20191342 T HR P20191342T HR P20191342 T1 HRP20191342 T1 HR P20191342T1
- Authority
- HR
- Croatia
- Prior art keywords
- antibody
- isolated
- tau
- phf
- isotype
- Prior art date
Links
- 102100040243 Microtubule-associated protein tau Human genes 0.000 claims 4
- 101710115937 Microtubule-associated protein tau Proteins 0.000 claims 3
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000007331 pathological accumulation Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000008929 regeneration Effects 0.000 claims 1
- 238000011069 regeneration method Methods 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Management, Administration, Business Operations System, And Electronic Commerce (AREA)
Claims (12)
1. Izolirano antitijelo koje veže PHF-tau koje sadrži VH SEQ ID NO: 37 i VL SEQ ID NO:38, ili njihovu humaniziranu verziju,
gdje spomenuta humanizirana verzija ima afinitet prema PHF-tau s konstantom disocijacije (KD) manjom od ili jednakojem 10-10 M, određenom s ProteOn.
2. Izolirano antitijelo prema zahtjevu 1, gdje je antitijelo IgG izotip, opcionalno gdje je antitijelo:
(a) IgG1 izotip,
(b) IgG2 izotip,
(c) IgG3 izotip, ili
(d) IgG4 izotip.
3. Izolirano antitijelo prema zahtjevu 1 ili zahtjevu 2, gdje je antitijelo fragment antitijela, kao što je Fab, Fab’, F(ab’)2 ili Fv fragment.
4. Izolirano antitijelo prema bilo kojem od zahtjeva 1-3, gdje je antitijelo humanizirano.
5. Izolirani polinukleotid koji kodira izolirano antitijelo prema bilo kojem od zahtjeva 1-4.
6. Vektor koji sadrži polinukleotid prema zahtjevu 5.
7. Stanica domaćin koja sadrži vektor prema zahtjevu 6.
8. Postupak dobivanja antitijela koje veže PHF-tau koji obuhvaća kultivaciju stanice domaćina prema zahtjevu 7 i regeneraciju antitijela proizvedenog od stanice domaćina.
9. Farmaceutski sastav koji sadrži antitijelo prema bilo kojem od zahtjeva 1-4 i farmaceutski prihvatljiv nosač.
10. Izolirano antitijelo prema bilo kojem od zahtjeva 1-4 za upotrebu u terapiji.
11. Izolirano antitijelo prema bilo kojem od zahtjeva 1-4 za upotrebu u liječenju ili prevenciji, ili smanjenju simptoma, neurodegenerativne bolesti koja uključuje patološko skupljanje tau u mozgu.
12. Izolirano antitijelo za upotrebu prema zahtjevu 11, gdje je neurodegenerativna bolest Alzheimerova bolest.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161577817P | 2011-12-20 | 2011-12-20 | |
| EP12859920.6A EP2794654B1 (en) | 2011-12-20 | 2012-12-19 | Anti-phf-tau antibodies and their uses |
| PCT/US2012/070486 WO2013096380A2 (en) | 2011-12-20 | 2012-12-19 | Anti-phf-tau antibodies and their uses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20191342T1 true HRP20191342T1 (hr) | 2019-11-01 |
Family
ID=48669693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20191342 HRP20191342T1 (hr) | 2011-12-20 | 2019-07-25 | Anti-phf-tau antitijela i njihove upotrebe |
Country Status (34)
| Country | Link |
|---|---|
| US (4) | US9371376B2 (hr) |
| EP (2) | EP2794654B1 (hr) |
| JP (4) | JP6306513B2 (hr) |
| KR (1) | KR101991681B1 (hr) |
| CN (2) | CN107226863B (hr) |
| AU (2) | AU2012359039B2 (hr) |
| BR (1) | BR112014015323B1 (hr) |
| CA (2) | CA2859665C (hr) |
| CO (1) | CO6980627A2 (hr) |
| CY (1) | CY1121862T1 (hr) |
| DK (1) | DK2794654T3 (hr) |
| EA (1) | EA027975B1 (hr) |
| EC (1) | ECSP14005975A (hr) |
| ES (1) | ES2738007T3 (hr) |
| GT (1) | GT201400127A (hr) |
| HK (2) | HK1203520A1 (hr) |
| HR (1) | HRP20191342T1 (hr) |
| HU (1) | HUE045656T2 (hr) |
| IL (3) | IL233051B (hr) |
| LT (1) | LT2794654T (hr) |
| MX (1) | MX350311B (hr) |
| MY (2) | MY186066A (hr) |
| NI (1) | NI201400061A (hr) |
| NZ (1) | NZ626269A (hr) |
| PH (1) | PH12014501427B1 (hr) |
| PL (1) | PL2794654T3 (hr) |
| PT (1) | PT2794654T (hr) |
| RS (1) | RS59024B1 (hr) |
| SG (1) | SG11201403106SA (hr) |
| SI (1) | SI2794654T1 (hr) |
| TR (1) | TR201910720T4 (hr) |
| UA (1) | UA114902C2 (hr) |
| WO (1) | WO2013096380A2 (hr) |
| ZA (1) | ZA201405317B (hr) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ626269A (en) * | 2011-12-20 | 2016-06-24 | Janssen Biotech Inc | Anti-phf-tau antibodies and their uses |
| KR102494798B1 (ko) | 2012-07-03 | 2023-02-06 | 워싱턴 유니버시티 | Tau에 대한 항체 |
| WO2014028777A2 (en) | 2012-08-16 | 2014-02-20 | Ipierian, Inc. | Methods of treating a tauopathy |
| US8980270B2 (en) | 2013-01-18 | 2015-03-17 | Ipierian, Inc. | Methods of treating a tauopathy |
| CN105939722A (zh) | 2014-02-14 | 2016-09-14 | 伊皮埃里安股份有限公司 | Tau肽，抗Tau抗体，及其使用方法 |
| JP2017521063A (ja) * | 2014-06-26 | 2017-08-03 | ヤンセン ファッシンズ アンド プリベンション ベーフェーＪａｎｓｓｅｎ Ｖａｃｃｉｎｅｓ ＆ Ｐｒｅｖｅｎｔｉｏｎ Ｂ．Ｖ． | 微小管結合タンパク質タウに特異的に結合する抗体及び抗原結合断片 |
| ZA201608812B (en) * | 2014-06-26 | 2019-08-28 | Janssen Vaccines & Prevention Bv | Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau |
| TWI664190B (zh) | 2014-06-27 | 2019-07-01 | 美商Ｃ２Ｎ醫療診斷有限責任公司 | 人類化抗－ｔａｕ抗體 |
| WO2016112078A2 (en) * | 2015-01-08 | 2016-07-14 | Janssen Biotech, Inc. | Anti-phf-tau antibodies and their uses |
| AR103713A1 (es) | 2015-02-26 | 2017-05-31 | Lilly Co Eli | Anticuerpos contra tau y sus usos |
| TWI827405B (zh) | 2015-06-05 | 2023-12-21 | 美商建南德克公司 | 抗-ｔａｕ抗體及使用方法 |
| CA2991451A1 (en) * | 2015-07-06 | 2017-01-12 | Ucb Biopharma Sprl | Tau-binding antibodies |
| CN107849105B (zh) | 2015-07-06 | 2021-09-17 | Ucb生物制药有限责任公司 | Tau结合抗体 |
| EP3448875A4 (en) * | 2016-04-29 | 2020-04-08 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| JP6949102B2 (ja) | 2016-08-09 | 2021-10-13 | イーライ リリー アンド カンパニー | 併用療法 |
| JP7193457B2 (ja) | 2016-12-07 | 2022-12-20 | ジェネンテック， インコーポレイテッド | 抗ｔａｕ抗体及び使用方法 |
| CA3045294A1 (en) | 2016-12-07 | 2018-06-14 | Genentech, Inc. | Anti-tau antibodies and methods of use |
| MA47499A (fr) | 2017-02-17 | 2019-12-25 | Denali Therapeutics Inc | Anticorps anti-tau et leurs procédés d'utilisation |
| JOP20180014A1 (ar) | 2017-02-27 | 2019-01-30 | Teijin Pharma Ltd | جسم مضاد متوافق مع البشر لعلاج أو الوقاية من الاضطرابات الإدراكية، وعملية لإنتاجه، وعامل لعلاج أو الوقاية من الاضطرابات الإدراكية باستخدامه |
| JOP20180021A1 (ar) * | 2017-03-16 | 2019-01-30 | Janssen Biotech Inc | الأجسام المضادة لتكتلات خيوط بروتين تاو (tau) الحلزونية المزدوجة واستخداماتها |
| JOP20200074A1 (ar) | 2017-10-16 | 2020-04-30 | Eisai R&D Man Co Ltd | أجسام مضادة ضد tau واستخداماتها |
| BR112020018193A2 (pt) * | 2018-03-05 | 2021-02-02 | Janssen Pharmaceutica Nv | ensaios para detectar neurodegeneração |
| SG11202008579UA (en) * | 2018-03-05 | 2020-10-29 | Janssen Pharmaceutica Nv | Anti-phf-tau antibodies and uses thereof |
| CA3095443A1 (en) * | 2018-03-28 | 2019-10-03 | Axon Neuroscience Se | Antibody-based methods of detecting and treating alzheimer's disease |
| JP2021530552A (ja) | 2018-07-31 | 2021-11-11 | イーライ リリー アンド カンパニー | 併用療法 |
| KR20230020394A (ko) | 2020-04-15 | 2023-02-10 | 보이저 테라퓨틱스, 인크. | Tau 결합 화합물 |
| US20230265175A1 (en) | 2020-06-25 | 2023-08-24 | Merck Sharp & Dohme Llc | High affinity antibodies targeting tau phosphorylated at serine 413 |
| CN117043183A (zh) | 2020-12-16 | 2023-11-10 | 沃雅戈治疗公司 | Tau结合化合物 |
| BR112023019546A2 (pt) | 2021-03-26 | 2023-10-31 | Janssen Biotech Inc | Anticorpos anti-tau e usos dos mesmos |
| KR20230162793A (ko) * | 2021-03-26 | 2023-11-28 | 얀센 바이오테크 인코포레이티드 | 쌍 나선형 필라멘트 타우에 대한 인간화 항체 및 이의 용도 |
| WO2023250388A1 (en) | 2022-06-22 | 2023-12-28 | Voyager Therapeutics, Inc. | Tau binding compounds |
| WO2024059739A1 (en) | 2022-09-15 | 2024-03-21 | Voyager Therapeutics, Inc. | Tau binding compounds |
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2012
- 2012-12-19 NZ NZ626269A patent/NZ626269A/en unknown
- 2012-12-19 KR KR1020147019911A patent/KR101991681B1/ko active IP Right Grant
- 2012-12-19 RS RS20190932A patent/RS59024B1/sr unknown
- 2012-12-19 MY MYPI2017000364A patent/MY186066A/en unknown
- 2012-12-19 EP EP12859920.6A patent/EP2794654B1/en active Active
- 2012-12-19 CN CN201710472573.8A patent/CN107226863B/zh active Active
- 2012-12-19 BR BR112014015323-0A patent/BR112014015323B1/pt active IP Right Grant
- 2012-12-19 PL PL12859920T patent/PL2794654T3/pl unknown
- 2012-12-19 MX MX2014007476A patent/MX350311B/es active IP Right Grant
- 2012-12-19 CA CA2859665A patent/CA2859665C/en active Active
- 2012-12-19 CN CN201280062971.8A patent/CN104024274B/zh active Active
- 2012-12-19 SG SG11201403106SA patent/SG11201403106SA/en unknown
- 2012-12-19 HU HUE12859920A patent/HUE045656T2/hu unknown
- 2012-12-19 CA CA3234629A patent/CA3234629A1/en active Pending
- 2012-12-19 TR TR2019/10720T patent/TR201910720T4/tr unknown
- 2012-12-19 WO PCT/US2012/070486 patent/WO2013096380A2/en active Application Filing
- 2012-12-19 UA UAA201408042A patent/UA114902C2/uk unknown
- 2012-12-19 PT PT12859920T patent/PT2794654T/pt unknown
- 2012-12-19 US US14/363,888 patent/US9371376B2/en active Active
- 2012-12-19 LT LT12859920T patent/LT2794654T/lt unknown
- 2012-12-19 AU AU2012359039A patent/AU2012359039B2/en active Active
- 2012-12-19 DK DK12859920.6T patent/DK2794654T3/da active
- 2012-12-19 SI SI201231610T patent/SI2794654T1/sl unknown
- 2012-12-19 MY MYPI2014701643A patent/MY178142A/en unknown
- 2012-12-19 JP JP2014548811A patent/JP6306513B2/ja active Active
- 2012-12-19 ES ES12859920T patent/ES2738007T3/es active Active
- 2012-12-19 EA EA201491224A patent/EA027975B1/ru not_active IP Right Cessation
- 2012-12-19 EP EP19173615.6A patent/EP3578567A1/en active Pending
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2014
- 2014-06-10 IL IL233051A patent/IL233051B/en active IP Right Grant
- 2014-06-19 NI NI201400061A patent/NI201400061A/es unknown
- 2014-06-20 EC ECIEPI20145975A patent/ECSP14005975A/es unknown
- 2014-06-20 GT GT201400127A patent/GT201400127A/es unknown
- 2014-06-20 CO CO14134449A patent/CO6980627A2/es unknown
- 2014-06-20 PH PH12014501427A patent/PH12014501427B1/en unknown
- 2014-07-18 ZA ZA2014/05317A patent/ZA201405317B/en unknown
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2015
- 2015-04-24 HK HK15103967.6A patent/HK1203520A1/xx unknown
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- 2016-04-26 US US15/138,635 patent/US9745371B2/en active Active
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2019
- 2019-06-10 JP JP2019108147A patent/JP6987809B2/ja active Active
- 2019-07-25 HR HRP20191342 patent/HRP20191342T1/hr unknown
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2020
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2021
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